Yogurt Prevents Colorectal Tumorigenesis in Apc < sup > Min/+ < /sup > Mice
CONCLUSION: Yogurt protects against intestinal polyposis in ApcMin/+ mice, and d-Lac may partially account for the chemopreventive effects above.PMID:38700077 | DOI:10.1002/mnfr.202300737 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Xiaojing Li Jin Qian Qinglong Liu Min Guo Hao Zhang Haitao Li Wei Chen Source Type: research
Curcumin and its anti-colorectal cancer potential: From mechanisms of action to autophagy
Phytother Res. 2024 May 3. doi: 10.1002/ptr.8220. Online ahead of print.ABSTRACTColorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy is an evolutionarily highly conserved degradation pathway involved in a variety of cellular processes, such as the maintenance of cellular homeostasis and clearance of foreign bodies, and its imbalance is associated with many diseases. However, the role of autophagy in CRC progression remains controversial, as it has a dual function, a...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Aranka Brockmueller Vicen ç Ruiz de Porras Mehdi Shakibaei Source Type: research
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells
CONCLUSIONS: In summary, vaspin observably reduces HG-mediated inhibition of PDLSCs OD by modulating the TGF-β1/Smad signaling pathway. Vaspin may be a potential therapeutic for periodontal tissue regeneration in diabetic patients.PMID:38699861 | DOI:10.1111/jre.13254 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Zhihui Jing Xinran Feng Xin Li Xiaoyu Zhang Chunling Pan Source Type: research
Knockdown of NADK promotes LUAD ferroptosis via NADPH/FSP1 axis
CONCLUSIONS: NADK is over-expressed in LUAD patients. Knockdown of NADK inhibited the proliferation of LUAD cells both in vitro and in vivo and promotes the Erastin/RSL3-induced ferroptosis of LUAD cells by down-regulating the NADPH/FSP1 axis.PMID:38700533 | DOI:10.1007/s00432-024-05752-z (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Xiangpeng Meng Fang Peng Shijie Yu Xinming Chi Wenchi Wang Shujuan Shao Source Type: research
Concentration-Dependent Effects of Boric Acid on Osteogenic Differentiation of Vascular Smooth Muscle Cells
Biol Trace Elem Res. 2024 May 3. doi: 10.1007/s12011-024-04204-6. Online ahead of print.ABSTRACTVascular calcification can be triggered by oxidative stress and inflammation. Although boron possesses antioxidant and anti-inflammatory properties, its effect on osteogenic differentiation of vascular smooth muscle cells (VSMCs) has yet to be examined. Therefore, we aimed to investigate the effect of boric acid (BA), the main form of boron in body fluids, on the osteogenic differentiation of VSMCs. Following the isolation of VSMCs, the effects of BA on cell proliferation were determined by MTT. The impact of various BA concentr...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Osama Al Khalif G ülay Sezer Source Type: research
Paradoxical and bimodal immune-mediated dermatological side effects of TNF- α inhibitors: A comprehensive review
In this study, we evaluate the immune-mediated dermatological side effects of DMARDS by reviewing and analyzing previous peer-reviewed research on the effects of TNF-α inhibitors in the treatment of skin diseases, as well as adverse effects of these drugs and some of the main causes of these effects.EXPERT OPINION: DMARDs are very effective in improving control of the above diseases. TNF-α inhibitors are an important group of DMARDs that are widely used. The paradoxical adverse events (PAEs) associated with the use of TNF-α inhibitors are divided into three categories: true paradoxical, borderline paradoxical, and non-p...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Elham Behrangi Farzan Moodi Alireza Jafarzadeh Azadeh Goodarzi Source Type: research
Coagulation and platelet biology at the intersection of health and disease: illustrated capsules of the 11th Symposium on Hemostasis at the University of North Carolina
Res Pract Thromb Haemost. 2024 Apr 3;8(3):102395. doi: 10.1016/j.rpth.2024.102395. eCollection 2024 Mar.ABSTRACTThe University of North Carolina Symposia on Hemostasis began in 2002, with The First Symposium on Hemostasis with a Special Focus on FVIIa and Tissue Factor. They have occurred biannually since and have maintained the primary goal of establishing a forum for the sharing of outstanding advances made in the basic sciences of hemostasis. The 2024 11th Symposium on Hemostasis will bring together leading scientists from around the globe to present and discuss the latest research related to coagulation factors and pla...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Maria Aleman Gowthami M Arepally Trevor Baglin Lorena Buitrago Pavel Davizon-Castillo Sanjana Dayal Matthew J Flick Gloria Gerber Yohei Hisada Krasimir Kolev Ana O'Loghlen Alireza R Rezaie Erica M Sparkenbaugh Evi X Stavrou Bet ül Ünlü Gregory M Vercel Source Type: research
Mesoscale Metabolic Channeling Revealed by Multimodal Microscopy
Res Sq [Preprint]. 2024 Apr 17:rs.3.rs-4096781. doi: 10.21203/rs.3.rs-4096781/v1.ABSTRACTMetabolic homeostasis within cells and tissues requires engagement of catabolic and anabolic pathways consuming nutrients needed to generate energy to drive these and other subcellular processes. However, the current understanding of cell homeostasis and metabolism, including how cells utilize nutrients, comes largely from tissue and cell models analyzed after fractionation. These bulk strategies do not reveal the spatial characteristics of cell metabolism at the single cell level, and how these aspects relate to the location of cells ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Rafael Arrojo E Drigo Aliyah Habashy Christopher Acree Keun-Young Kim Thomas Deerinck Emilee Patterson Louise Lantier Owen McGuinness Mark Ellisman Source Type: research
Regulation of Microtubule Stability in Pulmonary Microvascular Endothelial Cells in Rats with Severe Acute Pancreatitis: Qingyi Decoction is a Potential CDK5 Inhibitor
CONCLUSION: CDK5 has been identified as a critical target for pulmonary endothelial injury of SAP-ALI. QYD may partially alleviate microtubule disassembly by targeting the CDK5/NFAT5/GEF-H1 signaling pathway, thus relieving SAP-induced pulmonary microvascular endothelial cell injury.PMID:38699595 | PMC:PMC11063490 | DOI:10.2147/JIR.S451755 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Yinan Cao Fan Li Zhenxuan Sun Jin Liu Jie Liu Qi Yang Peng Ge Yalan Luo Hailong Chen Source Type: research
Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas
CONCLUSION: TRPA1 and TRPC1 immunoreactivites are increased in colorectal adenocarcinoma tissue compared with the healthy tissue. Furthermore, the immunoreactivity decreases as the grade of cancer increases.PMID:38699653 | PMC:PMC11063473 | DOI:10.2147/CMAR.S447549 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Ahmet Bozdag Tuncay Kuloglu Gokhan Artas Suleyman Aydin Source Type: research
Fracture haematoma proteomics
CONCLUSION: The early fxH proteome of the ETC group was characterized by the expression of immunomodulatory, mainly pro-inflammatory, proteins, whereas the early fxH proteome of the DCO group was more regenerative and osteogenic in nature. These findings match clinical observations, in which enhanced surgical trauma after multiple trauma causes dysbalanced inflammation, potentially leading to reduced tissue regeneration, and gained insights into regulatory mechanisms of fracture healing after severe trauma.PMID:38699779 | DOI:10.1302/2046-3758.135.BJR-2023-0323.R1 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Rald V M Groven Christel Kuik Johannes Greven Ümit Mert Freek G Bouwman Martijn Poeze Taco J Blokhuis Markus Huber-Lang Frank Hildebrand Berta Cillero-Pastor Martijn van Griensven Source Type: research
Histopathological and statistical study of corneal repair in rabbits. A new way to understand corneal recovery
This study was conducted using a formula that combines histologic data categorizing their presence and/or type as beneficial for corneal repair. No statistically significant differences were found between the experimental and control eyes regarding all clinical signs and OCT measurements. However, a linear model using histopathological results showed a period-implant mode interaction with statistical significance (p=0.010). The use of the single-layer amniotic membrane resulted in improved corneal recovery with the stromal side showing better performance in the first week and the epithelial side proving to be more effectiv...
Source: Histology and Histopathology - May 3, 2024 Category: Cytology Authors: Patricia Ram írez-Perdomo Juan Daniel Hern ández-Marrero Santiago Guill én-Molina Pedro Saavedra-Santana M ónica de León-Vera Eduardo Jos é Araujo-Ruano Juan Francisco Loro-Ferrer Juan Jos é Cabrera-Galván Juan Andr és Ramírez-González Source Type: research
SIRT1 maintains bone homeostasis by regulating osteoblast glycolysis through GOT1
In conclusion, our study suggested that Sirt1 played a crucial role in regulating osteoblast metabolism to maintain bone homeostasis through its deacetylase activity on GOT1. These findings provided a novel insight into the potential targeting of osteoblast metabolism for the treatment of bone-related diseases.PMID:38700532 | DOI:10.1007/s00018-023-05043-9 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - May 3, 2024 Category: Cytology Authors: Xinxin Jin Xulei Sun Xiao Ma Zixuan Qin Xin Gao Xiaomin Kang Huixia Li Hongzhi Sun Source Type: research
MyoD1 promotes the transcription of BIK and plays an apoptosis-promoting role in the development of gastric cancer
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Source: Cell Cycle - May 3, 2024 Category: Cytology Authors: Fei WuJinyuan ZhangQiuyu JiangQian LiFang LiJia LiWei LvXiaofei WangYannan QinChen HuangShuqun Zhanga Comprehensive Breast Care Center, The Second Affiliated Hospital of Xi ’an Jiaotong University, Xi’an, Chinab Biomedical Experiment Center, Xian Jiao Source Type: research
A de novo Mutation (p.Gln277X) of Cyclin D2 is Responsible for a Child with Megalencephaly –Polymicrogyria–Polydactyly–Hydrocephalus Syndrome
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - May 3, 2024 Category: Cytology Authors: Mei-Fang Zhao Song-Lin Zhang YangZiYu Xiang Qian Wang Gao-Hui Cao Ping-Ping Zhang Liang-Liang Fan Rong Yu Ya-Li Li Source Type: research
