Klotho-mediated activation of the anti-oxidant Nrf2/ARE signal pathway affects cell apoptosis, senescence and mobility in hypoxic human trophoblasts: involvement of Klotho in the pathogenesis of preeclampsia
The anti-aging gene Klotho is implicated in the pathogenesis of preeclampsia (PE), which is a pregnancy disease characterized by hypertension and proteinuria. Oxidative stress is closely associated with the wo... (Source: Cell Division)
Source: Cell Division - April 17, 2024 Category: Cytology Authors: Baomei Xu, Fang Cheng and Xiaolei Xue Tags: Research Source Type: research
lncRNA RMST is associated with the progression and prognosis of gastric cancer via miR-204-5p
Exploring novel biomarkers for gastric cancer holds promise for enhancing patients ’ therapy and survival rates. lncRNAs and miRNAs have emerged as important biomarkers for various human cancers. However, the r... (Source: Cell Division)
Source: Cell Division - April 12, 2024 Category: Cytology Authors: Huimei Cai, Chenhui Li and Zhou Wu Tags: Research Source Type: research
CIP/KIP and INK4 families as hostages of oncogenic signaling
CIP/KIP and INK4 families of Cyclin-dependent kinase inhibitors (CKIs) are well-established cell cycle regulatory proteins whose canonical function is binding to Cyclin-CDK complexes and altering their functio... (Source: Cell Division)
Source: Cell Division - April 1, 2024 Category: Cytology Authors: Lucia Csergeov á, David Krbušek and Radoslav Janoštiak Tags: Review Source Type: research
miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism
The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles of PDZK1 in HCC are unclear. Therefore, the aim of this study is to explore the role an... (Source: Cell Division)
Source: Cell Division - March 26, 2024 Category: Cytology Authors: Huihui Gao, Zhaofeng Gao, Xiaobei Liu, Xu Sun, Zhonghui Hu, Zhengwei Song, Cheng Zhang, Jianguo Fei and Xiaoguang Wang Tags: Research Source Type: research
GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction
Mechanisms and consequences of Gasdermin D (GSDMD) activation in alcoholic hepatitis (AH) are unclear. In the present study, we investigated whether GSDMD induces hepatocyte pyroptosis by regulating mitochondr... (Source: Cell Division)
Source: Cell Division - March 26, 2024 Category: Cytology Authors: Yandi Xie, Zilong Wang, Guangjun Song, Hui Ma and Bo Feng Tags: Research Source Type: research
Zinc finger protein 468 up-regulation of TFAM contributes to the malignant growth and cisplatin resistance of breast cancer cells
Because of the progress on the diagnosis and treatment for patients with breast cancer (BC), the overall survival of the patients has been improved. However, a number of BC patients cannot benefit from the exi... (Source: Cell Division)
Source: Cell Division - March 1, 2024 Category: Cytology Authors: Zhaoyang Jia, Feng Wang, Gongzhuo Li, Ping Jiang, Yuanxiu Leng, Longzhu Ke, Li Luo and Wei Gao Tags: Research Source Type: research
Ultrasonic microbubbles promote mesenchymal stem cell homing to the fibrotic liver via upregulation of CXCR4 expression
To investigate the mechanism of ultrasound microbubbles (UTMB) promoting stem cells homing to fibrotic liver. (Source: Cell Division)
Source: Cell Division - February 24, 2024 Category: Cytology Authors: Heming Xu, Yize Huang, Fasu Zhang, Wei Shi, Yan Cheng, Kai Yang, Pingping Tian, Fei Zhou, Yuan Wang, Xueqing Fang, Youliang Song, Bo Liu and Liwei Liu Tags: Research Source Type: research
Anti-cancer effects of Coix seed extract through KCTD9-mediated ubiquitination of TOP2A in lung adenocarcinoma
Coix seed extract (CSE), a traditional Chinese medicine, has been reported as an adjunctive therapy in cancers. However, the molecular targets are largely unclear. The study is designed to unveil its function ... (Source: Cell Division)
Source: Cell Division - February 20, 2024 Category: Cytology Authors: Jiuyang Jiang, Xue Li, Chun Zhang, Jiafu Wang and Jin Li Tags: Research Source Type: research
Exosome-derived lncRNA A1BG-AS1 attenuates the progression of prostate cancer depending on ZC3H13-mediated m6A modification
Exosome-derived long non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) modifications of lncRNAs have been shown crucial functions in prostate cancer (PCa). Herein, we aim to investigate the detailed mechanis... (Source: Cell Division)
Source: Cell Division - February 13, 2024 Category: Cytology Authors: Zhi Yang, Yu Luo, Fan Zhang and Likun Ma Tags: Research Source Type: research
Human Parathyroid Hormone (1 –34) accelerates skin wound healing through inducing cell migration via up-regulating the expression of Rac1
Delayed wound healing is a public issue that imposes a significant burden on both society and the patients themselves. To date, although numerous methods have been developed to accelerate the speed of wound cl... (Source: Cell Division)
Source: Cell Division - February 12, 2024 Category: Cytology Authors: Qingpeng Sun, Liya Zhou, Zhiyong Yu, Jun Zhang, Chao Zhang and Honglin Pi Tags: Research Source Type: research
Non-mitotic proliferation of malignant cancer cells revealed through live-cell imaging of primary and cell-line cultures
Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-c... (Source: Cell Division)
Source: Cell Division - February 10, 2024 Category: Cytology Authors: Iram Shazia Tyagi, Ho Yin Calvin Tsui, Si Chen, Xinyi Li, Wai-Kin Mat, Muhammad A. Khan, Lucas Brendan Choy, Ka-Yin Aden Chan, Tat-Ming Danny Chan, Chi-Ping Stephanie Ng, Ho-Keung Ng, Wai Sang Poon and Hong Xue Tags: Research Source Type: research
Cilostazol protects against degenerative cervical myelopathy injury and cell pyroptosis via TXNIP-NLRP3 pathway
Degenerative cervical myelopathy (DCM) is one of the most common and serious neurological diseases. Cilostazol has protective effects of anterior horn motor neurons and prevented the cell apoptosis. However, t... (Source: Cell Division)
Source: Cell Division - January 17, 2024 Category: Cytology Authors: Fei Xu, Zhuo Tian and Zhengguang Wang Tags: Research Source Type: research
Role of reactive oxygen species in ultraviolet-induced photodamage of the skin
Reactive oxygen species (ROS), such as superoxides (O2 •−) and hydroxyl groups (OH·), are short-lived molecules containing unpaired electrons. Intracellular ROS are believed to be mainly produced by the mitochond... (Source: Cell Division)
Source: Cell Division - January 12, 2024 Category: Cytology Authors: Min Wei, Xin He, Na Liu and Hui Deng Tags: Review Source Type: research
Jiedu Fuzheng decoction improves the proliferation, migration, invasion and EMT of non-small cell lung cancer via the Wnt/ β-catenin pathway
This study aimed to investigate the effect of Jiedu Fuzheng decoction (JFD) in non-small cell lung cancer (NSCLC) and its potential therapeutic mechanism. (Source: Cell Division)
Source: Cell Division - December 16, 2023 Category: Cytology Authors: Fang Fang, Xiaowei Jin, Jinming Meng, Jiaqi He, Jiaxiao Wang, Changhong Wang, Sheng Xie and Wei Shi Tags: Research Source Type: research
Downregulation of GDF15 suppresses ferroptosis and predicts unfavorable prognosis in clear cell renal cell carcinoma
Growth differentiation factor 15 (GDF15), a member of the transforming growth factor beta (TGF- β) superfamily, is involved in various pathophysiological processes such as anorexia, obesity, inflammation, and t... (Source: Cell Division)
Source: Cell Division - December 11, 2023 Category: Cytology Authors: Dongliang Yang, Zhongyin He, Jiawei Lu, Xiaolin Yuan, Haiyong Liu, Yagang Xue, Ting Chen and Hongxing Gu Tags: Research Source Type: research
