FSU team breaks new ground in study of malignant pediatric brain tumor
(Florida State University) FSU researchers identified a series of cancer-causing driver gene mutations and discovered that medulloblastoma is perhaps an even more dynamic and variable tumor than expected. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: news
No REST for medulloblastoma
(Source: ScienceNOW)
Source: ScienceNOW - January 24, 2019 Category: Science Authors: Ferrarelli, L. K. Tags: twis Source Type: news
Targeted treatment shrinks deadly pediatric brain tumors
(Sanford Burnham Prebys Medical Discovery Institute) For children--whose tiny bodies are still growing--chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 23, 2019 Category: Biology Source Type: news
Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma
In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway, specifically the SHH-α (children 3 to 16 years) and SHH-β (infants) subgroups. Neuronal maturation is greater in SHH-β than SHH-α tumors, but both correlate with poor overall patient survival. We studied the contribution of REST to MB using a transgenic mouse model (RESTTG) wherein conditional NeuroD2-controlled REST transgene expression in lineage-committed Ptch1+/– cerebellar granule neuron progenitors (CGNPs) accelerated tumorig...
Source: Signal Transduction Knowledge Environment - January 22, 2019 Category: Science Authors: Dobson, T. H. W., Tao, R.-H., Swaminathan, J., Maegawa, S., Shaik, S., Bravo-Alegria, J., Sharma, A., Kennis, B., Yang, Y., Callegari, K., Haltom, A. R., Taylor, P., Kogiso, M., Qi, L., Khatua, S., Goldman, S., Lulla, R. R., Fangusaro, J., MacDonald, T. J Tags: STKE Research Articles Source Type: news
Identifying Low-Risk Medulloblastoma to De-escalate Therapy Identifying Low-Risk Medulloblastoma to De-escalate Therapy
Children with brain tumors that have a low-risk chromosomal signature could eventually be given lower-intensity treatment, suggests a new analysis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Study holds promise for new pediatric brain tumor treatment
(Huntsman Cancer Institute) New research published in Nature Communications from scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U), in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 11, 2018 Category: Cancer & Oncology Source Type: news
High-resolution genomic map gives scientists unprecedented view of brain development
(St. Jude Children's Research Hospital) The research will not only aid basic understanding of brain development, but also provide a foundation for understanding the cellular origins of brain disorders caused by errors in development. These anatomical defects include Joubert syndrome, Dandy-Walker malformation and pontocerebellar hypoplasia. The database will enable future studies tracing the cellular origins of childhood brain tumors such as medulloblastoma, astrocytoma and ependymoma.Researchers worldwide can interact with the data via an interface St. Jude has created called Cell Seek. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 13, 2018 Category: Biology Source Type: news
A target for medulloblastoma
(Source: ScienceNOW)
Source: ScienceNOW - September 13, 2018 Category: Science Authors: Ferrarelli, L. K. Tags: twis Source Type: news
Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma
A major limitation of targeted cancer therapy is the rapid emergence of drug resistance, which often arises through mutations at or downstream of the drug target or through intrinsic resistance of subpopulations of tumor cells. Medulloblastoma (MB), the most common pediatric brain tumor, is no exception, and MBs that are driven by sonic hedgehog (SHH) signaling are particularly aggressive and drug-resistant. To find new drug targets and therapeutics for MB that may be less susceptible to common resistance mechanisms, we used a developmental phosphoproteomics approach in murine granule neuron precursors (GNPs), the developm...
Source: Signal Transduction Knowledge Environment - September 11, 2018 Category: Science Authors: Purzner, T., Purzner, J., Buckstaff, T., Cozza, G., Gholamin, S., Rusert, J. M., Hartl, T. A., Sanders, J., Conley, N., Ge, X., Langan, M., Ramaswamy, V., Ellis, L., Litzenburger, U., Bolin, S., Theruvath, J., Nitta, R., Qi, L., Li, X.-N., Li, G., Taylor, Tags: STKE Research Articles Source Type: news
Stem cells show promise as drug delivery tool for childhood brain cancer
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 29, 2018 Category: International Medicine & Public Health Source Type: news
Childhood Brain Tumor Radiation Can Hinder Memory
Radiation treatment for medulloblastoma, the most common type of childhood brain tumor, can leave young survivors struggling to remember recent events, a small study has found. But survivors' ability to recall things that happened before radiation wasn't affected. (Source: WebMD Health)
Source: WebMD Health - August 21, 2018 Category: Consumer Health News Source Type: news
SNMMI: Molecular imaging method monitors gene therapy
PHILADELPHIA - A new molecular imaging method can monitor the level and location...Read more on AuntMinnie.comRelated Reading:
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Machine learning may identify medulloblastoma subtypes
DWI-MRI could help show gene expression in tumors (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 26, 2018 Category: Radiology Source Type: news
Reviving the protector: new tactic against medulloblastoma
(Emory Health Sciences) Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 11, 2018 Category: Cancer & Oncology Source Type: news
St. Jude trial identifies a medulloblastoma subset that requires less aggressive therapy
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital researchers have identified a subtype of the brain tumor medulloblastoma that is associated with improved survival of infants treated with less aggressive, risk-adapted therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2018 Category: International Medicine & Public Health Source Type: news
Genetic analysis for certain childhood brain tumors soon a standard-of-care?
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) An international team of researchers from the Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), the European Molecular Biology Laboratory (EMBL) and the German Cancer Consortium (DKTK) together with colleagues at the St. Jude Children's Research Hospital in Memphis and the Hospital for Sick Children in Toronto has summarized hereditary gene defects which can trigger the development of certain malignant brain tumors (medulloblastoma). From their findings, the team has derived recommendations for routine genetic screening in medulloblastoma pa...
Source: EurekAlert! - Cancer - May 11, 2018 Category: Cancer & Oncology Source Type: news
