Identification of a novel matrix metalloproteinases-related prognostic signature in hepatocellular carcinoma
CONCLUSIONS: A novel MMPs-related signature can be used to predict the prognosis of HCC. The findings of this research could potentially impact the predictability of the prognosis and treatment of HCC.PMID:38761174 | DOI:10.18632/aging.205832 (Source: Aging)
Source: Aging - May 18, 2024 Category: Biomedical Science Authors: Xingxing Yuan Liuxin Yang Jiawei Gao Xu Mao Yali Zhang Wei Yuan Source Type: research
LncRNA SH3BP5-AS1 promotes hepatocellular carcinoma progression by sponging miR-6838-5p and activation of PTPN4
CONCLUSIONS: Our research suggests that SH3BP5-AS1 controls miR-6838-5p/PTPN4 in order to act as a new carcinogenic LncRNA during the growth of HCC cells.METHODS: The expression levels of SH3BP5-AS1, miR-6838-5p and PTPN4 were detected by qRT-PCR and Western blot. The effects of LncRNA SH3BP5-AS1/miR-6838-5p/PTPN4 on the proliferation, metastasis and glycolysis of HCC cells were clarified by experimental cellular functionality assays, cell derived xenograft and Glycolysis assay.PMID:38761175 | DOI:10.18632/aging.205811 (Source: Aging)
Source: Aging - May 18, 2024 Category: Biomedical Science Authors: Xinyang Zhao Xinfeng Zhu Chaowen Xiao Zouxiao Hu Source Type: research
PDIA3 driven STAT3/PD-1 signaling promotes M2 TAM polarization and aggravates colorectal cancer progression
CONCLUSIONS: PDIA3 augments the M2 polarization of tumor-associated macrophages via modulation of the STAT3/PD-1 cascade, thus invigorating the tumorous proliferation and dissemination in colorectal cancer. Such revelations position PDIA3 as an auspicious target for PD-1 blockade therapeutics, offering a promising foundation for rectifying colorectal carcinoma.PMID:38761176 | DOI:10.18632/aging.205847 (Source: Aging)
Source: Aging - May 18, 2024 Category: Biomedical Science Authors: Jianchun Fan Likun Wang Chunze Zhang Xueliang Wu Lei Han Xiaoyu Zhang Shuquan Gao Jun Xue Qi Zhang Source Type: research
Common immunological and prognostic features of lung and bladder cancer via smoking-related genes: PRR11 gene as potential immunotherapeutic target
This study aimed to identify smoking-related differential genes in NSCLC and BLCA, analyse their roles in patient prognosis and immune checkpoint therapy through subgroup analyses, and shed light on PRR11 as a crucial prognostic gene in both cancers. By examining PRR11 co-expressed genes, a prognostic model was constructed and its impact on immunotherapy for NSCLC and BLCA was evaluated. Molecular docking and tissue microarray analyses were conducted to explore the correlation between PRR11 and its reciprocal gene SPDL1. Additionally, miRNAs associated with PRR11 were analysed. The study confirmed a strong link between smo...
Source: Molecular Medicine - May 18, 2024 Category: Molecular Biology Authors: YaXuan Wang HaiXia Zhu Lu Zhang JiaXing He Ji Bo JianShe Wang BeiChen Ding MingHua Ren Source Type: research
Common immunological and prognostic features of lung and bladder cancer via smoking-related genes: PRR11 gene as potential immunotherapeutic target
This study aimed to identify smoking-related differential genes in NSCLC and BLCA, analyse their roles in patient prognosis and immune checkpoint therapy through subgroup analyses, and shed light on PRR11 as a crucial prognostic gene in both cancers. By examining PRR11 co-expressed genes, a prognostic model was constructed and its impact on immunotherapy for NSCLC and BLCA was evaluated. Molecular docking and tissue microarray analyses were conducted to explore the correlation between PRR11 and its reciprocal gene SPDL1. Additionally, miRNAs associated with PRR11 were analysed. The study confirmed a strong link between smo...
Source: J Cell Mol Med - May 18, 2024 Category: Molecular Biology Authors: YaXuan Wang HaiXia Zhu Lu Zhang JiaXing He Ji Bo JianShe Wang BeiChen Ding MingHua Ren Source Type: research
Association between the expression of epithelial –mesenchymal transition (EMT)-related markers and oncologic outcomes of colorectal cancer
ConclusionAbnormal expression of each marker was associated with lower OS, whereas abnormal expression of Vimentin and SMAD4 only was associated with lower DFS. (Source: Updates in Surgery)
Source: Updates in Surgery - May 18, 2024 Category: Surgery Source Type: research
Dynamic radiological features predict pathological response after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma
Neoadjuvant immunochemotherapy (NICT) plus esophagectomy has emerged as a promising treatment option for locally advanced esophageal squamous cell carcinoma (LA-ESCC). Pathologic complete response (pCR) is a k... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - May 18, 2024 Category: Research Authors: Yuli Ruan, Yue Ma, Ming Ma, Chao Liu, Dan Su, Xin Guan, Rui Yang, Hong Wang, Tianqin Li, Yang Zhou, Jianqun Ma and Yanqiao Zhang Tags: Research Source Type: research
Basal cell carcinoma has greater subclinical extension than squamous cell carcinoma: a cohort study
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - May 18, 2024 Category: Dermatology Source Type: research
Expression Pattern of Estrogen Receptor Alpha and Progesterone Receptor in Gallbladder Carcinoma and Their Association with Clinicopathological Parameters and Overall Survival
ConclusionAlthough nuclear expression of ER α was significantly associated with progressive disease factors but the positive expression was found in very small percentage of GBC cases. So anti-hormone therapy might be an option in patient with ER α positive gallbladder carcinoma. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 18, 2024 Category: Cancer & Oncology Source Type: research
Oral Myiasis —An Uncommon Finding in Modern Era
AbstractOral myiasis is a rare parasitic infestation of vital tissue of humans or other mammals by dipterous larvae (maggots) encountered in developing tropical countries owing to poor hygiene and financial deprivation. This disease often manifests in humid climate along with local factors, such as poor oral hygiene, debilitating conditions, alcoholism and poor quality of living favor the growth of larvae which predisposes toward the disease. It is mostly associated with various medical conditions, such as maxillofacial trauma, mental retardation with neglected households, poor oral hygiene and cancerous wounds. Herein, we...
Source: Journal of Maxillofacial and Oral Surgery - May 18, 2024 Category: ENT & OMF Source Type: research
Anti-Angiogenic Tyrosine Kinase Inhibitor-Related Toxicities Among Cancer Patients: A Systematic Review and Meta-Analysis
ConclusionsThis meta-analysis highlights the toxicity profiles of anti-angiogenic TKI monotherapies, and thus enables high-level recommendations for the choice of anti-angiogenic TKIs on the basis of the patient ’s age, ethnicity, comorbidities, and comedications, for personalized treatment. (Source: Targeted Oncology)
Source: Targeted Oncology - May 18, 2024 Category: Cancer & Oncology Source Type: research
Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers
Opinion StatementNon-melanoma skin cancers (NMSCs) are the most common malignancy and surgical excision is considered treatment of choice for the majority of cases. However, surgery can be very extensive in cases of large, multiple, or cosmetic-sensitive tumors located on areas such as scalp and face or genital region, leading to significant functional and cosmetic deficit. Aminolaevulinic acid photodynamic therapy (ALA-PDT) has emerged as a widely used approach in a variety of skin diseases, demonstrating remarkable efficacy in treatment of actinic keratosis, Bowen disease and basal cell carcinoma. Besides, when employed ...
Source: Current Treatment Options in Oncology - May 18, 2024 Category: Cancer & Oncology Source Type: research
V600E BRAF-mutated anaplastic thyroid carcinoma after radioactive iodine for Graves ’ disease: a case report and a review of the literature
DiscussionIt is not clear if the occurrence of ATC could be influenced by the RAI therapy for hyperthyroidism. Therefore, we reviewed the different cases and characteristics of ATC after RAI published so far in the literature. Patients were exclusively females, the median age at diagnosis was 66,5 years old (IQR: 51,5–69, range 29–75) and the median time occurring from RAI treatment and ATC diagnosis was 7 years. To our knowledge, here we report the first patient with V600E BRAF-mutation in ATC after RAI for Graves’ disease. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 18, 2024 Category: Radiology Source Type: research
Standard versus fractionated high-dose cisplatin plus radiation for locally advanced head and neck cancer: Results of the CisFRad (GORTEC 2015-02) randomized phase II trial
Chemoradiotherapy (CRT) is the standard of care in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), either post-operatively in patients at high-risk of recurrence [1,2] or as definitive CRT [3,4]. High-dose cisplatin, i.e. 100 mg/m2 every 3 weeks for 3 cycles (HD-Cis) has thus become the reference modality [4,5]. However, this treatment is associated with high toxicity (>80 % grade ≥ 3) [2,3], which compromises its administration, especially regarding the cumulative dose of cisplatin delivered concurrently with radiotherapy, as commonly 30–50 % of patients cannot receive the third cycle ...
Source: Radiotherapy and Oncology - May 18, 2024 Category: Radiology Authors: Christian Borel, Xu-Shan Sun, Alexandre Coutte, Guillaume Bera, Christian Sire, Sylvie Zanetta, Marc Alfonsi, Guillaume Janoray, Thierry Chatellier, Muriel Garcia-Ramirez, Elisabeta Gherga, Yasser Hammoud, Micka ël Burgy, Nelly Etienne-Selloum, Adeline P Source Type: research
Beyond histology: A tissue algorithm predictive of post-surgical recurrence in hepatocellular carcinomas, including TERT promoter mutation
In conclusion, NGS analysis in resected HCC could not only be used for future therapies but should be integrated with histopathology to predict the risk of tumor recurrence after surgical resection:TERT mutation is among the strongest predictors of tumor recurrence, together with tumor stage (dimensions) and the occurrence of MPVI, which should always be reported separately from the classic MVI. (Source: Virchows Archiv)
Source: Virchows Archiv - May 18, 2024 Category: Pathology Source Type: research
