Aggressive Mesothelioma Surgery Benefits More Patients
Patients diagnosed with the worst cases of pleural mesothelioma could benefit the most from the aggressive surgery they often are denied, according to one recent study.
The findings have raised questions about the restrictive surgery selection process at many specialty centers handling mesothelioma, the rare and aggressive cancer caused by asbestos exposure.
“In some cases, patients are not being offered the aggressive surgery that could help their quality of life,” lead author Dr. Wickii Vigneswaran, mesothelioma specialist and chief of thoracic surgery at the Loyola University Medical Center, told Asbestos.com. “Ou...
Source: Asbestos and Mesothelioma News - October 11, 2017 Category: Environmental Health Authors: Matt Mauney Tags: Aggressive Mesothelioma Surgery asbestos exposure Dr. Wickii Vigneswaran epithelial mesothelioma epithelioid histology extrapleural pneumonectomy Loyola mesothelioma program Loyola University Medical Center mesothelioma Chicago mesotheli Source Type: news
Qiagen Partners with Cell Diagnostics Company
ANGLE plc, a liquid biopsy company, has secured a valuable partnership with molecular testing giant Qiagen and an exclusive option agreement with Queen Mary University of London. ANGLE is known for Parsortix, its novel system for capturing and harvesting circulating tumor cells (CTCs) from blood.
A Large Selling Opportunity with Qiagen
The co-marketing partnership with Qiagen isn’t just a major win for ANGLE—it will also give Qiagen, which has more than 500,000 customers, an additional opportunity in the liquid biopsy space and the ability to offer ANGLE’s unique CTC harvesting technology alongside its own downstream...
Source: MDDI - September 19, 2017 Category: Medical Devices Authors: Marie Thibault Tags: IVD Source Type: news
Regulation of autophagy, NF-{kappa}B signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells
KRAS mutant non–small cell lung cancer (NSCLC) may be classified into epithelial or mesenchymal subtypes. Despite having the same "driver" mutation, mesenchymal NSCLCs are less responsive than are epithelial NSCLCs to inhibition of the RAS pathway. Identifying alternative networks that promote survival specifically in mesenchymal NSCLC may lead to more effective treatments for this subtype. Through their numerous targets in cellular signaling pathways, noncoding microRNAs (miRNAs) often function as tumor suppressors or oncogenes. In particular, some miRNAs regulate the epithelial-mesenchymal transition (EMT). We deri...
Source: Signal Transduction Knowledge Environment - September 12, 2017 Category: Science Authors: Mehta, A. K., Hua, K., Whipple, W., Nguyen, M.-T., Liu, C.-T., Haybaeck, J., Weidhaas, J., Settleman, J., Singh, A. Tags: STKE Research Articles Source Type: news
Mesothelioma Patients Survive Longer with Trimodal Treatment
Pleural mesothelioma patients who undergo aggressive multimodal treatment live almost twice as long after diagnosis than those who do not, according to a recent extensive study.
Researchers at MD Anderson Cancer Center in Texas found a combination of surgery, chemotherapy and radiation extended survival time significantly, regardless of disease histology or cancer stage.
“We recommend that all patients with [malignant pleural mesothelioma] be evaluated by multidisciplinary teams that are experienced in the management of mesothelioma for consideration of surgery-based, multimodality treatment,” the authors wrote...
Source: Asbestos and Mesothelioma News - September 5, 2017 Category: Environmental Health Authors: Matt Mauney Tags: biphasic histology Dr. Anne Tsao Dr. Boris Sepesi Dr. Daniel Gomez Dr. David Rice Dr. Mark Berry epithelial mesothelioma Journal of Clinical Oncology md anderson cancer center mesothelioma chemotherapy mesothelioma mortality surgery Source Type: news
New insight into how excess belly fat may increase cancer risk
Conclusion
This animal and laboratory study investigated the possible cellular relationship between excess body fat – specifically fat around the body organs – and cancer risk.
It seems one key mechanism by which excess visceral fat could stimulate healthy cells to develop into cancerous ones could be through FGF2 levels.
The researchers hope their study could pave the way for possible cancer prevention strategies by stopping FGF2 production in obese people with excess belly fat.
They even go as far as suggesting that blocking FGF2 receptors could be one part of a treatment approach after a diagnosis of breast or ski...
Source: NHS News Feed - September 1, 2017 Category: Consumer Health News Tags: Cancer Source Type: news
Loss of SPDEF and gain of TGFBI activity after androgen deprivation therapy promote EMT and bone metastasis of prostate cancer
Androgen deprivation therapy (ADT) targeting the androgen receptor (AR) is a standard therapeutic regimen for treating prostate cancer. However, most tumors progress to metastatic castration-resistant prostate cancer after ADT. We identified the type 1, 2, and 4 collagen–binding protein transforming growth factor–β (TGFβ)–induced protein (TGFBI) as an important factor in the epithelial-to-mesenchymal transition (EMT) and malignant progression of prostate cancer. In prostate cancer cell lines, AR signaling stimulated the activity of the transcription factor SPDEF, which repressed the expression o...
Source: Signal Transduction Knowledge Environment - August 15, 2017 Category: Science Authors: Chen, W.-Y., Tsai, Y.-C., Yeh, H.-L., Suau, F., Jiang, K.-C., Shao, A.-N., Huang, J., Liu, Y.-N. Tags: STKE Research Articles Source Type: news
Cytology versus HPV testing for cervical cancer screening in the general population: a DTA Review from the Cochrane Gynaecological, Neuro-oncology and Orphan Cancers Group, (CGNOC)
Cochrane Reviews are systematic reviews of research in health care and policy. They are internationally recognized as a high-quality source of evidence for decision-making. They collate and summarize all the best available research evidence on the effects of healthcare interventions or the accuracy of diagnostic tests into a systematic review.Diagnostic Test Accuracy Reviews (DTA) provide essential information regarding the accuracy of the available diagnostic tools for key decision makers, including patients, clinicians, guideline developers and researchers. The purpose of a Cochrane DTA review is very like the purpose ...
Source: Cochrane News and Events - August 14, 2017 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news
Gene editing brings pig organ transplant closer
Conclusion
This promising research shows that it can be possible to use gene editing techniques to eliminate retroviruses from pigs, removing one of the potential barriers to using genetically modified pigs as organ donors for humans.
There are a few points to note. As the researchers say, though they have shown that pig retroviruses can be passed onto human cells in the laboratory, we don't know what the effects would be in real life. We don't know whether pig retroviruses would be transferred to humans and whether they could cause cancers or immunodeficiency illnesses, for example.
The research is at an early stage. The ...
Source: NHS News Feed - August 11, 2017 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news
Gene-regulatory factors shown to improve pancreatic cancer response to chemotherapy
(Tokyo Medical and Dental University) TMDU researchers revealed that, in pancreatic cancer, the microRNAs miR-509-5p and miR-1243 can promote E-cadherin expression and thereby reduce the likelihood of cells undergoing epithelial-mesenchymal transition, or indeed reverse this transition. This ability to stop cells from adopting a phenotype linked to high migration and invasiveness was also shown to synergistically increase the cancer cell-killing efficacy of gemcitabine, which is promising for developing more effective combinatorial treatments for pancreatic cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 1, 2017 Category: Cancer & Oncology Source Type: news
ovarian epithelial fallopian cancer
Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 27, 2017 Category: General Medicine Source Type: news
SMART Protocol for Mesothelioma Adds Immunotherapy
In conclusion, we demonstrated the importance of the immune system in the benefit of clinical protocols using…radiation followed by surgery.”
The post SMART Protocol for Mesothelioma Adds Immunotherapy appeared first on Mesothelioma Center - Vital Services for Cancer Patients & Families. (Source: Asbestos and Mesothelioma News)
Source: Asbestos and Mesothelioma News - July 6, 2017 Category: Environmental Health Authors: Walter Pacheco Tags: emerging treatments for mesothelioma immunotherapy for mesothelioma SMART mesothelioma SMART protocol mesothelioma smart protocol mix with immunotherapy Source Type: news
The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b
Metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. The pathophysiological course of metastasis is mediated by the dynamic plasticity of cancer cells, which enables them to shift between epithelial and mesenchymal phenotypes through a transcriptionally regulated program termed epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET). Using a mouse model of spontaneous metastatic breast cancer, we investigated the molecular mediators of metastatic competence within a heterogeneous primary...
Source: Signal Transduction Knowledge Environment - June 13, 2017 Category: Science Authors: Zhou, W., Ye, X.-l., Xu, J., Cao, M.-G., Fang, Z.-Y., Li, L.-Y., Guan, G.-H., Liu, Q., Qian, Y.-H., Xie, D. Tags: STKE Research Articles Source Type: news
An elegans solution: Worm genetic screen maps cell-to-cell communication in human cancer
(Medical University of South Carolina) In the May 22, 2017, issue of Developmental Cell, researchers at the Medical University of South Carolina Hollings Cancer Center developed a cross-species genetic screen in worms to follow cell-to-cell communication in human cancer. The genome-wide screen is being used to chart a roadmap between mesodermal cells and epithelial cells in the tumor microenvironment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 22, 2017 Category: Cancer & Oncology Source Type: news
Moffitt Opens Mesothelioma Study for Rare Cancer Subtypes
The Moffitt Cancer Center in Tampa has opened a mesothelioma clinical trial involving an anti-cancer enzyme drug showing unprecedented success with the most difficult disease subtypes.
Patients with sarcomatoid and biphasic histology — the most treatment-resistant subtypes of mesothelioma — can now enroll in a phase 2/3 clinical trial involving the effectiveness of ADI-PEG 20 (pegylated arginine deiminase) in combination with standard chemotherapy.
Thoracic surgeon Dr. Jacques Fontaine, director of the Mesothelioma Research and Treatment Center at Moffitt, told Asbestos.com that he and fellow investigators are hoping t...
Source: Asbestos and Mesothelioma News - April 25, 2017 Category: Environmental Health Authors: Walter Pacheco Tags: doctor jacques fontaine improving mesothelioma prognosis mesothelioma chemotherapy with cisplatin mesothelioma clinical trial mesothelioma treatments moffitt cancer center Source Type: news
Epithelial Proliferation in Biopsies Tied to Breast Cancer Risk Epithelial Proliferation in Biopsies Tied to Breast Cancer Risk
Women with progressive epithelial proliferation across serial biopsies have an increased risk of breast cancer, while those with regression of initial proliferative disease without atypia face a lower risk compared with no change.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - April 14, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news
