LOXL1-AS1 contributes to metastasis in sonic-hedgehog medulloblastoma by promoting cancer stem-like phenotypes

CONCLUSIONS: This study proved the functional significance of LOXL1-AS1 in SHH-MB metastasis by its promotion of TGF-β2-mediated cancer stem-like phenotypes, providing both prognostic and therapeutic potentials for targeting SHH-MB metastasis.PMID:38689348 | DOI:10.1186/s13046-024-03057-0

Source: Cell Research - April 30, 2024 Category: Cytology Authors: Anh Duy Do Kuo-Sheng Wu Shing-Shung Chu Le Hien Giang Yu-Ling Lin Che-Chang Chang Tai-Tong Wong Chia-Ling Hsieh Shian-Ying Sung Source Type: research