Connecting Tumor Suppression and Fate Determination in Mammary Cancer Stem Cells: From Discovery to Preclinical Intervention

NCI’s Center for Cancer Research (CCR) Grand Rounds Prof. Pier Paolo Di Fiore is group leader at IFOM, an internationally competitive research institute in Milan, which he founded in 1998, and Director of the Molecular Medicine Program at IEO, a leading cancer care center in Milan. He is also Full Professor of General Pathology at the University of Milan, and co-founder of the post-graduate European School of Molecular Medicine. Dr. Di Fiore has dedicated his scientific career to deciphering the molecular mechanisms of cellular transformation, with emphasis on growth factor receptor signaling, endocytosis and stem cell biology. He recently uncovered a link between endocytosis and cancer by demonstrating that the endocytic protein and cell fate determinant, Numb, is a key tumor suppressor protein in breast cancer that functions at the level of the SC compartment. He has also identified several genomic signatures that form the basis of new clinical tools for the early detection of cancer and prognosis prediction. Air date: 6/10/2016 12:00:00 PM
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