OHSRP Education Series: IRB Review of Research Involving AI
Our speaker for this session is Benjamin C. Silverman, M.D. Dr. Silverman is the Senior IRB Chair at Mass General Brigham, Human Research Affairs. Additionally, Dr. Silverman is currently the Chair of the Mass General Brigham Embryonic Stem Cell Research Oversight Committee, Director of Ethics for the Institute for Technology in Psychiatry at McLean Hospital, and at Harvard Medical School, serves as an Instructor in Psychiatry and a Faculty Member in the Center for BioethicsObjectives for this session are as follows:Discuss ethical considerations raised by AIDiscuss IRB considerations for the review of research invol...
Source: Videocast - All Events - March 25, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH ProtIG seminar, Ling Hao: Capturing Organelle Dynamics in Neurons by Mass Spectrometry-based Omics Methods
Lysosomes and mitochondria are membrane-bound organelles in the cell and their dysfunctions have been linked to numerous human diseases, such as neurodegeneration, cancer, and cardiovascular disorders. These organelles are highly dynamic and frequently interact with other cellular components in a transient fashion, which are difficult to capture with traditional immunoprecipitation methods. Here, I will present our recent efforts in developing mass spectrometry-based multi-omics, proximity labeling, organelle isolation, and dynamic SILAC proteomic methods to characterize organelle microenvironment and protein dynamics in h...
Source: Videocast - All Events - February 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Immune evasion of stem cells in health and cancer
The Agudo lab is focused on the study of immune evasion of stem cells in both autoimmunity and cancer. Our goal is to identify targets to protect tissues for regeneration as well as mechanisms to ensure effective responses to immunotherapy in cancer patients. Dr. Agudo has recently discovered a population of quiescent cancer stem cells in breast cancer that survive during T cell attack and lead to resistance to immunotherapy.Air date: 11/29/2023 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinicopathologic Grand Rounds - Clinical Cases from the NIH Clinical Center: Hyperphosphatemic Familial Tumoral Calcinosis: Defining Pathomechanisms to Inform Treatment
Kelly L Roszko MD, PhDResearch Physician, Skeletal Disorders and Mineral Homeostasis SectionFaculty, Interinstitute Endocrine Training ProgramNational Institute of Dental and Craniofacial ResearchMichael Collins, MDSenior InvestigatorSkeletal Disorders& Mineral Homeostasis SectionSkeletal, Matrix,& MechanobiologyMechanisms of Development& Stem Cell FateNational Institute of Dental and Craniofacial ResearchBabak Saboury, MDPhysician-ScientistRadiology and Imaging SciencesClinical CenterDavid Kleiner, MD, PhDHead, Histopathology and Autopsy PathologySenior Research PhysicianLaboratory of PathologyCenter for Cance...
Source: Videocast - All Events - October 31, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FNIH Workshop on the Future of Regenerative Medicine and Cell-based therapies
Cellular Regenerative therapy seeks to treat diseases, restore normal cellular and organ structure and function, and provide long-standing benefits to patients using products such as pluripotent stem cells, engineered biomaterials and gene editing. The issues for use of these products include determining the quantity of supportive preclinical evidence needed prior to patient treatment, understanding the clinical information that should be captured, and production of quality product fit-for purpose – all in the context of an appropriate regulatory paradigm that facilitates patient access to safe and effective therapeutic ...
Source: Videocast - All Events - October 17, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FNIH Workshop on the Future of Regenerative Medicine and Cell-based therapies
Cellular Regenerative therapy seeks to treat diseases, restore normal cellular and organ structure and function, and provide long-standing benefits to patients using products such as pluripotent stem cells, engineered biomaterials and gene editing. The issues for use of these products include determining the quantity of supportive preclinical evidence needed prior to patient treatment, understanding the clinical information that should be captured, and production of quality product fit-for purpose – all in the context of an appropriate regulatory paradigm that facilitates patient access to safe and effective therapeutic ...
Source: Videocast - All Events - October 16, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
You contain multitudes: Somatic mutation and genomic diversity in human brain
Christopher Walsh is Bullard Professor of Pediatrics and Neurology at Harvard Medical School, Chief of the Division of Genetics at Boston Children's Hospital, and an Investigator of the Howard Hughes Medical Institute. He completed his M.D. and Ph.D. degrees at the University of Chicago. After a neurology residency and chief residency at Massachusetts General Hospital, he completed a research fellowship in genetics at Harvard Medical School. Dr. Walsh has studied patterns of neural stem cell division, cell fate choices, and cell migrations in the developing cerebral cortex, and has pioneered the analysis of human genetic d...
Source: Videocast - All Events - July 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS Lecture- William E. Paul Lecture by Diane Mathis
Dr. Mathis obtained a PhD from the University of Rochester, and performed postdoctoral studies at the Laboratoire de G é n é tique Mol é culaire des Eucaryotes in Strasbourg, France and at Stanford University Medical Center. She returned to Strasbourg at the end of 1983, establishing a laboratory at the LGME [later the Institut de Genetique et de Biologie Moleculare et Cellulaire (IGBMC)] in conjunction with Dr. Christophe Benoist. The lab moved to the Joslin Diabetes Center, Boston in 1999. Through 2008, Dr. Mathis was a Professor of Medicine at Brigham and Women ’ s Hospital and Harvard Medical School, and Associate...
Source: Videocast - All Events - July 17, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Bridging the Gap: Clinical and Basic Research to Understand COPD Mechanisms (Day 2)
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is hosting a two-day virtual workshop titled " Bridging the Gap Between Clinical and Basic Research to Understand COPD Mechanisms ” on Tuesday, June 13, and Wednesday, June 14th, 2023 from 10:00 a.m. – 4:00 p.m.
In the last decade, large longitudinal observational studies of COPD patients have collected enormous clinical, imaging, genetic, and other omics data, which have increased our understanding of the disease pathophysiology, progression, and pathogenesis. Meanwhile, technologies have advanced to all ow more powerful...
Source: Videocast - All Events - June 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Bridging the Gap Between Clinical and Basic Research to Understand COPD Mechanisms (Day 1)
The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is hosting a two-day virtual workshop titled " Bridging the Gap Between Clinical and Basic Research to Understand COPD Mechanisms ” on Tuesday, June 13, and Wednesday, June 14th, 2023 from 10:00 a.m. – 4:00 p.m.
In the last decade, large longitudinal observational studies of COPD patients have collected enormous clinical, imaging, genetic, and other omics data, which have increased our understanding of the disease pathophysiology, progression, and pathogenesis. Meanwhile, technologies have advanced to all ow more powerful...
Source: Videocast - All Events - June 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Insights Gained from Investigating Genomic Junk, Dr. Naomi Taylor
CCR Grand Rounds “ Insights Gained from Investigating Genomic Junk ”
Naomi Taylor, M.D., Ph.D.
Senior Investigator
Pediatric Oncology Branch
Center for Cancer Research, NCI
Friday, May 19, 2023
12:00 – 1:00 p.m.
Lipsett Amphitheater
(Masks required)
Also available to view via NIH Videocast.
Naomi Taylor received her M.D. and Ph.D. degrees from Yale University, studying the disruption of Epstein-Barr virus (EBV) latency under the direction of Dr. George Miller. She then returned to clinical pediatrics, pursuing training in b one marrow transplantation at Children ’ s Hospital Los Angeles. In 1996, Dr. Taylor...
Source: Videocast - All Events - May 16, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
A Fly's Eye View of Corneal Development
OBJECTIVES: 1) To understand the interplay between intrinsic transcription factors and extrinsic signals in retinal cell fate determination; 2) To appreciate the role of mechanical forces in shaping apical extracellular matrix structures such as the Drosophila corneal lens; 3) To understand how the Drosophila corneal lens can be used to model human corneal disease. LECTURE SUMMARY: The Drosophila corneal lens is a precisely curved structure made entirely of apical extracellular matrix that resembles the mammalian cornea in its ability to focus light onto the photoreceptors. The non-neuronal cone and pigment cells that...
Source: Videocast - All Events - April 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Exciting Hematopoietic Stem Cells
Prof. Gazit studies hematopoietic stem cells (HSCs) – the adult stem cells that give rise to all types of blood and immune cells. Not only are HSCs of vital importance for the entire blood and immune system, but they are also the functional unit enabling bone marrow transplants. HSCs are already saving tens of thousands of patients every year by using them in bone marrow transplants. Prof. Gazit ’ s lab seeks to directly reprogram blood cells back to HSCs in order to generate novel models for leukemia study and understand HSCs within the immune response. Using advanced molecular biology enables the discovery of key reg...
Source: Videocast - All Events - February 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Sequence Dependent RNA Pol II Pausing is a Determinant of Human Gene Expression
How Nucleic Acid Structure and Chromatin Environment Influence Gene Transcription
Jason Watts, MD, PhD
Earl Stadtman Investigator
Epigenetics& Stem Cell Biology Laboratory
Transcriptional Responses in Disease Group
National Institute of Environmental Health Sciences, NIEHSFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 2/15/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH/FDA IIG Seminar - Exciting Hematopoietic Stem Cells
Prof. Gazit studies hematopoietic stem cells (HSCs) – the adult stem cells that give rise to all types of blood and immune cells. Not only are HSCs of vital importance for the entire blood and immune system, but they are also the functional unit enabling bone marrow transplants. HSCs are already saving tens of thousands of patients every year by using them in bone marrow transplants. Prof. Gazit ’ s lab seeks to directly reprogram blood cells back to HSCs in order to generate novel models for leukemia study and understand HSCs within the immune response. Using advanced molecular biology enables the discovery of key reg...
Source: Videocast - All Events - February 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
