ASO Visual Abstract: Impact of Tumor Size on Survival Outcome in Esophageal Squamous Cell Carcinoma After Esophagectomy Following Neoadjuvant Chemotherapy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 8, 2024 Category: Cancer & Oncology Source Type: research
An extensive analysis of the prognostic and immune role of FOXO1 in various types of cancer
Braz J Med Biol Res. 2024 May 3;57:e13378. doi: 10.1590/1414-431X2024e13378. eCollection 2024.ABSTRACTForkhead Box O1 (FOXO1) has been reported to play important roles in many tumors. However, FOXO1 has not been studied in pan-cancer. The purpose of this study was to reveal the roles of FOXO1 in pan-cancer (33 cancers in this study). Through multiple public platforms, a pan-cancer analysis of FOXO1 was conducted to obtained FOXO1 expression profiles in various tumors to explore the relationship between FOXO1 expression and prognosis of these tumors and to disclose the potential mechanism of FOXO1 in these tumors. FOXO1 was...
Source: Braz J Med Biol Res - May 8, 2024 Category: Research Authors: Jie Li Chao Wang Xiao Xu Jun Chen Haijun Guo Source Type: research
Full-Length Genome Sequencing and Analysis of Hepatitis B Viruses Isolated from Iraqi Patients
Int J Microbiol. 2024 Apr 29;2024:6826495. doi: 10.1155/2024/6826495. eCollection 2024.ABSTRACTHepatitis B virus (HBV) causes liver diseases (chronic hepatitis, cirrhosis, and hepatocellular carcinoma) and is a leading health problem worldwide. Sequencing of the whole HBV genome provides insight into the virus genotype, subgenotype, serotype, genetic variation, and viral drug resistance. To date, no study has been conducted on the whole genome sequence of HBV obtained from Iraqi patients. Therefore, this is the first study to sequence clinical samples from these patients. Viral genomic DNA was isolated and amplified using ...
Source: International Journal of Microbiology - May 8, 2024 Category: Microbiology Authors: Yaseen I Mamoori Ibrahim A Ahmed Ayhan R Mahmood Safaa A Al-Waysi Source Type: research
Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors
CONCLUSIONS: BRAF-mutated NEC is sensitive to treatment with BRAF- and MEK-inhibitor combination. These results further support that DNA sequencing should be considered as standard of care in NECs to screen for potential treatment targets.PMID:38716076 | PMC:PMC11075439 | DOI:10.48101/ujms.v129.10660 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 8, 2024 Category: General Medicine Authors: Lovisa Falkman Anders Sundin Britt Skogseid Johan Botling Yvette Bernardo G öran Wallin Liang Zhang Staffan Welin Ieva Lase Kazhan Mollazadegan Joakim Crona Source Type: research
Effective management of lung spindle cell carcinoma with ipilimumab, nivolumab, carboplatin, and paclitaxel, demonstrating efficacy in brain metastases treatment
We report a unique case of spindle cell carci noma treated with ipilimumab+nivolumab+carboplatin+paclitaxel that resulted in long-term response and resolution of new brain metastasis. (Source: Respirology Case Reports)
Source: Respirology Case Reports - May 8, 2024 Category: Respiratory Medicine Authors: Susumu Noguchi,
Atsushi Okamoto,
Jun Nohara,
Manabu Ishitoko,
Toshiki Watanabe,
Takaya Nakamura Tags: CASE REPORT Source Type: research
Bilateral breast tuberculosis: A case report
Histopathology examination of the breast tissue showing sheets of degenerating neutrophils and lymphocytes admixed with aggregates of epitheliod histiocytes with necrotic background. Key Clinical MessageBreast tuberculosis is a rare clinical condition that has the potential to imitate breast cancer or pyogenic abscess. It is crucial to consider this in patients who have resistant breast abscesses or persistent sinuses, particularly in high-risk groups or locations. The main treatment for breast tuberculosis is antitubercular treatment.AbstractBilateral breast tuberculosis is a rare form of the disease that affects breasts....
Source: Clinical Case Reports - May 8, 2024 Category: General Medicine Authors: Yohannis Derbew Molla,
Mohammed Alemu Iberahim,
Hirut Tesfahun Alemu,
Samuel Addisu Abera Tags: CASE REPORT Source Type: research
Spindle cell carcinoma of the maxillary antrum presenting in the oral cavity: A case report
ConclusionsWe report a rare case of intra-oral spindle cell carcinoma diagnosed from a palatal lesion, which has only been reported in four cases previously at this site. Despite preceding encounters with multiple medical professionals, it is not clear whether an intra-oral examination was carried out which may have established the diagnosis earlier. It emphasizes the importance of full head& neck examination, including intraoral examination in presentations of unexplained and intractable orofacial pain. (Source: Oral Surgery)
Source: Oral Surgery - May 8, 2024 Category: ENT & OMF Authors: Conor O'Gorman,
Christina Tran,
Amanda Willis Tags: CASE REPORT Source Type: research
Evaluation of magnetic resonance imaging for bladder cancer detection following transurethral resection of bladder tumour (TURBT)
ConclusionNon-contrast MRI with DWI showed high sensitivity and relatively high specificity for detection of residual tumour after TURBT. Inter-reader agreement improved from fair to moderate with the addition of DWI. MRI can be useful after TURBT in order to guide further management.Graphical abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - May 8, 2024 Category: Radiology Source Type: research
The Barthel Index Predicts Surgical Textbook Outcomes Following Hepatectomy for Elderly Patients with Hepatocellular Carcinoma: A Multicenter Cohort Study
The burgeoning demand for hepatectomy in elderly patients with hepatocellular carcinoma (HCC) necessitates improved perioperative care. Geriatric populations frequently experience functional decline and frailty, predisposing them to adverse postoperative outcomes. The Barthel Index serves as a reliable measure for assessing functional capacity, and this study evaluates its impact on surgical textbook outcomes (TOs) in elderly HCC patients. (Source: American Journal of Surgery)
Source: American Journal of Surgery - May 8, 2024 Category: Surgery Authors: Tian Yang, Da-Qun Liu, Wei Qiu, Zhong-Qi Fan, Li-Yang Sun, Nan-Ya Wang, Hong Wang, Yi-Fan Yang, Jie Li, Ya-Hao Zhou, Ting-Hao Chen, Xian-Ming Wang, Wei-Min Gu, Ying-Jian Liang, Li-Hui Gu, Jia-Hao Xu, Ming-Da Wang, Xiao-Dong Sun, Guo-Yue Lv Source Type: research
Hepatic artery infusion chemotherapy combined with camrelizumab plus rivoceranib for hepatocellular carcinoma with portal vein tumor thrombosis: a multicenter propensity score-matching analysis
ConclusionIn the context of advanced HCC patients with PVTT, the combination regime of HAIC and camrelizumab plus rivoceranib demonstrates more excellent capacity for prolonging survival and offers a well-tolerated safety compared to the CR dual therapy approach. This triple regime represents a therapeutic modality of broad prospects and vast potential for HCC patients with PVTT. (Source: Hepatology International)
Source: Hepatology International - May 8, 2024 Category: Infectious Diseases Source Type: research
Is the TAE score a promising prognostic predictor for unresectable hepatocellular carcinoma treated with TACE plus lenvatinib with PD‑1 inhibitors? Further validation should be performed
(Source: Hepatology International)
Source: Hepatology International - May 8, 2024 Category: Infectious Diseases Source Type: research
Evaluating postoperative hernia incidence and risk factors following pelvic exenteration
ConclusionThis study found over one-third of PE patients developed a hernia postoperatively. This paper highlights the importance of careful perioperative planning and optimization of patients to minimize morbidity. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - May 8, 2024 Category: Gastroenterology Source Type: research
Efficacy and survival of nivolumab treatment for recurrent/unresectable esophageal squamous-cell carcinoma: real-world clinical data from a large multi-institutional cohort
ConclusionsCAR and PS before nivolumab treatment are useful in predicting long-term survival in recurrent/unresectable advanced ESCC patients with second-line or later nivolumab treatment.Trial RegistrationUMIN000040462 (Source: Esophagus)
Source: Esophagus - May 8, 2024 Category: Gastroenterology Source Type: research
Clinicopathological Characteristics, Prognostic Factors, and Treatment Outcomes of Patients with Oral Tongue Squamous Cell Carcinoma Treated with Glossectomy: A Tertiary Oncology Center Experience
This study aimed to explore clinical and histopathological characteristics, survival, and other post-surgical outcomes in patients with OTSCC treated with glossectomy through the Department of Otolaryngology-Head& Neck Surgery at the Ministry of National Guard Health Affairs (MNGHA) within our study period. This is a retrospective study carried out through the collection and analysis of data from medical charts of 56 patients with oral tongue cancer who were treated by glossectomy. Treatment was initiated from January 2010 to December 2021. Patient characteristics, tumor characteristics, treatment modality, failure pat...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 8, 2024 Category: ENT & OMF Source Type: research
Cancers, Vol. 16, Pages 1799: CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
erino-Torres
There are several well-described molecular mechanisms that influence cell growth and are related to the development of cancer. Chemokines constitute a fundamental element that is not only involved in local growth but also affects angiogenesis, tumor spread, and metastatic disease. Among them, the C-X-C motif chemokine ligand 12 (CXCL12) and its specific receptor the chemokine C-X-C motif receptor 4 (CXCR4) have been widely studied. The overexpression in cell membranes of CXCR4 has been shown to be associated with the development of different kinds of histological malignancies, such as adenocarcinomas, epid...
Source: Cancers - May 8, 2024 Category: Cancer & Oncology Authors: David Sanchis-Pascual Mar ía Isabel Del Olmo-García Stefan Prado-Wohlwend Carlos Zac-Romero Ángel Segura Huerta Javier Hern ández-Gil Luis Mart í-Bonmatí Juan Francisco Merino-Torres Tags: Review Source Type: research
