Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway
Exp Cell Res. 2024 May 13:114094. doi: 10.1016/j.yexcr.2024.114094. Online ahead of print.ABSTRACTPirarubicin (THP) is a new generation of cell cycle non-specific anthracycline-based anticancer drug. In the clinic, THP and THP combination therapies have been shown to be effective in hepatocellular carcinoma (HCC) patients with transcatheter arterial chemoembolisation (TACE) without serious side effects. However, drug resistance limits its therapeutic efficacy. Berberine (BBR), an isoquinoline alkaloid, has been shown to possess antitumour properties against various malignancies. However, the synergistic effect of BBR and T...
Source: Experimental Cell Research - May 16, 2024 Category: Cytology Authors: Haiyan He Meng He Yunxia Wang Haojun Xiong Yu Xiong Meihua Shan Dong Liu Ziyuan Guo Yuhong Kou Yan Zhang Mingzhen Yang Jiqin Lian Liangbo Sun Fengtian He Source Type: research
Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia
Cell Signal. 2024 May 17;120:111228. doi: 10.1016/j.cellsig.2024.111228. Online ahead of print.ABSTRACTCancer cells tend to live in hypoxic environment characterized by enhanced glycolysis and accumulation of lactate. Intracellular lactate is shown to drive a novel type of post-translational modification (PTM), lysine lactylation (Kla). Kla has been confirmed to affect the malignant progression of tumors such as hepatocellular carcinoma (HCC) and colon cancer, whereas the global lactylomic profiling of oral squamous cell carcinoma (OSCC) is unclear. Here, the integrative lactylome and proteome analyses by using liquid chro...
Source: Cellular Signalling - May 16, 2024 Category: Cytology Authors: Fan Song Chen Hou Yingzhao Huang Jianfeng Liang Hongshi Cai Guoli Tian Yaoqi Jiang Ziyi Wang Jinsong Hou Source Type: research
Expression Profiling of EMT Transcriptional Regulators ZEB1 and ZEB2 in Different Histopathological Grades of Oral Squamous Cell Carcinoma Patients
CONCLUSION: High expressions of ZEBs have been significantly associated with cancer progression and poor health. However, no association was found between OSCC with other clinicopathological features when compared to healthy controls.PMID:38751602 | PMC:PMC11092914 | DOI:10.2174/0113892029284920240212091903 (Source: Current Genomics)
Source: Current Genomics - May 16, 2024 Category: Genetics & Stem Cells Authors: Neha Baqai Rafat Amin Tehseen Fatima Zeba Ahmed Nousheen Faiz Source Type: research
Tertiary Lymphoid Structures Gene Signature Predicts Prognosis and Immune Infiltration Analysis in Head and Neck Squamous Cell Carcinoma
CONCLUSION: High TLS signature is a promising independent prognostic factor for HNSCC patients. Immunological analysis indicated a correlation between TLS and immune cell infiltration in HNSCC. These findings provide a theoretical basis for future applications of TLS signature in HNSCC prognosis and immunotherapy.PMID:38751598 | PMC:PMC11092909 | DOI:10.2174/0113892029278082240118053857 (Source: Current Genomics)
Source: Current Genomics - May 16, 2024 Category: Genetics & Stem Cells Authors: Aiyan Xing Dongxiao Lv Changshun Wu Kai Zhou Tianhui Zhao Lihua Zhao Huaqing Wang Hong Feng Source Type: research
Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion
J Inorg Biochem. 2024 May 8;257:112593. doi: 10.1016/j.jinorgbio.2024.112593. Online ahead of print.ABSTRACTFour Ru(II) complexes (A2-A5) were synthesized from the reaction of coumarin Schiff base ligands (7da2-tsc, 7da3-mtsc, 7da4-etsc and 7da5-ptsc) with [RuHCl(CO)(PPh3)3]. The compounds were characterized by FT-IR, UV-Vis, 1H, 13C and 31P NMR, mass spectrometry and crystallographic analysis. Calf Thymus DNA (CT-DNA) binding studies revealed the intercalative mode of binding of the complexes with DNA. The results of Bovine serum albumin (BSA) binding studies established the interaction between BSA followed static quenchi...
Source: Journal of Inorganic Biochemistry - May 16, 2024 Category: Biochemistry Authors: S Nandhini M Ranjani G Thiruppathi Y M Jaithanya G Kalaiarasi M Ravi G Prabusankar J G Malecki P Sundararaj R Prabhakaran Source Type: research
Dabrafenib Alleviates Hepatotoxicity Caused by Lenvatinib via Inhibiting the Death Receptor Signaling Pathway
In conclusion, our results validate that apoptosis caused by the death receptor signaling pathway is the key cause of lenvatinib-induced hepatotoxicity, and dabrafenib alleviates lenvatinib-induced hepatotoxicity by inhibiting this pathway.PMID:38754640 | DOI:10.1016/j.toxlet.2024.05.004 (Source: Toxicology Letters)
Source: Toxicology Letters - May 16, 2024 Category: Toxicology Authors: Xinyu Tao Mengting Cheng Xiangliang Huang Jiajia Chen Yunfang Zhou Ting Liu Xiaochun Zheng Nonger Shen Yiwen Zhang Peihua Luo Qiaojun He Hao Yan Ping Huang Source Type: research
Synthesis, characterization, and biological activity of cationic ruthenium-arene complexes with sulfur ligands
J Biol Inorg Chem. 2024 May 16. doi: 10.1007/s00775-024-02052-2. Online ahead of print.ABSTRACTFive cationic ruthenium-arene complexes with the generic formula [Ru(SAc)(S2C·NHC)(p-cymene)](PF6) (5a-e) were prepared in almost quantitative yields using a straightforward one-pot, two-step experimental procedure starting from [RuCl2(p-cymene)]2, an imidazol(in)ium-2-dithiocarboxylate (NHC·CS2) zwitterion, KSAc, and KPF6. These half-sandwich compounds were fully characterized by various analytical techniques and the molecular structures of two of them were solved by X-ray diffraction analysis, which revealed the existence of ...
Source: Journal of Biological Inorganic Chemistry : JBIC - May 16, 2024 Category: Chemistry Authors: Mohammed Zain Aldin Guillermo Zaragoza Eva Choquenet Guillaume Blampain Gilles Berger Lionel Delaude Source Type: research
Clinical versus Histological Assessment of Basal Cell Carcinoma Subtype and Thickness of Tumours Selected for Photodynamic Therapy
Acta Derm Venereol. 2024 May 15;104:adv18308. doi: 10.2340/actadv.v104.18308.ABSTRACTPhotodynamic therapy is an approved treatment for primary, superficial, and small nodular basal cell carcinomas with a thickness of < 2 mm located on low-risk sites. Histologically verified basal cell carcinomas clinically assessed as suited for photodynamic therapy were included. The study aimed to investigate the agreement between clinical and histological assessments of basal cell carcinoma subtypes and thickness of tumours selected for photodynamic therapy with histopathological evaluation as a reference. A total of 343 tumours were...
Source: Acta Derm Venereol A... - May 16, 2024 Category: Dermatology Authors: Erik M ørk Patricia Mj ønes Olav A Foss Cato M ørk Ingeborg M Bachmann Susanne Kroon Lars K Dotterud Per Helsing Øystein Vatne Eidi Christensen Source Type: research
Exposure-Response Analyses for Belzutifan to Inform Dosing Considerations and Labeling
J Clin Pharmacol. 2024 May 16. doi: 10.1002/jcph.2459. Online ahead of print.ABSTRACTBelzutifan (Welireg, Merck & Co., Inc., Rahway, NJ, USA) is an oral, potent hypoxia-inducible factor-2α inhibitor, recently approved in the United States for the treatment of von Hippel-Lindau (VHL) disease-associated renal cell carcinoma (RCC) and other VHL disease-associated neoplasms. Safety and efficacy were investigated in two clinical studies: a Phase 1 dose escalation/expansion study in solid tumors and RCC and a Phase 2 study in VHL-RCC. A population pharmacokinetic model was used to estimate belzutifan exposures to facilitate...
Source: The Journal of Clinical Pharmacology - May 16, 2024 Category: Drugs & Pharmacology Authors: Dhananjay D Marathe Petra M Jauslin Huub Jan Kleijn Carolina De Miranda Silva Anne Chain Anson K Abraham Eunkyung A Kauh Yanfang Liu Rodolfo F Perini Dinesh P de Alwis Lokesh Jain Source Type: research
Durable pembrolizumab response in metastatic MSS ARID1A-mutant undifferentiated carcinoma of the esophagus
We report a case of an 87-year-old female with advanced, pMMR/MSS, HER2-negative, ARID1A-mutant, undifferentiated carcinoma of the esophagus with a PD-L1 CPS of 20, who has shown a durable ongoing response to pembrolizumab monotherapy for 2 years now. The case highlights a favorable response, possibly attributed to the high CPS score combined with the ARID1A mutation, as recent research suggests that ARID1A mutations may increase immunotherapy susceptibility.PMID:38752926 | DOI:10.1080/1120009X.2024.2352986 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - May 16, 2024 Category: Cancer & Oncology Authors: Zohaib Ijaz Doga Kahramangil Kriti Gera Ilyas Sahin Source Type: research
Dihydroartemisinin breaks the positive feedback loop of YAP1 and GLUT1-mediated aerobic glycolysis to boost the CD8 < sup > + < /sup > effector T cells in hepatocellular carcinoma
In this study, we confirmed that inhibition of YAP1 expression lowers GLUT1-mediated aerobic glycolysis in HCC cells and enhances the activity of CD8+T cells in the tumor niche. Then, we found that DHA was bound to cellular YAP1 in HCC cells. YAP1 knockdown inhibited GLUT1-mediated aerobic glycolysis, whereas YAP1 overexpression promoted GLUT1-mediated aerobic glycolysis in HCC cells. Notably, liver-specific Yap1 knockout by AAV8-TBG-Cre suppressed HIF-1α and GLUT1 expression in tumors but not para-tumors in DEN/TCPOBOP-induced HCC mice. Even more crucial is that YAP1 forms a positive feedback loop with GLUT1-mediated aer...
Source: Biochemical Pharmacology - May 16, 2024 Category: Drugs & Pharmacology Authors: Yuting Gao Yi Gong Junlan Lu Yanguang Yang Yuman Zhang Yajun Xiong Xinli Shi Source Type: research
Clinical versus Histological Assessment of Basal Cell Carcinoma Subtype and Thickness of Tumours Selected for Photodynamic Therapy
Acta Derm Venereol. 2024 May 15;104:adv18308. doi: 10.2340/actadv.v104.18308.ABSTRACTPhotodynamic therapy is an approved treatment for primary, superficial, and small nodular basal cell carcinomas with a thickness of < 2 mm located on low-risk sites. Histologically verified basal cell carcinomas clinically assessed as suited for photodynamic therapy were included. The study aimed to investigate the agreement between clinical and histological assessments of basal cell carcinoma subtypes and thickness of tumours selected for photodynamic therapy with histopathological evaluation as a reference. A total of 343 tumours were...
Source: Acta Dermato-Venereologica - May 16, 2024 Category: Dermatology Authors: Erik M ørk Patricia Mj ønes Olav A Foss Cato M ørk Ingeborg M Bachmann Susanne Kroon Lars K Dotterud Per Helsing Øystein Vatne Eidi Christensen Source Type: research
Molecular Imaging and Therapy of Differentiated Thyroid Carcinoma in Adults
Cancer J. 2024 May-Jun 01;30(3):194-201. doi: 10.1097/PPO.0000000000000713.ABSTRACTDifferentiated thyroid carcinoma (DTC) has been increasing in incidence in the United States over the last several decades, although mortality rates have remained low. Radioactive iodine therapy (RAI-T) has been a mainstay of treatment for DTC since the 1940s. Imaging of DTC before and after RAI-T primarily focuses on molecular imaging of the sodium iodide symporter. The expanding understanding of the molecular profile of DTC has increased available treatment options. Incorporation of risk stratification to treatment approaches has led to de...
Source: Cancer Journal - May 16, 2024 Category: Cancer & Oncology Authors: Philipose Getachew Mulugeta Anthony W Chi Thomas Michael Anderson Source Type: research
Invasive lobular carcinoma of the breast; clinicopathologic profile and response to neoadjuvant chemotherapy over a 15-year period
CONCLUSIONS: Atypical ILCs have distinct characteristics. They are more frequently of a higher grade and demonstrate a superior response to NACT. Despite the latter, atypical ILCs have a worse 5-year DFS which should be taken into consideration in terms of prognostication and may assist patient selection for NACT.PMID:38754140 | DOI:10.1016/j.breast.2024.103739 (Source: Breast)
Source: Breast - May 16, 2024 Category: Cancer & Oncology Authors: N P Quirke C Cullinane M A Turk N Shafique D Evoy J Geraghty D McCartan C Quinn J M Walshe E McDermott C Rutherford R S Prichard Source Type: research
Lipid Identification of Biomarkers in Esophageal Squamous Cell Carcinoma by Lipidomic Analysis
Nutr Cancer. 2024 May 16:1-11. doi: 10.1080/01635581.2024.2350097. Online ahead of print.ABSTRACTLipids participate in many important biological functions through energy storage, membrane structure stabilization, signal transduction, and molecular recognition. Previous studies have shown that patients with esophageal squamous cell carcinoma (ESCC) have abnormal lipid metabolism. However, studies characterizing lipid metabolism in ESCC patients through lipidomics are limited. Plasma lipid profiles of 65 ESCC patients and 42 healthy controls (HC) were characterized by lipidomics-based ultraperformance liquid chromatography q...
Source: Nutrition and Cancer - May 16, 2024 Category: Cancer & Oncology Authors: Tingwei Si Daoqin Liu Lei Li Zichen Xu Luqing Jiang Ying Zhai Qiwen Wu Source Type: research
