How airway cells work together in regeneration and aging
Researchers at theEli and Edythe Broad Center of  Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases — creating more of themselves and producing mature airway cells — to regenerate lung tissue after an injury.The study, published in Cell Stem Cell, also sheds light on how aging can cause lung regeneration to go awry, which can lead to lung cancer and other diseases.  “There currently are few therapies that target the biology of lung diseases,” said Dr. Brigitte Gomperts,a profes...
Source: UCLA Newsroom: Health Sciences - July 27, 2020 Category: Universities & Medical Training Source Type: news

More Mesothelioma Cancer Centers Using Tumor Treating Fields
Tumor Treating Fields is one of the newest treatments on the market for pleural mesothelioma cancer patients with metastatic disease. The device is also available to patients with locally advanced cancer who are not candidates for mesothelioma surgery. Clinical trials of the treatment, previously known as NovoTTF-100L, extended the survival of mesothelioma patients by more than six months compared to those receiving only chemotherapy. The device is now called Optune Lua and has been available outside of clinical trials for over a year. More physicians and treatment centers are becoming certified to prescribe the treatmen...
Source: Asbestos and Mesothelioma News - July 21, 2020 Category: Environmental Health Authors: Fran Mannino Source Type: news

NCI Studying New Mesothelioma Immunotherapy Combination
Patients with mesothelioma are being recruited by the National Cancer Institute for a phase II clinical trial using a novel immunotoxin prior to pembrolizumab, a combination that has shown preliminary evidence of efficacy. This promising mesothelioma clinical trial involves the drug LMB-100, designed to make immunotherapy agents such as pembrolizumab, otherwise known as Keytruda, more effective. NCI’s trial includes separate cohorts for pleural and peritoneal types of mesothelioma. “This is a very good option for these patients,” medical oncologist Dr. Raffit Hassan, an acclaimed investigator at the Natio...
Source: Asbestos and Mesothelioma News - July 8, 2020 Category: Environmental Health Authors: Fran Mannino Source Type: news

Oncotarget: Epigenetic feedback and stochastic partitioning can drive resistance to EMT
(Impact Journals LLC) Oncotarget Volume 11, Issue 27 published " Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT " by Jia et al. which reported that Epithelial-mesenchymal transition (EMT) and its reverse process mesenchymal-epithelial transition are central to metastatic aggressiveness and therapy resistance in solid tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2020 Category: Cancer & Oncology Source Type: news

Moffitt researchers identify protein that causes epithelial cancers to spread
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in the July issue of Cancer Research, Elsa Flores, Ph.D., and her team discovered a key protein that oscillates its expression through microRNA regulation to facilitate cancer spread to distant organs. This protein is deltaNp63, a member of the p53 family of tumor suppressor genes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 6, 2020 Category: International Medicine & Public Health Source Type: news

Hidden Cause of Cancer?
When you’re tearing off a sheet of aluminum foil to cook with — or wrap your leftovers before you put them in the fridge — you probably never consider aluminum is a dangerous toxin. Truth is, aluminum is a heavy metal… just like lead, mercury and arsenic. It’s in our food… our cookware… even in the water we drink. Exposure to aluminum is a risk factor for cancer, Alzheimer’s, Parkinson’s, and bone disease, just to name a few. Our lungs, liver, and kidneys are able to eliminate a majority of the small amounts of aluminum we ingest through eating, drinking or breath...
Source: Al Sears, MD Natural Remedies - May 29, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Source Type: news

Cervical precancer identified by fluorescence, in a step toward bedside detection
(Tufts University) Researchers developed a method using fluorescence to detect precancerous metabolic and physical changes in individual epithelial cells lining the cervix, and can visualize those changes at different depths of the epithelial tissue near the surface. The method, which can detect precancerous lesions non-invasively and non-destructively, opens the door to early-stage bedside diagnostics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 19, 2020 Category: Cancer & Oncology Source Type: news

FDA Approves Olaparib/Bevacizumab Maintenance FDA Approves Olaparib/Bevacizumab Maintenance
The FDA has announced a new approved indication for olaparib in adults with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - May 12, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Epithelial GPS: Position of RNAi machinery is associated with epithelial identity
(Medical University of South Carolina) Researchers at the Medical University of South Carolina show in a new report that the RNA interference machinery, normally thought to reside in the nucleus or cytoplasm, predominantly localizes to these apical junctions and influences cell biology in the colon. Interestingly, in colon tumors, this localization is dysregulated and may shift the balance of RNAs to promote tumorigenesis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 8, 2020 Category: Cancer & Oncology Source Type: news

FDA Approves Expanded Olaparib Indication to Include Combination with Bevacizumab
The FDA expanded the indication of olaparib to include a combination regimen with bevacizumab for the first-line maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer. (Source: CancerNetwork)
Source: CancerNetwork - May 8, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

FDA Approves Niraparib for Advanced Ovarian Cancer
The FDA approved niraparib for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy. (Source: CancerNetwork)
Source: CancerNetwork - April 29, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Ovarian cancer: recognition and initial management [CG122], NICE (Published 27th April)
This guideline covers detecting, diagnosing and treating women (18 years and older) who have, or are suspected of having, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer or borderline ovarian cancer. It aims to enable earlier detection of ovarian cancer and improve initial treatment. This guideline was previously called ovarian cancer: the recognition and initial management of ovarian cancer. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 27, 2020 Category: Consumer Health News Source Type: news

Analysis of Stage I EFHWTs Treatment Finds Event-Free Survival and Overall Survival Rates Greater Than 95%
A recent study reported a 96.2% event-free survival rate and a 100% overall survival rate when investigating treatment option for stage I epithelial-predominant favorable-histology Wilms tumors in a population with a majority of patients under the age of 48 months. (Source: CancerNetwork)
Source: CancerNetwork - April 23, 2020 Category: Cancer & Oncology Authors: Matthew Fowler Source Type: news

Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies
Breast and mammary epithelial cells experience different local environments during tissue development and tumorigenesis. Microenvironmental heterogeneity gives rise to distinct cell regulatory states whose identity and importance are just beginning to be appreciated. Cellular states diversify when clonal three-dimensional (3D) spheroids are cultured in basement membrane, and one such state is associated with stress tolerance and poor response to anticancer therapeutics. Here, we found that this state was jointly coordinated by the NRF2 and p53 pathways, which were costabilized by spontaneous oxidative stress within 3D cult...
Source: Signal Transduction Knowledge Environment - April 14, 2020 Category: Science Authors: Pereira, E. J., Burns, J. S., Lee, C. Y., Marohl, T., Calderon, D., Wang, L., Atkins, K. A., Wang, C.-C., Janes, K. A. Tags: STKE Research Articles Source Type: news

Ex ­ tra ­ cel ­ lu ­ lar forces help epi ­ thelial cells stick to ­ gether
(University of Helsinki) Defects in the maintenance of the superficial tissue of the body, known as epithelial tissue, can help cancer cells achieve motility and metastasise. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2020 Category: International Medicine & Public Health Source Type: news

Extracellular forces help epithelial cells stick together
(University of Helsinki) Defects in the maintenance of the superficial tissue of the body, known as epithelial tissue, can help cancer cells achieve motility and metastasize. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 2, 2020 Category: Cancer & Oncology Source Type: news

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset of these cells generates metastases. We conducted an in vivo genome-wide CRISPR activation screen in CTCs from breast cancer patients to identify genes that promote distant metastasis in mice. Genes coding for ribosomal proteins and regulators of translation were enriched in this screen. Overexpression of RPL15, which encodes a component of the large ribosomal subunit, increased metastatic growth in multiple organs and selectively enhanced translation of other ribosomal proteins and cell cycle regulators. RNA sequencin...
Source: ScienceNOW - March 26, 2020 Category: Science Authors: Ebright, R. Y., Lee, S., Wittner, B. S., Niederhoffer, K. L., Nicholson, B. T., Bardia, A., Truesdell, S., Wiley, D. F., Wesley, B., Li, S., Mai, A., Aceto, N., Vincent-Jordan, N., Szabolcs, A., Chirn, B., Kreuzer, J., Comaills, V., Kalinich, M., Haas, W. Tags: Medicine, Diseases, Molecular Biology reports Source Type: news

Learning how cancer cells coordinate and collaborate to multiply and metastasize
(Osaka University) Researchers from Osaka University and the National Institute of Information and Communications Technology have cultured epithelial-like cancer cells on an artificial substrate and observed their collaborative self-organization into network structures that may function as nutritional conduits and provide vascular access. Understanding of the parameters that govern this coordinated behavior, including the various forces responsible, may explain tumor growth and metastasis, thus providing a basis for developing new anticancer drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 12, 2020 Category: Cancer & Oncology Source Type: news

Janssen Announces U.S. FDA Breakthrough Therapy Designation Granted for JNJ-6372 for the Treatment of Non-Small Cell Lung Cancer
RARITAN, NJ, March 10, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for JNJ-61186372 (JNJ-6372) for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) Exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy. JNJ-6372 is an EGFR-mesenchymal epithelial transition factor (MET) bispecific antibody that targets activating and resistant EGFR and MET mutations and amplifications.[1...
Source: Johnson and Johnson - March 10, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

FDA D.I.S.C.O.: Niraparib in Ovarian Cancer Transcript
FDA medical oncologists discuss the agency ’s March 2017 approval of niraparib for the maintenance treatment of patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 28, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

MicroRNA regulates process vital to placenta growth in early pregnancy
(University of South Florida (USF Health)) A study by University of South Florida Health (USF Health) researchers discovered how a very large human non-protein coding gene regulates epithelial-to-mesenchymal transition (EMT) -- a process that contributes to placental implantation during early pregnancy, as well as cancer progression and spread. EMT plays a key role in proper placenta growth, critical to the health of the mother and her growing fetus. The USF Health team showed that robustly activating the chromosome 19 microRNA cluster using CRISPR technology inhibited EMT. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2020 Category: International Medicine & Public Health Source Type: news

Duke Completes Largest Study of Mesothelioma in Women
This study of women included 275 cases of pleural mesothelioma and 79 cases of peritoneal. Papillary mesothelioma and localized mesothelioma cases were excluded. Previous reports have shown that 22% to 29% of mesothelioma cases involve women, but only 12% in this particular study. Other Notable Takeaways The majority of those studied were exposed to asbestos through household contact. Women who worked in occupations and industries associated with higher asbestos exposure had objective markers of exposure similar to men. Survival was longer for the epithelial subtype of mesothelioma and magnified with the per...
Source: Asbestos and Mesothelioma News - February 5, 2020 Category: Environmental Health Authors: Matt Mauney Source Type: news

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease
(Impact Journals LLC) The authors determined that tumor-derived ANGPTL2 stimulates lung epithelial cells, which is essential for primary tumor-induced neutrophil recruitment in lung and subsequent pre-metastatic niche formation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 5, 2020 Category: Cancer & Oncology Source Type: news

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell
(Impact Journals LLC) Oncotarget Volume 11, Issue 4: Treatment of human oral squamous cell carcinoma cell lines HSC3 and HSC4 with Clostridium perfringens enterotoxin, induced CLDN4 nuclear translocation to enhance epithelial-mesenchymal transition, stemness, cell proliferation, and invasive ability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 4, 2020 Category: Cancer & Oncology Source Type: news

Janssen to Highlight Depth of Solid Tumor Portfolio at ASCO GU
RARITAN, N.J., February 3, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today multiple data presentations from a robust solid tumor portfolio that will be featured at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place February 13-15 in San Francisco. Company-sponsored data presentations will include clinical results for ERLEADA® (apalutamide) and niraparib in prostate cancer; and BALVERSA™ (erdafitinib) in bladder cancer. “We are committed to improving outcomes in patients with prostate and bladder cancer where high unmet...
Source: Johnson and Johnson - February 3, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

Weekly Dose-Dense Chemo Not Recommended in First-Line Epithelial Ovarian Cancer Treatment
A study showed that first-line treatment for epithelial ovarian cancer using weekly dose-dense chemotherapy did not improve progression-free survival, compared with 3-weekly chemotherapy, in European women. (Source: CancerNetwork)
Source: CancerNetwork - December 20, 2019 Category: Cancer & Oncology Authors: Matthew Fowler Source Type: news

Researchers create accurate model of organ scarring using stem cells in a lab
Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.However, when healing is disrupted — whether by chronic injury or disease — the cells that make up scar tissue can go rogue, continuously dividing and spreading until the scar eventually strangles the organ it was intended to help heal, which can lead to organ failure.That progressive, out-of-control scarring is called fibrosis, and it can occur in any organ in the body. Fibrosis plays a major role in many dis...
Source: UCLA Newsroom: Health Sciences - December 11, 2019 Category: Universities & Medical Training Source Type: news

New Cochrane Review assesses different HPV vaccines and vaccine schedules in adolescent girls and boys
New evidence published in the Cochrane Library today provides further information on the benefits and harms of different human papillomavirus (HPV) vaccines and vaccine schedules in young women and men.HPV is the most common viral infection of the reproductive tract in both women and men globally (WHO 2017). Most people who have sexual contact will be exposed to HPV at some point in their life. In most people, their own immune system will clear the HPV infection.HPV infection can sometimes persist if the immune system does not clear the virus. Persistent infection with some ‘high-risk’ strains of HPV can lead t...
Source: Cochrane News and Events - November 20, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Article proposes important mucin link between microbial infections and many cancers
(University of North Carolina at Charlotte) In a review article, cancer biologists Pinku Mukherjee and Mukulika Bose argue that recent research suggests a mechanism that may implicate bacterial infections as important factors in epithelial cell cancers. The article points to microbial interactions that may alter the glycoprotein known as MUC1, triggering signaling pathways that cause cancer, including cancers of the colon, lungs, stomach, liver and pancreas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 18, 2019 Category: Cancer & Oncology Source Type: news

Adult fly intestine could help understand intestinal regeneration
Intestinal epithelial cells (IECs) are exposed to diverse types of environmental stresses such as bacteria and toxins, but the mechanisms by which epithelial cells sense stress are not well understood. New research by the universities of Bristol, Heidelberg and the German Cancer Research Center (DKFZ) have found that Nox-ROS-ASK1-MKK3-p38 signaling in IECs integrates various stresses to facilitate intestinal regeneration. (Source: University of Bristol news)
Source: University of Bristol news - September 25, 2019 Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Life Sciences, Faculty of Life Sciences, School of Cellular and Molecular Medicine, Institutes, Institutes, Elizabeth Blackwell; Press Release Source Type: news

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells
Semaphorins are a family of molecular signals that guide cell migration and are implicated in the regulation of cancer cells. In particular, transmembrane semaphorins are postulated to act as both ligands ("forward" mode) and signaling receptors ("reverse" mode); however, reverse semaphorin signaling in cancer is relatively less understood. Here, we identified a previously unknown function of transmembrane semaphorin 4C (Sema4C), acting in reverse mode, to elicit nonconventional TGF-β/BMP receptor activation and selective SMAD1/5 phosphorylation. Sema4C coimmunoprecipitated with TGFBRII and BMPR1, ...
Source: Signal Transduction Knowledge Environment - August 20, 2019 Category: Science Authors: Gurrapu, S., Franzolin, G., Fard, D., Accardo, M., Medico, E., Sarotto, I., Sapino, A., Isella, C., Tamagnone, L. Tags: STKE Research Articles Source Type: news

Mesothelioma Treatment in Toronto Moves from SMART to SMARTER
The Princess Margaret Cancer Center in Toronto has moved from SMART to SMARTER with the recent launch of its latest clinical trial for pleural mesothelioma patients. SMARTER is the acronym for Surgery for Mesothelioma After Radiation Therapy using Extensive pleural Resection, which also describes the latest clinical trial. The phase I clinical trial is an unconventional approach to treatment of mesothelioma: Find the maximum tolerated dosage of hypofractionated radiation to stimulate the immune system before aggressive surgery. It comes on the heels of the SMART protocol, which stands for Surgery for Mesothelioma After Rad...
Source: Asbestos and Mesothelioma News - July 31, 2019 Category: Environmental Health Authors: Walter Pacheco Source Type: news

Galectin-3 initiates epithelial-stromal paracrine signaling to shape the proteolytic microenvironment during corneal repair
Paracrine interactions between epithelial cells and stromal fibroblasts occur during tissue repair, development, and cancer. Crucial to these processes is the production of matrix metalloproteinases (MMPs) that modify the microenvironment. Here, we demonstrated that the carbohydrate-binding protein galectin-3 stimulated microenvironment remodeling in the cornea by promoting the paracrine action of secreted interleukin-1β (IL-1β). Through live cell imaging in vitro, we observed rapid activation of the MMP9 promoter in clusters of cultured human epithelial cells after direct heterotypic contact with single primary ...
Source: Signal Transduction Knowledge Environment - July 16, 2019 Category: Science Authors: AbuSamra, D. B., Mauris, J., Argüeso, P. Tags: STKE Research Articles Source Type: news

Similarities of small cell cancers to blood cancers could lead to better treatments
An interdisciplinary team of UCLA scientists has found that small cell neuroendocrine cancers from a range of tissues have a common molecular signature and share drug sensitivities with blood cancers. The discoveries could improve the diagnoses of these aggressive cancers and lead to the development of new treatments that build upon the lessons learned from successful blood cancer therapies.The study, led by senior authors  Thomas Graeber and Dr. Owen Witte,  both of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer ...
Source: UCLA Newsroom: Health Sciences - July 8, 2019 Category: Universities & Medical Training Source Type: news

Understanding sarcoma: from diagnosis to treatment
A cancer diagnosis can be scary and confusing, especially for a patient receiving a sarcoma diagnosis. What is sarcoma? Sarcoma is a rare cancer of the soft tissues and bone. Most types of cancer originate in the epithelial linings that cover exposed surfaces of the body and have direct exposure to environmental toxins. Sarcomas, however, originate from cells or tissues that lie below these lini ngs in the muscle, bone, cartilage, fat, blood vessels, smooth muscle and skeletal muscles. Any type… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 30, 2019 Category: Pharmaceuticals Authors: Dr. Kamal Ummed Source Type: news

Understanding sarcoma: from diagnosis to treatment
A cancer diagnosis can be scary and confusing, especially for a patient receiving a sarcoma diagnosis. What is sarcoma? Sarcoma is a rare cancer of the soft tissues and bone. Most types of cancer originate in the epithelial linings that cover exposed surfaces of the body and have direct exposure to environmental toxins. Sarcomas, however, originate from cells or tissues that lie below these lini ngs in the muscle, bone, cartilage, fat, blood vessels, smooth muscle and skeletal muscles. Any type… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - June 30, 2019 Category: Biotechnology Authors: Dr. Kamal Ummed Source Type: news

Mesothelioma Treatment Guidelines Not Followed Often Enough
Too many patients with pleural mesothelioma are going without treatment recommended by National Comprehensive Cancer Network guidelines, according to a recent study at Cedars-Sinai Medical Center in Los Angeles. Valuable survival time is being lost. The Annals of Thoracic Surgery published the study that looked at disparities in compliance with national treatment guidelines and their impact on overall survival. The National Comprehensive Cancer Network, along with the American Society of Clinical Oncology, recommends multimodal therapy — surgery, chemotherapy and possibly radiation therapy — for mesothelioma pa...
Source: Asbestos and Mesothelioma News - June 12, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

Nintedanib Worsens Outcomes Along With Chemo in Advanced Ovarian Cancer
A phase II trial showed that the addition of nintedanib to neoadjuvant chemotherapy did not benefit patients with advanced epithelial ovarian cancer. (Source: CancerNetwork)
Source: CancerNetwork - June 11, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Does Maintenance Rucaparib Improve Post-Progression Outcomes in Ovarian Cancer?
Researchers tested maintenance therapy with rucaparib in a phase III trial of patients with recurrent epithelial ovarian cancer who experienced response to platinum-based chemotherapy. (Source: CancerNetwork)
Source: CancerNetwork - June 10, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Benefit of Single-Agent Carboplatin in Vulnerable, Elderly Patients With Ovarian Cancer
The EWOC-1 trial looked at single-agent carboplatin in  vulnerable, elderly patients with stage III/IV epithelial ovarian cancer vs weekly or every 3 weeks carboplatin/paclitaxel. (Source: CancerNetwork)
Source: CancerNetwork - June 5, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

New study explains how inflammation causes gastric cancer
(Kanazawa University) Researchers from Kanazawa University and the Japan Agency for Medical Research and Development have solved the decades-old mystery of how stomach bacterium Helicobacter pylori causes gastric cancer. Using mouse models and human cancer cell lines, they showed that inflammation resulting from bacterial infection leads to the proliferation of gastric epithelial cells, which ultimately form gastric tumors. By blocking the protein pathway responsible for this proliferation, they prevented gastric tumor formation. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 16, 2019 Category: Biology Source Type: news

Survival Improves for Peritoneal Mesothelioma Patients in Finland
Survival time improved significantly for peritoneal mesothelioma patients in Finland who underwent a combination of surgery and chemotherapy, according to a recently released study. The five-year survival rate was 66 percent. The median survival was 62 months. According to a smaller, previous study in Finland, the median survival without treatment was just four months after diagnosis. “Despite these advances in treatment…the majority of patients with malignant peritoneal mesothelioma receive only palliative care of systemic chemotherapy, leaving many eligible patients without the benefit of this more invasive...
Source: Asbestos and Mesothelioma News - April 1, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

New study confirms EpCAM as promising target for cancer immunotherapy
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers have shown that cancer immunotherapy targeting the tumor biomarker epithelial cell adhesion molecule (EpCAM) is safe and nontoxic in mice and can significantly delay tumor formation and growth. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 28, 2019 Category: International Medicine & Public Health Source Type: news

SGO 2019: Pembrolizumab Combo Shows Clinical Benefit for Recurrent Epithelial Ovarian Cancer
Results of a phase II trial evaluating pembrolizumab in combination with bevacizumab and oral metronomic cyclophosphamide were presented at SGO 2019. (Source: CancerNetwork)
Source: CancerNetwork - March 19, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

Study: Less-Invasive Mesothelioma Surgery Yields Better Results
A team of researchers at the Hyogo College of Medicine in Nishinomiya, Japan, studied the outcomes for pleural mesothelioma patients who received surgery at their facility between 2004 and 2016. The results: More aggressive surgery did not help mesothelioma patients live longer. “We showed that introducing less-invasive surgical techniques could decrease surgical risks without compromising survival,” the researchers wrote in their study, published in January in Seminars in Thoracic and Cardiovascular Surgery. “Surgery that is less invasive than conventional extrapleural pneumonectomy could achieve lower ...
Source: Asbestos and Mesothelioma News - March 14, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

Mesothelioma Treatment Combines Proton and Photodynamic Therapy
Intraoperative photodynamic therapy combined with novel proton radiation improved survival time significantly for recent patients with advanced-stage pleural mesothelioma. The study — the first to measure the impact of this combination — involved 10 consecutive patients treated at the University of Pennsylvania’s Abramson Cancer Center. The treatment regimen resulted in a 90 percent, two-year disease control rate and an impressive 30.3-month median overall survival from the time of diagnosis. All 10 patients were diagnosed before treatment began with stage 3 or stage 4 disease, which typically results in ...
Source: Asbestos and Mesothelioma News - March 12, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

Neoadjuvant Chemotherapy in Advanced Ovarian Cancer Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
Which patients with epithelial ovarian cancer should be considered for neoadjuvant chemotherapy followed by interval debulking surgery?Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 28, 2019 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Chronic TGF-{beta} exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition
Tumors comprise cancer stem cells (CSCs) and their heterogeneous progeny within a stromal microenvironment. In response to transforming growth factor–β (TGF-β), epithelial and carcinoma cells undergo a partial or complete epithelial-mesenchymal transition (EMT), which contributes to cancer progression. This process is seen as reversible because cells revert to an epithelial phenotype upon TGF-β removal. However, we found that prolonged TGF-β exposure, mimicking the state of in vivo carcinomas, promotes stable EMT in mammary epithelial and carcinoma cells, in contrast to the reversible EMT induced ...
Source: Signal Transduction Knowledge Environment - February 26, 2019 Category: Science Authors: Katsuno, Y., Meyer, D. S., Zhang, Z., Shokat, K. M., Akhurst, R. J., Miyazono, K., Derynck, R. Tags: STKE Research Articles Source Type: news

Elucidation of molecular-targeted drug resistance mechanism by lung cancer cells
(Kanazawa University) We revealed that ALK-positive lung cancer cells, treated with crizonitib, a molecular target drug, acquired resistance to the drug not only by genetic mutation but also by concomitant epithelial-to-mesenchymal transition (EMT). Further, in animal experiments, mesenchymal cancer cells due to EMT were shown to revert to epithelial ones by quisinostat, a histone deacetylase (HDAC) inhibitor; they regained sensitivity to the molecular-targeted drug. These results indicate a significant potential of overcoming resistance to molecular-targeted drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 25, 2019 Category: Cancer & Oncology Source Type: news

How Could Machine Learning and Radiomics Improve Ovarian Cancer Care?
A score derived from CT imaging using a machine learning radiomics approach was able to reliably identify epithelial ovarian cancer patients with poor survival outcomes. (Source: CancerNetwork)
Source: CancerNetwork - February 22, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news