NIDCR Clinical Research Fellowship Grand Round: The temporomandibular Joint (TMJ)
The temporomandibular joint (TMJ) is the synovial joint of craniofacial complex and is critical for dental occlusion, mastication, and speech. TMJ trauma and diseases, such as osteoarthritis, are debilitating and compromise quality of life. Current TMJ treatments are two-fold, involving either palliative care or invasive total joint replacement surgeries. There are no minimally invasive, regenerative TMJ therapies. We have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat and vascularized bone. Here we define heterogeneous populations of TMJ fibrocartilage stem cells and the...
Source: Videocast - All Events - October 9, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Grand Rounds: Women in Science - Targeted therapy for fibrous dysplasia/McCune-Albright syndrome: Lessons learned and new approaches
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a mosaic disease resulting in fractures, pain, and disability. G α s mutations disrupt differentiation of skeletal stem cells, leading to marrow fibrosis and increased bone-resorbing osteoclasts. The resulting bone develops one or many expansile, deforming lesions. There are no effective treatments for FD/MAS, and clinical studies have been challenging due to knowledge gaps in pathogenesis, natural history, and clinically relevant endpoints for clinical trials. Anti-resorptive therapy with bisphosphonates has been advocated due to prominent osteoclastogenesis in FD ti...
Source: Videocast - All Events - September 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Grand Rounds: Women in Science – Stem Cells in Jaw Growth and Disease
NIDCR Grand Rounds
The temporomandibular joint (TMJ) is a complex joint and the only bilateral joints that must function together as one unit to support mastication and speech. TMJ trauma and diseases, such as osteoarthritis, can be debilitating and severely reduce quality of life. Current TMJ treatments generally involve either pain management or invasive surgeries, such as total joint replacement surgery. There are no minimally invasive, regenerative TMJ therapies. Dr. Embree and her lab have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat, and vascularized bone. She has...
Source: Videocast - All Events - February 27, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Sayer Vision Research Lecture: Translating RPE Biology into Disease Treatments using iPS Cells
12th Sayer Vision Research Lecture
Dr. Bharti's laboratory developed and functionally validated in vitro models of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelial cells (RPE). The RPE cells, matured on a biodegradable scaffold, formed a functional monolayer patch. The FDA recently approved a phase I/IIa safety and feasibility clinical trial to test an autologous iPSC-RPE patch in patients with the geographic atrophy form of age-related macular degeneration.Air date: 4/21/2020 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Rear Admiral (Upper Half) Richard W. Childs Flag Promotion Ceremony
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Next Generation National ATE Center of Excellence for Biotechnology and Life Sciences
At the Next Generation National Advanced Technological Education (ATE) Center of Excellence
for Biotechnology and Life Sciences located at the City College of San Francisco in San Francisco, California, instructional materials teach students to use aseptic techniques to manipulate mouse stem cells ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - June 12, 2019 Category: Science Source Type: video
Neuroscience Seminar: Time to Wake Up: Regulation of Neural Stem Cell Quiescence and Reactivation
NIH Neuroscience Series Seminar
Stem cell populations in tissues as varied as blood, gut and brain spend much of their time in a mitotically dormant, quiescent, state. A key point of regulation is the decision between quiescence and proliferation. The ability to reactivate neural stem cells in situ raises the prospect of potential future therapies for brain repair after damage or neurodegenerative disease.
Understanding the molecular basis for stem cell reactivation is an essential first step in this quest. In Drosophila, quiescent neural stem cells are easily identifiable and amenable to genetic manipulation, making them ...
Source: Videocast - All Events - June 7, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Neuroscience Series Seminar: Time to wake up: regulation of neural stem cell quiescence and reactivation
NIH Neuroscience Series SeminarFor more information go tohttps://neuroscience.nih.gov/neuroseries/home.aspxAir date: 6/10/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 7, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Stem Cell Symposium 2019
The 2019 NIH Stem Cell Symposium will be videocast on Monday May 13th 2019. The Symposium is supported by the National Institute for Neurological Disorders and Stroke and co-organized by members of NINDS, NIDCR, NHLBI and NCATS. This event boasts some distinguished extramural researchers as well as a mix of established intramural investigators and junior staff. Topics will cover adult as well as pluripotent stem cells, new technologies and translational research.For more information go tohttps://meetings.ninds.nih.gov/Home/Index/20182Air date: 5/13/2019 8:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - May 9, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI Sayer Lecture: Clinical features and molecular basis of the cerebellar-retinal degenerative disorder SpinoCerebellar Ataxia type 7: From mechanism to therapy
NEI Sayer Lecture
Spinocerebellar ataxia type 7 (SCA7) is an inherited neurological disorder characterized by cerebellar and retinal degeneration. SCA7 patients develop atrophy of the cerebellar cortex and the brainstem, and exhibit extensive loss of cerebellar Purkinje cells. An important feature of SCA7, that allows it to be distinguished from the 40+ other SCAs, is retinal degeneration. Full field electroretinograms of SCA7 patients reveal marked dysfunction of cone photoreceptor cells prior to rod photoreceptor abnormalities, establishing SCA7 as a cone-rod dystrophy. As retinal disease progresses, rod photoreceptors b...
Source: Videocast - All Events - April 11, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Hematopoietic Stem Cell Derivation from Pluripotent Stem Cells
The NHLBI 70th Anniversary Lecture Series is designed to highlight not only significant advancements in the field of heart, lung, blood, and sleep research, but to also provide a visionary perspective of the promising opportunities ahead including addressing some of the most compelling questions and critical challenges elicited in the 2016 NHLBI Strategic Vision. The lectures include presentations from thought leaders in the medical field. All clinicians, trainees including fellows, medical students, Ph.D. students, healthcare and research professionals, and interested members of the public. The sixth and final lecture in ...
Source: Videocast - All Events - October 22, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Travelling through tissues one cell at a time: the Human Cell Atlas and barrier tissues
NIH Director's Wednesday Afternoon Lecture Series
Dr. Teichmann's group seeks to elucidate general principles of gene expression and protein complex assembly. Her lab is trying to understand how changes in cell state are regulated at the transcriptomic and epigenetic levels by studying the differentiation of mouse T helper (Th) cells and embryonic stem cells (mESC) at the single cell level. Her lab uses and develops both computational and experimental approaches in the field of single cell genomics to address our questions. Her lab also study protein complexes in terms of their 3D structure, structural evolution and the pr...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Special CCR Grand Rounds: 1) Pooled CRISPR Screens for Cancer Biology and 2) Dietary control of intestinal stem cells in physiology and disease
Special CCR Grand Rounds – 2018 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture
The Wachtel Cancer Research Award is presented to young cancer researchers who have made outstanding contributions to the cancer field.
This is the sixth lecture for the AAAS Martin and Rose Wachtel Cancer Research Award sponsored by the American Association for the Advancement of Science(AAAS) and Science Translational Medicine. The National Cancer Institute (NCI) Center for Cancer Research (CCR) is co-hosting the event.Air date: 8/10/2018 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - August 6, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Time to wake up: regulation of neural stem cell quiescence and reactivation
NIH Neuroscience Series SeminarFor more information go tohttps://neuroscience.nih.gov/neuroseries/home.aspxAir date: 6/10/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 27, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Decoding the genome regulatory program for T-cell identity
NIH Director ’ s Wednesday Afternoon Lecture Series
The Rothenberg group ’ s research is at the interface of immunology, stem cell developmental biology, systems biology, and genomics. They study gene regulation and development of T lymphocytes, gene networks controlling hematopoietic cell fates, and mechanisms underlying the dynamics of single-cell developmental decisions.Air date: 6/27/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
