Novel concepts in radiation-induced normal tissue injury
NIH Director's Seminar Series
Radiation therapy is delivered to over one half of all cancer patients. Efforts to enhance the efficacy of radiation have centered on technologic improvements in radiation delivery and leveraging a growing understanding of tumor radiobiology. Despite numerous recent advances in radiation delivery techniques, radiation exposure of normal tissues within the treatment volume can result in chronic injury, such as fibrosis and organ dysfunction. The study of radiation injury models has provided insight into the molecular events leading to radiation injury. Chronic oxidative stress after exposu...
Source: Videocast - All Events - May 31, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Hijacking the Hematopoietic System and Other Dirty Tricks that Breast Cancers Play
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. McAllister is an Associate Scientist in the Hematology Division at Brigham & Women’s Hospital and an Assistant Professor of Medicine at Harvard Medical School in Boston. She received her undergraduate degree at the University of Michigan in Ann Arbor and completed her Ph.D. studies in molecular and cellular biology at Washington University School of Medicine in St. Louis. She joined Robert Weinberg’s laboratory at the Whitehead Institute for Biomedical Research as a postdoctoral fellow where she established new pre-clinical models to study breast cancer pa...
Source: Videocast - All Events - May 9, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Role of RNA Editing in Malignant Reprogramming
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Catriona Jamieson, M.D., Ph.D., is Associate Professor of Medicine, Chief of the Division of Regenerative Medicine, Co-Leader of the Hematologic Malignancies Program in the Division of Hematology-Oncology and Director of Stem Cell Research at the Moores UC San Diego Cancer Center. Dr. Jamieson specializes in myeloproliferative neoplasms (MPNs) and leukemia. Myeloproliferative neoplasms are a family of clonal bone marrow disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack...
Source: Videocast - All Events - April 4, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The life of breath: the role of stem cells in lung maintenance and repair
Presented by: Brigid L. M. Hogan, Ph.D., FRS, George Barth Geller Professor and Chair, Department of Cell Biology; Director, Stem Cell and Regenerative Medicine Program; Professor, Department of Pediatrics, Duke University Medical CenterCategory: WALS - Wednesday Afternoon LecturesAired date: 03/23/2016 (Source: Videocast - All Events)
Source: Videocast - All Events - March 25, 2016 Category: Journals (General) Tags: Past Events Source Type: video
Bone regenerative engineering: a convergence approach
NIH Director’s Wednesday Afternoon Lecture Series
The treatment of injuries to bone that necessitate bone regeneration continues to be a major challenge for the orthopaedic surgeon. This burden is compounded by the constraints of supply and morbidity associated with autograft tissue, the gold standard of repair. The use of allografts, xenografts, or metal and ceramic implants overcomes many of the limitations associated with autografts but fails to provide a viable solution. Dr. Cato T. Laurencin has worked in the area of bone engineering with a focus on biomaterial selection, scaffold development, cell selection, cell/...
Source: Videocast - All Events - March 14, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
The life of breath: the role of stem cells in lung maintenance and repair
NIH Director’s Wednesday Afternoon Lecture Series
The goal of the Hogan laboratory is to understand how resident stem and progenitor cells maintain the complex tissue architecture and multiple functions of the mammalian lung. They also use a variety of strategies to understand how stem cells restore lung function following different kinds of damage, and how cytokines and other agents impact the stem cell niche. Their work involves mouse genetic models, organoid cultures and the genetic manipulation of primary cells derived from the human lung. For more information go to https://oir.nih.gov/walsAir date: 3/23/2016 3:00:0...
Source: Videocast - All Events - March 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Predicting the incidence of cancer: Does natural selection pick holographic networks?
Director's Seminar Series
Maintenance of function in many tissues in adult animals requires controlled somatic stem cell replication. The vast majority of these replication events are uneventful, as there are multiple levels of quality control: DNA damage repair mechanisms, paracrine signaling and the extracellular matrix, the immune system, and likely others that have not been uncovered. Our work has modeled tissue development and homeostasis processes in a variety of tissues: adipose tissue, beta cells in the islets of Langerhans, the development of the overall endocrine pancreas, and liver regeneration after partial h...
Source: Videocast - All Events - March 3, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
When Watson and Crick Get Linked: DNA Interstrand Crosslink Repair and Human Disease
NCI’s Center for Cancer Research (CCR) Grand Rounds
Dr. Smogorzewska received her B.S. in molecular biology and biochemistry from the University of Southern California in 1995, her Ph.D. from The Rockefeller University in 2002 where she was mentored by Dr. Titia de Lange and her M.D. from Weill Cornell Medical College in 2003. Following a residency in clinical pathology at Massachusetts General Hospital, she joined Harvard Medical School as a postdoctoral fellow in Stephen Elledge's lab in 2005. She joined The Rockefeller University as an assistant professor in 2009 and was promoted to associate professor in 2015.
...
Source: Videocast - All Events - February 1, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
iPS Cell Technology, Gene Editing and Disease Research
CCR Eminent Lectures
Rudolf Jaenisch, a Whitehead Institute Founding Member, focuses on understanding epigenetic regulation of gene expression (the biological mechanisms that affect how genetic information is converted into cell structures but that don’t alter the genes in the process). Most recently, this work has led to major advances in our understanding of embryonic stem cells and “induced pluripotent stem” (IPS) cells, which appear identical to embryonic stem cells but can be created from adult cells without using an egg.
In 2007, the Jaenisch lab was one of three labs worldwide that reported successfully takin...
Source: Videocast - All Events - January 22, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
How to make pancreatic beta cells for diabetics
Wednesday Afternoon Lecture Series
Dr. Melton is interested in the developmental biology of the pancreas and in understanding the stem cells that give rise to the pancreas. In the lecture, he will discuss the challenges of making stem-cell-derived pancreatic beta cells. A primary problem for insulin-dependent diabetics is the absence (in type 1 diabetes) or dysfunction (in type 2 diabetes) of pancreatic beta cells. The ability to direct the differentiation human stem cells into beta cells opens up the possibility of using these cells for research into the causes of beta-cell loss. In addition, stem-cell-derived beta cell...
Source: Videocast - All Events - January 22, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Demystifying Medicine 2016: Trauma in the Modern Age: Injury and Stem Cells
Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.For more information go to https://demystifyingmedicine.od.nih.gov/
Air date: 4/19/2016 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 1, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
TRACO 2015: Stem Cells - Epigenetics
Presented by: D. Salomon; M. VermaCategory: TRACOAired date: 11/09/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - November 11, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Forcing Tumor Progression
NCI’s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Dr. Valerie Weaver is the Director of the Center for Bioengineering and Tissue Regeneration in the Surgery Department. She also jointly oversees the UCSF Brain Tumor Microenvironment Program and co-directs the Bay Area Physical Sciences and Oncology Program. During Dr. Weaver’s tenure at LBNL she was awarded a California Breast Cancer Research Grant and received a Distinguished LBNL Scientist award for he...
Source: Videocast - All Events - November 9, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
Novel Roles for Stem Cells in Skeletal Muscle Adaptation and Aging
Presented by: Dr. Charlotte Peterson, University of Kentucky, College of Health Sciences Category: GeroscienceAired date: 11/05/2015 (Source: Videocast - All Events)
Source: Videocast - All Events - November 9, 2015 Category: Journals (General) Tags: Past Events Source Type: video
Pluripotent Stem Cells in Neuroscience:Research and Application
NINDS presents a symposium intended to bring together the intramural neuroscience community interested in using pluripotent stem cells in their research or other applications. It will highlight some of the research being performed on campus with the goal of fostering new collaborations intramurally. The inclusion of distinguished extramural leaders in the neuroscience field will also stimulate new ideas and discussion.Air date: 10/26/2015 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - October 23, 2015 Category: Journals (General) Tags: Upcoming Events Source Type: video
