FDA grants regular approval to pembrolizumab and lenvatinib for advanced endometrial carcinoma
- Oncology - Cancer (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 27, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

BRAF Mutation in Preoperative Thyroid FNA Specimens BRAF Mutation in Preoperative Thyroid FNA Specimens
Is preoperative BRAF testing useful in guiding the extent of lymph node dissection in papillary thyroid carcinoma?American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 22, 2021 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

FDA Fully Approves Combination for Advanced Endometrial Cancer FDA Fully Approves Combination for Advanced Endometrial Cancer
Pembrolizumab plus lenvatinib for the treatment of patients with advanced endometrial carcinoma is now fully approved.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 22, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA grants regular approval to pembrolizumab and lenvatinib for advanced endometrial carcinoma
- Oncology - Cancer (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - July 22, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA Approves Keytruda (pembrolizumab) Plus Lenvima (lenvatinib) Combination for Patients With Certain Types of Advanced Endometrial Carcinoma
KENILWORTH& WOODCLIFF, N.J.--(BUSINESS WIRE) July 22, 2021 -- Merck (NYSE: MRK), known as MSD outside the United States and Canada, and Eisai Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved the combination of... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 22, 2021 Category: Drugs & Pharmacology Source Type: news

Study Supports Chemopreventive Effect of Statins on Liver Cancer in NASH Cirrhosis Study Supports Chemopreventive Effect of Statins on Liver Cancer in NASH Cirrhosis
New research provides supporting evidence for chemopreventive effects of statins on hepatocellular carcinoma in patients with nonalcoholic steatohepatitis cirrhosis.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 20, 2021 Category: Gastroenterology Tags: Hematology-Oncology News Source Type: news

Second- and Later-Line Treatment of Metastatic RCC Second- and Later-Line Treatment of Metastatic RCC
When first-line treatments for metastatic renal cell carcinoma fail, what are the next options?Current Opinion in Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 19, 2021 Category: Consumer Health News Tags: Urology Journal Article Source Type: news

Oncotarget: Cutaneous apocrine sweat gland carcinoma
(Impact Journals LLC) Together these Oncotarget results describe the first ever CAC case with a BRCAness genetic background. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Cellular uptake of nanoparticles keys for further development of temperature sensing
(Kazan Federal University) The article represents the transmission electron microscopy (TEM) and flow cytometry study of A-549 (human lung carcinoma) cellular uptake of Pr3+:LaF3 nanoparticles. The Pr3+:LaF3 nanoparticles are promising platforms for cell nano-sensors. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 16, 2021 Category: Biology Source Type: news

Hepatocellular Carcinoma, Novel Therapies on the Horizon Hepatocellular Carcinoma, Novel Therapies on the Horizon
Recent advancements have led to the identification and development of potential new treatment options for hepatocellular carcinoma.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 15, 2021 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Metformin Use May Curb BCC Risk Metformin Use May Curb BCC Risk
The decrease in basal cell carcinoma (BCC) risk was seen across all metformin dosing levels, but the reason for this remains unclear.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 15, 2021 Category: Cancer & Oncology Tags: Dermatology News Source Type: news

ctDNA Identifies Patients Who Benefit From Immunotherapy in MIUC ctDNA Identifies Patients Who Benefit From Immunotherapy in MIUC
For patients with muscle-invasive urothelial carcinoma (MIUC), detectable ctDNA after surgery is a marker of poor prognosis and of response to the immunotherapy.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 14, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Study sheds light on precise personalized hepatocellular carcinoma medicine
(Dalian Institute of Chemical Physics, Chinese Academy Sciences) Scientists identified hepatocellular carcinoma (HCC) subtypes with distinctive metabolic phenotypes through bioinformatics and machine learning methods, and elucidated the potential mechanisms based on a metabolite-protein interaction network and multi-omics data. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 12, 2021 Category: Cancer & Oncology Source Type: news

FDA Approves Expanded Indication for Merck ’s Keytruda (pembrolizumab) in Locally Advanced Cutaneous Squamous Cell Carcinoma (cSCC)
Keytruda Is Now Approved for the Treatment of Patients With Recurrent or Metastatic or Locally Advanced cSCC That Is Not Curable by Surgery or Radiation KENILWORTH, N.J.--(BUSINESS WIRE) July 6, 2021 -- Merck (NYSE: MRK), known as MSD... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 6, 2021 Category: Drugs & Pharmacology Source Type: news

Tislelizumab Benefit in HCC Undimmed by Prior Therapies Tislelizumab Benefit in HCC Undimmed by Prior Therapies
Patients with advanced hepatocellular carcinoma (HCC) can achieve durable responses, and overall survival is"encouraging" with the novel immunotherapy, even after multiple prior therapies.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 6, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Relationship between chromosomal instability and senescence revealed in the fly Drosophila
(Institute for Research in Biomedicine (IRB Barcelona)) Researchers at IRB Barcelona's Development and Growth Control lab have revealed the mechanisms by which cells enter senescence because of an imbalance in the number of chromosomes. Chromosomal instability is a common trait in most solid tumours, such as carcinoma, and fully understanding its relationship with cancer can help identify new therapeutic targets. The results have been published in the journal Developmental Cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 6, 2021 Category: International Medicine & Public Health Source Type: news

Oncotarget: Epithelial-mesenchymal transitions create endothelial cells and tumor growth
(Impact Journals LLC) Cells that have undergone EMT can promote tumor growth and neovascularization either indirectly, by promoting endothelial transdifferentiation of carcinoma cells, or directly, by acquiring an endothelial phenotype, with FOXC2 playing key roles in these processes (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2021 Category: Cancer & Oncology Source Type: news

Consumer Health: UV radiation and your skin
July is UV Safety Month, which makes this a good time to learn more about the harmful effects of ultraviolet, or UV, radiation from sunlight or tanning beds. Skin cancer is the most common type of cancer, according to the American Cancer Society. Skin cancer develops primarily on areas of sun-exposed skin, including the scalp, face, lips, ears, neck, chest, arms, hands and legs.  The three main types of skin cancer are basal cell carcinoma, squamous cell carcinoma and melanoma.… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 4, 2021 Category: Databases & Libraries Source Type: news

More Frequent Ultrasound Screening for People at High Risk for Liver Cancer May Be Worth It More Frequent Ultrasound Screening for People at High Risk for Liver Cancer May Be Worth It
Regular ultrasound screening with an interval between six and 12 months or less may lead to earlier detection of hepatocellular carcinoma in high-risk patients, according to a study from Taiwan.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 2, 2021 Category: Gastroenterology Tags: Hematology-Oncology News Source Type: news

Oncotarget: Treatment outcomes in patients with advanced hepatocellular carcinoma
(Impact Journals LLC) In CTP class A patients, IGF/CTP score B was associated with shorter PFS and OS (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 28, 2021 Category: Cancer & Oncology Source Type: news

Genetic study of liver cancer reveals new drug target
(PLOS) Drugs targeting the gene MAGEA3 may help block the growth of hepatocellular carcinoma (HCC), the most common type of primary liver cancer and one of the leading causes of cancer deaths in the country. That's one conclusion of a new study analyzing the genetics of HCC tumors published June 24th in the journal PLOS Genetics by Augusto Villanueva of the Icahn School of Medicine at Mount Sinai and colleagues. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 24, 2021 Category: Cancer & Oncology Source Type: news

HPV Vaccine in Management of HPV-associated Cutaneous Lesions HPV Vaccine in Management of HPV-associated Cutaneous Lesions
Is there a role for the HPV vaccine in treating HPV-related dermatologic conditions such as common warts, genital warts, keratinocyte carcinoma, and epidermodysplasia verruciformis?Skin Therapy Letter (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 18, 2021 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

DCIS: Biosignature Helps Guide Post-Lumpectomy Decisions DCIS: Biosignature Helps Guide Post-Lumpectomy Decisions
A new biosignature tool helps with treatment decisions after lumpectomy for ductal carcinoma in situ (DCIS), eg, by identifying those who can skip radiotherapy.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 17, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Sensitive and specific detecting biomarker of radiation-resistant nasopharyngeal carcinoma
(World Scientific) In our study, we constructed a detecting platform based on TpTta-COF nanosheets and fluorescent probe. The TpTta-COF nanosheets can adsorb single-stranded DNA (ss-DNA) probes and quench the fluorescence of ss-DNA. The method enables to capture miR-205 sensitively in aqueous solution with a detection limit of 4.78 nM in the range 0-500 nM and R2 = 0.989, and the method offers great specificity in that it can distinguish the target miRNA from mismatch non-target miRNAs. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2021 Category: International Medicine & Public Health Source Type: news

Saliva Test to Detect HPV-Associated Throat Cancer Saliva Test to Detect HPV-Associated Throat Cancer
A new clinically validated saliva test has demonstrated high accuracy in detecting HPV-positive oropharyngeal squamous cell carcinoma.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 16, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

MD Anderson research highlights for June 16, 2021
(University of Texas M. D. Anderson Cancer Center) The University of Texas MD Anderson Cancer Center's Research Highlights provides a glimpse into recently published studies in basic, translational and clinical cancer research from MD Anderson experts. Current advances include a new combination therapy for acute myeloid leukemia (AML), a greater understanding of persistent conditions after AML remission, the discovery of a universal biomarker for exosomes, the identification of a tumor suppressor gene in hepatocellular carcinoma (HCC) and characterization of a new target to treat Clostridioides difficile (C. difficile) inf...
Source: EurekAlert! - Cancer - June 16, 2021 Category: Cancer & Oncology Source Type: news

Neoadjuvant and Adjuvant Treatment Approaches for HCC Neoadjuvant and Adjuvant Treatment Approaches for HCC
Learn more about the current neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma and the promising new options on the horizon.Chinese Clinical Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 15, 2021 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Adjuvant Nivolumab Slows Muscle - Invasive Urothelial Carcinoma
Disease - free survival was longer with adjuvant nivolumab in intention - to - treat population, for those with PD - L1 expression at least 1 percent (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 14, 2021 Category: Cancer & Oncology Tags: Oncology, Pharmacy, Surgery, Urology, Journal, Source Type: news

Adjuvant Nivolumab Slows Muscle-Invasive Urothelial Carcinoma
MONDAY, June 14, 2021 -- For patients with high-risk muscle-invasive urothelial carcinoma who have had radical surgery, disease-free survival is significantly longer with nivolumab than placebo, according to a study published in the June 3 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 14, 2021 Category: Pharmaceuticals Source Type: news

Toward the first drug to treat a rare, lethal liver cancer
(Rockefeller University) After scouring more than 5,000 compounds, scientists have identified several new classes of therapeutics that may help treat fibrolamellar carcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 14, 2021 Category: Cancer & Oncology Source Type: news

New Phase 3 Study Results Show IMBRUVICA ® (ibrutinib)-Based Combination Regimen as an All-Oral Fixed-Duration Treatment Demonstrated Superior Progression-Free Survival in Adult Patients with Previously Untreated Chronic Lymphocytic Leukemia
Raritan, N.J., June 12, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced primary results from the pivotal Phase 3 GLOW study (NCT03462719) evaluating fixed-duration IMBRUVICA® plus venetoclax (I+V) compared to chlorambucil plus obinutuzumab (Clb+O) for first-line treatment of elderly or unfit patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study demonstrated superior progression-free survival (PFS) of a once-daily, all-oral, fixed-duration regimen of I+V versus Clb+O as first-line treatment of CLL; the study also showed improved duratio...
Source: Johnson and Johnson - June 12, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

FDA approves nivolumab plus cabozantinib for advanced renal cell carcinoma
Hematology / Oncology News Burst (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - June 11, 2021 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Oncotarget: Infiltration in human skin squamous-cell carcinoma
(Impact Journals LLC) Over the last few years, oncology research is increasingly focused on the understanding of mutual interactions between cancer, stromal and immune cells in the tumor microenvironment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 7, 2021 Category: Cancer & Oncology Source Type: news

Oncotarget: The drug sensitivity of hepatocellular cancer cells
(Impact Journals LLC) 'Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death worldwide, with a poor median survival time after diagnosis of six months.' (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 7, 2021 Category: Cancer & Oncology Source Type: news

ASCO: Pembrolizumab Ups DFS in High-Risk Resected Clear-Cell RCC
FRIDAY, June 4, 2021 -- For patients with fully resected intermediate-high-risk or high-risk clear-cell renal cell carcinoma (ccRCC), adjuvant therapy with pembrolizumab yields a significant and clinically meaningful improvement in disease-free... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 4, 2021 Category: Pharmaceuticals Source Type: news

Oncotarget: Inflammatory microenvironment & hepatic macrophage in hepatocellular carcinoma
(Impact Journals LLC) " The incidence of hepatocellular carcinoma (HCC) is increasing worldwide, and HCC is amongst the leading causes of cancer death globally. " (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 4, 2021 Category: International Medicine & Public Health Source Type: news

Adjuvant Immunotherapy Benefit in Resected Kidney Cancer Adjuvant Immunotherapy Benefit in Resected Kidney Cancer
After surgery, progression-free survival was significantly longer for patients with high-risk renal carcinoma who received immunotherapy with pembrolizumab than for those who received placebo.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 3, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Oncotarget: Lung squamous cell carcinoma tumors reveal therapeutic alterations
(Impact Journals LLC) " Lung cancer is the leading cause of cancer-related deaths across the globe with more than 1.7 million deaths annually. " (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 2, 2021 Category: Cancer & Oncology Source Type: news

Oncotarget: E6-specific inhibitors as therapeutics for HPV+ head and neck carcinomas
(Impact Journals LLC) " Head and neck squamous cell carcinomas (HNSCC) are heterogeneous tumors that arise in the upper respiratory tract and are the 6th most common cancer worldwide by incidence. " (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 2, 2021 Category: Cancer & Oncology Source Type: news

Janssen Highlights Commitment to Advancing Transformative Innovations in Oncology with Scientific Updates from Deep, Diverse Pipeline and Portfolio at ASCO and EHA Virtual Scientific Programs
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 30 company-sponsored studies, including six oral presentations, will be featured during the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8. Janssen presentations will include new data and updates for both approved and investigational therapeutics that are being studied for the treatment of various solid tumors and blood cancers. Immediately following ASCO, additional data will be featured during the European Hematology Association (EHA) Virtual Congress, June 9-17. A ...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Transarterial embolisation not cost effective vs sorafenib for hepatocellular carcinoma
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - June 1, 2021 Category: Drugs & Pharmacology Source Type: news

Indigenous Americans: Global DNA pattern and gene expression signature in liver cancer
(Impact Journals LLC) Hepatocellular carcinoma (HCC), the main form of primary liver cancer, is one of the leading causes of tumor-related death worldwide. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 31, 2021 Category: Cancer & Oncology Source Type: news

Is NUT Carcinoma Curable?
Title: Is NUT Carcinoma Curable?Category: Diseases and ConditionsCreated: 5/28/2021 12:00:00 AMLast Editorial Review: 5/28/2021 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - May 28, 2021 Category: Cancer & Oncology Source Type: news

Head and neck cancer cells hijack nearby healthy tissue, promoting further invasion of cancer cells
(University of Michigan) Up to half of patients with head and neck squamous cell carcinoma will experience tumor recurrence or new tumors--tumors that often spread and are difficult to treat. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 26, 2021 Category: Cancer & Oncology Source Type: news

EU Panel Likes Monotherapy Cemiplimab for Two Cancers EU Panel Likes Monotherapy Cemiplimab for Two Cancers
In Europe, the Committee for Medicinal Products for Human Use (CHMP) adopted positive opinions for cemiplimab as monotherapy in lung cancer and basal cell carcinoma.International Approvals (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - May 25, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Alert Source Type: news

HCV Cure Before HCC Diagnosis Associated With Improved Survival HCV Cure Before HCC Diagnosis Associated With Improved Survival
Do patients with HCV-related hepatocellular carcinoma who have achieved HCV cure before HCC diagnosis have improved survival compared with patients who are viraemic at HCC diagnosis?Journal of Viral Hepatitis (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - May 25, 2021 Category: Transplant Surgery Tags: Gastroenterology Journal Article Source Type: news

Cancer symptoms: How to identify skin cancer when it is a squamous cell carcinoma
CANCER of the skin can fall into two categories: basal cell carcinoma and squamous cell carcinoma , with the latter being more dangerous. SCCs can become invasive, growing into deep layers of the skin and can metastasise. (Source: Daily Express - Health)
Source: Daily Express - Health - May 23, 2021 Category: Consumer Health News Source Type: news

Cancer symptoms: The appearance of skin cancer to look out for – basal cell carcinoma
CANCER may develop on skin exposed to the sun, especially on the face, head and neck. Slow-growing basal cell carcinoma can have a distinctive appearance. Find out what to look out for at Express.co.uk. (Source: Daily Express - Health)
Source: Daily Express - Health - May 22, 2021 Category: Consumer Health News Source Type: news

RYBREVANTTM (amivantamab-vmjw) Receives FDA Approval as the First Targeted Treatment for Patients with Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations
May 21, 2021 (HORSHAM, P.A.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the U.S. Food and Drug Administration (FDA) has granted the accelerated approval of RYBREVANTTM (amivantamab-vmjw) for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy.[1] RYBREVANTTM is the first fully-human, bispecific antibody approved for the treatment of patients with NSCLC t...
Source: Johnson and Johnson - May 21, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Dana-Farber researchers present key studies at ASCO annual meeting
(Dana-Farber Cancer Institute) Dana-Farber Cancer Institute researchers are presenting at the 2021 Annual Meeting of the American Society of Clinical Oncology (ASCO). Toni K. Choueiri, MD, will present results from the randomized, double-blind, phase III KEYNOTE-564 trial evaluating pembrolizumab versus placebo after surgery in patients with renal cell carcinoma during ASCO's Plenary Session. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 20, 2021 Category: Cancer & Oncology Source Type: news