The cGAS-Ku80 complex regulates the balance between two end joining subpathways
Cell Death & Differentiation, Published online: 25 April 2024; doi:10.1038/s41418-024-01296-4The cGAS-Ku80 complex regulates the balance between two end joining subpathways (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - April 25, 2024 Category: Cytology Authors: Haiping Zhang Lijun Jiang Xinyi Du Zhen Qian Guizhu Wu Ying Jiang Zhiyong Mao Source Type: research
A comparison of clinical features between neurobrucellosis and tuberculous meningitis
This study aims to compare the clinical manifestations, imaging findings, routine tests, biochemistry indicators and cerebrospinal fluid cytology between neurobrucellosis and tuberculous meningitis. The object... (Source: BMC Neurology)
Source: BMC Neurology - April 25, 2024 Category: Neurology Authors: Yueli Zou, Liqing Wang, Yi Li, Yaning Wu, Junying He and Xiujun Yu Tags: Research Source Type: research
The genome of the colonial hydroid Hydractinia reveals that their stem cells use a toolkit of evolutionarily shared genes with all animals [RESOURCES]
Hydractinia is a colonial marine hydroid that shows remarkable biological properties, including the capacity to regenerate its entire body throughout its lifetime, a process made possible by its adult migratory stem cells, known as i-cells. Here, we provide an in-depth characterization of the genomic structure and gene content of two Hydractinia species, Hydractinia symbiolongicarpus and Hydractinia echinata, placing them in a comparative evolutionary framework with other cnidarian genomes. We also generated and annotated a single-cell transcriptomic atlas for adult male H. symbiolongicarpus and identified cell-type marker...
Source: Genome Research - April 25, 2024 Category: Genetics & Stem Cells Authors: Schnitzler, C. E., Chang, E. S., Waletich, J., Quiroga-Artigas, G., Wong, W. Y., Nguyen, A.-D., Barreira, S. N., Doonan, L. B., Gonzalez, P., Koren, S., Gahan, J. M., Sanders, S. M., Bradshaw, B., DuBuc, T. Q., Febrimarsa, , de Jong, D., Nawrocki, E. P., Tags: RESOURCES Source Type: research
Comparative study of conventional exfoliative cytology and centrifuged liquid ‑based cytology in oral leukoplakia and oral squamous cell carcinoma patients
Conclusion: CLBC is better and give clearer vision as compared to conventional cytology and can be used in the early diagnosis.Key Words: Cytology, early diagnosis, leukoplakia, oral cancer HighlightR. Jayabalan: Pubmed,Google Scholar (Source: Dental Research Journal)
Source: Dental Research Journal - April 24, 2024 Category: Dentistry Source Type: research
Diagnostic interobserver agreement for thyroid fine-needle aspirates: Effects of reviewer experience and molecular diagnostics
CONCLUSIONS: Atypia of undetermined significance of thyroid FNAs harboring BRAF V600E is uncommon yet relatively reproducible, particularly among pathologists with experience. It is advisable to sequence BRAF across V600 in such cases.PMID:38656386 | DOI:10.1093/ajcp/aqae043 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 24, 2024 Category: Pathology Authors: Hamza N Gokozan Maria Mostyka Theresa Scognamiglio James P Solomon Shaham Beg Evan Stern Abha Goyal Momin T Siddiqui Jonas J Heymann Source Type: research
Isolation of < em > Schistosoma haematobium < /em > in Bronchoalveolar Lavage in an Immunocompromised Individual: A Case Report
We report a rare case of a 51-year-old People Living with HIV male, managed in a tertiary care hospital in west India in May 2023, vegetable vendor who was admitted with complaints of dysphagia, odynophagia, fever and chest pain for 3 days, cough and breathlessness for 1 month. Chest x-ray and CT scan were suggestive of hypodense fluid collection with rim enhancement along right lateral and posterior aspect of thoracic esophagus. All routine investigations and urine cultures were sent, which turned to be inconclusive. Upper Gastrointestinal scopy was suggestive of pangastritis. Fiberoptic bronchoscopy was done with no stru...
Source: Iranian Journal of Parasitology - April 24, 2024 Category: Parasitology Authors: Shailesh Bhanudas Meshram Hiral Gulab Ramnani Spandana Chaudhury Source Type: research
Association of Cadherin-Related Family Member 1 with Traumatic Brain Injury
Cell Mol Neurobiol. 2024 Apr 24;44(1):41. doi: 10.1007/s10571-024-01476-3.ABSTRACTThe cadherin family plays a pivotal role in orchestrating synapse formation in the central nervous system. Cadherin-related family member 1 (CDHR1) is a photoreceptor-specific calmodulin belonging to the expansive cadherin superfamily. However, its role in traumatic brain injury (TBI) remains largely unknown. CDHR1 expression across various brain tissue sites was analyzed using the GSE104687 dataset. Employing a summary-data-based Mendelian Randomization (SMR) approach, integrated analyses were performed by amalgamating genome-wide associatio...
Source: Cellular and Molecular Neurobiology - April 24, 2024 Category: Cytology Authors: Yong'An Jiang Peng Chen YangYang Zhao Yan Zhang Source Type: research
Correction: GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms
Cell Mol Neurobiol. 2024 Apr 24;44(1):40. doi: 10.1007/s10571-024-01475-4.NO ABSTRACTPMID:38656458 | DOI:10.1007/s10571-024-01475-4 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 24, 2024 Category: Cytology Authors: Tongyu Zhang Gang Zuo Hongqi Zhang Source Type: research
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice
Dev Cell. 2024 Apr 22:S1534-5807(24)00227-2. doi: 10.1016/j.devcel.2024.04.002. Online ahead of print.ABSTRACTRNA-binding proteins (RBPs), as key regulators of mRNA fate, are abundantly expressed in the testis. However, RBPs associated with human male infertility remain largely unknown. Through bioinformatic analyses, we identified 62 such RBPs, including an evolutionarily conserved RBP, DEAD-box helicase 20 (DDX20). Male germ-cell-specific inactivation of Ddx20 at E15.5 caused T1-propsermatogonia (T1-ProSG) to fail to reenter cell cycle during the first week of testicular development in mice. Consequently, neither the fou...
Source: Developmental Cell - April 24, 2024 Category: Cytology Authors: Dingfeng Zou Kai Li Luying Su Jun Liu Yan Lu Rong Huang Mengzhen Li Xinyu Mang Qi Geng Pengyu Li Jielin Tang Zhixin Yu Zexuan Zhang Dingyao Chen Shiying Miao Jia Yu Wei Yan Wei Song Source Type: research
Assessment of the anti-inflammatory and biological properties of Bioroot Flow: A novel bioceramic sealer
CONCLUSIONS: Taken together, these findings indicate that BRF can potentially enhance cell differentiation by promoting the expression of essential genes related to bone and cement formation. In addition, BRF and TFbc displayed anti-inflammatory effects.PMID:38657320 | DOI:10.1016/j.tice.2024.102391 (Source: Tissue and Cell)
Source: Tissue and Cell - April 24, 2024 Category: Cytology Authors: Sergio L ópez-García Jos é L Sanz Laura Murcia David Garc ía-Bernal Adri án Lozano Leopoldo Forner Francisco J Rodr íguez-Lozano Ricardo E O ñate-Sánchez Source Type: research
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK
Cell Metab. 2024 Apr 16:S1550-4131(24)00118-9. doi: 10.1016/j.cmet.2024.03.014. Online ahead of print.ABSTRACTThe accumulation of lipid droplets (LDs) in aging and Alzheimer's disease brains is considered a pathological phenomenon with unresolved cellular and molecular mechanisms. Utilizing stimulated Raman scattering (SRS) microscopy, we observed significant in situ LD accumulation in microglia of tauopathy mouse brains. SRS imaging, combined with deuterium oxide (D2O) labeling, revealed heightened lipogenesis and impaired lipid turnover within LDs in tauopathy fly brains and human neurons derived from induced pluripotent...
Source: Cell Metabolism - April 24, 2024 Category: Cytology Authors: Yajuan Li Daniel Munoz-Mayorga Yuhang Nie Ningxin Kang Yuren Tao Jessica Lagerwall Carla Pernaci Genevieve Curtin Nicole G Coufal Jerome Mertens Lingyan Shi Xu Chen Source Type: research
The diverse functions of DYRK2 in response to cellular stress
Histol Histopathol. 2024 Apr 8:18744. doi: 10.14670/HH-18-744. Online ahead of print.ABSTRACTTo maintain microenvironmental and cellular homeostasis, cells respond to multiple stresses by activating characteristic cellular mechanisms consisting of receptors, signal transducers, and effectors. Dysfunction of these mechanisms can trigger multiple human diseases as well as cancers. Dual-specificity tyrosine-regulated kinases (DYRKs) are members of the CMGC group and are evolutionarily conserved from yeast to mammals. Previous studies revealed that DYRK2 has important roles in the regulation of the cell cycle and survival in c...
Source: Histology and Histopathology - April 24, 2024 Category: Cytology Authors: Akira Kawamura Saishu Yoshida Kiyotsugu Yoshida Source Type: research
Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury
CONCLUSIONS: Taken together, these data suggest that ASC-CS represents a potent therapeutic option to improve established AKI.PMID:38659070 | DOI:10.1186/s13287-024-03736-x (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Md Mahbub Ullah Jason A Collett Jacob C Monroe Dmitry Traktuev Michael Coleman Keith L March David P Basile Source Type: research
Simple modeling of familial Alzheimer's disease using human pluripotent stem cell-derived cerebral organoid technology
CONCLUSION: Our model effectively recapitulates AD pathology. Hence, it is a valuable platform for understanding the mechanisms underlying AD pathogenesis and can be used to test the efficacy of anti-AD drugs.PMID:38659053 | DOI:10.1186/s13287-024-03732-1 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Mu Seog Choe Han Cheol Yeo Joong Sun Kim Jean Lee Hae Jun Lee Hyung-Ryong Kim Kyung Min Baek Na-Yeon Jung Murim Choi Min Young Lee Source Type: research
Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes
CONCLUSION: circSOD2 competitively sponges miR-532-3p to activate the TXNIP/NLRP3 inflammasome signaling pathway, promoting pyroptosis in NAFLD.PMID:38659023 | DOI:10.1186/s40001-024-01817-4 (Source: Cell Research)
Source: Cell Research - April 24, 2024 Category: Cytology Authors: FengJuan Chen YuFeng Xing ZhiJie Chen XiaoMan Chen Jie Li Si Gong Fang Luo QingXian Cai Source Type: research
