Stem Cells, Aging & Aging Stem Cells
NIH Director ’ s Wednesday Afternoon Lecture Series
A leader in the field of stem cell biology, Dr. Wagers ’ groundbreaking research has uncovered new migratory pathways and signaling networks that regulate the functioning of hematopoietic stem cells. Understanding how these cells function could lead to better treatments for a range of diseases, including cancer, anemia and diabetes.Air date: 4/5/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 29, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The cyst nematode hijacks the stem cells to create feeding sites
A group of scientists led by the University of Missouri have been studying the cyst nematode and have found clues as to how they use small chains of amino acids, or peptides, to feed on soybean roots. Now, nematodes engage in a little "molecular mimicry," producing identical peptides to activate ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - March 15, 2017 Category: Science Source Type: video
CANCELLED - Exploring the behavioral responses to danger one millisecond at a time
The NIH Neuroscience Seminar scheduled for today, February 13, has been cancelled. Our speaker, Clifford Woolf, was unable to fly out of Boston due to a large snow storm. An attempt will be made to reschedule.
NIH Neuroscience Series Seminar
Neuronal plasticity, its mechanistic basis, how it contributes to the normal and abnormal functions of the nervous system, and how it can be a target for therapy comprise the major focus of Dr. Woolf ’ s investigations. Specifically, he studies neural plasticity in relation to pain, regeneration, neurodegenerative disorders and developmental neurobiology.
Dr. Woolf has spearheaded d...
Source: Videocast - All Events - February 13, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Targeting Breast Cancer Stem Cells: Challenges and Opportunities
CCR Eminent Lectures
This monthly lecture series has been established to bring in prominent speakers to stimulate discussion of cutting-edge research areas and facilitate exchange of ideas, possibly leading to fruitful collaborations.Air date: 2/27/2017 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 7, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Control of Epithelial Stem Cell Fate in Cancer and Wound Healing
NCI ’ s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Air date: 3/10/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 7, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Researchers use stem cells to regenerate the external layer of a human heart
A process using human stem cells can generate the cells that cover the external surface of a human heart -- epicardium cells -- according to a multidisciplinary team of researchers.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 7, 2017 Category: Science Source Type: video
Human pluripotent stem cells in understanding genetic cardiovascular disease and effects of drugs
NIH Director ’ s Wednesday Afternoon Lecture Series
There's a growing interest in how the derivation of many different cell types from human pluripotent stem cells-embryonic stem cells (HESCs) and induced pluripotent stem cells (hiPS cells)-could be used for potential cell therapy and as a platform for drug discovery and toxicity. In particular, new methods of introducing specific disease mutations into human pluripotent stem cells and/or reprogramming them to derive hiPS cells, allow the creation of disease models " in a dish " so scientists can study ways to treat diseases or slow them down. To move the field forward, ...
Source: Videocast - All Events - January 23, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Bone Marrow Aging and the PTH Receptor: A Model of Integrative Physiology
Trans-NIH GeroScience Interest Group (GSIG)
Dr. Cliff Rosen is a Senior Scientist and the Director of the Center for Clinical and Translational Research at the Maine Medical Center Research Institute (MMCRI). His laboratory studies the mesenchymal stem cell fate as it relates to the switch between pre-adipocytes and pre-osteoblasts. The focus of these efforts relates to cell autonomous factors such as substrate utilization and bioenergetics of the osteoblast and cell non-autonomous determinants such as parathyroid hormone and sympathetic tone. Dr. Rosen ’ s current projects, supported by the NIH, revolve around the origi...
Source: Videocast - All Events - January 10, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Human pluripotent stem cells: the new patient?
NIH Director ’ s Wednesday Afternoon Lecture Series
Derivation of many different cell types from human pluripotent stem cells (embryonic stem cells or HESCs and induced pluripotent stem cells or hiPS cells) is an area of growing interest both for potential cell therapy and as a platform for drug discovery and toxicity. Most particularly, the recent availability of methods to introduce specific disease mutations into human pluripotent stem cells and/or to derive these cells as hiPS cells by reprogramming from any patient of choice, are creating unprecedented opportunities to create disease models “ in a dish ” and stu...
Source: Videocast - All Events - December 23, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Using human stem cells to understand and treat diabetes
NIH Director's Wednesday Afternoon Lecture Series
We study how the pancreas normally develops and use that information to grow and develop pancreatic cells (Islets of Langerhans). Our laboratory focuses on the directed differentiation of stem cells to create functional pancreatic beta cells that can be used for research on the cause(s) of diabetes as well as exploring the use of stem cell-derived islets for transplantation.For more information go tohttps://oir.nih.gov/walsAir date: 12/15/2016 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 6, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Roles of regulatory RNAs & RNA-binding proteins in (re)programming patterns of gene expression
NIH Director's Seminar Series
The Integrative Immunobiology Section is interested in understanding how gene expression programs are orchestrated in our cells, particularly stem cells. Specifically, the laboratory studies how these systems are controlled by non-coding RNAs and RNA-binding proteins. Our major goal is to discover novel molecular circuits that control cell fates in the hematopoietic and immune systems, since perturbations in their genetic regulatory networks underlie many diseases. To address these fundamental issues, we employ an integrative systems biology approach to reverse engineer the molecular logic of ...
Source: Videocast - All Events - November 14, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Merkel Cells and Merkel Cell Carcinoma
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Brownell is a Board Certified Dermatologist and a Fellow of the American Academy of Dermatology. He obtained degrees in electrical engineering and mathematics prior to undergoing MD/PhD training at Baylor College of Medicine. Dr. Brownell completed a dermatology residency at the New York University School of Medicine, and a postdoctoral research fellowship in the laboratory of Dr. Alexandra Joyner at the Sloan-Kettering Institute. On the clinical faculty at the Memorial Sloan-Kettering Cancer Center, his practice focused on patients with high-risk skin cancers. In...
Source: Videocast - All Events - September 20, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
NIH Research Festival Plenary Session III - Cell-based immune therapies
Cell-based immune therapies, such as immunotherapy for cancer, are among the hottest topics in clinical research. A centuries-old concept of stimulating the immune system to fight a non-infectious disease, immunotherapy became a viable treatment that doctors could exert some degree of control over as a result of pioneering research at the NCI in the 1960s and 1970s on monoclonal antibodies (Michael Potter) and Interleukin-2 (Robert Gallo). Building on such advances, NCI ’ s Steven Rosenberg, M.D., Ph.D. was the first to recognize the potential of Il-2 and apply it as a novel anti-cancer agent, in 1984. Rosenberg has spen...
Source: Videocast - All Events - September 12, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
iPS Cell Technology, Gene Editing and Disease Research
CCR Eminent Lecture
Rudolf Jaenisch, a Whitehead Institute Founding Member, focuses on understanding epigenetic regulation of gene expression (the biological mechanisms that affect how genetic information is converted into cell structures but that don’t alter the genes in the process). Most recently, this work has led to major advances in our understanding of embryonic stem cells and “induced pluripotent stem” (IPS) cells, which appear identical to embryonic stem cells but can be created from adult cells without using an egg.
In 2007, the Jaenisch lab was one of three labs worldwide that reported successfully taking...
Source: Videocast - All Events - June 8, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Connecting Tumor Suppression and Fate Determination in Mammary Cancer Stem Cells: From Discovery to Preclinical Intervention
NCI’s Center for Cancer Research (CCR) Grand Rounds
Prof. Pier Paolo Di Fiore is group leader at IFOM, an internationally competitive research institute in Milan, which he founded in 1998, and Director of the Molecular Medicine Program at IEO, a leading cancer care center in Milan. He is also Full Professor of General Pathology at the University of Milan, and co-founder of the post-graduate European School of Molecular Medicine.
Dr. Di Fiore has dedicated his scientific career to deciphering the molecular mechanisms of cellular transformation, with emphasis on growth factor receptor signaling, endocytosis and stem cel...
Source: Videocast - All Events - June 6, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
