Effect of stability of PTEN on hepatocellular carcinoma
CONCLUSIONS: On the one hand, our study revealed that CRISPR-Cas12a might play an important role in the screening and prognosis of HCC as a new clinical method to detect PTEN mutation.PMID:38687946 | DOI:10.4103/jcrt.jcrt_349_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yilin Hu Hongliang Mei Tianji Luan Huiling Sun Qiping Lu Rong Liu Source Type: research
Local therapy combined with anti-PD-1 immunotherapy for advanced lung adenocarcinoma: A case report
J Cancer Res Ther. 2024 Apr 1;20(2):739-744. doi: 10.4103/jcrt.jcrt_1600_23. Epub 2024 Apr 30.ABSTRACTLung adenocarcinoma (LUAD) encompasses all lung epithelial cancers except small-cell lung cancer. Although programmed cell death protein 1 (PD-1) inhibitors, such as pembrolizumab, and other Food and Drug Administration-approved immune checkpoint inhibitors, offer new hope for LUAD treatment, LUAD's overall efficacy remains limited. Thus, the combination of immunotherapy with other therapeutic approaches has gained widespread attention. Local therapy is an optimal method for treating many advanced unresectable lung cancers...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Na Wu Xiaoxin Yang Yan Zhai Wei Lu Source Type: research
Evaluation of stromal myofibroblasts in oral submucous fibrosis and its malignant transformation: An immunohistochemical study
CONCLUSIONS: The expression of MFs exhibited a gradual increase as the disease progressed from mild to malignant transformation, indicating the contributory role of MFs in the fibrogenesis and potential tumorigenesis associated with OSF.PMID:38687943 | DOI:10.4103/jcrt.jcrt_498_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Ziyi Liu Wenwu Hu Zhongyan Shan Sixuan Liu Zhigang Yao Hongzhi Quan Source Type: research
Activation of M2 macrophage autophagy by rapamycin increases the radiosensitivity of colorectal cancer xenografts
CONCLUSIONS: Therefore, autophagy-activated M2 supernatant can downregulate the expression of the antiapoptotic genes Livin and Survivin in CRC xenografts, improving the radiosensitivity of CRC by inducing apoptosis in combination with radiotherapy and inhibiting the growth of transplanted tumors.PMID:38687942 | DOI:10.4103/jcrt.jcrt_215_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Lening Shao Yongyou Wu Jianping Cao Fengyun Zhong Xiaodong Yang Chungen Xing Source Type: research
Combination low-dose cyclophosphamide with check-point blockade and ionizing radiation promote an abscopal effect in mouse models of melanoma
CONCLUSIONS: Compared with traditional strategies, for the first time, we demonstrated that a triple treatment strategy remarkably increased the number of radiation-induced tumor-infiltrating CD8 + T-cells, effectively decreasing infiltrating Tregs, and promoting an abscopal effect. Thus, we describe a novel and effective therapeutic approach by combining multiple strategies to target several tumor-mediated immune inhibitory mechanisms.PMID:38687945 | DOI:10.4103/jcrt.jcrt_616_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Xing Luo Ming Zeng Source Type: research
Tumor-targeted gypenoside nanodrug delivery system with double protective layers
CONCLUSIONS: We have established a tumor-targeted nanodrug delivery system that can target and kill liver cancer cells and may provide a strategy for preparing new nanodrug-loaded preparations of traditional Chinese medicine.PMID:38687941 | DOI:10.4103/jcrt.jcrt_134_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Zongqiang Lai Facheng Bai Tao Pu Jun Li Lining Wu Zhou Zhou Nuo Yang Source Type: research
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research
Microwave ablation combined with percutaneous vertebroplasty for treating painful non-small cell lung cancer with spinal metastases under real-time temperature monitoring
CONCLUSIONS: MWA combined with PVP can significantly relieve pain and improve patients' quality of life, which implied this is an effective treatment option for painful NSCLC with spinal metastases. Additionally, its efficacy should be further verified through the mid- and long-term studies.PMID:38687923 | DOI:10.4103/jcrt.jcrt_1074_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Linlin Wu Miaomiao Hu Peishun Li Qirong Man Qianqian Yuan Xusheng Zhang Yuanyuan Qiu Lili Chen Jing Fan Kaixian Zhang Source Type: research
Immunostimulatory effects of thermal ablation: Challenges and future prospects
J Cancer Res Ther. 2024 Apr 1;20(2):531-539. doi: 10.4103/jcrt.jcrt_2484_23. Epub 2024 Apr 30.ABSTRACTThis literature explores the immunostimulatory effects of thermal ablation in the tumor microenvironment, elucidating the mechanisms such as immunogenic cell death, tumor-specific antigens, and damage-associated molecular patterns. Furthermore, it outlines critical issues associated with thermal ablation-induced immunostimulatory challenges and offers insights into future research avenues and potential therapeutic strategies.PMID:38687922 | DOI:10.4103/jcrt.jcrt_2484_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Peng Liu Zhigang Wei Xin Ye Source Type: research
New advances in the treatment of chondrosarcoma under the PD-1/PD-L1 pathway
J Cancer Res Ther. 2024 Apr 1;20(2):522-530. doi: 10.4103/jcrt.jcrt_2269_23. Epub 2024 Apr 30.ABSTRACTBone sarcomas encompass a group of spontaneous mesenchymal malignancies, among which osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma are the most common subtypes. Chondrosarcoma, a relatively prevalent malignant bone tumor that originates from chondrocytes, is characterized by endogenous cartilage ossification within the tumor tissue. Despite the use of aggressive treatment approaches involving extensive surgical resection, chemotherapy, and radiotherapy for patients with osteosarcoma, chondrosarcoma, and chordom...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jiawei Yin Peng Ren Source Type: research
Incidence of thromboembolic events in non-small cell lung cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis
J Cancer Res Ther. 2024 Apr 1;20(2):509-521. doi: 10.4103/jcrt.jcrt_1031_23. Epub 2024 Apr 30.ABSTRACTThe incidence of thromboembolic events (TEs) in non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs) has rarely been reported. The MEDLINE, EMBASE, and the Cochrane Library databases were searched. The primary outcome was the incidence of TEs, and the secondary outcome was the relationship between TEs and overall survival (OS) following ICI therapy. A subgroup analysis of TE incidents was performed according to the TE type and combination regimens. The I2 statistic was used to determ...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Miaomiao Yang Hongxin Cao Congcong Wang Caiyan Yu Ping Sun Source Type: research
T cell characteristics impact response and resistance to T cell-redirecting bispecific antibodies in multiple myeloma
CONCLUSIONS: Primary resistance is characterized by a low T-cell/MM cell-ratio and Treg-driven immunosuppression, while reduced T-cell fitness due to continuous BsAb-mediated T-cell activation may contribute to development of acquired resistance.PMID:38687588 | DOI:10.1158/1078-0432.CCR-23-3333 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Christie P M Verkleij Chloe A O'Neill Marloes E C Broekmans Kristine A Frerichs Wassilis S C Bruins Carolien Duetz Sandy Kruyswijk Serena R Baglio Sheri Skerget Rocio Montes de Oca Sonja Zweegman Raluca I Verona Tuna Mutis Niels W C J van de Donk Source Type: research
Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
Cancer Res Commun. 2024 Apr 24;4(4):1120-1134. doi: 10.1158/2767-9764.CRC-23-0468.ABSTRACTCombinations of immune checkpoint inhibitors (ICI, including anti-PD-1/PD-L1) and chemotherapy have been FDA approved for metastatic and early-stage triple-negative breast cancer (TNBC), but most patients do not benefit. B7-H4 is a B7 family ligand with proposed immunosuppressive functions being explored as a cancer immunotherapy target and may be associated with anti-PD-L1 resistance. However, little is known about its regulation and effect on immune cell function in breast cancers. We assessed murine and human breast cancer cells to...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Elizabeth C Wescott Xiaopeng Sun Paula Gonzalez-Ericsson Ann Hanna Brandie C Taylor Violeta Sanchez Juliana Bronzini Susan R Opalenik Melinda E Sanders Julia Wulfkuhle Rosa I Gallagher Henry Gomez Claudine Isaacs Vijaya Bharti John T Wilson Tarah J Ballin Source Type: research
FOXP4-AS1 promotes CD8(+) T cell exhaustion and esophageal cancer immune escape through USP10-stabilized PD-L1
Immunol Res. 2024 Apr 30. doi: 10.1007/s12026-024-09482-9. Online ahead of print.ABSTRACTEsophageal cancer (EC) is the 9th most frequently diagnosed malignancy globally with unfavorable prognosis. Immune escape is one of the principal factors leading to poor survival, however, the mechanism underlying immune escape remains largely uninvestigated. The xenograft mouse model and EC cell-CD8+ cytotoxic T lymphocytes (CTLs) co-culture system were established. Immunohistochemistry, qRT-PCR or western blot were employed to detect the levels of long non-coding RNA (lncRNA) FOXP4-AS1, PD-L1, USP10 and other molecules. The abundance...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Guo-Yi Shen Yi Zhang Rong-Zhi Huang Zhi-Yong Huang Le-Yi Yang Ding-Zhu Chen Shao-Bin Yang Source Type: research
Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects
Cancer Res Commun. 2024 Apr 30. doi: 10.1158/2767-9764.CRC-24-0071. Online ahead of print.ABSTRACTChronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment (TME) driving activation of NF-κB signaling and the unfolded protein response (UPR). Malignant cells have higher basal levels of UPR posing a unique therapeutic window to combat CLL cell growth using pharmacological agents that induce accumulation of misfolded proteins. Frontline CLL therapeutics that directly target BCR signaling such as Bruton-tyrosine kinase (BTK) inhib...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Alexandria P Eiken Audrey L Smith Sydney A Skupa Elizabeth Schmitz Sandeep Rana Sarbjit Singh Siddhartha Kumar Jayapal Reddy Mallareddy Aguirre A de Cubas Akshay Krishna Achyuth Kalluchi M Jordan Rowley Christopher R D'Angelo Matthew A Lunning R Gregory B Source Type: research
