Moffitt researchers identify protein that causes epithelial cancers to spread
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in the July issue of Cancer Research, Elsa Flores, Ph.D., and her team discovered a key protein that oscillates its expression through microRNA regulation to facilitate cancer spread to distant organs. This protein is deltaNp63, a member of the p53 family of tumor suppressor genes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 6, 2020 Category: International Medicine & Public Health Source Type: news
Hidden Cause of Cancer?
When you’re tearing off a sheet of aluminum foil to cook with — or wrap your leftovers before you put them in the fridge — you probably never consider aluminum is a dangerous toxin.
Truth is, aluminum is a heavy metal… just like lead, mercury and arsenic.
It’s in our food… our cookware… even in the water we drink.
Exposure to aluminum is a risk factor for cancer, Alzheimer’s, Parkinson’s, and bone disease, just to name a few.
Our lungs, liver, and kidneys are able to eliminate a majority of the small amounts of aluminum we ingest through eating, drinking or breathing.1
But alumi...
Source: Al Sears, MD Natural Remedies - May 29, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Source Type: news
Cervical precancer identified by fluorescence, in a step toward bedside detection
(Tufts University) Researchers developed a method using fluorescence to detect precancerous metabolic and physical changes in individual epithelial cells lining the cervix, and can visualize those changes at different depths of the epithelial tissue near the surface. The method, which can detect precancerous lesions non-invasively and non-destructively, opens the door to early-stage bedside diagnostics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 19, 2020 Category: Cancer & Oncology Source Type: news
FDA Approves Olaparib/Bevacizumab Maintenance FDA Approves Olaparib/Bevacizumab Maintenance
The FDA has announced a new approved indication for olaparib in adults with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - May 12, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
FDA Approves Expanded Olaparib Indication to Include Combination with Bevacizumab
The FDA expanded the indication of olaparib to include a combination regimen with bevacizumab for the first-line maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer. (Source: CancerNetwork)
Source: CancerNetwork - May 8, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news
Epithelial GPS: Position of RNAi machinery is associated with epithelial identity
(Medical University of South Carolina) Researchers at the Medical University of South Carolina show in a new report that the RNA interference machinery, normally thought to reside in the nucleus or cytoplasm, predominantly localizes to these apical junctions and influences cell biology in the colon. Interestingly, in colon tumors, this localization is dysregulated and may shift the balance of RNAs to promote tumorigenesis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 8, 2020 Category: Cancer & Oncology Source Type: news
FDA Approves Niraparib for Advanced Ovarian Cancer
The FDA approved niraparib for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy. (Source: CancerNetwork)
Source: CancerNetwork - April 29, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news
Ovarian cancer: recognition and initial management [CG122], NICE (Published 27th April)
This guideline covers detecting, diagnosing and treating women (18 years and older) who have, or are suspected of having, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer or borderline ovarian cancer. It aims to enable earlier detection of ovarian cancer and improve initial treatment.
This guideline was previously called ovarian cancer: the recognition and initial management of ovarian cancer. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 27, 2020 Category: Consumer Health News Source Type: news
Analysis of Stage I EFHWTs Treatment Finds Event-Free Survival and Overall Survival Rates Greater Than 95%
A recent study reported a 96.2% event-free survival rate and a 100% overall survival rate when investigating treatment option for stage I epithelial-predominant favorable-histology Wilms tumors in a population with a majority of patients under the age of 48 months. (Source: CancerNetwork)
Source: CancerNetwork - April 23, 2020 Category: Cancer & Oncology Authors: Matthew Fowler Source Type: news
Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies
Breast and mammary epithelial cells experience different local environments during tissue development and tumorigenesis. Microenvironmental heterogeneity gives rise to distinct cell regulatory states whose identity and importance are just beginning to be appreciated. Cellular states diversify when clonal three-dimensional (3D) spheroids are cultured in basement membrane, and one such state is associated with stress tolerance and poor response to anticancer therapeutics. Here, we found that this state was jointly coordinated by the NRF2 and p53 pathways, which were costabilized by spontaneous oxidative stress within 3D cult...
Source: Signal Transduction Knowledge Environment - April 13, 2020 Category: Science Authors: Pereira, E. J., Burns, J. S., Lee, C. Y., Marohl, T., Calderon, D., Wang, L., Atkins, K. A., Wang, C.-C., Janes, K. A. Tags: STKE Research Articles Source Type: news
Extracellular forces help epithelial cells stick together
(University of Helsinki) Defects in the maintenance of the superficial tissue of the body, known as epithelial tissue, can help cancer cells achieve motility and metastasize. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 2, 2020 Category: Cancer & Oncology Source Type: news
Ex tra cel lu lar forces help epi thelial cells stick to gether
(University of Helsinki) Defects in the maintenance of the superficial tissue of the body, known as epithelial tissue, can help cancer cells achieve motility and metastasise. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 2, 2020 Category: International Medicine & Public Health Source Type: news
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a small subset of these cells generates metastases. We conducted an in vivo genome-wide CRISPR activation screen in CTCs from breast cancer patients to identify genes that promote distant metastasis in mice. Genes coding for ribosomal proteins and regulators of translation were enriched in this screen. Overexpression of RPL15, which encodes a component of the large ribosomal subunit, increased metastatic growth in multiple organs and selectively enhanced translation of other ribosomal proteins and cell cycle regulators. RNA sequencin...
Source: ScienceNOW - March 25, 2020 Category: Science Authors: Ebright, R. Y., Lee, S., Wittner, B. S., Niederhoffer, K. L., Nicholson, B. T., Bardia, A., Truesdell, S., Wiley, D. F., Wesley, B., Li, S., Mai, A., Aceto, N., Vincent-Jordan, N., Szabolcs, A., Chirn, B., Kreuzer, J., Comaills, V., Kalinich, M., Haas, W. Tags: Medicine, Diseases, Molecular Biology reports Source Type: news
Learning how cancer cells coordinate and collaborate to multiply and metastasize
(Osaka University) Researchers from Osaka University and the National Institute of Information and Communications Technology have cultured epithelial-like cancer cells on an artificial substrate and observed their collaborative self-organization into network structures that may function as nutritional conduits and provide vascular access. Understanding of the parameters that govern this coordinated behavior, including the various forces responsible, may explain tumor growth and metastasis, thus providing a basis for developing new anticancer drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 12, 2020 Category: Cancer & Oncology Source Type: news
Janssen Announces U.S. FDA Breakthrough Therapy Designation Granted for JNJ-6372 for the Treatment of Non-Small Cell Lung Cancer
RARITAN, NJ, March 10, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation for JNJ-61186372 (JNJ-6372) for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) Exon 20 insertion mutations, whose disease has progressed on or after platinum-based chemotherapy. JNJ-6372 is an EGFR-mesenchymal epithelial transition factor (MET) bispecific antibody that targets activating and resistant EGFR and MET mutations and amplifications.[1] Cu...
Source: Johnson and Johnson - March 10, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
