Cell cycle regulation
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Hines, P. J. Tags: Botany, Cell Biology twis Source Type: news
WAVE-ing T cell activation off
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Scanlon, S. T. Tags: Cell Biology, Immunology twis Source Type: news
Laser-controlled receptor clustering
(Source: ScienceNOW)
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Ray, L. B. Tags: Biochemistry, Cell Biology twis Source Type: news
Molecular mechanism of cytokinin-activated cell division in Arabidopsis
Mitogens trigger cell division in animals. In plants, cytokinins, a group of phytohormones derived from adenine, stimulate cell proliferation. Cytokinin signaling is initiated by membrane-associated histidine kinase receptors and transduced through a phosphorelay system. We show that in the Arabidopsis shoot apical meristem (SAM), cytokinin regulates cell division by promoting nuclear shuttling of Myb-domain protein 3R4 (MYB3R4), a transcription factor that activates mitotic gene expression. Newly synthesized MYB3R4 protein resides predominantly in the cytoplasm. At the G2-to-M transition, rapid nuclear accumulation of MYB...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Yang, W., Cortijo, S., Korsbo, N., Roszak, P., Schiessl, K., Gurzadyan, A., Wightman, R., Jönsson, H., Meyerowitz, E. Tags: Botany, Cell Biology r-articles Source Type: news
WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity
Cytoskeletal regulatory protein dysfunction has been etiologically linked to inherited diseases associated with immunodeficiency and autoimmunity, but the mechanisms involved are incompletely understood. Here, we show that conditional Wave2 ablation in T cells causes severe autoimmunity associated with increased mammalian target of rapamycin (mTOR) activation and metabolic reprogramming that engender spontaneous activation and accelerated differentiation of peripheral T cells. These mice also manifest diminished antigen-specific T cell responses associated with increased inhibitory receptor expression, dysregulated mitocho...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Liu, M., Zhang, J., Pinder, B. D., Liu, Q., Wang, D., Yao, H., Gao, Y., Toker, A., Gao, J., Peterson, A., Qu, J., Siminovitch, K. A. Tags: Cell Biology, Immunology, Online Only r-articles Source Type: news
Photoinduced receptor confinement drives ligand-independent GPCR signaling
Cell-cell communication relies on the assembly of receptor-ligand complexes at the plasma membrane. The spatiotemporal receptor organization has a pivotal role in evoking cellular responses. We studied the clustering of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) and established a photoinstructive matrix with ultrasmall lock-and-key interaction pairs to control lateral membrane organization of hormone neuropeptide Y2 receptors in living cells by light. Within seconds, receptor clustering was modulated in size, location, and density. After in situ confinement, changes ...
Source: ScienceNOW - March 25, 2021 Category: Science Authors: Sanchez, M. F., Els-Heindl, S., Beck-Sickinger, A. G., Wieneke, R., Tampe, R. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news
Key human embryo stage mimicked in the lab
(Source: ScienceNOW)
Source: ScienceNOW - March 18, 2021 Category: Science Authors: Leslie, M. Tags: Cell Biology, Development In Depth Source Type: news
Biologists revel in pinpointing active genes in tissue samples
(Source: ScienceNOW)
Source: ScienceNOW - March 18, 2021 Category: Science Authors: Pennisi, E. Tags: Cell Biology In Depth Source Type: news
The ISSCR launches new digital scientific series on computational stem cell biology
(International Society for Stem Cell Research) The International Society for Stem Cell Research (ISSCR) is launching a new three-part digital series on Computational Stem Cell Biology starting 15 March, 2021. This series is part of the Society's growing portfolio of topic-specific digital scientific programming for members - also offered to non-members for fee. All ISSCR Digital programs are available live and on-demand. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 12, 2021 Category: Biology Source Type: news
Noncanonical scaffolding of G{alpha}i and {beta}-arrestin by G protein-coupled receptors
Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific Gα protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arrestin–mediated signaling have been considered separable. We show here that GPCRs promote a direct interaction between Gαi protein subtype family members and β-arrestins regardless of their canonical Gα protein subtype coupling. Gαi:β-arrestin complexes bound extracellular signal–regulated kinase (ERK), and their disr...
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Smith, J. S., Pack, T. F., Inoue, A., Lee, C., Zheng, K., Choi, I., Eiger, D. S., Warman, A., Xiong, X., Ma, Z., Viswanathan, G., Levitan, I. M., Rochelle, L. K., Staus, D. P., Snyder, J. C., Kahsai, A. W., Caron, M. G., Rajagopal, S. Tags: Cell Biology, Online Only r-articles Source Type: news
Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus
The lung alveolus is the functional unit of the respiratory system required for gas exchange. During the transition to air breathing at birth, biophysical forces are thought to shape the emerging tissue niche. However, the intercellular signaling that drives these processes remains poorly understood. Applying a multimodal approach, we identified alveolar type 1 (AT1) epithelial cells as a distinct signaling hub. Lineage tracing demonstrates that AT1 progenitors align with receptive, force-exerting myofibroblasts in a spatial and temporal manner. Through single-cell chromatin accessibility and pathway expression (SCAPE) ana...
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Zepp, J. A., Morley, M. P., Loebel, C., Kremp, M. M., Chaudhry, F. N., Basil, M. C., Leach, J. P., Liberti, D. C., Niethamer, T. K., Ying, Y., Jayachandran, S., Babu, A., Zhou, S., Frank, D. B., Burdick, J. A., Morrisey, E. E. Tags: Cell Biology, Development, Online Only r-articles Source Type: news
Another way for GPCRs to signal
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Ray, L. B. Tags: Cell Biology twis Source Type: news
Transitioning lung for postnatal life
(Source: ScienceNOW)
Source: ScienceNOW - March 11, 2021 Category: Science Authors: Purnell, B. A. Tags: Cell Biology, Development twis Source Type: news
Tour the Applewhite Lab
Cell biologist Derek Applewhite gives a peek inside his laboratory at Reed College. (Source: The Scientist)
Source: The Scientist - March 9, 2021 Category: Science Tags: Videos Source Type: news
Characterization of a common progenitor pool of the epicardium and myocardium
This study provides detailed insights into the formation of early cardiac cell types, with particular relevance to the development of cell-based cardiac regenerative therapies. (Source: ScienceNOW)
Source: ScienceNOW - March 4, 2021 Category: Science Authors: Tyser, R. C. V., Ibarra-Soria, X., McDole, K., Arcot Jayaram, S., Godwin, J., van den Brand, T. A. H., Miranda, A. M. A., Scialdone, A., Keller, P. J., Marioni, J. C., Srinivas, S. Tags: Cell Biology, Development, Online Only r-articles Source Type: news
