Neuroscience Seminar: Time to Wake Up: Regulation of Neural Stem Cell Quiescence and Reactivation

NIH Neuroscience Series Seminar Stem cell populations in tissues as varied as blood, gut and brain spend much of their time in a mitotically dormant, quiescent, state. A key point of regulation is the decision between quiescence and proliferation. The ability to reactivate neural stem cells in situ raises the prospect of potential future therapies for brain repair after damage or neurodegenerative disease. Understanding the molecular basis for stem cell reactivation is an essential first step in this quest. In Drosophila, quiescent neural stem cells are easily identifiable and amenable to genetic manipulation, making them a powerful model with which to study the transition between quiescence and proliferation. These stem cells exit quiescence in response to a nutrition-dependent signal from the fat body, a tissue that plays a key role in the regulation of metabolism and growth. Dr. Brand lab combines cutting-edge genetic and molecular approaches with advanced imaging techniques to study the reactivation of Drosophila neural stem cells in vivo. This enables them to deduce the sequence of events from the level of the organism, to the tissue, the cell, and finally the genome.For more information go tohttps://neuroscience.nih.gov/neuroseries/home.aspxAir date: 6/10/2019 12:00:00 PM
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