The Hedgehog Pathway and the Race against Tumor Resistance

NCI ’ s Center for Cancer Research (CCR) Grand Rounds Dr. Oro is a Professor of Dermatology, Associate Director of the Center for Definitive and Curative Medicine, a member of the Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Cancer Institute at Stanford University, and the Cancer Biology and Stem Cell graduate student programs. He trained in the medical scientist program at the Salk Institute under Ron Evans lab, working on functions of novel orphan nuclear receptors in model systems. During Dermatology residency/fellowship in Matthew Scott ’ s lab at Stanford, he helped solidify the link between the hedgehog pathway and human cancer. In his own lab in the Program in Epithelial Biology at Stanford, Dr. Oro has extended the original studies focusing on the role of skin stem cells to understand in tissue regeneration and carcinogenesis. He has a longstanding interest in the mechanisms of hedgehog signaling in hair follicle regeneration, and in the pathogenesis of the most common human tumor, basal cell carcinoma of the skin. As a practicing physician, he led the clinical trials developing the first human hedgehog pathway inhibitor in skin cancer. His recent focus is on tumor evolution and novel resistance-associated signaling pathways. His interest in the mechanisms of human skin development and early ectodermal differentiation has led to the development of Therapeutic Reprogramming, the use of in vitro human skin differentiation protocols and ...
Source: Videocast - All Events - Category: Journals (General) Tags: Upcoming Events Source Type: video