The Role of RNA Editing in Malignant Reprogramming

NCI’s Center for Cancer Research (CCR) Grand Rounds Dr. Catriona Jamieson, M.D., Ph.D., is Associate Professor of Medicine, Chief of the Division of Regenerative Medicine, Co-Leader of the Hematologic Malignancies Program in the Division of Hematology-Oncology and Director of Stem Cell Research at the Moores UC San Diego Cancer Center. Dr. Jamieson specializes in myeloproliferative neoplasms (MPNs) and leukemia. Myeloproliferative neoplasms are a family of clonal bone marrow disorders in which the body overproduces blood cells. Myeloproliferative neoplasms can cause many forms of blood clotting including heart attack, stroke, deep venous thrombosis, and pulmonary emboli and can develop into acute myeloid leukemia. Although some effective treatments are available, they are laden with serious side effects. In addition, individuals can become resistant to the treatments. Dr. Jamieson studies the mutant stem cells and progenitor cells in myeloproliferative neoplasms. These cells can give rise to cancer stem cells. Cancer stem cells may lie low to evade chemotherapy and then activate again later, causing disease progression and resistance to treatment. Her goal is to find more selective, less toxic therapies.Air date: 4/8/2016 12:00:00 PM
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