Energy sensor AMPK γ does not exist in isolation from AMPKα or interact with PPP6C in muscle and liver from humans and mice

In a recent study published in Molecular Cell, Zhou and colleagues provide evidence to suggest that the energy-sensing gamma ( γ) subunit of AMPK regulates translation via phosphatase PPP6C independently of the catalytic AMPK alpha (α) subunit.1 The authors used HEK239T cells to demonstrate that energy stress by glucose deprivation sequesters PPP6C to AMPKβγ dimer complexes, which alleviates dephosphorylation of eukaryo tic translation elongation factor 2 (eEF2) Thr56 and arrests protein translation elongation to conserve energy.

Source: Molecular Cell - May 2, 2024 Category: Cytology Authors: Rasmus Kj øbsted, Jesper Bratz Birk, Nicolas Oldenburg Eskesen, Jørgen Frank Pind Wojtaszewski Tags: Letter Source Type: research