Researchers discover a new method to regulate cell plasticity
(Institute for Research in Biomedicine (IRB Barcelona)) Researchers at IRB Barcelona's Cellular Plasticity and Disease Laboratory propose a more efficient way to limit cell plasticity without causing cell damage.The new method sheds light on processes in which cell plasticity is important, such as cancer and immunology.The study has been published in the journal Nature Cell Biology and has been supported by " la Caixa " Foundation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 28, 2020 Category: International Medicine & Public Health Source Type: news
Researchers identify 'druggable' signaling pathway that stimulates lung tissue repair
(Children's Hospital of Philadelphia) Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration, which is necessary for recovery from multiple lung injuries. The findings, which were published today in Nature Cell Biology, could lead to better therapies for patients with lung disease, including acute respiratory distress syndrome (ARDS) due to COVID-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 28, 2020 Category: Infectious Diseases Source Type: news
Dissecting membrane dislocation
(Source: ScienceNOW)
Source: ScienceNOW - September 23, 2020 Category: Science Authors: Hurtley, S. M. Tags: Biochemistry, Cell Biology twis Source Type: news
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase
Organelle identity depends on protein composition. How mistargeted proteins are selectively recognized and removed from organelles is incompletely understood. Here, we found that the orphan P5A–adenosine triphosphatase (ATPase) transporter ATP13A1 (Spf1 in yeast) directly interacted with the transmembrane segment (TM) of mitochondrial tail–anchored proteins. P5A-ATPase activity mediated the extraction of mistargeted proteins from the endoplasmic reticulum (ER). Cryo–electron microscopy structures of Saccharomyces cerevisiae Spf1 revealed a large, membrane-accessible substrate-binding pocket that alternate...
Source: ScienceNOW - September 23, 2020 Category: Science Authors: McKenna, M. J., Sim, S. I., Ordureau, A., Wei, L., Harper, J. W., Shao, S., Park, E. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news
Advanced Flow Cytometry Uncovers T Cell Biology
Download this white paper to understand T cell phenotype and function to improve therapeutics research! (Source: The Scientist)
Source: The Scientist - September 23, 2020 Category: Science Tags: The Marketplace Source Type: news
NIH funds research into differences in glioblastoma between males and females
(Cleveland Clinic) A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females. The researchers will delve into the genetics, epigenetics and cell biology of glioblastoma - the most common and deadliest brain tumor in adults - to better understand the physiologic processes which may lead to more personalized therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news
Roche receives FDA approval for expanded use of the CINtec PLUS Cytology test to aid clinicians in preventing cervical cancer
Basel, 16 September 2020 — Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced U.S. Food and Drug Administration (FDA) approval for the expanded use of CINtec®PLUS Cytology, the first triage test based on biomarker technology for women whose cervical cancer screening results are positive for high-risk types of human papillomavirus (HPV). Additional information from this test supports clinical decisions about which women will benefit most from immediate follow-up. Laboratories can now use CINtecPLUS Cytology to triage positive results from the cobas ® HPV Test run on the fully integrated, automated and high-throughput co...
Source: Roche Investor Update - September 16, 2020 Category: Pharmaceuticals Source Type: news
Roche receives FDA approval for expanded use of the CINtec PLUS Cytology test to aid clinicians in preventing cervical cancer
Basel, 16 September 2020 — Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced U.S. Food and Drug Administration (FDA) approval for the expanded use of CINtec®PLUS Cytology, the first triage test based on biomarker technology for women whose cervical cancer screening results are positive for high-risk types of human papillomavirus (HPV). Additional information from this test supports clinical decisions about which women will benefit most from immediate follow-up. Laboratories can now use CINtecPLUS Cytology to triage positive results from the cobas ® HPV Test run on the fully integrated, automated and high-throughput co...
Source: Roche Media News - September 16, 2020 Category: Pharmaceuticals Source Type: news
Narrow path charted for editing genes of human embryos
(Source: ScienceNOW)
Source: ScienceNOW - September 9, 2020 Category: Science Authors: Cohen, J. Tags: Cell Biology, Medicine, Diseases, Scientific Community In Depth Source Type: news
Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation
In this study, we reconstituted autophagosome nucleation using recombinant components from yeast. We found that Atg9 proteoliposomes first recruited the phosphatidylinositol 3-phosphate kinase complex, followed by Atg21, the Atg2-Atg18 lipid transfer complex, and the E3-like Atg12–Atg5-Atg16 complex, which promoted Atg8 lipidation. Furthermore, we found that Atg2 could transfer lipids for Atg8 lipidation. In selective autophagy, these reactions could potentially be coupled to the cargo via the Atg19-Atg11-Atg9 interactions. We thus propose that Atg9 vesicles form seeds that establish membrane contact sites to initiat...
Source: ScienceNOW - September 2, 2020 Category: Science Authors: Sawa-Makarska, J., Baumann, V., Coudevylle, N., von Bülow, S., Nogellova, V., Abert, C., Schuschnig, M., Graef, M., Hummer, G., Martens, S. Tags: Biochemistry, Cell Biology, Online Only r-articles Source Type: news
Reconstituting autophagosome nucleation
(Source: ScienceNOW)
Source: ScienceNOW - September 2, 2020 Category: Science Authors: Hurtley, S. M. Tags: Biochemistry, Cell Biology twis Source Type: news
Researchers identify RNA molecule that helps lung cancer cells evade immune system
(Rockefeller University Press) Researchers in Spain have identified a non-coding RNA molecule that helps lung cancer cells proliferate and avoid being killed by the body's immune cells. The study, which will be published August 27 in the Journal of Cell Biology (JCB), suggests that targeting this RNA molecule could boost the effectiveness of immunotherapies that are currently only successful in ~20% of lung cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 27, 2020 Category: Cancer & Oncology Source Type: news
You can find your own way
(Source: ScienceNOW)
Source: ScienceNOW - August 26, 2020 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Computers, Mathematics twis Source Type: news
Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown
We describe how self-generated gradients, created by cells locally degrading attractant, allow single cells to navigate long, tortuous paths and make accurate choices between live channels and dead ends. This allows cells to solve complex mazes efficiently. Cells’ accuracy at finding live channels was determined by attractant diffusivity, cell speed, and path complexity. Manipulating these parameters directed cells in mathematically predictable ways; specific combinations can even actively misdirect them. We propose that the length and complexity of many long-range migratory processes, including inflammation and germ...
Source: ScienceNOW - August 26, 2020 Category: Science Authors: Tweedy, L., Thomason, P. A., Paschke, P. I., Martin, K., Machesky, L. M., Zagnoni, M., Insall, R. H. Tags: Cell Biology, Computers, Mathematics, Online Only r-articles Source Type: news
Remodeling senescent blood vessels
(Source: ScienceNOW)
Source: ScienceNOW - August 19, 2020 Category: Science Authors: Hurtley, S. M. Tags: Cell Biology, Medicine, Diseases twis Source Type: news
