IIG Seminar - Tissue-Resident Memory T cells in cancer.
The Mami-Choua ï b laboratory has identified several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response. In particular: the influence of TGF- β on the expression and signaling of CD103 in CD8+ resident memory T cells (TRM), and the role of this integrin to sustain specific cytotoxicity and to promote T-cell recruitment within epithelial tumor regions; the role of hypoxia, epithelial-mesenchymal transition (EMT) and p53 in controlling tumor cell susceptibility to T-cell-mediated killing; and the effect of Von Hippel-Lindau (VHL) gene mutations in promoting PD-L1 ex...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Lasker Scholar lecture: Cell Therapy for Epithelial Cancers
Lasker Scholar lecture
Cell therapy is an emerging treatment modality that is highly effective in hematological cancers. Research by Dr. Hinrichs ’ s team has demonstrated the potential to extend cell therapy to the treatment of common epithelial cancers. Treatment of patients with human papillomavirus (HPV)-associated cancers with tumor-infiltrating lymphocytes showed durable, complete tumor responses, apparently curing some patients with metastatic cancer. A more “ off the shelf ” approach with peripheral blood T cells genetically engineered to target the HPV E7 antigen also demonstrated robust clinical activity wi...
Source: Videocast - All Events - April 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Cell Therapy for Epithelial Cancers
Cell therapy is an emerging treatment modality that is highly effective in hematological cancers. Research by Dr. Hinrichs ’ s team has demonstrated the potential to extend cell therapy to the treatment of common epithelial cancers. Treatment of patients with human papillomavirus (HPV)-associated cancers with tumor-infiltrating lymphocytes showed durable, complete tumor responses, apparently curing some patients with metastatic cancer. A more “ off the shelf ” approach with peripheral blood T cells genetically engineered to target the HPV E7 antigen also demonstrated robust clinical activity with extensive tumor regr...
Source: Videocast - All Events - February 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Race and the Molecular Biology Of Breast Cancer: A Pathologist ’ s View From the Bench to the Bedside
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Gardner is a clinically trained pathologist that studies chromatin based-mechanism of transcriptional control in both cancers of lymphoid and epithelial origin. Recently we have refocused the efforts in my lab to define and reveal how alteration and/or disruption of gene regulation contributes to cancer incidence, evolution, and outcome. An essential and overarching goal of this effort is to translate the biological implications of these observations into principles and tenets that will have a broader impact on the molecular understanding of disease. The ultimate ob...
Source: Videocast - All Events - February 28, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Interferon-induced transmembrane proteins block Zika virus infection and prevent a non-apoptotic, paraptosis-like cell death pathway
We report that ZIKV induces massive vacuolization followed by “ implosive ” cell death in human epithelial cells, primary skin fibroblasts and astrocytes, a phenomenon which is exacerbated when IFITM3 levels are low. It is reminiscent of paraptosis, a caspase-independent, non-apoptotic form of cell death associated with the formation of large cytoplasmic vacuoles. We further show that ZIKV-induced vacuoles are derived from the endoplasmic reticulum (ER) and dependent on the PI3K/Akt signaling axis. Inhibiting the Sec61 ER translocon in ZIKV-infected cells blocked vacuole formation and viral production. Our results prov...
Source: Videocast - All Events - June 12, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Epithelial molecules shaping immunosurveillance by local T cells
Immunology Interest Group Seminar Series
The thesis of conventional immunology is centralized control whereby responses to infection within tissues are decided within lymph nodes, from which effector T lymphocytes are dispatched to quell regional disturbances. But this cannot explain the observation that many tissues at steady state are T cell-rich. Do such cells simply provide responses to infection or do they provide more generalized means to sustain tissue integrity and organ function? Likewise, how are such cells able to respond to acute stress but not drive constitutive tissue inflammation? And, how do immune cell –...
Source: Videocast - All Events - May 8, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
The Hedgehog Pathway and the Race against Tumor Resistance
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Oro is a Professor of Dermatology, Associate Director of the Center for Definitive and Curative Medicine, a member of the Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Cancer Institute at Stanford University, and the Cancer Biology and Stem Cell graduate student programs. He trained in the medical scientist program at the Salk Institute under Ron Evans lab, working on functions of novel orphan nuclear receptors in model systems. During Dermatology residency/fellowship in Matthew Scott ’ s lab at Stanford, he helped solidify the link ...
Source: Videocast - All Events - May 1, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Control of Epithelial Stem Cell Fate in Cancer and Wound Healing
NCI ’ s Center for Cancer Research (CCR) Grand Rounds is a weekly lecture series addressing current research in clinical and molecular oncology. Speakers are leading national and international researchers and clinicians.Air date: 3/10/2017 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 7, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Exploring Molecular Linkages to Modifiable Risk in Breast Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Gardner received his B.S. from Yale University and earned his M.D. and Ph.D. from the Johns Hopkins University School of Medicine where he studied the regulation of membrane skeletal proteins in the Department of Cellular Biology and Anatomy. He completed residency training in anatomic pathology at the National Cancer Institute and is board certified in Anatomic Pathology. Dr. Gardner has had a long term interest in the cellular and molecular biology of gene regulation and, while at NIH, has been developing strategies to define pathways and mechanisms of transcrip...
Source: Videocast - All Events - January 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Why do most patients with epithelial cancers not respond to T cell checkpoint blockade?
NCI Center for Cancer Research Eminent Lecture
Over the past 40 years, Dr. Fearon has made contributions to our understanding of innate immunity, B cell signal transduction, memory T cells, and, most recently, cancer immunology. During the past 10 years, Dr. Fearon has trained 15 PhD and MB/PhD students at the University of Cambridge. Former post-doctoral fellows now have faculty or staff positions at outstanding institutions such as Harvard Medical School, the NIAID, University of Cambridge, King’s College London, University of Leicester, and the University of Ryukyus. His past work with a genetically engineered mous...
Source: Videocast - All Events - April 20, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Anita B. Roberts Lecture: Neurotrophic Factor α-1: A Key Regulator of Neuroprotection, Depression and Cancer Metastasis
Anita B. Roberts Lecture Series
Dr. Peng Loh will give the fifteenth lecture in the Anita B. Roberts lecture series, which highlights outstanding research achievements of women scientists in the Intramural Research Program.
The Anita B. Roberts Lecture Series, "Distinguished Women Scientists at NIH, highlights outstanding research achievements of women scientists at the NIH. The seminar is dedicated to Dr. Anita Roberts and honors her role as an exceptional mentor and scientist.
Anita joined the NIH in 1976 and spent 30 years at NCI, rising to Chief of the Laboratory of Cell Regulation and Carcinogenesis. She die...
Source: Videocast - All Events - November 14, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
