PID1 gene enhances effectiveness of chemotherapy on brain cancer cells
(Children's Hospital Los Angeles) Investigators at The Saban Research Institute of Children's Hospital Los Angeles have found that the gene PID1 enhances killing of medulloblastoma and glioblastoma cells. Medulloblastoma is the most commonly occurring malignant primary brain tumor in children; glioblastoma is the most commonly occurring malignant primary brain tumor in adults. Results of this study will be published in Scientific Reports on April 11. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2017 Category: Global & Universal Source Type: news
Caution needed for drugs in development for most common malignant pediatric brain tumor
(St. Jude Children's Research Hospital) Researchers at St. Jude Children's Research Hospital have studied how a crucial cancer-related protein plays a role in one of the most aggressive forms of medulloblastoma, the most common malignant brain tumor of childhood. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 21, 2017 Category: Cancer & Oncology Source Type: news
Molecular'on switch' could point to treatments for pediatric brain tumor
Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 24, 2017 Category: Science Source Type: news
Molecular 'on switch' could point to treatments for pediatric brain tumor
(Massachusetts General Hospital) Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 24, 2017 Category: Cancer & Oncology Source Type: news
Husband-wife team at Children ’s Mercy declares war on brain cancer
Children ’s Mercy Chief Scientific Officer Tom Curran and Assistant Professor of Pediatrics Jessie Ng have a long history. The husband-and-wife duo have worked together for more than a decade, evaluating pediatric brain cancer treatments.
Before Curran joined Children’s Mercy in February 2016, Ng worked for Curran at the Children’s Hospital of Philadelphia, where he led translational childhood cancer research. Among numerous projects, he and Ng tested a new treatment for medulloblastoma, the… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - January 17, 2017 Category: American Health Authors: Elise Reuter Source Type: news
ASTRO releases updated APBI guide
The American Society for Radiation Oncology (ASTRO) has released an updated...Read more on AuntMinnie.comRelated Reading:
ASTRO: PET predicts outcomes in vulvar cancer patients
ASTRO: Radiation boost cuts local recurrence in DCIS patients
ASTRO: Negative PET/CT doesn't always mean dormant NSCLC
ASTRO: Prostate cancer has 3 molecular subtypes
ASTRO: OK to cut RT dose for primary medulloblastoma (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 17, 2016 Category: Radiology Source Type: news
Genetic signaling pathway blocks formation of a cancer in the cerebellum
A signaling pathway has the potential to block a type of cancer in the cerebellum, suggests new research. The work is focused on brain tumor formation in animal models of medulloblastoma, the most common malignant brain tumor diagnosed in children. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 8, 2016 Category: Science Source Type: news
Adding Chemotherapy in Medulloblastoma Linked With Improved Survival
A recent retrospective study found that adding chemotherapy to postoperative treatment of craniospinal radiation for adults with medulloblastoma improves survival. (Source: CancerNetwork)
Source: CancerNetwork - November 4, 2016 Category: Cancer & Oncology Authors: Benjamin Kann, MD Tags: Brain Tumors Radiation Oncology Source Type: news
Could targeting a gene linked to microcephaly lead to a better brain cancer treatment?
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers report preclinical findings showing promise for targeting a gene linked to microcephaly in infants as a treatment for medulloblastoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2016 Category: Cancer & Oncology Source Type: news
Shortened RT works for low-risk prostate cancer patients
A shortened, higher-dose radiation therapy (RT) protocol is safe for low-risk...Read more on AuntMinnie.comRelated Reading:
ASTRO: PET predicts outcomes in vulvar cancer patients
ASTRO: Radiation boost cuts local recurrence in DCIS patients
ASTRO: Negative PET/CT doesn't always mean dormant NSCLC
ASTRO: Prostate cancer has 3 molecular subtypes
ASTRO: OK to cut RT dose for primary medulloblastoma (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 4, 2016 Category: Radiology Source Type: news
Markers Could Improve Treatment Stratification for Pediatric Medulloblastoma
The use of an intensified treatment regimen to treat metastatic medulloblastoma in children and adolescents conferred an overall favorable survival, according to the results of a recent study. However, patients within varying subgroups and with certain biologic parameters did not have uniform outcomes. (Source: CancerNetwork)
Source: CancerNetwork - October 3, 2016 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Brain Tumors Pediatric Cancers Source Type: news
ASTRO: OK to cut RT dose for primary medulloblastoma
Reduced doses for radiation therapy (RT) for pediatric medulloblastoma at the...Read more on AuntMinnie.comRelated Reading:
Pediatric proton therapy treatments on the rise
SNMMI: PET, MRI may predict pediatric brain tumor outcomes
ASTRO: Study lauds proton therapy
Imaging advances therapy assessment
Proton therapy offers hope to pediatric brain cancer patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 26, 2016 Category: Radiology Source Type: news
Medulloblastoma patients should receive both chemotherapy and radiation post-surgery
The addition of chemotherapy to postoperative treatment for adults with medulloblastoma improves survival, new research demonstrates. Medulloblastoma (MB) is the most common brain tumor in children, but is relatively rare in adults. Chemotherapy use in adult MB is largely based on pediatric outcomes, and its effectiveness has been unclear. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 26, 2016 Category: Science Source Type: news
DelMar, Accurexa ink deal for chemotherapy combo
DelMar Pharmaceuticals and Accurexa said today that they inked a deal to collaborate on a combination chemotherapy for local treatment of brain cancer.
The agreement calls for DelMar to supply the drug dianhydrogalactitol (VAL-083) as part of a combination with another chemotherapeutic, either temozolomide or carmustine, for local delivery to the tumor via Accurexa’s ACX-31 implantable polymer wafer. DelMar said its drug proved successful in more than 40 clinical trials sponsored by the U.S. National Cancer Institute, winning orphan drug designation as a treatment for gliomas, medulloblastoma and ovarian cancer in Apr...
Source: Mass Device - September 7, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Drug-Device Combinations Neurological Oncology Pharmaceuticals Research & Development Accurexa Inc. DelMar Pharmaceuticals Source Type: news
Deferring Postoperative RT for Pediatric Medulloblastoma Affected Survival
The deferral of postoperative radiotherapy is increasing among children with medulloblastoma, and this deferral of treatment was associated with worse survival. (Source: CancerNetwork)
Source: CancerNetwork - August 26, 2016 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Brain Tumors News Source Type: news
