Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis
. (Source: Cell Cycle)
Source: Cell Cycle - May 2, 2024 Category: Cytology Authors: Dawid Soba ńskiPaweł BogdałRafał StaszkiewiczMałgorzata SobańskaMichał FilipowiczRyszard Adam CzepkoDamian StrojnyBeniamin Oskar Grabareka Department of Neurosurgery, Szpital sw. Rafala in Cracow, Cracow, Polandb Collegium Medicum, WSB University, Source Type: research
GTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1
Nasopharyngeal carcinoma (NPC) is a malignant tumor with poor survival rate. G2 and S phase-expressed ‐1 (GTSE1) takes part in the progression of diverse tumors as an oncogene, but its role and potential mechan... (Source: Cell Division)
Source: Cell Division - May 2, 2024 Category: Cytology Authors: Jiadi Dong, Jingjing Chen, Yidong Wu and Jiangyu Yan Tags: Research Source Type: research
Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice
In a recent study published in Molecular Cell, Zhou and colleagues provide evidence to suggest that the energy-sensing gamma ( γ) subunit of AMPK regulates translation via phosphatase PPP6C independently of the catalytic AMPK alpha (α) subunit.1 The authors used HEK239T cells to demonstrate that energy stress by glucose deprivation sequesters PPP6C to AMPKβγ dimer complexes, which alleviates dephosphorylation of eukaryo tic translation elongation factor 2 (eEF2) Thr56 and arrests protein translation elongation to conserve energy. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Rasmus Kj øbsted, Jesper Bratz Birk, Nicolas Oldenburg Eskesen, Jørgen Frank Pind Wojtaszewski Tags: Letter Source Type: research
Keeping cGAS in check: SPSB3 promotes nuclear cGAS degradation for maintaining immune homeostasis
In a recent publication in Nature, Xu et al. discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Ruey-Hwa Chen Tags: Spotlight Source Type: research
eIF4G as a switch for heat shock mRNA translation
The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al. demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Yi Liu, Peiguo Yang Tags: Preview Source Type: research
DDX21: The link between m6A and R-loops
In this issue of Molecular Cell, Hao et al.1 demonstrate that the RNA helicase DDX21 recruits the m6A methyltransferase complex to R-loops, ensuring proper transcription termination and genome stability. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Guillaume Lavergne, Jean-Yves Roignant Tags: Preview Source Type: research
Response to: Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice
In our paper “Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha,”1 we demonstrated that knockout (KO) of AMPKγ, but not AMPKα, suppressed phosphorylation of eukaryotic translation elongation factor 2 (eEF2) induced by energy starvation. We further identified PPP 6C as a phosphatase of eEF2, and AMP-bound AMPKγ sequesters PPP6C, thereby blocking dephosphorylation of eEF2. These findings implicate diverse mechanisms of energy sensor AMPKγ in regulating cellular energy response. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Qi Zhou, Xiaolei Cao, Bin Zhao Tags: Letter Source Type: research
Polyphosphate attachment to lysine repeats is a non-covalent protein modification
Lysine polyphosphorylation was posited to be a covalent linkage of polyphosphate (polyP) to lysine sidechains within proteins. Neville et al. find that this modification is non-covalent and sensitive to ionic strength and alkaline pH. Lysine residues alone drive polyP modification via electrostatic interaction with polyP. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Nolan Neville, Kirsten Lehotsky, Kody A. Klupt, Michael Downey, Zongchao Jia Tags: Matters Arising Source Type: research
Differential contribution for ERK1 and ERK2 kinases in BRAFV600E-triggered phenotypes in adult mouse models
Cell Death & Differentiation, Published online: 02 May 2024; doi:10.1038/s41418-024-01300-xDifferential contribution for ERK1 and ERK2 kinases in BRAFV600E-triggered phenotypes in adult mouse models (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - May 2, 2024 Category: Cytology Authors: Giuseppe Bosso Ana Carolina Cintra Herpst Oscar Lagu ía Sarah Adetchessi Rosa Serrano Maria A. Blasco Source Type: research
H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation
Cell Death & Differentiation, Published online: 02 May 2024; doi:10.1038/s41418-024-01302-9H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - May 2, 2024 Category: Cytology Authors: Na Deng Gaizhen Li Leilei Zhang Peiran Wang Mengying Liu Bo He Yedong Tang Han Cai Jinhua Lu Haibin Wang Wenbo Deng Haili Bao Shuangbo Kong Source Type: research
Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
(Molecular Cell 82, 4700 –4711.e1–e12; December 15, 2022) (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Qi Zhou, Bingbing Hao, Xiaolei Cao, Lin Gao, Zhenyue Yu, Yang Zhao, Mingrui Zhu, Guoxuan Zhong, Fangtao Chi, Xiaoming Dai, Jizhong Mao, Yibing Zhu, Ping Rong, Liang Chen, Xueli Bai, Cunqi Ye, Shuai Chen, Tingbo Liang, Li Li, Xin-Hua Feng, Minjia Tan, Bin Tags: Correction Source Type: research
On the covalent nature of lysine polyphosphorylation
Post-translational modifications of proteins (PTMs) introduce an extra layer of complexity to cellular regulation. Although phosphorylation of serine, threonine, and tyrosine residues is well-known as PTMs, lysine is, in fact, the most heavily modified amino acid, with over 30 types of PTMs on lysine having been characterized. One of the most recently discovered PTMs on lysine residues is polyphosphorylation, which sees linear chains of inorganic polyphosphates (polyP) attached to lysine residues. (Source: Molecular Cell)
Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Cristina Azevedo, Filipy Borghi, Xue Bessie Su, Adolfo Saiardi Tags: Matters Arising Response Source Type: research
IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype
Am J Physiol Cell Physiol. 2024 Mar 4. doi: 10.1152/ajpcell.00654.2023. Online ahead of print.ABSTRACTSkeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current human skeletal muscle models in vitro are incapable of fully recapitulating its physiological functions especially muscle contractility. By supplementation of insulin-like growth factor 1 (IGF1), a growth factor secreted by myofibers in vivo, we aimed to overcome these limitations. We monitored the differentiation process starting from primary human CD56-positive myoblasts in...
Source: Am J Physiol Cell Ph... - May 1, 2024 Category: Cytology Authors: Simon I Dreher Paul Grubba Christine von Toerne Alessia Moruzzi Jennifer Maurer Thomas Goj Andreas L Birkenfeld Andreas Peter Peter Loskill Stefanie M Hauck Cora Weigert Source Type: research
Brachyury Promotes Extracellular Matrix Synthesis through Transcriptional Regulation of Smad3 in Nucleus Pulposus
In conclusion, this study reveals that Bry positively regulates the synthesis of collagen II and aggrecan in NP through transcriptional activation of Smad3.PMID:38690917 | DOI:10.1152/ajpcell.00475.2023 (Source: Am J Physiol Cell Ph...)
Source: Am J Physiol Cell Ph... - May 1, 2024 Category: Cytology Authors: Yanzhang Xia Yinghui Wu Yuhao Gong Caichun Yue Linfeng Tao Tianwen Xin Cong Shen Yue Zhu Minghong Shen Jun Shen Source Type: research
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway
This study establishes the crucial role of CD200R in HG-induced oxidative stress and identifies potential therapeutic avenues for the treatment of DR.PMID:38692160 | DOI:10.1016/j.tice.2024.102381 (Source: Tissue and Cell)
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Yaguang Hu Ting Wei Shan Gao Ning Gao Li Chen Qiaochu Cheng Source Type: research
