Bridging the Gap: Clinical and Basic Research to Understand COPD Mechanisms (Day 2)

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) is hosting a two-day virtual workshop titled " Bridging the Gap Between Clinical and Basic Research to Understand COPD Mechanisms ” on Tuesday, June 13, and Wednesday, June 14th, 2023 from 10:00 a.m. – 4:00 p.m. In the last decade, large longitudinal observational studies of COPD patients have collected enormous clinical, imaging, genetic, and other omics data, which have increased our understanding of the disease pathophysiology, progression, and pathogenesis. Meanwhile, technologies have advanced to all ow more powerful animal, organ/tissue, cellular, and organoid systems that could enable further mechanistic understanding. However, the findings of clinical research have not readily mapped into hypothesis-driven basic research. COPD is clinically complex and heterogeneous. A variety of hypotheses h ave been raised for mechanisms of COPD onset and progression, including airway and parenchyma epithelial injury and abnormal tissue repair and remodeling, pulmonary vasculature and lymphatic dysfunction, immune cell dysfunction and recurrent inflammation, progenitor/stem cell dysfunction and inadequ ate repair, excessive protease activity, autoimmunity, cell death (apoptosis, necrosis, necroptosis, ferroptosis, etc.), senescence and accelerated aging, oxidative stress, fibrosis, and genetic risk. However, we lack consensus on mechanisms driving COPD onset and progression, likely...
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