Tracking defects caused by brain tumor mutation yields insight to advance targeted therapy
(St. Jude Children's Research Hospital) St. Jude Children's Research Hospital scientists have gained ground toward developing more targeted therapies for the most common childhood brain tumor. The findings appear today in the Journal of Molecular Biology. The findings involve the DDX3X gene. In 2012, the St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project highlighted DDX3X as a promising focus for efforts to develop targeted therapies against medulloblastoma. Such treatments target the genetic mistakes that give rise to the brain tumor's four subtypes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 8, 2015 Category: Global & Universal Source Type: news
Tracking defects caused by brain tumor mutation yields insight to advance targeted therapy
St. Jude Children’s Research Hospital scientists show that mutations in the DDX3X gene lead to different molecular defects; findings will aid efforts to develop more individualized therapy of medulloblastoma. (Janet F. Partridge, PhD) (Source: St. Jude Children's Research Hospital)
Source: St. Jude Children's Research Hospital - May 8, 2015 Category: Pediatrics Source Type: news
An Award-Winning Cancer Researcher Says U.S. Science Has Never Been More Imperiled
WASHINGTON -- Around 6:30 p.m. on Wednesday, 150 or so people gathered in an otherwise empty National Press Club in downtown D.C.
Hours earlier, in the room down the hall, Sen. Ted Cruz (R-Texas) had drawn throngs of press during an appearance before the Hispanic Chamber of Commerce. Now, none remained. Instead, attendees still in their work attire sat around tables sipping wine and eating moderately moist chicken dinners, waiting to hear from the guest of the night, a doctor from the Boston Children's Hospital whom few in D.C. -- outside those walls -- knew of.
Dr. Frederick Alt, a 66-year-old Harvard professor of gene...
Source: Science - The Huffington Post - April 30, 2015 Category: Science Source Type: news
Promising drug target identified in medulloblastoma
(Dana-Farber Cancer Institute) Scientists at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have identified a protein critical to both the normal development of the brain and, in many cases, the development of medulloblastoma, a fast-growing brain tumor that usually strikes children under 10. As reported in Developmental Cell, when the researchers cut the level of the protein Eya1 in half in mice prone to develop medulloblastoma, the animals' risk of dying from the disease dropped dramatically. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 26, 2015 Category: Cancer & Oncology Source Type: news
Scientists map out how childhood brain tumors relapse
The unique genetic paths that the childhood brain tumor medulloblastoma follows when the disease comes back has been mapped out, researchers report. Scientists looked at biopsies from the relapsed tumours of 29 patients. They found a range of changes that only appeared when the disease returned and were responsible for the cancer becoming more aggressive. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 18, 2014 Category: Science Source Type: news
Scientists map out how childhood brain tumors relapse
(Cancer Research UK) Researchers have discovered the unique genetic paths that the childhood brain tumor medulloblastoma follows when the disease comes back (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 18, 2014 Category: Cancer & Oncology Source Type: news
Brain tumor: Key found for suppression of growth in medulloblastomas
A key factor that can suppress medulloblastoma, the most frequent child brain tumor, has been identified by researchers. Medulloblastoma is the most common brain tumor in children, and its treatment remains inefficient. The work opens new perspectives on the diagnosis and treatment of these brain tumors with the discovery of a key factor called BCL6, able to suppress the growth of medulloblastomas in mice and in human tumor cells in culture. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 9, 2014 Category: Science Source Type: news
Sonic Hedgehog protein causes DNA damage and the development child brain tumors
(University of Montreal) Scientists at the Institut de recherches cliniques de Montreal and the University of Montreal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumor found in children. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 13, 2014 Category: Cancer & Oncology Source Type: news
Discovery could prevent development of brain tumors in children
A mechanism that promotes the progression of medulloblastoma, the most common brain tumor found in children, has been discovered by researchers. The team found that a protein known as Sonic Hedgehog induces DNA damage causes the cancer to develop. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 2, 2014 Category: Science Source Type: news
A discovery could prevent the development of brain tumors in children
(Institut de recherches cliniques de Montreal) Scientists at the IRCM in Montréal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumor found in children. The team, led by Frédéric Charron, Ph.D., found that a protein known as Sonic Hedgehog induces DNA damage, which causes the cancer to develop. This important breakthrough will be published in the Oct. 13 issue of the prestigious scientific journal Developmental Cell. The editors also selected the article to be featured on the journal's cover. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 2, 2014 Category: Cancer & Oncology Source Type: news
A discovery could prevent the development of brain tumours in children
(Institut de recherches cliniques de Montreal) Scientists at the IRCM in Montréal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumour found in children. The team, led by Frédéric Charron, PhD, found that a protein known as Sonic Hedgehog induces DNA damage, which causes the cancer to develop. This important breakthrough will be published in the October 13 issue of the prestigious scientific journal Developmental Cell. The editors also selected the article to be featured on the journal's cover. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 2, 2014 Category: Global & Universal Source Type: news
