Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
CONCLUSION: No clear associations were observed between diet and NAFLD cirrhosis nor HCC. Although accompanied by low precision, possible lowered risks of HCC by substituting SFA with carbohydrates or milk with fermented milk might be of interest, but needs replication in other cohorts.PMID:38797249 | DOI:10.1016/j.ajcnut.2024.05.018 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - May 26, 2024 Category: Nutrition Authors: Frid én M Warensj ö Lemming E Lind L Vessby J Rosqvist F Ris érus U Source Type: research
A nurse-led multidomain intervention to improve the management of chemotherapy-induced nausea and vomiting in patients with head and neck cancers: A randomized controlled trial
CONCLUSIONS: Nurse-led multidomain intervention can reduce the incidence and the severity of CINV in patients with HNSCC who were treated with cisplatin-based chemotherapy, and thus reduced the influence of CINV on patients' quality of life.THE CLINICAL TRIAL REGISTRATION NUMBER: NCT05792228.PMID:38797114 | DOI:10.1016/j.ejon.2024.102615 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - May 26, 2024 Category: Nursing Authors: Jiayan Cao Changlian Chen Yueyang Wang Miaomiao Liu Xuya Han Hong Li Source Type: research
Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA
Biochem Pharmacol. 2024 May 24:116315. doi: 10.1016/j.bcp.2024.116315. Online ahead of print.ABSTRACTOC-2 plays a vital role in tumor growth, metastasis and angiogenesis, but molecular mechanism how OC-2 regulates angiogenic factors is unclear. We found that OC-2 was highly expressed in HepG2, COLO, MCF-7, SKOV3 cells and rectum carcinoma tissues, and angiogenic factors levels were positively related to OC-2. Then OC-2 KD inhibited the tumor growth, metastasis and angiogenesis process in vitro and vivo. ChIP-Seq showed that 228 target genes of OC-2 were identified and they were associated with tumor growth, metastasis, ang...
Source: Biochemical Pharmacology - May 26, 2024 Category: Drugs & Pharmacology Authors: Ligang Zhang Cunjie Li Xinran Song Raoqing Guo Wenli Zhao Chunyan Liu Xi Chen Qifang Song Binhua Wu Ning Deng Source Type: research
Prognosis of transarterial chemoembolization-sorafenib compared to transarterial chemoembolization-alone in hepatocellular carcinoma stage C: a systematic review
CONCLUSION: The results of this systematic review suggested that TACE-sorafenib combination therapy in patients with HCC BCLC-C improves OS superior compared to TACE-alone, without a notable increase in adverse events.PMID:38797810 | DOI:10.1186/s43046-024-00224-4 (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - May 26, 2024 Category: Cancer & Oncology Authors: Rahmad Mulyadi Irsan Hasan Prijo Sidipratomo Pungky Permata Putri Source Type: research
Targeting BMP2 for therapeutic strategies against hepatocellular carcinoma
CONCLUSION: This study highlights the role of BMP2 in tumor angiogenesis and HCC progression. Targeting BMP2 could be a promising therapeutic strategy against HCC.PMID:38797016 | DOI:10.1016/j.tranon.2024.101970 (Source: Translational Oncology)
Source: Translational Oncology - May 26, 2024 Category: Cancer & Oncology Authors: Ping Li You Shang Liying Yuan Jialing Tong Quan Chen Source Type: research
Single-stranded pre-methylated 5mC adapters uncover the methylation profile of plasma ultrashort Single-stranded cell-free DNA
We describe the '5mCAdpBS-Seq' workflow in which pre-methylated 5mC (5-methylcytosine) single-stranded adapters are ligated to heat-denatured cfDNA before bisulfite conversion. This method retains only DNA fragments that are unaltered by bisulfite treatment, resulting in less biased uscfDNA methylation analysis. Using 5mCAdpBS-Seq, uscfDNA had lower levels of DNA methylation (∼15%) compared to mncfDNA and was enriched in promoters and CpG islands. Hypomethylated uscfDNA fragments were enriched in upstream transcription start sites (TSSs), and the intensity of enrichment was correlated with expressed genes of hemopoietic ...
Source: Cell Research - May 26, 2024 Category: Cytology Authors: Jordan C Cheng Neeti Swarup Marco Morselli Wei-Lun Huang Mohammad Aziz Christa Caggiano Misagh Kordi Abhijit A Patel David Chia Yong Kim Feng Li Fang Wei Noah Zaitlen Kostyantyn Krysan Steve Dubinett Matteo Pellegrini David T W Wong Source Type: research
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis
Transl Res. 2024 May 24:S1931-5244(24)00107-5. doi: 10.1016/j.trsl.2024.05.007. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is among the most fatal types of malignancy, with a high prevalence of relapse and limited treatment options. As a critical regulator of ferroptosis and redox homeostasis, glutathione peroxidase 4 (GPX4) is commonly upregulated in HCC and is hypothesized to facilitate cancer metastasis, but this has not been fully explored in HCC. Here, we report that up-regulated GPX4 expression in HCC is strongly associated with tumor metastasis. FACS-based in vivo and in vitro analysis revealed tha...
Source: Cell Research - May 26, 2024 Category: Cytology Authors: Ruogu Pan Zhenjun Zhao Dongwei Xu Chunlai Li Qiang Xia Source Type: research
Frequent Immunohistochemical Expression of Transcriptional Repressor GATA Binding 1 in Salivary Gland Neoplasms: A Sensitive but Nonspecific Marker
CONCLUSIONS.—: TRPS1 is positive in most benign and malignant SGNs. Its expression in several nonbreast-non-SG carcinomas indicates that it lacks specificity for breast and SG carcinomas, even if considering only high-positive IRS. Addition of SOX10 can increase discriminatory utility of TRPS1.PMID:38797518 | DOI:10.5858/arpa.2023-0444-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 26, 2024 Category: Laboratory Medicine Authors: Sanjay Sriram Aanchal Kakkar Chetna Sarma Ria Mahendru Rajeev Kumar Kavneet Kaur Alok Thakar Svs Deo Source Type: research
A Microfluidic, Multi-Antibody Cell Capture Method to Evaluate Tumor Cells in Cerebrospinal Fluid in Patients With Suspected Leptomeningeal Metastases
CONCLUSIONS.—: This assay demonstrated the ability to detect and enumerate epithelial cells in contrived and clinical specimens in an accurate and reproducible fashion. The use of cell capture assays in CSF may be useful as a sensitive test for the diagnosis and longitudinal monitoring of LMD from solid tumors.PMID:38797516 | DOI:10.5858/arpa.2023-0295-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 26, 2024 Category: Laboratory Medicine Authors: Nathan T Sweed Hao-Ching Hsiao Barbara Blouw Tony J Pircher Deanna Fisher Katrina Rose Naluz Julie Ann Mayer Michael C Dugan Akanksha Sharma Jose Carrillo Santosh Kesari Source Type: research
Comparison of tissue biomarkers between non-schistosoma and schistosoma-associated urothelial carcinoma
CONCLUSION: Due to lower UroplakinIII expression, S-UBC is supposed to have a poorer prognosis. Hormonal therapy is not hypothesized due to a very minimal ERα expression in both NS-UBC and S-UBC. Regarding immunotherapy, anti-TNF-α is suggested for S-UBC whilst in NS-UBC, blockading PDL1 might be useful. Targeted EGFR therapy seems to carry emphasized outcomes in S-UBC. Correlations encourage combined immune therapy in NS-UBC; nevertheless, in S-UBC, combined anti-EGFR and PDL1 seem to be of benefit.PMID:38796863 | DOI:10.1016/j.tice.2024.102416 (Source: Tissue and Cell)
Source: Tissue and Cell - May 26, 2024 Category: Cytology Authors: Nashwah Samir AlHariry Enas A El Saftawy Basma Emad Aboulhoda Ahmed H Abozamel Mansour A Alghamdi Amany E Hamoud Walaa Abd Elgawad Khalil Ghanam Source Type: research
Facile one-pot synthesis of Ir(III) Bodipy polymeric gemini nanoparticles for tumor selective NIR photoactivated anticancer therapy
Biomaterials. 2024 May 21;309:122618. doi: 10.1016/j.biomaterials.2024.122618. Online ahead of print.ABSTRACTOver the last decades, a variety of metal complexes have been developed as chemotherapeutic agents. Despite the promising therapeutic prospects, the vast majority of these compounds suffer from low solubility, poor pharmacological properties, and most importantly poor tumor accumulation. To circumvent these limitations, herein, the incorporation of cytotoxic Ir(III) complexes and a variety of photosensitizers into polymeric gemini nanoparticles that selectively accumulate in the tumorous tissue and could be activate...
Source: Biomaterials - May 26, 2024 Category: Materials Science Authors: Ganghao Liang Nicol ás Montesdeoca Dongsheng Tang Bin Wang Haihua Xiao Johannes Karges Kun Shang Source Type: research
GPX4 transcriptionally promotes liver cancer metastasis via GRHL3/PTEN/PI3K/AKT axis
Transl Res. 2024 May 24:S1931-5244(24)00107-5. doi: 10.1016/j.trsl.2024.05.007. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is among the most fatal types of malignancy, with a high prevalence of relapse and limited treatment options. As a critical regulator of ferroptosis and redox homeostasis, glutathione peroxidase 4 (GPX4) is commonly upregulated in HCC and is hypothesized to facilitate cancer metastasis, but this has not been fully explored in HCC. Here, we report that up-regulated GPX4 expression in HCC is strongly associated with tumor metastasis. FACS-based in vivo and in vitro analysis revealed tha...
Source: Translational Research : the journal of laboratory and clinical medicine - May 26, 2024 Category: Laboratory Medicine Authors: Ruogu Pan Zhenjun Zhao Dongwei Xu Chunlai Li Qiang Xia Source Type: research
TMX2 potentiates cell viability of hepatocellular carcinoma by promoting autophagy and mitophagy
In conclusion, our findings emphasize the pivotal role of TMX2 in driving the HCC cell viability by promoting both autophagy and mitophagy. These results suggest that TMX2 May serve as a prognostic marker and promising therapeutic target for HCC treatment.PMID:38797513 | DOI:10.1080/15548627.2024.2358732 (Source: Autophagy)
Source: Autophagy - May 26, 2024 Category: Cytology Authors: Weiyu Zhang Yao Tang Pengfei Yang Yutong Chen Zhijie Xu Chunhui Qi Hongbin Huang Ruiyang Liu Haorui Qin Haoying Ke Caini Huang Fuyuan Xu Pengfei Pang Zhiju Zhao Hong Shan Fei Xiao Source Type: research
Long-term toxicity evaluation of aristolochic acid-IIIa in mice
Toxicology. 2024 May 24:153838. doi: 10.1016/j.tox.2024.153838. Online ahead of print.ABSTRACTAristolochic acid (AA)-IIIa is an AA analog present in Aristolochiaceae plants. To evaluate the chronic toxicity of AA-IIIa, mice were intragastrically administered with media control, 1mg/kg AA-IIIa, and 10mg/kg AA-IIIa, and designated as the control (CTL), AA-IIIa low dose (AA-Ⅲa-L), and AA-IIIa high dose (AA-Ⅲa-H) groups, respectively. AA-IIIa was administered three times a week, every other day, for 24 weeks (24-week time point). Thereafter, some mice were sacrificed immediately, while others were sacrificed 29 or 50 weeks...
Source: Toxicology - May 26, 2024 Category: Toxicology Authors: Lianmei Wang Yuan Wang Yong Zhao Chunying Li Yan Yi Jingzhuo Tian Guiqin Li Zhong Xian Fang Wang Jing Meng Yushi Zhang Jiayin Han Chen Pan Suyan Liu Meiting Liu Chenyue Liu Aihua Liang Source Type: research
The association analysis between fatigue and body composition loss in patients with nasopharyngeal carcinoma during radiotherapy: An observational longitudinal study
CONCLUSIONS: Loss of weight, BMI, body fat rate, and lean body weight could be used to independently evaluate the development of fatigue in patients with NPC during radiotherapy. Positive associations between fatigue and weekly body composition loss were found in patients with certain characteristics.PMID:38797492 | DOI:10.1016/j.radonc.2024.110340 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 26, 2024 Category: Radiology Authors: Jihong Song Xinru Yang Jieling Wu Zilan Wu Sitian Niu Litao Zhuo Wenlong Lu Jinru Ye Yan Fang Zhiying Zhan Hairong Zhang Xiaomei Li Jinsheng Hong Li Su Source Type: research
