Stem Cells Restore Some Vision in Blind Mice
WEDNESDAY, Aug. 15, 2018 -- Scientists say they have restored some degree of vision in blind lab mice, by activating stem cells in their eyes. The procedure is the first of its kind and the researchers hope it will lead to treatments for incurable... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 15, 2018 Category: General Medicine Source Type: news

This matrix delivers healing stem cells to injured elderly muscles
(Georgia Institute of Technology) Muscles of the elderly and of patients with Duchene muscular dystrophy have trouble regenerating. A new nanohydrogel with muscle stem cells has boosted muscle growth in mouse models while protecting the stem cells from immune reactions that usually weaken or destroy them. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 15, 2018 Category: International Medicine & Public Health Source Type: news

Artificial Intelligence scanner 'as good as eye experts'
AI system developed at Moorfields made right referral in 94% of cases Related items fromOnMedica Tackle continuing eye care crisis now, royal college urges Hunt Stem cell 'patch' offers hope for macular degeneration Eye health care placing avoidable pressure on GPs in London Fund cheap supplement for degenerative eye disease, NHS urged (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 14, 2018 Category: UK Health Source Type: news

FDA Warns Against Long - Term Azithromycin Use for Some
Warning for blood cancer patients who have undergone donor stem cell transplant (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - August 13, 2018 Category: Cancer & Oncology Tags: Infections, Oncology, Pharmacy, Pulmonology, Journal, Source Type: news

FDA Warns Against Long-Term Azithromycin Use for Some
MONDAY, Aug. 13, 2018 -- The U.S. Food and Drug Administration is warning patients with cancers of the blood or lymph nodes who undergo a donor stem cell transplant not to take azithromycin, as long-term use of the antibiotic has been associated... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 13, 2018 Category: Pharmaceuticals Source Type: news

Platelet-rich plasma does not promote stem cell-mediated cartilage repair
(Mary Ann Liebert, Inc./Genetic Engineering News) Platelet-rich plasma (PRP) is believed to provide pain relief and help improve joint function in degenerative joint disease, but a new study has shown that it does not act by promoting stem cell proliferation or enhance the cartilage formation capabilities of mesenchymal stem cells (MSCs). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 13, 2018 Category: International Medicine & Public Health Source Type: news

BioEclipse looks to synergistic therapies to topple stubborn cancers
For the last 20 years, Pamela Contag has studied cancer. And in that time, the world’s understanding of cancer has changed dramatically. “I remember when people were saying ‘One gene, one protein,” which we now know is wrong,” she told Drug Delivery Business News. “And then we thought cancer was a disruption in proliferation and really it’s about modulating programmed cell death and stem cells and the tumor microenvironment. And in fact, there’s this huge immunity component to the disease process. “So we’ve changed a lot from thinking about it as a proliferat...
Source: Mass Device - August 9, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Oncology Pharmaceuticals bioeclipsetherapeutics Source Type: news

Tbx6 revealed as crucial to heart and skeleton formation from stem cells
(University of Tsukuba) In a study of over 50 transcription factors, Tbx6 alone was able to stimulate mesoderm formation in laboratory-grown stem cells, and could cause those stem cells to become cardiovascular or musculoskeletal cells; the University of Tsukuba-led research team found that this essential role of Tbx6 in mesoderm and cardiovascular speci?cation is conserved from lower organisms to mammals. This research report validated a new direct reprogramming-based approach that may enhance future regenerative medicine research. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 9, 2018 Category: Biology Source Type: news

Back to the future: breast cancer reprises pathways found in fetal cells
(Salk Institute) Salk Institute scientists have uncovered a reason for the uncanny likeness between cells in the most malignant cancers and the embryonic cells of the organ in which the cancer originated: cells in human basal-like breast cancers share features with the embryonic mammary (breast) stem cells that are the progenitors of all cell types in the mammary gland (of a mouse). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 7, 2018 Category: Cancer & Oncology Source Type: news

Stowers breakthrough could make stem cells available where bone marrow matches aren't
A new discovery by the Stowers Institute of Medical Research could make more resources available to patients who might not have a bone marrow transplant match available. In cases where a patient with leukemia or a blood disorder doesn't have a bone marrow match, blood-forming adult stem cells from the umbilical cord can be transplanted. Just 30 percent of patients have a donor match in their family. However, adult patients need about two cords' worth for treatmen t, meaning there aren't enough available… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - August 6, 2018 Category: American Health Authors: Elise Reuter Source Type: news

Stowers breakthrough could make stem cells available where bone marrow matches aren't
A new discovery by the Stowers Institute of Medical Research could make more resources available to patients who might not have a bone marrow transplant match available. In cases where a patient with leukemia or a blood disorder doesn't have a bone marrow match, blood-forming adult stem cells from the umbilical cord can be transplanted. Just 30 percent of patients have a donor match in their family. However, adult patients need about two cords' worth for treatmen t, meaning there aren't enough available… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 6, 2018 Category: Biotechnology Authors: Elise Reuter Source Type: news

Created line of spinal cord neural stem cells shows diverse promise
(University of California - San Diego) Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods of time. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 6, 2018 Category: International Medicine & Public Health Source Type: news

The Use and Misuse of PRP, Stem Cells and Biologics in Orthopaedics
Amid the swirl of competing claims about platelet-rich plasma, stem cells, and other biologic therapies stands the orthopaedic surgeon, like a lighthouse, to guide the public and patients who are hoping to benefit from the claims made about these agents.  (Source: Orthogate - Latest News)
Source: Orthogate - Latest News - August 5, 2018 Category: Orthopaedics Tags: Featured Editors Choice News Source Type: news

Stem cell transplants to be used in treating Crohn's disease
(Queen Mary University of London) A clinical trial has begun which will use stem cell transplants to grow a new immune system for people with untreatable Crohn's disease -- a painful and chronic intestinal disease which affects at least 115,000 people in the UK. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 5, 2018 Category: International Medicine & Public Health Source Type: news

FDA Warns Against Long-Term Zmax Use in Certain Cancer Patients
(MedPage Today) -- Heightened risk of relapse, death seen in study of stem cell transplant recipients (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - August 3, 2018 Category: American Health Source Type: news

FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients
The FDA warns of an increased risk for relapse of hematologic malignancy and for death when azithromycin is used to prevent bronchiolitis obliterans syndrome in hematopoietic stem cell transplant patients.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 3, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA warns about increased risk of cancer relapse with long-term use of azithromycin (Zithromax, Zmax) antibiotic after donor stem cell transplant
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 3, 2018 Category: Drugs & Pharmacology Source Type: news

New research opens door to expanding stem cells available for transplants
(Stowers Institute for Medical Research) Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 3, 2018 Category: International Medicine & Public Health Source Type: news

UCLA researchers discover how the body regenerates blood vessel lining
Normal wear and tear damages the blood vessel lining, which is called the endothelial lining. The body, however, has the ability to initiate molecular activity that regenerates and repairs this damage. Now, researchers at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have for the first time followed this regeneration in progress and identified the genes and proteins responsible for spurring it. Their findings could eventually lead to novel methods to repair more severe blood vessel damage, including damage that can result from placing stents — metal or plast ic mes...
Source: UCLA Newsroom: Health Sciences - August 2, 2018 Category: Universities & Medical Training Source Type: news

Can Arthritic Dogs Benefit From Stem Cell Therapy?
In this study, stem cells were gathered from fat tissue in each dog and injected back into the same dog at the site of the arthritic joint. The dog was able to go home the same day as the procedure. (Source: WebMD Health)
Source: WebMD Health - August 2, 2018 Category: Consumer Health News Source Type: news

Can Arthritic Dogs (and Their Owners) Benefit From Stem Cell Injections?
THURSDAY, Aug. 2, 2018 -- If dogs with arthritis can gain benefit from stem cell injections, maybe people can, too. That's the opinion of an Italian veterinarian who oversaw the stem cell procedures in 130 arthritic dogs. " For at least six months,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 2, 2018 Category: General Medicine Source Type: news

Can Arthritic Dogs (and Their Owners) Benefit From Stem Cell Injections?
Title: Can Arthritic Dogs (and Their Owners) Benefit From Stem Cell Injections?Category: Health NewsCreated: 8/2/2018 12:00:00 AMLast Editorial Review: 8/2/2018 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - August 2, 2018 Category: Rheumatology Source Type: news

HAIRY MERISTEM with WUSCHEL confines CLAVATA3 expression to the outer apical meristem layers
The control of the location and activity of stem cells depends on spatial regulation of gene activities in the stem cell niche. Using computational and experimental approaches, we have tested and found support for a hypothesis for gene interactions that specify the Arabidopsis apical stem cell population. The hypothesis explains how the WUSCHEL gene product, synthesized basally in the meristem, induces CLAVATA3-expressing stem cells in the meristem apex but, paradoxically, not in the basal domain where WUSCHEL itself is expressed. The answer involves the activity of the small family of HAIRY MERISTEM genes, which prevent t...
Source: ScienceNOW - August 2, 2018 Category: Science Authors: Zhou, Y., Yan, A., Han, H., Li, T., Geng, Y., Liu, X., Meyerowitz, E. M. Tags: Botany, Development reports Source Type: news

Enough but not too many stem cells
(Source: ScienceNOW)
Source: ScienceNOW - August 2, 2018 Category: Science Authors: Hines, P. J. Tags: Botany, Development twis Source Type: news

Getting Micro: The Deal With Stem Cells
Stem cells represent an exciting scientific frontier, but they're also capable of producing some scary results.(Image credit: SAM PANTHAKY/AFP/Getty Images) (Source: NPR Health and Science)
Source: NPR Health and Science - August 1, 2018 Category: Consumer Health News Source Type: news

A breakthrough for understanding GBM: Origin cells for deadly brain tumors identified
(The Korea Advanced Institute of Science and Technology (KAIST)) A new study by KAIST researchers identified where the mutation causing glioblastoma starts. According to the study, neural stem cells away from the tumor mass are the cells of origin that contain mutation drivers for glioblastoma, one of the most aggressive brain tumor. This breakthrough research, reported in Nature on August 1, 2018, gives insights for understanding why glioblastomas almost always grow back, even after surgery, and suggests novel ways to treat glioblastoma, which was previously thought to be incurable. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 1, 2018 Category: Cancer & Oncology Source Type: news

Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice
(University of Illinois at Urbana-Champaign) After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that's more aggressive and resistant to treatment. University of Illinois researchers have developed a molecular probe that seeks out these elusive cells and lights them up so they can be identified, tracked and studied not only in cell cultures, but in their native environment: the body. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 1, 2018 Category: International Medicine & Public Health Source Type: news

NYSCF partners with TOOLGEN, NSAGE to integrate gene editing and stem cell technologies
(New York Stem Cell Foundation) The New York Stem Cell Foundation (NYSCF) Research Institute today announced a strategic partnership with Korean firms ToolGen, Inc., and nSAGE, Inc.. In a Memorandum of Understanding, the organizations agreed to collaborate in the development of innovative therapeutics by leveraging cutting-edge gene editing and stem cell technologies. NYSCF will be a strategic partner to a new company being created for this purpose by ToolGen and nSAGE. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - August 1, 2018 Category: International Medicine & Public Health Source Type: news

Trial Launched to Treat Parkinson's with Reprogrammed Stem Cells
Surgeons will inject approximately 5 million dopamine-producing progenitor cells into patients' brains. (Source: The Scientist)
Source: The Scientist - July 31, 2018 Category: Science Tags: News & Opinion Source Type: news

Alzheimer's Drug Debate; Concussion Tests; Stem Cells and Parkinson's
(MedPage Today) -- News and commentary from the world of neurology and neuroscience (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - July 31, 2018 Category: Neurology Source Type: news

Trial Launched to Treat Parkinson & rsquo;s with Reprogrammed Stem Cells
(Source: The Scientist)
Source: The Scientist - July 31, 2018 Category: Science Tags: News & Opinion Source Type: news

Robot expert predicts the rise of a human-bot hybrid species in the next 100 years
(Natural News) Today’s advancement in stem cell research and artificial chromosomes may help humans make babies with robots in the future, leading artificial intelligence expert Dr. David Levy claimed. According to the author of Love and Sex with Robots, the development of human-robot hybrids may well occur within the next 100 years. Dr. Levy’s predictions were based on a number of studies that... (Source: NaturalNews.com)
Source: NaturalNews.com - July 30, 2018 Category: Consumer Health News Source Type: news

First human trial of stem cells against Parkinson's to start in Japan
The first human trial using a kind of stem cell to treat Parkinson's disease will begin this week. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 30, 2018 Category: Consumer Health News Source Type: news

Stem Cells: Opportunities, Hurdles, and Promises
The Scientist is bringing together a panel of experts to discuss the grand opportunity stem cells represent. (Source: The Scientist)
Source: The Scientist - July 30, 2018 Category: Science Tags: Sponsored Webinars Source Type: news

Stem Cells: Opportunities, Hurdles, and Promises
(Source: The Scientist)
Source: The Scientist - July 30, 2018 Category: Science Source Type: news

Japan scientists to use 'reprogrammed' stem cells to fight Parkinson's
Japanese scientists said on Monday they will start clinical trials next month on a treatment for Parkinson's disease, transplanting "reprogrammed" stem cells into brains, seeking a breakthrough in treating the neurodegenerative disorder. (Source: Reuters: Health)
Source: Reuters: Health - July 30, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Unsafe Ocular Stem Cell Treatments Prevalent Unsafe Ocular Stem Cell Treatments Prevalent
Experimental stem cell therapies for eye conditions have resulted in serious adverse events, including blinding complications, and should be avoided, investigators caution.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 27, 2018 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

U of G study is first to find evidence that leopard geckos can make new brain cells
(University of Guelph) University of Guelph researchers have discovered the type of stem cell allowing geckos to create new brain cells. This finding provides evidence that lizards may also be able to regenerate parts of the brain after injury. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 27, 2018 Category: International Medicine & Public Health Source Type: news

This engineered heart ventricle helps with studying arrhythmia and cardiomyopathy
[Luke MacQueen and Michael Rosnach/Harvard University]While engineered heart tissues can replicate muscle contraction and electrical activity in a dish, many aspects of heart disease can only adequately be captured in 3D. In a report published online yesterday by Nature Biomedical Engineering, researchers describe a scale model of a heart ventricle, built to replicate the chamber’s architecture, physiology and contractions. Cardiac researchers at Boston Children’s Hospital think it could help them find treatments for congenital heart diseases. Building a 3D engineered heart ventricle Collaborators from the Harv...
Source: Mass Device - July 26, 2018 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog Vector Blog Source Type: news

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Models of gene control have emerged from genetic and biochemical studies, with limited consideration of the spatial organization and dynamics of key components in living cells. We used live-cell superresolution and light-sheet imaging to study the organization and dynamics of the Mediator coactivator and RNA polymerase II (Pol II) directly. Mediator and Pol II each form small transient and large stable clusters in living embryonic stem cells. Mediator and Pol II are colocalized in the stable clusters, which associate with chromatin, have properties of phase-separated condensates, and are sensitive to transcriptional inhibi...
Source: ScienceNOW - July 26, 2018 Category: Science Authors: Cho, W.-K., Spille, J.-H., Hecht, M., Lee, C., Li, C., Grube, V., Cisse, I. I. Tags: Biochemistry, Cell Biology reports Source Type: news

Happy 40th Birthday IVF. Now let ’s discuss your dirty secret | Zeynep Gurtin
As the world ’s first IVF baby tuns 40, it’s time to make fertility treatment more widely available in the UK and abroadToday marks the40th anniversary of the first IVF birth. Louise Brown, born in Oldham General Hospital in 1978, was heralded by the world ’s press as a British medical marvel and a beacon of hope for people with fertility problems. Forty years later, IVF has unquestionably transformed the lives of millions of men and women, giving them the children they so deeply desired. But, despite its evident positives, IVF also hides a dirty se cret: its benefits remain largely limited to those who c...
Source: Guardian Unlimited Science - July 25, 2018 Category: Science Authors: Zeynep Gurtin Tags: IVF Fertility problems Health Society NHS Health policy Public services policy Politics UK news Reproduction Biology Science Source Type: news

Artificial Mouse Embryo Made in a Laboratory
The embryo, grown in a dish from several types of stem cells, went through gastrulation, a significant stage in development. (Source: The Scientist)
Source: The Scientist - July 25, 2018 Category: Science Tags: News & Opinion Source Type: news

A new milestone in laboratory grown human brain tissue
(Case Western Reserve University) A cutting-edge laboratory technique that turns human stem cells into brain-like tissue now recapitulates human brain development more accurately than ever, according to a new study from Case Western Reserve University School of Medicine. The study, published in Nature Methods, demonstrates how to grow brain 'organoids' -- self-organizing mini spheres that now contain all the major cell types found in the human cerebral cortex -- in laboratory dishes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 25, 2018 Category: International Medicine & Public Health Source Type: news

Scientists Take Step Towards Creating Artificial Embryos Scientists Take Step Towards Creating Artificial Embryos
An international team of scientists has moved closer to creating artificial embryos after using mouse stem cells to make structures capable of taking a crucial step in the development of life.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - July 24, 2018 Category: Transplant Surgery Tags: Pathology & Lab Medicine News Source Type: news

A fight for sight that we all need to join | Letters
Betty Boothroyd, former Speaker of the House of Commons, calls for more research funding for eye healthRe your article on age-related macular degeneration (G2, 16 July), this week the eye research charityFight for Sight is launching a campaign to raise awareness of eye health and the desperate need for more research funding. This is an issue close to my heart. Many people of my age are starting to have difficulty with their sight and over 2 million people in the UK are affected by sight loss – a figure set to double by 2050. The answer lies in research. Breakthroughs have already led to pioneering treatment...
Source: Guardian Unlimited Science - July 24, 2018 Category: Science Authors: Letters Tags: Medical research Society Health Science Source Type: news

Adult neurogenesis and its role in brain injury and psychiatric diseases - Hayashi Y, Jinnou H, Sawamoto K, Hitoshi S.
In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions, the walls of the lateral ventricles and the subgranular zone of the hippocampus, which generate new neurons for the olfactory bulb and dentate gyrus, respectively. The... (Source: SafetyLit)
Source: SafetyLit - July 24, 2018 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Researchers characterize 'mutational burden' of human induced pluripotent stem cells
(University of California - San Diego) In a new study, published in this week's issue of Cell Reports, researchers at the University of California San Diego School of Medicine scrutinized the whole genome sequences of 18 induced pluripotent stem cell lines derived from skin cells that they had reprogrammed to identify and characterize somatic mutations. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 24, 2018 Category: International Medicine & Public Health Source Type: news

The transcription factor Lef1 switches partners from {beta}-catenin to Smad3 during muscle stem cell quiescence
Skeletal muscle stem cells (MuSCs), also known as satellite cells, persist in adult mammals by entering a state of quiescence (G0) during the early postnatal period. Quiescence is reversed during damage-induced regeneration and re-established after regeneration. Entry of cultured myoblasts into G0 is associated with a specific, reversible induction of Wnt target genes, thus implicating members of the Tcf and Lef1 (Tcf/Lef) transcription factor family, which mediate transcriptional responses to Wnt signaling, in the initiation of quiescence. We found that the canonical Wnt effector β-catenin, which cooperates with Tcf/...
Source: Signal Transduction Knowledge Environment - July 24, 2018 Category: Science Authors: Aloysius, A., DasGupta, R., Dhawan, J. Tags: STKE Research Articles Source Type: news

Asymmetrex Proposes “Stemgene Therapy” to Emphasize the Importance of...
The founder and director of stem cell biotechnology company Asymmetrex, James L. Sherley, M.D., Ph.D., continues to lead the company’s public service mission of disseminating timely scientific...(PRWeb July 24, 2018)Read the full story at https://www.prweb.com/releases/asymmetrex_proposes_stemgene_therapy_to_emphasize_the_importance_of_tissue_stem_cells_for_successful_gene_therapy/prweb15643127.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - July 24, 2018 Category: Pharmaceuticals Source Type: news

Health care roundup: Compass Health ’s $21 million funding plan; Nohla receives orphan drug status
Compass Health is building a new facility in Everett; Nohla Therapeutics' is improving stem cell transplants; and Remote Medical International has acquired a UK company. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 23, 2018 Category: Biotechnology Authors: Coral Garnick Source Type: news