Deciphering the Pancreatic Cancer Microbiome in Mainland China: Impact of Exiguobacterium/Bacillus ratio on Tumor Progression and Prognostic Significance
Pharmacol Res. 2024 Apr 29:107197. doi: 10.1016/j.phrs.2024.107197. Online ahead of print.ABSTRACTThe existing body of research underscores the critical impact of intratumoral microbiomes on the progression of pancreatic ductal adenocarcinoma (PDAC), particularly in reshaping the tumor microenvironment and influencing gemcitabine resistance. However, peritumoral tissues' microbiome, distinct from PDAC tumors, remain understudied, and Western-centric analyses overlooking potential variations in dietary-influenced microbiomes. Our study addresses this gap by 16S rRNA sequencing of PDAC tumors and matched peritumoral tissues ...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Zhengyan Zhang Ting Wang Ming Xu Zhihan Zhang Huaizhi Wang Jing Xue Wei Wang Source Type: research
Effective bridging strategies prior to infusion with tisagenlecleucel results in high response rates and long-term remission in relapsed/refractory large B-cell lymphoma: findings from a German monocentric study
CONCLUSION: The study underscores the importance of minimal tumor burden at CAR-T initiation, emphasizing the need for suitable bridging regimens. The findings advocate for clinical trials and further real-world analyses to optimize CAR-T cell therapy outcomes by identifying the most effective bridging strategies.PMID:38693452 | DOI:10.1007/s00432-024-05765-8 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Farina Eigendorff Irina Filimonova Sebastian Scholl Anne Sayer-Klink Silke Rummler Christa Kunert Klaus Pietschmann Andrea Wittig Andreas Hochhaus Ulf Schnetzke Source Type: research
Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia
Exp Cell Res. 2024 Apr 29:114061. doi: 10.1016/j.yexcr.2024.114061. Online ahead of print.ABSTRACTAcute myocardial infarction (AMI) is a prevalent cardiovascular disease with high morbidity and mortality rates worldwide. Pyroptosis is an inflammatory form of programmed cell death that has been linked to various pathological conditions. However, its exact contribution to the onset and progression of heart injury in AMI has not yet fully elucidated. Herein, we established mouse AMI model by ligating the left anterior descending artery and performed transcriptome analysis during the early phase of AMI. Mouse HL-1 and human AC...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Xing Ye Zi-Jie Lin Guang-Hui Hong Zhi-Min Wang Run-Ting Dou Jun-Yi Lin Jian-Hui Xie Yi-Wen Shen Source Type: research
The potential role of circular RNAs -regulated PI3K signaling in non-small cell lung cancer: Molecular insights and clinical perspective
Pathol Res Pract. 2024 Apr 16;257:155316. doi: 10.1016/j.prp.2024.155316. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC), accounting for more than 80% of all cases, is the predominant form of lung cancer and the leading cause of cancer-related deaths worldwide. Significant progress has been made in diagnostic techniques, surgical interventions, chemotherapy protocols, and targeted therapies at the molecular level, leading to enhanced treatment outcomes in patients with NSCLC. Extensive evidence supports the use of circular RNAs (circRNAs), a specific category of naturally occurring non-coding small RNAs (...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Samaneh Kahkesh Seyedeh Mahdieh Khoshnazar Yasaman Gholinezhad Shakiba Esmailzadeh Seyed Ali Hosseini Mina Alimohammadi Alireza Mafi Source Type: research
EDTA enables to alleviate impacts of metal ions on conjugative transfer of antibiotic resistance genes
This study aimed to fill this gap by investigating the impacts of a typical complexing agent ethylenediaminetetraacetic acid (EDTA) on the conjugative transfer of plasmid-mediated ARGs induced by a range of heavy metal ions. At the environmentally relevant concentration (0.64 mg L-1) of metal ions, all the tested metal ions (Mg2+, Ca2+, Co2+, Pb2+, Ni2+, Cu2+, and Fe3+) promoted conjugative transfer of ARGs, while an inhibitory effect was observed at a relatively higher concentration (3.20 mg L-1). In contrast, EDTA (0.64 mg L-1) alleviated the effects of metal ions on ARGs conjugation transfer, evidenced by 11 %-66 % redu...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Hu Li Qi Wang Yanjie Wang Yue Liu Jian Zhou Tiecheng Wang Lingyan Zhu Jianhua Guo Source Type: research
Design, synthesis, and evaluation of antitumor activity of Mobocertinib derivatives, a third-generation EGFR inhibitor
Bioorg Chem. 2024 Apr 22;147:107390. doi: 10.1016/j.bioorg.2024.107390. Online ahead of print.ABSTRACTMobocertinib, as a structural analog of the third generation TKI Osimertinib, can selectively act on the EGFRex20 mutation. We have structurally modified Mobocertinib to obtain new EGFR inhibitors. In this paper, we chose Mobocertinib as a lead compound for structural modification to investigate the effect of Mobocertinib derivatives on EGFRT790M mutation. We designed and synthesized 63 Mobocertinib derivatives by structural modification using the structural similarity strategy and the bioelectronic isoarrangement principl...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Dang Fan Han Zhang Lei Duan Li Long Shan Xu Yuanbiao Tu Linxiao Wang Pengwu Zheng Wufu Zhu Source Type: research
From oncogenes to tumor suppressors: The dual role of ncRNAs in fibrosarcoma
Pathol Res Pract. 2024 Apr 25;258:155329. doi: 10.1016/j.prp.2024.155329. Online ahead of print.ABSTRACTFibrosarcoma is a challenging cancer originating from fibrous tissues, marked by aggressive growth and limited treatment options. The discovery of non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and small interfering RNAs (siRNAs), has opened new pathways for understanding and treating this malignancy. These ncRNAs play crucial roles in gene regulation, cellular processes, and the tumor microenvironment. This review aims to explore the impact of ncRNAs on fibrosarcoma's pathogenesi...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Imran Kazmi Muhammad Afzal Waleed Hassan Almalki Renuka Jyothi S Sami I Alzarea Ashwani Kumar Aashna Sinha Neelima Kukreti Haider Ali None Abida Source Type: research
Concomitant urea stabilization and phosphorus recovery from source-separated fresh urine in magnesium anode-based peroxide-producing electrochemical cells
In this study, we investigated the recovery of nitrogen (N) and phosphorus (P) from fresh source-separated urine with a novel electrochemical cell equipped with a magnesium (Mg) anode and carbon-based gas-diffusion cathode. Recovery of P, which exists primarily as phosphate (PO43-) in urine, was achieved through pH-driven precipitation. Maximizing N recovery requires simultaneous approaches to address urea and ammonia (NH3). NH3 recovery was possible through precipitation in struvite with soluble Mg supplied by the anode. Urea was stabilized with electrochemically synthesized hydrogen peroxide (H2O2) from the cathode. H2O2...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Philip H Arve Marc Mason Dyllon G Randall Prithvi Simha Sudeep C Popat Source Type: research
MSCs promote the efferocytosis of large peritoneal macrophages to eliminate ferroptotic monocytes/macrophages in the injured endometria
CONCLUSION: The data collectively demonstrated first the roles of LPMs via removal of ferroptotic monocytes/macrophages and provided a novel mechanism of MSCs in repairing the endometrial injury.PMID:38693589 | DOI:10.1186/s13287-024-03742-z (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Jiali Wang Jingman Li Lijie Yin Xiuzhu Wang Yue Dong Guangfeng Zhao Sunan Shen Yayi Hou Source Type: research
How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
NPJ Microgravity. 2024 May 1;10(1):50. doi: 10.1038/s41526-024-00395-3.ABSTRACTPeriodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microg...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Craig R G Willis Marco Calvaruso Debora Angeloni Sarah Baatout Alexandra Benchoua Juergen Bereiter-Hahn Daniele Bottai Judith-Irina Buchheim Eug énie Carnero-Diaz Sara Castiglioni Duccio Cavalieri Gabriele Ceccarelli Alexander Chouker Francesca Cialdai G Source Type: research
Correction: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression
J Exp Clin Cancer Res. 2024 May 2;43(1):131. doi: 10.1186/s13046-024-03051-6.NO ABSTRACTPMID:38693552 | DOI:10.1186/s13046-024-03051-6 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Yaya Qiao Meng Su Huifang Zhao Huanle Liu Chenxi Wang Xintong Dai Lingling Liu Guangju Liu Huanran Sun Mingming Sun Jiyan Wang Zhen Li Jun Fan Quan Zhang Chunshen Li Fangmin Situ Jun Xue Zhenghu Jia Chunze Zhang Shuai Zhang Changliang Shan Source Type: research
Optimizing Spectronaut Search Parameters to Improve Data Quality with Minimal Proteome Coverage Reductions in DIA Analyses of Heterogeneous Samples
J Proteome Res. 2024 May 1. doi: 10.1021/acs.jproteome.3c00671. Online ahead of print.ABSTRACTData-independent acquisition has seen breakthroughs that enable comprehensive proteome profiling using short gradients. As the proteome coverage continues to increase, the quality of the data generated becomes much more relevant. Using Spectronaut, we show that the default search parameters can be easily optimized to minimize the occurrence of false positives across different samples. Using an immunological infection model system to demonstrate the impact of adjusting search settings, we analyzed Mus musculus macrophages and compa...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Christa P Baker Roland Bruderer James Abbott J Simon C Arthur Alejandro J Brenes Source Type: research
Response to comment on: Long-term outcomes of penile squamous cell carcinoma in men age 50 years old compared with men > 50 years old
Int J Impot Res. 2024 Apr 30. doi: 10.1038/s41443-024-00894-7. Online ahead of print.NO ABSTRACTPMID:38693208 | DOI:10.1038/s41443-024-00894-7 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Karl H Pang Giuseppe Fallara Asif Muneer Hussain M Alnajjar Source Type: research
SIT1 identifies circulating hypoactive T cells with elevated cytotoxic molecule secretion in systemic lupus erythematosus patients
This study aims to elucidate the expression and functionality of SIT1 in circulating CD8/CD4 + T cells in humans and to delineate its significance in systemic lupus erythematosus (SLE) patients. We employed multiparametric flow cytometry to investigate the expression of SIT1 in circulating CD8/CD4 + T cells and their respective subsets, comparing healthy controls (HCs) with SLE patients. Furthermore, we assessed the levels of granzyme B, perforin, IL-17, and IFN-γ in SIT1-related CD8/CD4 + T cells from both HCs and SLE patients, both before and after PMA stimulation. Clinically, we conducted receiver operating characteris...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Ainizati Hasimu Ayibaota Bahabayi Ziqi Xiong Qi Li Zhonghui Zhang Xingyue Zeng Mohan Zheng Zihang Yuan Chen Liu Source Type: research
Research on the Effect and Mechanism of Selenium on Colorectal Cancer Through TRIM32
In conclusion, our findings provided evidence that Se inhibited the growth of colorectal cancer cells by down-regulating TRIM32.PMID:38691306 | DOI:10.1007/s12011-024-04206-4 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Xiaohua Cai Yintong Su Jiayu Ning Xingxing Fan Mei Shen Source Type: research
