The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization
In this study, we analyzed RNA-seq data from sGBM patients' glioma tissues with or without ZM fusion,and found that stemness and macrophage markers were more highly expressed in sGBM patients harboring ZM than in those without ZM fusion. ZM enhanced the self-renewal and proliferation of GSCs, thereby accelerating glioma progression. In addition, ZM-positive GSCs facilitated the infiltration of TAMs and drove their polarization toward an immunosuppressive phenotype, which was primarily accomplished through the extracellular secretion of ISG20. Our research identified the MET-STAT3-ISG20 axis within GSCs, thus demonstrating ...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Yuxin Wang Jinghao Suo Zhixing Wang Kunnian Ran Yuan Tian Wei Han Yanwei Liu Xiaozhong Peng Source Type: research
PELI1 overexpression contributes to pancreatic cancer progression through upregulating ubiquitination-mediated INPP5J degradation
In conclusion, the results suggest that INPP5J, decreased by PELI1 through ubiquitination, may promote PC progression. The PELI1-INPP5J axis represents a potential therapeutic targetable node for PC.PMID:38685520 | DOI:10.1016/j.cellsig.2024.111194 (Source: Cellular Signalling)
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Wenyang Zhou Xin Deng Liling Liu Yifeng Yuan Xiangpeng Meng Jia Ma Source Type: research
TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes
Autophagy. 2024 Apr 30:1-21. doi: 10.1080/15548627.2024.2338576. Online ahead of print.ABSTRACTObesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis inhibitor, whether it plays a role in the metabolism of lipids is unknown. Here, we found that TIGAR transgenic (TIGAR+/+) mice exhibited increased fat mass and trended to obesity pheno...
Source: Autophagy - April 30, 2024 Category: Cytology Authors: Tian Zhang Ke-Gang Linghu Jia Tan Mingming Wang Diao Chen Yan Shen Junchao Wu Mingjun Shi Yuxia Zhou Lei Tang Lirong Liu Zheng-Hong Qin Bing Guo Source Type: research
Chromosome fusion and programmed DNA elimination shape karyotypes of nematodes
Curr Biol. 2024 Apr 23:S0960-9822(24)00462-7. doi: 10.1016/j.cub.2024.04.022. Online ahead of print.ABSTRACTAn increasing number of metazoans undergo programmed DNA elimination (PDE), where a significant amount of DNA is selectively lost from the somatic genome during development. In some nematodes, PDE leads to the removal and remodeling of the ends of all germline chromosomes. In several species, PDE also generates internal breaks that lead to sequence loss and increased numbers of somatic chromosomes. The biological significance of these karyotype changes associated with PDE and the origin and evolution of nematode PDE ...
Source: Current Biology - April 30, 2024 Category: Biology Authors: James R Simmons Brandon Estrem Maxim V Zagoskin Ryan Oldridge Sobhan Bahrami Zadegan Jianbin Wang Source Type: research
YBX1 as a prognostic biomarker and potential therapeutic target in hepatocellular carcinoma: A comprehensive investigation through bioinformatics analysis and in vitro study
CONCLUSIONS: YBX-1 serves as a favorable prognostic indicator in various cancers, particularly in liver hepatocellular carcinoma. Targeting YBX1 in HCC offers potential therapeutic strategies. This work paves the way for fresh insights into targeted therapeutic approaches for cancers, especially benefiting liver hepatocellular carcinoma patients.PMID:38688048 | DOI:10.1016/j.tranon.2024.101965 (Source: Translational Oncology)
Source: Translational Oncology - April 30, 2024 Category: Cancer & Oncology Authors: Zizhen Li Wenhua Lu Feng Yin Amin Huang Source Type: research
TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes
Autophagy. 2024 Apr 30:1-21. doi: 10.1080/15548627.2024.2338576. Online ahead of print.ABSTRACTObesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis inhibitor, whether it plays a role in the metabolism of lipids is unknown. Here, we found that TIGAR transgenic (TIGAR+/+) mice exhibited increased fat mass and trended to obesity pheno...
Source: Autophagy - April 30, 2024 Category: Cytology Authors: Tian Zhang Ke-Gang Linghu Jia Tan Mingming Wang Diao Chen Yan Shen Junchao Wu Mingjun Shi Yuxia Zhou Lei Tang Lirong Liu Zheng-Hong Qin Bing Guo Source Type: research
Circ_PABPC1 promotes the malignancy of gastric cancer through interacting with ILK to activate NF- κB pathway
CONCLUSION: circ_PABPC1 promotes the malignancy of GC cells through binding to ILK to activate NF-κB signaling pathway .PMID:38688434 | DOI:10.1016/j.yexcr.2024.114058 (Source: Experimental Cell Research)
Source: Experimental Cell Research - April 30, 2024 Category: Cytology Authors: Siqi Yan Zhu Wang Dongqiang Lan Junjie Niu Xiaolan Jian Fengjiao He Weizhi Tang Chunhong Hu Wei Liu Source Type: research
PELI1 overexpression contributes to pancreatic cancer progression through upregulating ubiquitination-mediated INPP5J degradation
In conclusion, the results suggest that INPP5J, decreased by PELI1 through ubiquitination, may promote PC progression. The PELI1-INPP5J axis represents a potential therapeutic targetable node for PC.PMID:38685520 | DOI:10.1016/j.cellsig.2024.111194 (Source: Cellular Signalling)
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Wenyang Zhou Xin Deng Liling Liu Yifeng Yuan Xiangpeng Meng Jia Ma Source Type: research
The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization
In this study, we analyzed RNA-seq data from sGBM patients' glioma tissues with or without ZM fusion,and found that stemness and macrophage markers were more highly expressed in sGBM patients harboring ZM than in those without ZM fusion. ZM enhanced the self-renewal and proliferation of GSCs, thereby accelerating glioma progression. In addition, ZM-positive GSCs facilitated the infiltration of TAMs and drove their polarization toward an immunosuppressive phenotype, which was primarily accomplished through the extracellular secretion of ISG20. Our research identified the MET-STAT3-ISG20 axis within GSCs, thus demonstrating ...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Yuxin Wang Jinghao Suo Zhixing Wang Kunnian Ran Yuan Tian Wei Han Yanwei Liu Xiaozhong Peng Source Type: research
IRAK1 deficiency potentiates the efficacy of radiotherapy in repressing cervical cancer development
In this study, we evaluated IRAK1 expression in radiotherapy-treated cervical cancer tissues and found that IRAK1 expression is negatively associated with the efficacy of radiotherapy. Consistently, ionizing radiation (IR)-treated HeLa and SiHa cervical cancer cells express a lower level of IRAK1 than control cells. Depletion of IRAK1 resulted in reduced activation of the NF-κB pathway, decreased cell viability, downregulated colony formation efficiency, cell cycle arrest, increased apoptosis, and impaired migration and invasion in IR-treated cervical cancer cells. Conversely, overexpressing IRAK1 mitigated the anti-cance...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Wenjuan Chen Xingyun Xie Chengying Liu Jingrong Liao Yuting Wei Rongrong Wu Jinsheng Hong Source Type: research
The cGAS/STING signaling pathway is involved in sevoflurane induced neuronal necroptosis via regulating microglia M1 polarization
CONCLUSION: These results suggest that sevoflurane can regulate microglial M1 polarization by activating the cGAS/STING signaling pathway and increasing immune factor release, thus accelerating the neuronal necroptosis induced by calcium overload.PMID:38688381 | DOI:10.1016/j.cellsig.2024.111195 (Source: Cellular Signalling)
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Qi Zhang Yanan Li Yanqin Liu Xin Wang Yonghui Yang Lei Shi Source Type: research
A critical suppression feedback loop determines soybean photoperiod sensitivity
Dev Cell. 2024 Apr 23:S1534-5807(24)00229-6. doi: 10.1016/j.devcel.2024.04.004. Online ahead of print.ABSTRACTPhotoperiod sensitivity is crucial for soybean flowering, adaptation, and yield. In soybean, photoperiod sensitivity centers around the evening complex (EC) that regulates the transcriptional level of the core transcription factor E1, thereby regulating flowering. However, little is known about the regulation of the activity of EC. Our study identifies how E2/GIGANTEA (GI) and its homologs modulate photoperiod sensitivity through interactions with the EC. During long days, E2 interacts with the blue-light receptor ...
Source: Developmental Cell - April 30, 2024 Category: Cytology Authors: Xiaohui Zhao Haiyang Li Lingshuang Wang Jianhao Wang Zerong Huang Haiping Du Yaru Li Jiahui Yang Milan He Qun Cheng Xiaoya Lin Baohui Liu Fanjiang Kong Source Type: research
BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1
In conclusion, the BPTF/FOXC1 axis was identified as a key promotor in glioma development and may be a potential target in the inhibition of glioma development.PMID:38686761 | DOI:10.14670/HH-18-748 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 30, 2024 Category: Cytology Authors: Yanling Pan Feng Yuan Zhiren Lin Yijie Li Source Type: research
LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes
CONCLUSIONS: This study proved the functional significance of LOXL1-AS1 in SHH-MB metastasis by its promotion of TGF-β2-mediated cancer stem-like phenotypes, providing both prognostic and therapeutic potentials for targeting SHH-MB metastasis.PMID:38689348 | DOI:10.1186/s13046-024-03057-0 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Anh Duy Do Kuo-Sheng Wu Shing-Shung Chu Le Hien Giang Yu-Ling Lin Che-Chang Chang Tai-Tong Wong Chia-Ling Hsieh Shian-Ying Sung Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
CONCLUSIONS: KCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC.PMID:38689322 | DOI:10.1186/s40001-024-01844-1 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Wei Zhang Xiao-Song Chen Ying Wei Xiao-Min Wang Xian-Jin Chen Bang-Teng Chi Lin-Qing Huang Rong-Quan He Zhi-Guang Huang Qi Li Gang Chen Juan He Mei Wu Source Type: research
