The Role of RNA Editing in Malignant Reprogramming
NCI’s Center for Cancer Research (CCR) Grand Rounds Dr. Catriona Jamieson, M.D., Ph.D., is Associate Professor of Medicine, Chief of the Division of Regenerative Medicine, Co-Leader of the Hematologic Malignancies Program in the Division of Hematology-Oncology and Director of Stem Cell Research at the Moores UC San Diego Cancer Center. Dr. Jamieson specializes in myeloproliferative neoplasms (MPNs) and leukemia. Myeloproliferative neoplasms are a family of clonal bone marrow disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack, stroke, deep venous thrombosis, and pulmonary emboli and can develop into acute myeloid leukemia. Although some effective treatments are available, they are laden with serious side effects. In addition, individuals can become resistant to the treatments. Dr. Jamieson studies the mutant stem cells and progenitor cells in myeloproliferative neoplasms. These cells can give rise to cancer stem cells. Cancer stem cells may lie low to evade chemotherapy and then activate again later, causing disease progression and resistance to treatment. Her goal is to find more selective, less toxic therapies.Air date: 4/8/2016 12:00:00 PM
ConclusionsWe established the feasibility of initiating and managing patients in a monthly text-based symptom-monitoring program. The provision of smartphones and patient navigation were unique and vital components of this program.
ConclusionPatients recovering at home following major cancer surgery regarded electronic symptom-monitoring and feedback as acceptable and beneficial. Patients perceived that the system enhanced information provision and provided a direct link to their care team. Patients felt that the system provided reassurance at a time of uncertainty and isolation, enabling them to feel in control of their symptoms and recovery.
ConclusionElectronic patient-reported outcomes are perceived as valuable for variable reasons by Black and White cancer populations, with greater perceived value for communicating with clinicians reported among Blacks. To optimize equitable uptake of ePROs, oncology practices should offer several ePRO options (e.g., web-based, phone-based), as well as paper-based options, and consider the e-health literacy needs of patients during implementation.
I don’t do Twitter cause social media is cancer so I will post here instead: 1. Social justice - we need more diversity in the specialty and need to stop the white male micro aggressions and unconscious biases. 2. Burnout - this needs to improve. What better way to do this than academic expansion and consolidation? As we all know physicians in academic satellites are deliriously happy, content and have a major say in what their RN/MBA overlords wish to do. 3. Jobs - Potters tweeted... Read more
Our United Council of Neurological Subspecialties (UCNS)-accredited program is offering a one- or two-year fellowship position beginning immediately. Our fellowship goal is to train exceptional and well-rounded neurointensivists who excel in patient care, research, and education. Fellows gain clinical experience though rotating in our busy contemporary neurocritical ICU and the neurocritical care consult service in our certified Comprehensive Stroke and Level 1 Trauma Center... Read more
Suicide risk significantly elevated for survivors alive beyond the age of 28 years; risk was lower for women than men
Conclusions: Pure and mixed variants of DM were found to have similar clinicopathologic characteristics. Patients with the mixed histologic subtype were more likely to have mitoses, but no difference in the therapeutic management or patient survival was seen between the 2 subtypes.
PANCREATIC cancer develops when cancerous cells in the pancreas - an organ in the top part of your tummy - divide and multiply uncontrollably. One telltale sign of this process can surface immediately after having a poo.
A recent study describes new methods to generate cartilage tissue from stem cells. This is a significant step towards developing innovative treatments for painful joints.
A major gap exists in the present spectrum of efforts to develop the means to treat aging, rejuvenate the old, and turn back age-related conditions. An the one hand, a small number of promising potential therapies to treat the mechanisms of aging can at present be applied by physicians off-label, or otherwise without the need for a great deal of interaction with the FDA. On the other hand, there are a good hundred or more clinical indications, specific age-related conditions recognized by regulatory authorities, that might be improved by these therapies. Several hundred small, informal trials could be run, starting now, gi...
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