Log in to search using one of your social media accounts:

 

AAAS announces animal and avian sciences professor Iqbal Hamza as a 2017 Fellow
(University of Maryland) Dr. Iqbal Hamza of the University of Maryland has been named a Fellow of the American Association for the Advancement of Science (AAAS). Election as an AAAS Fellow is an honor bestowed upon AAAS members by their peers. Dr. Hamza was elected for groundbreaking discoveries and distinguished contributions on the biochemical and cell biology mechanisms underlying heme and iron trafficking and their regulation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 22, 2017 Category: International Medicine & Public Health Source Type: news

Turtles & technology advance understanding of lung abnormality
(Louisiana State University Health Sciences Center) A study of an unusual snapping turtle with one lung found shared characteristics with humans born with one lung who survive beyond infancy. Digital 3-D anatomical models created by Emma Schachner, PhD, Assistant Professor of Cell Biology& Anatomy at LSU Health New Orleans School of Medicine, made the detailed research possible. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 21, 2017 Category: International Medicine & Public Health Source Type: news

FDA releases framework guidelines for regenerative med development
The FDA this week laid out guidelines for a new framework it’s implementing for the development and oversight of regenerative medicine products including novel cellular therapies. The framework is laid out through four guidance documents which build on the FDA’s existing regulatory approach and describe more clearly which products are regulated as drugs, devices and biological products, according to a new FDA release. The documents include new science-based processes for ensuring the safety and effectiveness of such products and a risk-based framework for how it plans to enforce actions against potentially harm...
Source: Mass Device - November 17, 2017 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Regenerative Medicine Regulatory/Compliance Source Type: news

SUNY downstate receives $2 million for research into vision-threatening diseases
(SUNY Downstate Medical Center) Brahim Chaqour, PhD, professor of cell biology and ophthalmology at SUNY Downstate Medical Center, has received two awards to support research into treatment of currently incurable vision-threatening diseases. The new awards, totaling $2,008,973, are from the National Eye Institute of the National Institutes of Health (NIH). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 14, 2017 Category: International Medicine & Public Health Source Type: news

Study led by MIT Portugal faculty and alumni finds how to increase the survival time of stem cells
(MIT Portugal Program) A team of researchers from the Faculty of Medicine at the University of Coimbra, led by Dr. Lino Ferreira, MIT Portugal Program Faculty and researcher at the Center for Neuroscience and Cell Biology (CNC) in collaboration with Langer Lab at MIT (USA), has developed a new technology, which is promising to understand and treat ischemic diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 9, 2017 Category: Biology Source Type: news

New tools offer clues to how the human brain takes shape
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Gibbons, A. Tags: Cell Biology, Development, Genetics, Neuroscience In Depth Source Type: news

The need to regulate replication fork speed
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Gomez-Gonzalez, B., Aguilera, A. Tags: Cell Biology, Molecular Biology perspective Source Type: news

Cell cycle proteins moonlight in multiciliogenesis
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Levine, M., Holland, A. Tags: Cell Biology, Development perspective Source Type: news

Metabolic regulation of genome stability
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Mao, S. Tags: Cell Biology, Molecular Biology twis Source Type: news

Taming mitosis for differentiation
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Development twis Source Type: news

SAMTOR joins the family
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Hurtley, S. M. Tags: Biochemistry, Cell Biology twis Source Type: news

Redox-sensitive alteration of replisome architecture safeguards genome integrity
DNA replication requires coordination between replication fork progression and deoxynucleotide triphosphate (dNTP)–generating metabolic pathways. We find that perturbation of ribonucleotide reductase (RNR) in humans elevates reactive oxygen species (ROS) that are detected by peroxiredoxin 2 (PRDX2). In the oligomeric state, PRDX2 forms a replisome-associated ROS sensor, which binds the fork accelerator TIMELESS when exposed to low levels of ROS. Elevated ROS levels generated by RNR attenuation disrupt oligomerized PRDX2 to smaller subunits, whose dissociation from chromatin enforces the displacement of TIMELESS from ...
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M.-B., Choudhary, C., Lukas, J. Tags: Cell Biology, Molecular Biology reports Source Type: news

Calibrated mitotic oscillator drives motile ciliogenesis
Cell division and differentiation depend on massive and rapid organelle remodeling. The mitotic oscillator, centered on the cyclin-dependent kinase 1–anaphase-promoting complex/cyclosome (CDK1-APC/C) axis, spatiotemporally coordinates this reorganization in dividing cells. Here we discovered that nondividing cells could also implement this mitotic clocklike regulatory circuit to orchestrate subcellular reorganization associated with differentiation. We probed centriole amplification in differentiating mouse-brain multiciliated cells. These postmitotic progenitors fine-tuned mitotic oscillator activity to drive the or...
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Al Jord, A., Shihavuddin, A., Servignat dAout, R., Faucourt, M., Genovesio, A., Karaiskou, A., Sobczak-Thepot, J., Spassky, N., Meunier, A. Tags: Cell Biology, Development reports Source Type: news

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its site of activation. We identified SAMTOR, a previously uncharacterized protein, which inhibits mTORC1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) for RagA/B. We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 complex by binding directly to SAMTOR with a dissociation constant of approximately 7 μM. In cells, methionine starv...
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Gu, X., Orozco, J. M., Saxton, R. A., Condon, K. J., Liu, G. Y., Krawczyk, P. A., Scaria, S. M., Harper, J. W., Gygi, S. P., Sabatini, D. M. Tags: Biochemistry, Cell Biology reports Source Type: news

Webinar | Deciphering cancer: Investigating cell death mechanisms
(Source: ScienceNOW)
Source: ScienceNOW - November 9, 2017 Category: Science Authors: Strasser, A., Letai, A. G. Tags: Biochemistry, Cell Biology, Development, Medicine, Diseases, Molecular Biology opms-sups Source Type: news

Stem cell and leukemia expert wins prestigious medal
(Academy of Medical Sciences (UK)) Dr. Cristina Lo Celso, a Reader in Stem Cell Biology at Imperial College London, has been announced as the winner of the Foulkes Foundation Medal 2017. The Foulkes Medal is awarded biennially to a rising star within biomedical research for contributing important and significant impacts to the field before, or in, their first independent position. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 7, 2017 Category: Cancer & Oncology Source Type: news

Breaking cell symmetry
(National University of Singapore) A team of researchers from the Mechanobiology Institute, Singapore at the National University of Singapore, along with colleagues from Temasek Life Sciences Laboratory and A*STAR's Institute of Molecular and Cell Biology in Singapore, has uncovered a novel mechanism for establishing cell polarity that relies on tension force induced clustering of proteins. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 6, 2017 Category: Biology Source Type: news

IOS Press acquires StemBook
(IOS Press) IOS Press, an international publisher providing content for scientific, technical and medical communities, is proud to announce that it has acquired StemBook, an online open access review of stem cell biology that was launched by the Harvard Stem Cell Institute (HSCI) in collaboration with the MIND Informatics group at Massachusetts General Hospital in 2008. IOS Press will update, develop, expand and relaunch the site in spring 2018 in collaboration with HSCI. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 6, 2017 Category: International Medicine & Public Health Source Type: news

Latest chapter of WormBook on the cell biology of the mitochondrion now available
The latest chapter of WormBook is now available: Cell Biology of the Mitochondrion by Alexander M. van der Bliek, Margaret M. Sedensky and Phil G. Morgan. (Source: WormBase)
Source: WormBase - November 3, 2017 Category: Genetics & Stem Cells Authors: Ranjana Kishore Tags: brief communication external website news paper of interest wormbook Source Type: news

Fantastic journey: How newborn neurons find their proper place in the adult brain
(Cold Spring Harbor Laboratory) This week in the Journal of Cell Biology, Professor Linda Van Aelst and colleagues at Cold Spring Harbor Laboratory (CSHL) describe for the first time (in mice) how baby neurons -- precursors called neuroblasts, generated from a permanent pocket of stem cells in a brain area called the V-SVZ -- make an incredible journey from their place of birth through a special tunnel called the RMS to their target destination in the olfactory bulb. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 2, 2017 Category: International Medicine & Public Health Source Type: news

Fantastic journey: How newborn neurons to find their proper place in the adult brain
(Cold Spring Harbor Laboratory) This week in the Journal of Cell Biology, Professor Linda Van Aelst and colleagues at Cold Spring Harbor Laboratory (CSHL) describe for the first time (in mice) how baby neurons -- precursors called neuroblasts, generated from a permanent pocket of stem cells in a brain area called the V-SVZ -- make an incredible journey from their place of birth through a special tunnel called the RMS to their target destination in the olfactory bulb. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2017 Category: International Medicine & Public Health Source Type: news

Ribosomopathies: Theres strength in numbers
Ribosomopathies are a group of human disorders most commonly caused by ribosomal protein haploinsufficiency or defects in ribosome biogenesis. These conditions manifest themselves as physiological defects in specific cell and tissue types. We review current molecular models to explain ribosomopathies and attempt to reconcile the tissue specificity of these disorders with the ubiquitous requirement for ribosomes in all cells. Ribosomopathies as a group are diverse in their origins and clinical manifestations; we use the well-described Diamond-Blackfan anemia (DBA) as a specific example to highlight some common features. We ...
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Mills, E. W., Green, R. Tags: Cell Biology, Medicine, Diseases, Molecular Biology, Online Only review Source Type: news

Sponsored Collection | Changing perspectives on daylight: Science, technology, and culture
(Source: ScienceNOW)
Source: ScienceNOW - November 2, 2017 Category: Science Tags: Botany, Cell Biology, Medicine, Diseases, Neuroscience, Pharmacology, Toxicology opms-sups Source Type: news

Spindle asymmetry drives non-Mendelian chromosome segregation
Genetic elements compete for transmission through meiosis, when haploid gametes are created from a diploid parent. Selfish elements can enhance their transmission through a process known as meiotic drive. In female meiosis, selfish elements drive by preferentially attaching to the egg side of the spindle. This implies some asymmetry between the two sides of the spindle, but the molecular mechanisms underlying spindle asymmetry are unknown. Here we found that CDC42 signaling from the cell cortex regulated microtubule tyrosination to induce spindle asymmetry and that non-Mendelian segregation depended on this asymmetry. Cort...
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Akera, T., Chmatal, L., Trimm, E., Yang, K., Aonbangkhen, C., Chenoweth, D. M., Janke, C., Schultz, R. M., Lampson, M. A. Tags: Cell Biology reports Source Type: news

ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons
Interfaces between organelles are emerging as critical platforms for many biological responses in eukaryotic cells. In yeast, the ERMES complex is an endoplasmic reticulum (ER)–mitochondria tether composed of four proteins, three of which contain a SMP (synaptotagmin-like mitochondrial-lipid binding protein) domain. No functional ortholog for any ERMES protein has been identified in metazoans. Here, we identified PDZD8 as an ER protein present at ER-mitochondria contacts. The SMP domain of PDZD8 is functionally orthologous to the SMP domain found in yeast Mmm1. PDZD8 was necessary for the formation of ER-mitochondria...
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Hirabayashi, Y., Kwon, S.-K., Paek, H., Pernice, W. M., Paul, M. A., Lee, J., Erfani, P., Raczkowski, A., Petrey, D. S., Pon, L. A., Polleux, F. Tags: Cell Biology r-articles Source Type: news

Making the right contacts
(Source: ScienceNOW)
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology twis Source Type: news

Molecular mechanisms behind ribosomopathies
(Source: ScienceNOW)
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Medicine, Diseases, Molecular Biology twis Source Type: news

How selfish genes get their way
(Source: ScienceNOW)
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology twis Source Type: news

Competing chromosomes explain junk DNA
(Source: ScienceNOW)
Source: ScienceNOW - November 2, 2017 Category: Science Authors: McNally, F. J. Tags: Cell Biology perspective Source Type: news

Mediating ER-mitochondrial cross-talk
(Source: ScienceNOW)
Source: ScienceNOW - November 2, 2017 Category: Science Authors: Lombardi, A. A., Elrod, J. W. Tags: Cell Biology perspective Source Type: news

Cell Biology: Cellular power outage
(Ludwig-Maximilians-Universit ä t M ü nchen) Protein aggregation is a hallmark of many neurodegenerative diseases. Even in normal cells, such deposits can accumulate in mitochondria, blocking energy production, but a newly described quality control system can mitigate the problem. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 27, 2017 Category: Biology Source Type: news

Sponsored Collection | Sharper Images: Exploring Confocal and Superresolution Microscopy
(Source: ScienceNOW)
Source: ScienceNOW - October 26, 2017 Category: Science Tags: Botany, Cell Biology, Medicine, Diseases, Neuroscience, Pharmacology, Toxicology opms-sups Source Type: news

Webinar | Unlocking the elusive mind: The role of protein biomarkers in understanding neurodegenerative disease
(Source: ScienceNOW)
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Galasko, D. R., Zetterberg, H., Blennow, K. Tags: Biochemistry, Cell Biology, Development, Medicine, Diseases, Molecular Biology opms-sups Source Type: news

Obstruction of pilus retraction stimulates bacterial surface sensing
It is critical for bacteria to recognize surface contact and initiate physiological changes required for surface-associated lifestyles. Ubiquitous microbial appendages called pili are involved in sensing surfaces and facilitating downstream behaviors, but the mechanism by which pili mediate surface sensing has been unclear. We visualized Caulobacter crescentus pili undergoing dynamic cycles of extension and retraction. Within seconds of surface contact, these cycles ceased, which coincided with synthesis of the adhesive holdfast required for attachment. Physically blocking pili imposed resistance to pilus retraction, which...
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Ellison, C. K., Kan, J., Dillard, R. S., Kysela, D. T., Ducret, A., Berne, C., Hampton, C. M., Ke, Z., Wright, E. R., Biais, N., Dalia, A. B., Brun, Y. V. Tags: Cell Biology, Microbiology reports Source Type: news

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress
Regulated exocytosis by secretory organelles is important for malaria parasite invasion and egress. Many parasite effector proteins, including perforins, adhesins, and proteases, are extensively proteolytically processed both pre- and postexocytosis. Here we report the multistage antiplasmodial activity of the aspartic protease inhibitor hydroxyl-ethyl-amine–based scaffold compound 49c. This scaffold inhibits the preexocytosis processing of several secreted rhoptry and microneme proteins by targeting the corresponding maturases plasmepsins IX (PMIX) and X (PMX), respectively. Conditional excision of PMIX revealed its...
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Pino, P., Caldelari, R., Mukherjee, B., Vahokoski, J., Klages, N., Maco, B., Collins, C. R., Blackman, M. J., Kursula, I., Heussler, V., Brochet, M., Soldati-Favre, D. Tags: Cell Biology, Microbiology reports Source Type: news

Elucidating a bacterial sense of touch
(Source: ScienceNOW)
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Microbiology twis Source Type: news

Plasmodium parasite entrance and exit
(Source: ScienceNOW)
Source: ScienceNOW - October 26, 2017 Category: Science Authors: Ash, C. Tags: Cell Biology, Microbiology twis Source Type: news

Structure of human mTORC1 components
(Source: ScienceNOW)
Source: ScienceNOW - October 19, 2017 Category: Science Authors: Ray, L. B. Tags: Biochemistry, Cell Biology twis Source Type: news

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
The LAMTOR [late endosomal and lysosomal adaptor and MAPK (mitogen-activated protein kinase) and mTOR (mechanistic target of rapamycin) activator] complex, also known as "Ragulator," controls the activity of mTOR complex 1 (mTORC1) on the lysosome. The crystal structure of LAMTOR consists of two roadblock/LC7 domain–folded heterodimers wrapped and apparently held together by LAMTOR1, which assembles the complex on lysosomes. In addition, the Rag guanosine triphosphatases (GTPases) associated with the pentamer through their carboxyl-terminal domains, predefining the orientation for interaction with mTORC1. I...
Source: ScienceNOW - October 19, 2017 Category: Science Authors: de Araujo, M. E. G., Naschberger, A., Fürnrohr, B. G., Stasyk, T., Dunzendorfer-Matt, T., Lechner, S., Welti, S., Kremser, L., Shivalingaiah, G., Offterdinger, M., Lindner, H. H., Huber, L. A., Scheffzek, K. Tags: Biochemistry, Cell Biology reports Source Type: news

Bolstering fat cells offers potential new leukemia treatment
(McMaster University) Killing cancer cells indirectly by powering up fat cells in the bone marrow could help acute myeloid leukemia patients, says a study from McMaster University published in Nature Cell Biology. Researchers with the McMaster Stem Cell and Cancer Research Institute found that boosting adipocytes, or fat cells, located in the bone morrow suppressed cancerous leukemia cells but -- in a surprise to the research team -- also induced the regeneration of healthy blood cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 16, 2017 Category: Biology Source Type: news

Sponsored Collection | Accelerating the path from structure to function through integrated structural biology solutions
(Source: ScienceNOW)
Source: ScienceNOW - October 12, 2017 Category: Science Tags: Botany, Cell Biology, Medicine, Diseases, Neuroscience, Pharmacology, Toxicology opms-sups Source Type: news

Webinar | Overcoming the evils of fixation and storage: Getting the most out of your FFPE samples
(Source: ScienceNOW)
Source: ScienceNOW - October 5, 2017 Category: Science Authors: Gupta, M., (Zhihong) Zhang, J., Strengman, E. E. Tags: Biochemistry, Cell Biology, Development, Medicine, Diseases, Molecular Biology opms-sups Source Type: news

Mitotic transcription and waves of gene reactivation during mitotic exit
Although the genome is generally thought to be transcriptionally silent during mitosis, technical limitations have prevented sensitive mapping of transcription during mitosis and mitotic exit. Thus, the means by which the interphase expression pattern is transduced to daughter cells have been unclear. We used 5-ethynyluridine to pulse-label transcripts during mitosis and mitotic exit and found that many genes exhibit transcription during mitosis, as confirmed with fluorescein isothiocyanate–uridine 5'-triphosphate labeling, RNA fluorescence in situ hybridization, and quantitative reverse transcription polymerase chai...
Source: ScienceNOW - October 5, 2017 Category: Science Authors: Palozola, K. C., Donahue, G., Liu, H., Grant, G. R., Becker, J. S., Cote, A., Yu, H., Raj, A., Zaret, K. S. Tags: Cell Biology reports Source Type: news

Webinar | The rise of whole genome microbial sequencing: A new era for human microbiome analysis
(Source: ScienceNOW)
Source: ScienceNOW - September 28, 2017 Category: Science Authors: Segre, J., Pollard, K. Tags: Biochemistry, Cell Biology, Development, Medicine, Diseases, Molecular Biology opms-sups Source Type: news

Assistant Professor of Biology
Penn State Hazleton invites applications for a faculty position, Assistant Professor of Biology, (Tenure-Track, 36 weeks) to begin August 2018, or as negotiated. Responsibilities: Teach two to three courses (9 contact hours) each semester using traditional, hybrid and/or online delivery methods. Teaching assignments would consist primarily of introductory, lab-based courses in biology for science majors, and general education courses in the successful applicant’s area of expertise. Teaching assignments may require teaching day, evening and/or Saturday classes as needed. Publish in refereed journals. Support undergra...
Source: AIBS Classifieds - September 27, 2017 Category: Biology Authors: AIBS Classifieds Tags: Other Positions Available Source Type: news

USPSTF Offers Updated Cervical Cancer Screening Regimen
A new draft statement from the U.S. Preventive Services Task Force includes a recommendation to screen women ages 30-65 for cervical cancer every three years using cytology alone or every five years using high-risk HPV testing alone. (Source: AAFP News)
Source: AAFP News - September 22, 2017 Category: Primary Care Source Type: news

Research Technician in Molecular and Cell Biology at Imperial College London
Salary: £27,190 -£29,250 per annumContract: Full Time Fixed Term up to four yearsCampus: Hammersmith Campus Closing Date: Tuesday 3 October 2017 (Midnight BST)A Research Technician position in Molecular and Cell Biology is available in the Department of Medicine, Imperial College London. You will work on a programme funded by a Wellcome Trust Joint Investigator Award entitled Cellular thyroid hormone availability: regulation of development and tissue repair, and pathogenesis of degenerative disease.&nb...
Source: Society for Endocrinology - September 21, 2017 Category: Endocrinology Source Type: news

Location, location, location
(Source: ScienceNOW)
Source: ScienceNOW - September 21, 2017 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Engineering twis Source Type: news

Phase separation and cellular organization
(Source: ScienceNOW)
Source: ScienceNOW - September 21, 2017 Category: Science Authors: Ray, L. B. Tags: Biochemistry, Cell Biology twis Source Type: news

RNA localization feeds translation
(Source: ScienceNOW)
Source: ScienceNOW - September 21, 2017 Category: Science Authors: Gaspar, I., Ephrussi, A. Tags: Cell Biology, Engineering perspective Source Type: news