Fracture haematoma proteomics

CONCLUSION: The early fxH proteome of the ETC group was characterized by the expression of immunomodulatory, mainly pro-inflammatory, proteins, whereas the early fxH proteome of the DCO group was more regenerative and osteogenic in nature. These findings match clinical observations, in which enhanced surgical trauma after multiple trauma causes dysbalanced inflammation, potentially leading to reduced tissue regeneration, and gained insights into regulatory mechanisms of fracture healing after severe trauma.PMID:38699779 | DOI:10.1302/2046-3758.135.BJR-2023-0323.R1

Source: Cell Research - May 3, 2024 Category: Cytology Authors: Rald V M Groven Christel Kuik Johannes Greven Ümit Mert Freek G Bouwman Martijn Poeze Taco J Blokhuis Markus Huber-Lang Frank Hildebrand Berta Cillero-Pastor Martijn van Griensven Source Type: research