Researchers find potential to make brain cancers in children respond better to treatment
(McMaster University) Research has identified a small molecule compound that can activate the Wnt pathway in non-Wnt subtypes of medulloblastoma, making these aggressive forms of cancer more responsive to therapies. The work also found the Wnt pathway, which has historically been considered cancer-promoting, to function as a cancer inhibitor in certain contexts. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 28, 2020 Category: Cancer & Oncology Source Type: news

Leukemia drug shows the potential to treat aggressive pediatric brain c â ncer
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) When tested in vitro, arsenic trioxide killed tumor cells and prevented the formation of new colonies. This leukemia drug also boosted the effect of radiation therapy on medulloblastoma, a type of central nervous system tumor most common in children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 21, 2020 Category: International Medicine & Public Health Source Type: news

Intraventricular Methotrexate Betters Survival in Medulloblastoma Intraventricular Methotrexate Betters Survival in Medulloblastoma
Intraventricular methotrexate and systemic chemotherapy produced favorable survival outcomes in patients with desmoplastic medulloblastoma and medulloblastoma with extensive nodularity in new study.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 20, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Inherited mutation can predispose children to a type of brain tumor
(St. Jude Children's Research Hospital) Collaboration co-led by researchers at St. Jude Children's Research Hospital discovers a novel predisposition gene in pediatric medulloblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2020 Category: Cancer & Oncology Source Type: news

Brain tumors in children: Hereditary genetic defect destabilizes protein regulation
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) The causes of 40 percent of all cases of certain medulloblastoma - dangerous brain tumors affecting children - are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the Hopp Children's Cancer Center (KiTZ), the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world, which have just been published in the scientific journal Nature. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2020 Category: Cancer & Oncology Source Type: news

Understanding brain tumors in children
(European Molecular Biology Laboratory) The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2020 Category: Cancer & Oncology Source Type: news

Targeting a transporter to treat SHH medulloblastoma
(St. Jude Children's Research Hospital) Scientists at St. Jude Children's Research Hospital have identified a novel target for a type of pediatric brain tumor. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 31, 2020 Category: International Medicine & Public Health Source Type: news

Digital FDG-PET offers insights to hearing loss
The use of digital PET to measure FDG uptake in the area of the brain devoted...Read more on AuntMinnie.comRelated Reading: Flat-panel CT helps refine pitch for cochlear implant users ARRS: CBCT outperforms MDCT for hearing loss IMRT reduces risk of hearing loss in pediatric medulloblastoma patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 30, 2020 Category: Radiology Source Type: news

Researchers identify novel potential combination therapy for childhood brain tumors
(Write Science Right) Brazilian researchers working in collaboration with Canadian scientists demonstrated that all medulloblastoma tumor subtypes express two stem cell markers: BMI1 and CD133. When they induced DNA chromatin relaxation, tumor cell viability was reduced with down-regulation of BMI1 and CD133. These anti-tumor effects could be potentiated by concurrent inhibition of MAPK/ERK signaling. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 20, 2020 Category: Cancer & Oncology Source Type: news

Better Intellectual Outcomes After Proton Beam for Brain Cancer Better Intellectual Outcomes After Proton Beam for Brain Cancer
Children with medulloblastoma had better intellectual outcomes when treated with proton beam radiotherapy than with traditional radiotherapy.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 9, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Leukemia drug shows promise for treating a childhood brain cancer
A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego. (Source: World Pharma News)
Source: World Pharma News - September 23, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Boy is diagnosed with a brain tumour after his mother blamed his headaches on too much PlayStation 
Lucca Larkin, 10, from Radcliffe in Greater Manchester, developed headaches in August. He was diagnosed with a medulloblastoma brain tumour at the end of the month. (Source: the Mail online | Health)
Source: the Mail online | Health - September 19, 2019 Category: Consumer Health News Source Type: news

Cancer sufferer has been given the all-clear after treatment in Turkey that was denied on the NHS
Toni Ilsley's son Charlie, now 12, from Reading, was diagnosed with the brain tumour medulloblastoma when he was just eight years old in 2015. It spread to his spine last year. (Source: the Mail online | Health)
Source: the Mail online | Health - August 29, 2019 Category: Consumer Health News Source Type: news

To understand a childhood brain tumor, researchers turn to single-cell analysis
(St. Jude Children's Research Hospital) Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also has implications for how medulloblastoma is classified, which may eventually shape clinical care. The work appears as an advance online publication today in Nature. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 24, 2019 Category: Cancer & Oncology Source Type: news

Super-enhancers: novel target for pancreatic ductal adenocarcinoma
(Rapamycin Press) Among many pathways of cancer progression that PDAC relies on, anomalous activation of the sonic hedgehog pathway has shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 26, 2019 Category: Cancer & Oncology Source Type: news

FSU team breaks new ground in study of malignant pediatric brain tumor
(Florida State University) FSU researchers identified a series of cancer-causing driver gene mutations and discovered that medulloblastoma is perhaps an even more dynamic and variable tumor than expected. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: news

No REST for medulloblastoma
(Source: ScienceNOW)
Source: ScienceNOW - January 24, 2019 Category: Science Authors: Ferrarelli, L. K. Tags: twis Source Type: news

Targeted treatment shrinks deadly pediatric brain tumors
(Sanford Burnham Prebys Medical Discovery Institute) For children--whose tiny bodies are still growing--chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 23, 2019 Category: Biology Source Type: news

Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma
In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway, specifically the SHH-α (children 3 to 16 years) and SHH-β (infants) subgroups. Neuronal maturation is greater in SHH-β than SHH-α tumors, but both correlate with poor overall patient survival. We studied the contribution of REST to MB using a transgenic mouse model (RESTTG) wherein conditional NeuroD2-controlled REST transgene expression in lineage-committed Ptch1+/– cerebellar granule neuron progenitors (CGNPs) accelerated tumorig...
Source: Signal Transduction Knowledge Environment - January 22, 2019 Category: Science Authors: Dobson, T. H. W., Tao, R.-H., Swaminathan, J., Maegawa, S., Shaik, S., Bravo-Alegria, J., Sharma, A., Kennis, B., Yang, Y., Callegari, K., Haltom, A. R., Taylor, P., Kogiso, M., Qi, L., Khatua, S., Goldman, S., Lulla, R. R., Fangusaro, J., MacDonald, T. J Tags: STKE Research Articles Source Type: news

Identifying Low-Risk Medulloblastoma to De-escalate Therapy Identifying Low-Risk Medulloblastoma to De-escalate Therapy
Children with brain tumors that have a low-risk chromosomal signature could eventually be given lower-intensity treatment, suggests a new analysis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Study holds promise for new pediatric brain tumor treatment
(Huntsman Cancer Institute) New research published in Nature Communications from scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U), in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 11, 2018 Category: Cancer & Oncology Source Type: news

High-resolution genomic map gives scientists unprecedented view of brain development
(St. Jude Children's Research Hospital) The research will not only aid basic understanding of brain development, but also provide a foundation for understanding the cellular origins of brain disorders caused by errors in development. These anatomical defects include Joubert syndrome, Dandy-Walker malformation and pontocerebellar hypoplasia. The database will enable future studies tracing the cellular origins of childhood brain tumors such as medulloblastoma, astrocytoma and ependymoma.Researchers worldwide can interact with the data via an interface St. Jude has created called Cell Seek. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 13, 2018 Category: Biology Source Type: news

A target for medulloblastoma
(Source: ScienceNOW)
Source: ScienceNOW - September 13, 2018 Category: Science Authors: Ferrarelli, L. K. Tags: twis Source Type: news

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma
A major limitation of targeted cancer therapy is the rapid emergence of drug resistance, which often arises through mutations at or downstream of the drug target or through intrinsic resistance of subpopulations of tumor cells. Medulloblastoma (MB), the most common pediatric brain tumor, is no exception, and MBs that are driven by sonic hedgehog (SHH) signaling are particularly aggressive and drug-resistant. To find new drug targets and therapeutics for MB that may be less susceptible to common resistance mechanisms, we used a developmental phosphoproteomics approach in murine granule neuron precursors (GNPs), the developm...
Source: Signal Transduction Knowledge Environment - September 11, 2018 Category: Science Authors: Purzner, T., Purzner, J., Buckstaff, T., Cozza, G., Gholamin, S., Rusert, J. M., Hartl, T. A., Sanders, J., Conley, N., Ge, X., Langan, M., Ramaswamy, V., Ellis, L., Litzenburger, U., Bolin, S., Theruvath, J., Nitta, R., Qi, L., Li, X.-N., Li, G., Taylor, Tags: STKE Research Articles Source Type: news

Stem cells show promise as drug delivery tool for childhood brain cancer
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 29, 2018 Category: International Medicine & Public Health Source Type: news

Childhood Brain Tumor Radiation Can Hinder Memory
Radiation treatment for medulloblastoma, the most common type of childhood brain tumor, can leave young survivors struggling to remember recent events, a small study has found. But survivors' ability to recall things that happened before radiation wasn't affected. (Source: WebMD Health)
Source: WebMD Health - August 21, 2018 Category: Consumer Health News Source Type: news

SNMMI: Molecular imaging method monitors gene therapy
PHILADELPHIA - A new molecular imaging method can monitor the level and location...Read more on AuntMinnie.comRelated Reading: SNMMI: AI can avoid patient misidentification on PET/CT SNMMI: New therapy aids patients with neuroendocrine tumors SNMMI 2018: A year of promotion and ongoing challenges Machine learning may identify medulloblastoma subtypes DWI-MRI could help show gene expression in tumors (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 26, 2018 Category: Radiology Source Type: news

Reviving the protector: new tactic against medulloblastoma
(Emory Health Sciences) Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 11, 2018 Category: Cancer & Oncology Source Type: news

St. Jude trial identifies a medulloblastoma subset that requires less aggressive therapy
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital researchers have identified a subtype of the brain tumor medulloblastoma that is associated with improved survival of infants treated with less aggressive, risk-adapted therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2018 Category: International Medicine & Public Health Source Type: news

Genetic analysis for certain childhood brain tumors soon a standard-of-care?
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) An international team of researchers from the Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), the European Molecular Biology Laboratory (EMBL) and the German Cancer Consortium (DKTK) together with colleagues at the St. Jude Children's Research Hospital in Memphis and the Hospital for Sick Children in Toronto has summarized hereditary gene defects which can trigger the development of certain malignant brain tumors (medulloblastoma). From their findings, the team has derived recommendations for routine genetic screening in medulloblastoma pa...
Source: EurekAlert! - Cancer - May 11, 2018 Category: Cancer & Oncology Source Type: news

Genetic counseling and testing proposed for patients with the brain tumor medulloblastoma
(St. Jude Children's Research Hospital) Researchers have created the first genetic screening guidelines for medulloblastoma patients after identifying gene variations that make carriers susceptible to develop the brain tumor and possibly other cancers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 9, 2018 Category: International Medicine & Public Health Source Type: news

PD-L1 expression in medulloblastoma: An evaluation by subgroup
This study evaluated the expression of PD-L1 and markers of immune mediated resistance in human medulloblastoma, the most common malignant pediatric brain tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 2, 2018 Category: Cancer & Oncology Source Type: news

Funding the search for a cancer cure
Rider and Victoria McDowell made a fortune together, and produced real riches with the birth of three boys. But five years ago their son Errol was diagnosed with medulloblastoma, a rare brain cancer. After an experimental drug slowed the disease, they are now helping fund research in pediatric brain cancer in the hope of finding a cure. Tracy Smith reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - April 15, 2018 Category: Consumer Health News Source Type: news

Deep learning performs superresolution MSK MRI
A deep-learning algorithm can transform low-resolution, thick-slice knee MR...Read more on AuntMinnie.comRelated Reading: Machine learning may identify medulloblastoma subtypes Is artificial intelligence ethical in healthcare? Deep learning may produce sharp reductions in DBT dose AI can help distinguish lung nodules on CT scans Can AI help in the fight against gadolinium deposition? (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - April 11, 2018 Category: Radiology Source Type: news

Machine learning may identify medulloblastoma subtypes
The combination of machine learning and radiomics can predict the molecular...Read more on AuntMinnie.comRelated Reading: Is artificial intelligence ethical in healthcare? Deep learning may produce sharp reductions in DBT dose Deep learning can detect intracranial calcifications on CT Deep learning can quantify CAC on low-dose CT Deep-learning algorithm can stratify lung nodule risk (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 22, 2018 Category: Radiology Source Type: news

In the eye of the medulloblastoma
(CNRS) Can genes normally expressed only in the eye be activated in brain tumors? Such a phenomenon, though surprising, has been observed in certain types of medulloblastoma, pediatric tumors of the cerebellum. Researchers from the CNRS, Institut Curie, Inserm and Universit é Paris-Sud, together with colleagues at St. Jude Children's Research Hospital, have pinpointed the role of these genes in the tumor process, thus offering new therapeutic targets. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 12, 2018 Category: Cancer & Oncology Source Type: news

Atoh1, a potential Achilles' heel of Sonic Hedgehog medulloblastoma
(Baylor College of Medicine) Tyrosine 78 in Atoh1 is phosphorylated exclusively in 'tumor-initiating cells' in sonic hedgehog medulloblastoma and reducing the levels of Atoh1 promotes tumor regression in mice and provides a potential future strategy for treating this type of tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 12, 2017 Category: Cancer & Oncology Source Type: news

New weakness found in most common childhood malignant brain tumor
(Queen Mary University of London) A new weakness found in medulloblastoma, the most common form of childhood brain tumor, could lead to more personalized medicine and improved treatment for some patients, according to an early study by Queen Mary University of London. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 5, 2017 Category: Cancer & Oncology Source Type: news

Promising Target for Treating Brain Tumors in Children
New hope for children with highly aggressive brain tumors like atypical teratoid/rhabdoid tumor (AT/RT) and medulloblastoma (Source: Disabled World)
Source: Disabled World - November 28, 2017 Category: Disability Tags: Brain Cancers Source Type: news

Promising target for treating brain tumors in children
(Ann& Robert H. Lurie Children's Hospital of Chicago) Findings published in Oncotarget offer new hope for children with highly aggressive brain tumors like atypical teratoid/rhabdoid tumor (AT/RT) and medulloblastoma. Previously, the authors of the study have shown that an experimental drug that inhibits polo-like kinase 4 (PLK4) stopped pediatric brain tumor growth in vitro. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 27, 2017 Category: International Medicine & Public Health Source Type: news

Florida boy diagnosed with brain tumor after concussion
Logan Silva, seven, was diagnosed with medulloblastoma, a fast-growing brain tumor. After getting a concussion, the boy from Florida suffered extreme headaches which turned out to be a tumor. (Source: the Mail online | Health)
Source: the Mail online | Health - November 3, 2017 Category: Consumer Health News Source Type: news

New study discovers faulty genes underlying brain tumours
A new in-depth study funded by Cancer Research UK has shown that medulloblastoma brain tumours have faulty genes underlying the disease. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - July 27, 2017 Category: Pharmaceuticals Source Type: news

Definitive genomic study reveals alterations driving most medulloblastoma brain tumors
(St. Jude Children's Research Hospital) An international consortium co-led by St. Jude Children's Research Hospital completed a landmark study of most common pediatric brain tumor, revealing new cancer genes, laying the foundation to expand precision medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2017 Category: Cancer & Oncology Source Type: news

Researchers identify a key controller of biological machinery in cell's 'antenna'
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumor medulloblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 6, 2017 Category: Cancer & Oncology Source Type: news

PID1 gene enhances effectiveness of chemotherapy on brain cancer cells
The gene PID1 enhances killing of medulloblastoma and glioblastoma cells, investigators have found. Medulloblastoma is the most commonly occurring malignant primary brain tumor in children; glioblastoma is the most commonly occurring malignant primary brain tumor in adults. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 11, 2017 Category: Science Source Type: news

PID1 gene enhances effectiveness of chemotherapy on brain cancer cells
(Children's Hospital Los Angeles) Investigators at The Saban Research Institute of Children's Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma and glioblastoma cells. Medulloblastoma is the most commonly occurring malignant primary brain tumor in children; glioblastoma is the most commonly occurring malignant primary brain tumor in adults. Results of this study will be published in Scientific Reports on April 11. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2017 Category: Global & Universal Source Type: news

Caution needed for drugs in development for most common malignant pediatric brain tumor
(St. Jude Children's Research Hospital) Researchers at St. Jude Children's Research Hospital have studied how a crucial cancer-related protein plays a role in one of the most aggressive forms of medulloblastoma, the most common malignant brain tumor of childhood. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 21, 2017 Category: Cancer & Oncology Source Type: news

Molecular'on switch' could point to treatments for pediatric brain tumor
Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 24, 2017 Category: Science Source Type: news

Molecular 'on switch' could point to treatments for pediatric brain tumor
(Massachusetts General Hospital) Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 24, 2017 Category: Cancer & Oncology Source Type: news

Husband-wife team at Children ’s Mercy declares war on brain cancer
Children ’s Mercy Chief Scientific Officer Tom Curran and Assistant Professor of Pediatrics Jessie Ng have a long history. The husband-and-wife duo have worked together for more than a decade, evaluating pediatric brain cancer treatments. Before Curran joined Children’s Mercy in February 2016, Ng worked for Curran at the Children’s Hospital of Philadelphia, where he led translational childhood cancer research. Among numerous projects, he and Ng tested a new treatment for medulloblastoma, the… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - January 17, 2017 Category: American Health Authors: Elise Reuter Source Type: news