Lockdown for genome parasites
(IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences) Researchers at GMI - Gregor Mendel Institute of Molecular Plant Biology of the Austrian Academy of Sciences - uncover an ingenious mechanism by which Arabidopsis safeguards the integrity of its genome. The paper is published in the journal Nature Cell Biology. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 8, 2021 Category: Biology Source Type: news

Pollen PCP-B peptides unlock a stigma peptide-receptor kinase gating mechanism for pollination
Sexual reproduction in angiosperms relies on precise communications between the pollen and pistil. The molecular mechanisms underlying these communications remain elusive. We established that in Arabidopsis, a stigmatic gatekeeper, the ANJEA–FERONIA (ANJ–FER) receptor kinase complex, perceives the RAPID ALKALINIZATION FACTOR peptides RALF23 and RALF33 to induce reactive oxygen species (ROS) production in the stigma papillae, whereas pollination reduces stigmatic ROS, allowing pollen hydration. Upon pollination, the POLLEN COAT PROTEIN B-class peptides (PCP-Bs) compete with RALF23/33 for binding to the ANJ&ndash...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Liu, C., Shen, L., Xiao, Y., Vyshedsky, D., Peng, C., Sun, X., Liu, Z., Cheng, L., Zhang, H., Han, Z., Chai, J., Wu, H.-M., Cheung, A. Y., Li, C. Tags: Botany, Cell Biology r-articles Source Type: news

QSER1 protects DNA methylation valleys from de novo methylation
DNA methylation is essential to mammalian development, and dysregulation can cause serious pathological conditions. Key enzymes responsible for deposition and removal of DNA methylation are known, but how they cooperate to regulate the methylation landscape remains a central question. Using a knockin DNA methylation reporter, we performed a genome-wide CRISPR-Cas9 screen in human embryonic stem cells to discover DNA methylation regulators. The top screen hit was an uncharacterized gene, QSER1, which proved to be a key guardian of bivalent promoters and poised enhancers of developmental genes, especially those residing in D...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Dixon, G., Pan, H., Yang, D., Rosen, B. P., Jashari, T., Verma, N., Pulecio, J., Caspi, I., Lee, K., Stransky, S., Glezer, A., Liu, C., Rivas, M., Kumar, R., Lan, Y., Torregroza, I., He, C., Sidoli, S., Evans, T., Elemento, O., Huangfu, D. Tags: Cell Biology, Development, Online Only r-articles Source Type: news

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
G protein–coupled receptors (GPCRs) are key regulators of information transmission between cells and organs. Despite this, we have only a limited understanding of the behavior of GPCRs in the apo state and the conformational changes upon agonist binding that lead to G protein recruitment and activation. We expressed and purified unmodified apo and peptide-bound calcitonin gene–related peptide (CGRP) receptors from insect cells to determine their cryo–electron microscopy (cryo-EM) structures, and we complemented these with analysis of protein conformational dynamics using hydrogen-deuterium exchange mass s...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Josephs, T. M., Belousoff, M. J., Liang, Y.-L., Piper, S. J., Cao, J., Garama, D. J., Leach, K., Gregory, K. J., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D., Sexton, P. M. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news

Targeting microRNAs could unmask hidden vulnerability in breast cancer stem cells
(Rockefeller University Press) Researchers in Italy have identified a pair of microRNA molecules that help maintain a population of cancerous stem cells that drive the growth of breast cancers and initiate tumor relapse after treatment. The study, which will be published April 2 in the Journal of Cell Biology (JCB), reveals that targeting these microRNAs makes cancer stem cells more susceptible to some chemotherapies and could potentially improve the prognosis of patients with aggressive forms of breast cancer. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 2, 2021 Category: Biology Source Type: news

USC Stem Cell study identifies molecular 'switch' that turns precursors into kidney cells
(Keck School of Medicine of USC) Kidney development is a balancing act between the self-renewal of stem and progenitor cells to maintain and expand their numbers, and the differentiation of these cells into more specialized cell types. In a new study from the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC, a team of scientists demonstrates the importance of a molecule calledβ-catenin in striking this balance. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 1, 2021 Category: International Medicine & Public Health Source Type: news

Optogenetics: Light regulates an enzyme
(University of W ü rzburg) New tool for cell biology: W ü rzburg researchers have developed a light sensor with an enzyme function that can be switched on and off with different light colours. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 29, 2021 Category: Biology Source Type: news

Cell cycle regulation
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Hines, P. J. Tags: Botany, Cell Biology twis Source Type: news

WAVE-ing T cell activation off
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Scanlon, S. T. Tags: Cell Biology, Immunology twis Source Type: news

Laser-controlled receptor clustering
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Ray, L. B. Tags: Biochemistry, Cell Biology twis Source Type: news

Molecular mechanism of cytokinin-activated cell division in Arabidopsis
Mitogens trigger cell division in animals. In plants, cytokinins, a group of phytohormones derived from adenine, stimulate cell proliferation. Cytokinin signaling is initiated by membrane-associated histidine kinase receptors and transduced through a phosphorelay system. We show that in the Arabidopsis shoot apical meristem (SAM), cytokinin regulates cell division by promoting nuclear shuttling of Myb-domain protein 3R4 (MYB3R4), a transcription factor that activates mitotic gene expression. Newly synthesized MYB3R4 protein resides predominantly in the cytoplasm. At the G2-to-M transition, rapid nuclear accumulation of MYB...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Yang, W., Cortijo, S., Korsbo, N., Roszak, P., Schiessl, K., Gurzadyan, A., Wightman, R., Jönsson, H., Meyerowitz, E. Tags: Botany, Cell Biology r-articles Source Type: news

WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity
Cytoskeletal regulatory protein dysfunction has been etiologically linked to inherited diseases associated with immunodeficiency and autoimmunity, but the mechanisms involved are incompletely understood. Here, we show that conditional Wave2 ablation in T cells causes severe autoimmunity associated with increased mammalian target of rapamycin (mTOR) activation and metabolic reprogramming that engender spontaneous activation and accelerated differentiation of peripheral T cells. These mice also manifest diminished antigen-specific T cell responses associated with increased inhibitory receptor expression, dysregulated mitocho...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Liu, M., Zhang, J., Pinder, B. D., Liu, Q., Wang, D., Yao, H., Gao, Y., Toker, A., Gao, J., Peterson, A., Qu, J., Siminovitch, K. A. Tags: Cell Biology, Immunology, Online Only r-articles Source Type: news

Photoinduced receptor confinement drives ligand-independent GPCR signaling
Cell-cell communication relies on the assembly of receptor-ligand complexes at the plasma membrane. The spatiotemporal receptor organization has a pivotal role in evoking cellular responses. We studied the clustering of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) and established a photoinstructive matrix with ultrasmall lock-and-key interaction pairs to control lateral membrane organization of hormone neuropeptide Y2 receptors in living cells by light. Within seconds, receptor clustering was modulated in size, location, and density. After in situ confinement, changes ...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Sanchez, M. F., Els-Heindl, S., Beck-Sickinger, A. G., Wieneke, R., Tampe, R. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news

Key human embryo stage mimicked in the lab
(Source: ScienceNOW)
Source: ScienceNOW - March 18, 2021 Category: Science Authors: Leslie, M. Tags: Cell Biology, Development In Depth Source Type: news

Biologists revel in pinpointing active genes in tissue samples
(Source: ScienceNOW)
Source: ScienceNOW - March 18, 2021 Category: Science Authors: Pennisi, E. Tags: Cell Biology In Depth Source Type: news

The ISSCR launches new digital scientific series on computational stem cell biology
(International Society for Stem Cell Research) The International Society for Stem Cell Research (ISSCR) is launching a new three-part digital series on Computational Stem Cell Biology starting 15 March, 2021. This series is part of the Society's growing portfolio of topic-specific digital scientific programming for members - also offered to non-members for fee. All ISSCR Digital programs are available live and on-demand. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 12, 2021 Category: Biology Source Type: news

Another way for GPCRs to signal
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Ray, L. B. Tags: Cell Biology twis Source Type: news

Transitioning lung for postnatal life
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Purnell, B. A. Tags: Cell Biology, Development twis Source Type: news

Noncanonical scaffolding of G{alpha}i and {beta}-arrestin by G protein-coupled receptors
Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific Gα protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arrestin–mediated signaling have been considered separable. We show here that GPCRs promote a direct interaction between Gαi protein subtype family members and β-arrestins regardless of their canonical Gα protein subtype coupling. Gαi:β-arrestin complexes bound extracellular signal–regulated kinase (ERK), and their disr...
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Smith, J. S., Pack, T. F., Inoue, A., Lee, C., Zheng, K., Choi, I., Eiger, D. S., Warman, A., Xiong, X., Ma, Z., Viswanathan, G., Levitan, I. M., Rochelle, L. K., Staus, D. P., Snyder, J. C., Kahsai, A. W., Caron, M. G., Rajagopal, S. Tags: Cell Biology, Online Only r-articles Source Type: news

Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus
The lung alveolus is the functional unit of the respiratory system required for gas exchange. During the transition to air breathing at birth, biophysical forces are thought to shape the emerging tissue niche. However, the intercellular signaling that drives these processes remains poorly understood. Applying a multimodal approach, we identified alveolar type 1 (AT1) epithelial cells as a distinct signaling hub. Lineage tracing demonstrates that AT1 progenitors align with receptive, force-exerting myofibroblasts in a spatial and temporal manner. Through single-cell chromatin accessibility and pathway expression (SCAPE) ana...
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Zepp, J. A., Morley, M. P., Loebel, C., Kremp, M. M., Chaudhry, F. N., Basil, M. C., Leach, J. P., Liberti, D. C., Niethamer, T. K., Ying, Y., Jayachandran, S., Babu, A., Zhou, S., Frank, D. B., Burdick, J. A., Morrisey, E. E. Tags: Cell Biology, Development, Online Only r-articles Source Type: news

Tour the Applewhite Lab
Cell biologist Derek Applewhite gives a peek inside his laboratory at Reed College. (Source: The Scientist)
Source: The Scientist - March 9, 2021 Category: Science Tags: Videos Source Type: news

Forming the early heart
(Source: ScienceNOW)
Source: ScienceNOW - March 4, 2021 Category: Science Authors: Purnell, B. A. Tags: Cell Biology, Development twis Source Type: news

Characterization of a common progenitor pool of the epicardium and myocardium
This study provides detailed insights into the formation of early cardiac cell types, with particular relevance to the development of cell-based cardiac regenerative therapies. (Source: ScienceNOW)
Source: ScienceNOW - March 4, 2021 Category: Science Authors: Tyser, R. C. V., Ibarra-Soria, X., McDole, K., Arcot Jayaram, S., Godwin, J., van den Brand, T. A. H., Miranda, A. M. A., Scialdone, A., Keller, P. J., Marioni, J. C., Srinivas, S. Tags: Cell Biology, Development, Online Only r-articles Source Type: news

New research will enhance corona safety during cruises
(Abo Akademi University) Researchers within Cell Biology and Industrial Management at Å bo Akademi University have developed models aimed at ensuring corona safety during cruises. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 1, 2021 Category: International Medicine & Public Health Source Type: news

Ciliary motors locked closed by Shulin
(Source: ScienceNOW)
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Molecular Biology twis Source Type: news

Following cancer through the body
(Source: ScienceNOW)
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Zahn, L. M. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Shulin packages axonemal outer dynein arms for ciliary targeting
The main force generators in eukaryotic cilia and flagella are axonemal outer dynein arms (ODAs). During ciliogenesis, these ~1.8-megadalton complexes are assembled in the cytoplasm and targeted to cilia by an unknown mechanism. Here, we used the ciliate Tetrahymena to identify two factors (Q22YU3 and Q22MS1) that bind ODAs in the cytoplasm and are required for ODA delivery to cilia. Q22YU3, which we named Shulin, locked the ODA motor domains into a closed conformation and inhibited motor activity. Cryo–electron microscopy revealed how Shulin stabilized this compact form of ODAs by binding to the dynein tails. Our fi...
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Mali, G. R., Ali, F. A., Lau, C. K., Begum, F., Boulanger, J., Howe, J. D., Chen, Z. A., Rappsilber, J., Skehel, M., Carter, A. P. Tags: Cell Biology, Molecular Biology r-articles Source Type: news

Liver homeostasis is maintained by midlobular zone 2 hepatocytes
The liver is organized into zones in which hepatocytes express different metabolic enzymes. The cells most responsible for liver repopulation and regeneration remain undefined, because fate mapping has only been performed on a few hepatocyte subsets. Here, 14 murine fate-mapping strains were used to systematically compare distinct subsets of hepatocytes. During homeostasis, cells from both periportal zone 1 and pericentral zone 3 contracted in number, whereas cells from midlobular zone 2 expanded in number. Cells within zone 2, which are sheltered from common injuries, also contributed to regeneration after pericentral and...
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Wei, Y., Wang, Y. G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., Lin, Y.-H., Hsieh, M.-H., Albrecht, J. H., Le, P. T., Rosen, C. J., Wang, T., Zhu, H. Tags: Cell Biology, Development, Online Only r-articles Source Type: news

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
We report deeply resolved phylogenies for tens of thousands of cancer cells traced over months of growth and dissemination. This revealed stark heterogeneity in metastatic capacity, arising from preexisting and heritable differences in gene expression. We demonstrate that these identified genes can drive invasiveness and uncovered an unanticipated suppressive role for KRT17. We also show that metastases disseminated via multidirectional tissue routes and complex seeding topologies. Overall, we demonstrate the power of tracing cancer progression at subclonal resolution and vast scale. (Source: ScienceNOW)
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Quinn, J. J., Jones, M. G., Okimoto, R. A., Nanjo, S., Chan, M. M., Yosef, N., Bivona, T. G., Weissman, J. S. Tags: Cell Biology, Medicine, Diseases, Online Only r-articles Source Type: news

Tissue regeneration: Reserve or reverse?
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Shivdasani, R. A., Clevers, H., de Sauvage, F. J. Tags: Cell Biology perspective Source Type: news

Organoids regenerate human bile ducts
(Source: ScienceNOW)
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Kelly, P. N. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Organoid technology holds great promise for regenerative medicine but has not yet been applied to humans. We address this challenge using cholangiocyte organoids in the context of cholangiopathies, which represent a key reason for liver transplantation. Using single-cell RNA sequencing, we show that primary human cholangiocytes display transcriptional diversity that is lost in organoid culture. However, cholangiocyte organoids remain plastic and resume their in vivo signatures when transplanted back in the biliary tree. We then utilize a model of cell engraftment in human livers undergoing ex vivo normothermic perfusion to...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Sampaziotis, F., Muraro, D., Tysoe, O. C., Sawiak, S., Beach, T. E., Godfrey, E. M., Upponi, S. S., Brevini, T., Wesley, B. T., Garcia-Bernardo, J., Mahbubani, K., Canu, G., Gieseck, R., Berntsen, N. L., Mulcahy, V. L., Crick, K., Fear, C., Robinson, S., Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Plant evolution driven by interactions with symbiotic and pathogenic microbes
During 450 million years of diversification on land, plants and microbes have evolved together. This is reflected in today’s continuum of associations, ranging from parasitism to mutualism. Through phylogenetics, cell biology, and reverse genetics extending beyond flowering plants into bryophytes, scientists have started to unravel the genetic basis and evolutionary trajectories of plant-microbe associations. Protection against pathogens and support of beneficial, symbiotic, microorganisms are sustained by a blend of conserved and clade-specific plant mechanisms evolving at different speeds. We propose that symbiosis...
Source: ScienceNOW - February 18, 2021 Category: Science Authors: Delaux, P.-M., Schornack, S. Tags: Botany, Evolution, Online Only review Source Type: news

Automated Dual Stain Cytology in Cervical Cancer Screening Automated Dual Stain Cytology in Cervical Cancer Screening
Automating the scanning and evaluation of dual stain slides can help improve the efficiency of cervical cancer screening, but how accurate is it?Journal of the National Cancer Institute (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 16, 2021 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

John Bishop obituary
My friend and colleague John Bishop, who has died aged 85, was a pioneer of molecular cell biology whose career bridged a remarkable era in life sciences – from genes to genetic engineering.Born in Edinburgh, to Mary (nee Oliver) and Robert Bishop, John was raised in the nearby town of Bo ’ness, where his father was a shopkeeper. He won a scholarship to attend George Heriot’s school in Edinburgh, and then studied genetics at Edinburgh University (BSc with first-class honours, 1957), and took a PhD in the same department. In 1959 he married Jill Spowart, a fellow student.Continue reading... (Source: Guardi...
Source: Guardian Unlimited Science - February 12, 2021 Category: Science Authors: Richard Lathe Tags: Biochemistry and molecular biology Genetics Science Source Type: news

Regulating multiple body clocks
(Source: ScienceNOW)
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Alderton, G. Tags: Cell Biology, Engineering, Medicine, Diseases twis Source Type: news

Communicating clocks shape circadian homeostasis
Circadian clocks temporally coordinate physiology and align it with geophysical time, which enables diverse life-forms to anticipate daily environmental cycles. In complex organisms, clock function originates from the molecular oscillator within each cell and builds upward anatomically into an organism-wide system. Recent advances have transformed our understanding of how clocks are connected to achieve coherence across tissues. Circadian misalignment, often imposed in modern society, disrupts coordination among clocks and has been linked to diseases ranging from metabolic syndrome to cancer. Thus, uncovering the physiolog...
Source: ScienceNOW - February 11, 2021 Category: Science Authors: Koronowski, K. B., Sassone-Corsi, P. Tags: Cell Biology, Engineering, Medicine, Diseases, Online Only review Source Type: news

Lung Cancer Cytology in the Times of Coronavirus Lung Cancer Cytology in the Times of Coronavirus
Cytopathology plays a key role in the diagnosis and management of lung cancer. In what ways has the current pandemic impacted the handling and processing of these samples?Translational Lung Cancer Research (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 4, 2021 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

The makings of anisosomes
(Source: ScienceNOW)
Source: ScienceNOW - February 4, 2021 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Molecular Biology twis Source Type: news

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
In this study, we found that RNA binding–deficient TDP-43 (produced by neurodegeneration-causing mutations or posttranslational acetylation in its RNA recognition motifs) drove TDP-43 demixing into intranuclear liquid spherical shells with liquid cores. These droplets, which we named "anisosomes", have shells that exhibit birefringence, thus indicating liquid crystal formation. Guided by mathematical modeling, we identified the primary components of the liquid core to be HSP70 family chaperones, whose adenosine triphosphate (ATP)–dependent activity maintained the liquidity of shells and cores. In vivo...
Source: ScienceNOW - February 4, 2021 Category: Science Authors: Yu, H., Lu, S., Gasior, K., Singh, D., Vazquez-Sanchez, S., Tapia, O., Toprani, D., Beccari, M. S., Yates, J. R., Da Cruz, S., Newby, J. M., Lafarga, M., Gladfelter, A. S., Villa, E., Cleveland, D. W. Tags: Cell Biology, Molecular Biology, Online Only r-articles Source Type: news

New Amivantamab Data from CHRYSALIS Study Show Robust Clinical Activity and Durable Responses in Patients with Metastatic or Unresectable Non-Small Cell Lung Cancer and EGFR Exon 20 Insertion Mutations
January 28, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data from the Phase 1 CHRYSALIS study, which evaluated amivantamab in patients with metastatic or unresectable non-small cell lung cancer (NSCLC) and epidermal growth factor receptor (EGFR) exon 20 insertion mutations whose disease progressed on or after platinum-based chemotherapy.1 These data were presented for the first time in an oral presentation at the International Association for the Study of Lung Cancer’s (IASLC) 2020 World Conference on Lung Cancer (WCLC) Singapore. The key findings sho...
Source: Johnson and Johnson - January 29, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Maintaining muscle
(Source: ScienceNOW)
Source: ScienceNOW - January 28, 2021 Category: Science Authors: Ray, L. B. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
Treatments are lacking for sarcopenia, a debilitating age-related skeletal muscle wasting syndrome. We identifed increased amounts of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The consequent reduction in PGE2 signaling contributed to muscle atrophy in aged mice and results from 15-PGDH–expressing myofibers and interstitial cells, such as macrophages, within muscle. Overexpression of 15-PGDH in young muscles induced atrophy. Inhibition of 15-PGDH, by targeted genetic depletion or a small-molecule inhibi...
Source: ScienceNOW - January 28, 2021 Category: Science Authors: Palla, A. R., Ravichandran, M., Wang, Y. X., Alexandrova, L., Yang, A. V., Kraft, P., Holbrook, C. A., Schürch, C. M., Ho, A. T. V., Blau, H. M. Tags: Cell Biology, Medicine, Diseases, Online Only r-articles Source Type: news

Separation anxiety
(Source: ScienceNOW)
Source: ScienceNOW - January 21, 2021 Category: Science Authors: Leslie, M. Tags: Biochemistry, Cell Biology Feature Source Type: news

Researchers link cellular transport pathway to aggressive brain cancer
(Rockefeller University Press) Researchers at McGill University have identified a new cellular pathway that limits the growth and spread of brain tumors by controlling the recycling of cell surface receptor proteins. The study, which will be published January 14 in the Journal of Cell Biology (JCB), suggests that the pathway, which involves a protein called Rab35, is defective in many patients with glioblastoma and that restoring Rab35's activity could be a new therapeutic strategy for this deadly form of brain cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 14, 2021 Category: Cancer & Oncology Source Type: news

Anemone shows mechanism of rapid evolution
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Pennisi, E. Tags: Cell Biology, Evolution In Depth Source Type: news

A key complex in B cell activation
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Vinson, V. Tags: Biochemistry, Cell Biology twis Source Type: news

A cascade of NO in Alzheimer's disease
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Ray, L. B. Tags: Cell Biology, Medicine, Diseases twis Source Type: news

Ancestry and evolution in cell biology
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Ash, C. Tags: Cell Biology twis Source Type: news

Selective destruction of senescent cells
(Source: ScienceNOW)
Source: ScienceNOW - January 14, 2021 Category: Science Authors: Nusinovich, Y. Tags: Cell Biology twis Source Type: news