Research on the Effect and Mechanism of Selenium on Colorectal Cancer Through TRIM32
In conclusion, our findings provided evidence that Se inhibited the growth of colorectal cancer cells by down-regulating TRIM32.PMID:38691306 | DOI:10.1007/s12011-024-04206-4 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Xiaohua Cai Yintong Su Jiayu Ning Xingxing Fan Mei Shen Source Type: research
Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models
In conclusion, the deficiency of the nuclear hormone receptor nhr-210 in alpha-synuclein expressing strain of C. elegans, results in altered mitochondrial function, coupled with alterations in vital metabolite levels. These findings underline the functional and physiological importance of nhr-210 enrichment in CEPsh glia.PMID:38691171 | DOI:10.1007/s00018-024-05179-2 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Rohil Hameed Anam Naseer Ankit Saxena Mahmood Akbar Pranoy Toppo Arunabh Sarkar Sanjeev K Shukla Aamir Nazir Source Type: research
Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance
CONCLUSIONS: We identify a previously unappreciated cDC mechanism mediating Treg tumor infiltration after RT. Our findings suggest blocking the cDC1-CCL22-Treg axis augments RT efficacy. αEGFR-IFNα added to RT provided robust antitumor responses better than systemic free interferon administration, and may overcome clinical limitations to interferon therapy. Our findings highlight the complex behavior of cDC after RT and provide novel therapeutic strategies for overcoming RT-driven immunosuppression to improve RT efficacy.PMID:38691100 | DOI:10.1158/1078-0432.CCR-23-3616 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Jason Bugno Liangliang Wang Xianbin Yu Xuezhi Cao Jiaai Wang Xiaona Huang Kaiting Yang Andras Piffko Katherine Chen Stephen Y Luo Emile Naccasha Yuzhu Hou Sherry Fu Chuan He Yang-Xin Fu Hua Laura Liang Ralph R Weichselbaum Source Type: research
Tocilizumab in the treatment of steroid refractory immune-related hepatotoxicity: a case series and review of the literature
Melanoma Res. 2024 Apr 29. doi: 10.1097/CMR.0000000000000969. Online ahead of print.ABSTRACTWith the widespread use of immune checkpoint inhibitors, management of immune-related adverse effects specific to these treatments became an important research era in patient management. Among these, immune-related hepatotoxicity (IRH) is an adverse event that can be fatal. While the first-line treatment of IRH is well established, there is still no consensus regarding the management approach for steroid-refractory, severe IRH. Here, we report four patients with metastatic melanoma who developed IRH during antiprogrammed cell death ...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Ahmet Anil Ozluk Damla Gunenc Saadet Sim Yildirim Burcak Karaca Source Type: research
Exploring chemical space, scaffold diversity, and activity landscape of spleen tyrosine kinase active inhibitors
This study aims to comprehensively characterize 576 inhibitors targeting Spleen Tyrosine Kinase (SYK), a non-receptor tyrosine kinase primarily found in haematopoietic cells, with significant relevance to B-cell receptor function. The objective is to gain insights into the structural requirements essential for potent activity, with implications for various therapeutic applications. Through chemoinformatic analyses, we focus on exploring the chemical space, scaffold diversity, and structure-activity relationships (SAR). By leveraging ECFP4 and MACCS fingerprints, we elucidate the relationship between chemical compounds and ...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: None Danishuddin M Z Malik M Kashif S Haque J J Kim Source Type: research
CD4 < sup > + < /sup > T and CD8 < sup > + < /sup > T Cells in Uterus Exhibit Both Selective Dysfunction and Residency Signatures
In this study, we fully compared the immunological properties of αβT cells between uterus and blood using mouse and human sample. It showed that most of CD4+T cells and CD8+T cells in murine uterus and human endometrium were tissue resident memory T cells which highly expressed tissue residence markers CD69 and/or CD103. In addition, both CD4+T cells and CD8+T cells in uterus highly expressed inhibitory molecular PD-1 and cytokine IFN-γ. Uterine CD4+T cells highly expressed IL-17 and modulated by transcription factor pSTAT3. Moreover, we compared the similarities and differences between human and murine uterine T cell p...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Shuangpeng Kang Shuiping Jin Xueying Mao BinSheng He Changyou Wu Source Type: research
Editor's Note: Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
Clin Cancer Res. 2024 May 1;30(9):1994. doi: 10.1158/1078-0432.CCR-24-0856.NO ABSTRACTPMID:38690597 | DOI:10.1158/1078-0432.CCR-24-0856 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Warren Fiskus Rekha Rao Ramesh Balusu Siddhartha Ganguly Jianguo Tao Eduardo Sotomayor Uma Mudunuru Jacqueline E Smith Stacey L Hembruff Peter Atadja Victor E Marquez Kapil Bhalla Source Type: research
Spatial distribution of tumor-associated macrophages in an orthotopic prostate cancer mouse model
In this study, we investigated the spatial density of innate immune cell populations within NOD.SCID orthotopic prostate cancer xenografts following microinjection of human DU145 prostate cancer cells. Our laboratory has previously developed nanoscale liposomes that attach to leukocytes via conjugated E-selectin (ES) and kill cancer cells via TNF-related apoptosis inducing ligand (TRAIL). Immunohistochemistry (IHC) staining was performed on tumor samples to identify and quantify leukocyte infiltration for different periods of tumor growth and E-selectin/TRAIL (EST) liposome treatments. We examined the spatial-temporal dyna...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Korie A Grayson Joshua D Greenlee Lauren E Himmel Lauren A Hapach Cynthia A Reinhart-King Michael R King Source Type: research
Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases
J Inflamm Res. 2024 Apr 24;17:2531-2546. doi: 10.2147/JIR.S457092. eCollection 2024.ABSTRACTFerroptosis, a type of programmed cell death that relies on iron, is distinct in terms of its morphological, biochemical and genetic features. Unlike other forms of cell death, such as autophagy, apoptosis, necrosis, and pyroptosis, ferroptosis is primarily caused by lipid peroxidation. Cells that die due to iron can potentially trigger an immune response which intensifies inflammation and causes severe inflammatory reactions that eventually lead to multiple organ failure. In recent years, ferroptosis has been identified in an incre...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Lujian Zhu Jing Zhou Chen Yu Lei Gu Qin Wang Hanglu Xu Yin Zhu Maodong Guo Minli Hu Wei Peng Hao Fang Haizhen Wang Source Type: research
Electroconductive cardiac patch based on bioactive PEDOT:PSS hydrogels
This study introduces a synthetic patch with a bioactive surface designed to swiftly restore functionality to the damaged myocardium. The patch combines a composite, soft, and conductive hydrogel-based on (3,4-ethylenedioxythiophene):polystyrene-sulfonate (PEDOT:PSS) and polyvinyl alcohol (PVA). This cardiac patch exhibits a reasonably high electrical conductivity (40 S/cm) and a stretchability up to 50% of its original length. Our findings reveal its resilience to 10% cyclic stretching at 1 Hz with no loss of conductivity over time. To mediate a strong cell-scaffold adhesion, we biofunctionalize the hydrogel with a N-cadh...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Erwan Sauvage Justin Matta Cat-Thy Dang Jiaxin Fan Graziele Cruzado Fabio Cicoira G éraldine Merle Source Type: research
Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance
Curr Opin Cell Biol. 2024 Apr 30;88:102364. doi: 10.1016/j.ceb.2024.102364. Online ahead of print.ABSTRACTFirst identified in dividing cells as revolving clusters of actin filaments, these are now understood as mitochondrially-associated actin waves that are active throughout the cell cycle. These waves are formed from the polymerization of actin onto a subset of mitochondria. Within minutes, this F-actin depolymerizes while newly formed actin filaments assemble onto neighboring mitochondria. In interphase, actin waves locally fragment the mitochondrial network, enhancing mitochondrial content mixing to maintain organelle ...
Source: Current Opinion in Cell Biology - May 1, 2024 Category: Cytology Authors: Stephen M Coscia Andrew S Moore Yvette C Wong Erika L F Holzbaur Source Type: research
Integrity of RNA in long-term-stored cervical liquid-based cytology samples: implications for biomarker research
Biotechniques. 2024 May 1. doi: 10.2144/btn-2023-0112. Online ahead of print.ABSTRACTBiobanks of cervical screening (LBC) samples annotated with disease status are an invaluable resource to support the development of tools for the risk stratification of disease. Although there is growing interest in the assessment of RNA-based biomarkers, little is known on the suitability and durability of stored clinical samples (commonly used in cervical screening) to support RNA-based research. RNA was extracted from 260 stored LBC samples. Storage at -80°C or -25°C allowed isolation of sufficient RNA for further analysis. RNA was fo...
Source: BioTechniques - May 1, 2024 Category: Biotechnology Authors: Madeleine P J White Andrew Stevenson Hana Elasifer Chris Davies Kyriaki Nomikou Kate Cuschieri Sheila V Graham Source Type: research
The ASCB and MBoC: Our cell biology power couple
Mol Biol Cell. 2024 May 1;35(5):ed1. doi: 10.1091/mbc.E24-04-0148.NO ABSTRACTPMID:38691466 | DOI:10.1091/mbc.E24-04-0148 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 1, 2024 Category: Molecular Biology Authors: Matthew D Welch Source Type: research
Overexpressing Bcl-2 enhances murine chimeric antigen receptor T cell therapy against solid tumor
AbstractChimeric antigen receptor T (CART) cell therapy has demonstrated promising potential in the treatment of hematologic malignancies. However, its application to solid tumors is limited due to the restrictive nature of the tumor microenvironment, resulting in functional failure and poor persistence of CART cells. Overexpression of Bcl-2 in human CART cells (hCART) has been found to significantly enhance their anti-apoptotic effects both in vitro and in vivo. Nevertheless, the evaluation of hCART cells in preclinical studies has predominantly relied on immunodeficient mice xenograft tumor models, making it challenging ...
Source: Human Cell - May 1, 2024 Category: Cytology Source Type: research
BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1
In conclusion, the BPTF/FOXC1 axis was identified as a key promotor in glioma development and may be a potential target in the inhibition of glioma development.PMID:38686761 | DOI:10.14670/HH-18-748 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 30, 2024 Category: Cytology Authors: Yanling Pan Feng Yuan Zhiren Lin Yijie Li Source Type: research
