Correction to: Anemia and  PET imaging
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 23, 2021 Category: Radiology Source Type: research

Timing of diuretics in diuresis renography
ConclusionNo consensus could be found for a preferred time point of diuretics administration during a diuresis renography. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 19, 2021 Category: Radiology Source Type: research

18F-Florbetaben: a potential nuclear protagonist in the diagnosis of cardiac amyloidosis
ConclusionsThe correct use of PET with 18F-florbetaben can allow to obtain an earlier diagnosis of immunoglobulin light chain amyloidosis allowing to anticipate the initiation of specific therapies and, possibly, increasing patient survival. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 16, 2021 Category: Radiology Source Type: research

Global research trends in COVID-19 with MRI and PET/CT: a scoping review with bibliometric and network analyses
ConclusionCOVID-19 pandemic is still spreading worldwide, and the knowledge about its different facets continues advancing. MRI and PET/CT are being used in more than 50% of the selected studies; research trends span seven categories, no only the diagnostic but others like socio-economic impact and pathogenesis Developed countries had an advantage by having hospitals with more resources, including MRI and PET/CT facilities in the same institution to supplement basic assessment in patients with COVID-19. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 14, 2021 Category: Radiology Source Type: research

The clinical utility of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography in guiding myocardial revascularisation
ConclusionThe current evidence is insufficient for clinicians in LMIC or remote areas in HIC without access to catheterisation laboratories to refrain from referring patients for viability imaging. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 13, 2021 Category: Radiology Source Type: research

[68Ga]-Pentixafor PET/CT imaging of lymphoproliferative malignancies
ConclusionOur results demonstrate [68Ga]-Pentixafor uptake in different subtypes of NHL and CLL; however, the potential complementary role of [68Ga]-Pentixafor PET/CT towards personalized diagnostic concepts remains yet to be determined by further studies. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 12, 2021 Category: Radiology Source Type: research

Heterogeneity of estrogen receptor based on 18F-FES PET imaging in breast cancer patients
Conclusion18F-FES PET imaging is expected to non-invasively and comprehensively characterize inter-patient and intra-patient heterogeneity of ER, and reveal the correlation between this heterogeneity and clinical decision-making. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 6, 2021 Category: Radiology Source Type: research

Chest computed tomography in COVID-19 infection
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 5, 2021 Category: Radiology Source Type: research

Performance of 18F-FDG-PET/CT as a next step in the search of occult primary tumors for patients with head and neck squamous cell carcinoma of unknown primary: a systematic review and meta-analysis
Conclusions18F-FDG PET/CT is useful as a next step in the search of occult primary tumors in HNSCC-UP patients defined by endoscopy with or without CT/MRI. However, in light of the high false-positive proportion, confirmatory histological investigations should be viewed as necessary practice upon positive PET/CT findings. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 1, 2021 Category: Radiology Source Type: research

68Ga-PSMA PET/CT and mpMRI for primary lymph node staging of intermediate to high-risk prostate cancer: a systematic review and meta-analysis of diagnostic test accuracy
ConclusionBoth imaging techniques have high specificity for the detection of nodal metastases of PCa.68Ga-PSMA PET/CT has the advantage of being more sensitive and making it possible to detect distant metastases during the same examination. These modalities may play a complementary role in the diagnosis of PCa. Given the paucity of data and methodological limitations of the included studies, large scale trials are necessary to confirm their clinical values. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 28, 2021 Category: Radiology Source Type: research

Diagnostic performance of 18F-FDG PET/CT in pediatric lymphoma infiltrating bone marrow: a meta-analysis
Conclusion18F-FDG PET/CT showed high specificity and sensitivity in detecting pediatric lymphoma infiltrating bone marrow. In addition, it is not necessary to perform bone marrow biopsy for patients with positive18F-FDG PET/CT. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 23, 2021 Category: Radiology Source Type: research

The role of 18F-FDG PET/CT radiomics in lymphoma
Conclusions18F-FDG PET/CT textural and radiomic features may be useful tools in lymphoma for histological prediction, prognostic assessment and bone marrow involvement definition. Further studies are needed to integrate radiomics in clinical multi-omic models. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 20, 2021 Category: Radiology Source Type: research

PET-guided gamma knife radiosurgery in brain tumors: a brief review
ConclusionsAlthough not enough studies were available on the role of PET imaging for guiding GKRS, it would seem that the integration of PET data into GKRS treatment planning may represent an important step toward further developments in radiosurgery, especially GKRS. Yet, there is no definite indication for pre-GKRS PET imaging; however, most of the studies used PET imaging when there were lesions with an ill-defined border in MRI. It seems that [11C]MET PET might provide more accurate imaging data than 2-[18F]FDG for lesion targeting; however, studies with head to head comparison of these two modalities are needed. (Sour...
Source: Clinical and Translational Imaging - July 19, 2021 Category: Radiology Source Type: research

A spotlight on redifferentiation strategies and target modulation in differentiated thyroid cancer
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 16, 2021 Category: Radiology Source Type: research

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation
ConclusionsCurrently, [18F]FDG PET/CT in oncology is globally accepted and standardized in main diagnostic algorithms for neoplasms. In recent years, the ever-closer collaboration among different European associations has tried to overcome the absence of a standardization also in the field of inflammation and infections. The collaboration of several nuclear medicine centers with a long experience in this field, as well as among different AIMN focus groups represents a further attempt in this direction. We hope that this document will be the basis for a “common nuclear physicians’ language” throughout all ...
Source: Clinical and Translational Imaging - July 10, 2021 Category: Radiology Source Type: research

Should FDG PET/CT or PET/MR replace WBC scan in infectious and inflammatory disease?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 10, 2021 Category: Radiology Source Type: research

Breaking the paradigm to renew the Nuclear Medicine Department …
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 10, 2021 Category: Radiology Source Type: research

Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimer ’s disease, and neuropsychological measures
ConclusionsStrong evidence suggests that atrophy of the AD vulnerable regions is associated with CSF and PET biomarkers and cognitive measures. These relationships may be potentially helpful in characterizing the preclinical and clinical stages of MCI and AD and predicting AD progression. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 1, 2021 Category: Radiology Source Type: research

Anemia and PET imaging
ConclusionPET imaging is useful for assessing various types of anemia. It is also important to be aware of anemia-related PET findings to avoid mistaking them for malignancy or metastases. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 30, 2021 Category: Radiology Source Type: research

Health technology assessment for PSMA-PET: striving towards a cost-effective management of prostate cancer
ConclusionPSMA-PET has the potential to save time and reduce costs from a patient and health-care perspective, by providing a more accurate disease staging and leading to more effective, personalized, imaging-guided approach. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 26, 2021 Category: Radiology Source Type: research

Peptide receptor radionuclide therapy for GEP-NET: consolidated knowledge and innovative applications
ConclusionPRRT is now recognized as an effective treatment strategy for well-differentiated SSTR-positive NETs with a very high disease control and overall limited toxicity. Further optimization of PRRT employment is warranted to further increase efficacy and reduce toxicity. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 24, 2021 Category: Radiology Source Type: research

Amyloid PET in the diagnostic workup of neurodegenerative disease
AbstractSeveral radiotracers have been employed to bind amyloid plaques in the brain for the differential diagnosis of neurodegenerative disease, open the possibility to measure in vivo pathogenic processes implicated in Alzheimer disease (AD) and have the potential to detect disease processes at the earliest stages with a potential role in clinical trials ’ longitudinal assessment. Visual reading is clinically adequate in clearly positive or negative cases but the adoption of validated and standardized quantification methods of amyloid-PET to diagnose AD in research and clinical settings has become essential. The pr...
Source: Clinical and Translational Imaging - June 23, 2021 Category: Radiology Source Type: research

Toward radiotheranostics in cancer stem cells: a promising initial step for tumour eradication
ConclusionThere is an essential need to consider the combination of conventional cancer treatment methods and specific CSCs therapies to complete eradication of heterogeneous tumour mass. Nuclear molecular imaging with an incorporated theranostic approach is a proposed platform that combines diagnostics and therapy as well as facilitates individual patient treatment. Currently, there are only early steps, but these steps display promising results of CSC-targeting using the theranostics approach. Further high-throughput research should be directed towards the greater development of the theranostics approach in CSCs to impro...
Source: Clinical and Translational Imaging - June 22, 2021 Category: Radiology Source Type: research

Ultrasound and shear-wave elastography patterns of COVID-19 mRNA vaccine-related axillary, supra and subclavicular lymphadenopathy
AbstractIn this pictorial essay, we illustrate the ultrasound appearance of COVID-19 Pfizer-BioNTech vaccine-related lymph node abnormalities, which can occur at different stations ipsilateral to the site of vaccination, after either first or second vaccine dose and can represent a diagnostic dilemma when encountered in patients with underlying conditions. Typically, they appear as enlarged hypoechoic nodes with loss of fat hilum, increased hilar and cortical vascularization at color-Doppler, but low to intermediate cortical consistence at shear-wave elastography. Asymmetric or diffuse cortical thickening is also frequentl...
Source: Clinical and Translational Imaging - June 18, 2021 Category: Radiology Source Type: research

Humbug in a nuclear medicine department?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 7, 2021 Category: Radiology Source Type: research

A multicenter survey of current practices of 99mTc-methoxy-isobutyl-isonitrile (MIBI) imaging for the diagnosis of thyroid nodules: more standardization is essential
ConclusionsOur survey supports the urgent need of standardized interpretation criteria of thyroid MIBI imaging in order to improve its diagnostic performance and make results comparable in clinical practice. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 2, 2021 Category: Radiology Source Type: research

An easy and practical guide for imaging infection/inflammation by [18F]FDG PET/CT
ConclusionsDespite [18F]FDG is currently used in several inflammatory and infective diseases, standardized interpretation criteria are still needed in most cases. It is, therefore, foreseen the execution of multicentre clinical studies that, by adopting the same acquisition and interpretation criteria, may contribute to the standardization of this imaging modality. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 1, 2021 Category: Radiology Source Type: research

Impact of 18F-FDG PET on the management of recurrent breast cancer: a meta-analysis
Conclusions18F-FDG PET has a major impact on the management of patients with breast cancer after curative surgery. These findings suggest that18F-FDG PET should be performed in patients with breast cancer in cases involving equivocal or suspicious recurrence/metastasis on conventional imaging or in cases involving elevated tumor markers during follow-up. However, this study does not support the routine use of18F-FDG PET for surveillance in breast cancer. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 1, 2021 Category: Radiology Source Type: research

Assessment of therapy response to Regorafenib by 18F-DOPA-PET/CT in patients with recurrent high-grade gliomas: a case series
DiscussionThese preliminary findings suggest that18F-DOPA PET/CT allows an early and reliable assessment of metabolic response to the REG treatment. A major advantage of PET seems to be obtained in patients in whom MR is unable to differentiate non-response vs tumor pseudo-progression. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 1, 2021 Category: Radiology Source Type: research

Spotlight on: guideline on current good radiopharmacy practice (cGRPP) for the small-scale preparation of radiopharmaceuticals published in EJNMMI Radiopharmacy and Chemistry (2021)6:8
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 28, 2021 Category: Radiology Source Type: research

Chest computed tomography as a primary tool in COVID-19 detection: an update meta-analysis
ConclusionChest CT has high SEN, but the SPE is not ideal. It is highly recommended to use a combination of different diagnostic tools to achieve sufficient SEN and SPE. It should be taken into account as a diagnostic tool for current COVID-19 detection, especially for patients with symptoms. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 26, 2021 Category: Radiology Source Type: research

The role of PET radiomic features in prostate cancer: a systematic review
ConclusionTo date, although PET literature appears still too narrow to draw definitive conclusions, PET-derived RFs appear promising in PCa. ML seems an important tool that may contribute to the widespread use of radiomics and subsequent implementation in the clinical setting. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 25, 2021 Category: Radiology Source Type: research

Methodological quality of systematic reviews used in clinical practice guidelines: focus on clinical imaging
ConclusionThe  methodological quality of systematic reviews in guidelines for intervention radiology and mammography screening was lower than that in guidelines for other topics. Diagnostic imaging guidelines should also be assessed for the quality of systematic review evidence underlying their recommendations . (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 22, 2021 Category: Radiology Source Type: research

Prevalence of physiological uptake in the pancreas on somatostatin receptor-based PET/CT: a systematic review and a meta-analysis
ConclusionsHigh radiopharmaceutical uptake in the head and uncinate process of the pancreas is frequent at somatostatin receptor-based PET/CT and it should be recognized by nuclear medicine physicians to prevent unnecessary additional investigations. In addition, next generation PET/CT tomographs might increase the prevalence of this finding. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 21, 2021 Category: Radiology Source Type: research

Methods for preparation and administration of lutetium-177 oxodotreotide 3.7  GBq: proceedings from an Italian advisory board
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 20, 2021 Category: Radiology Source Type: research

Performance of 18 F-FDG-PET/CT as a next step in the search of occult primary tumors for patients with head and neck squamous cell carcinoma of unknown primary: a systematic review and meta-analysis
Conclusions18F-FDG PET/CT is useful as a next step in the search of occult primary tumors in HNSCC-UP patients defined by endoscopy with or without CT/MRI. However, in light of the high false-positive proportion, confirmatory histological investigations should be viewed as necessary practice upon positive PET/CT findings. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 15, 2021 Category: Radiology Source Type: research

PET findings after COVID-19 vaccination: “Keep Calm and Carry On”
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 13, 2021 Category: Radiology Source Type: research

Correction to: Lean approach to improving performance and efficiency in a nuclear medicine department
A correction to this paper has been published: https://doi.org/10.1007/s40336-021-00427-y (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 10, 2021 Category: Radiology Source Type: research

Magnetic resonance imaging in mood disorders: a bibliometric analysis from 1999 to 2020
ConclusionBrain structure and network, sex differences, and treatment-associated brain changes are key topics of future research. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 6, 2021 Category: Radiology Source Type: research

Breast cancer: initial workup and staging with FDG PET/CT
ConclusionFDG-PET/CT is useful for staging patients with breast cancer, starting from clinical stage IIB. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 27, 2021 Category: Radiology Source Type: research

Applying thyroid cancer guidelines: a difficult task
AbstractClinical practice guidelines are a powerful tool in Medicine and provide evidence-based guidance on decision-making regarding diagnosis, management, and treatment. However, the implementation of guidelines can be quite challenging in certain cases. Applying Thyroid Cancer guidelines appears to be a difficult task, particularly regarding the decision for Iodine-131 therapy. The main reason for this, is the great number of available guidelines as well as, their partially controversial suggestions, while often guidelines prove to be rather confusing. All the aforementioned convert clinical practice from pure sciences ...
Source: Clinical and Translational Imaging - April 19, 2021 Category: Radiology Source Type: research

Impact of 18 F-FDG PET on the management of recurrent breast cancer: a meta-analysis
Conclusions18F-FDG PET has a major impact on the management of patients with breast cancer after curative surgery. These findings suggest that18F-FDG PET should be performed in patients with breast cancer in cases involving equivocal or suspicious recurrence/metastasis on conventional imaging or in cases involving elevated tumor markers during follow-up. However, this study does not support the routine use of18F-FDG PET for surveillance in breast cancer. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 15, 2021 Category: Radiology Source Type: research

Somatostatin receptor imaging and therapy in differentiated thyroid cancer: a ray of hope or the flash before total darkness?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 5, 2021 Category: Radiology Source Type: research

Androgen deprivation therapy and its modulation of PSMA expression in prostate cancer: mini review and case series of patients studied with sequential [ 68 Ga]-Ga-PSMA-11 PET/CT
ConclusionsAlthough clinical evidence remains inconclusive, a short-term ADT administration may seem to increase PSMA expression in some selected cases, while long-term ADT might have the opposite effect at least in castrate sensitive prostate cancer (CSPC) patients, even if potentially leading to an early selection of those lesions most at risk of becoming castrate resistant. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 23, 2021 Category: Radiology Source Type: research

Is it all about money?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 12, 2021 Category: Radiology Source Type: research

Prevalence of thyroid dysfunction in patients with COVID-19: a systematic review
ConclusionLiterature data show that thyroid dysfunction is present in a significant percentage of patients with COVID-19. Assessment of thyroid function may be considered in symptomatic COVID-19 patients to have a baseline before introducing thyroid-interfering drugs and those requiring high-intensity care. Further, well-designed studies are needed to better elucidate the impact of COVID-19 on thyroid function and inform thyroid function testing and thyroid dysfunction management in COVID-19 patients. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 11, 2021 Category: Radiology Source Type: research

Systematic review of lung shunt fraction quantification comparing SPECT/CT and planar scintigraphy for yttrium 90 radioembolization planning
ConclusionThe current clinical assessment of LSF is substantially overestimated by 2D planar scintigraphy when compared to 3D SPECT/CT. However, unclearness of blinding between the index test and reference standard was an area of quality concern. Hence, further randomized or prospective studies are needed to strengthen the role of SPECT/CT in lung shunt fraction estimation. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 10, 2021 Category: Radiology Source Type: research

Lean approach to improving performance and efficiency in a nuclear medicine department
ConclusionLean tools have the potential to reduce error and costs and improve quality. Because Radiology and Nuclear Medicine departments are similar concerning patient processes, they have plenty of potentials to benefit from systematic Lean adoption. We believe these principles can be applied to other health care delivery areas. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 9, 2021 Category: Radiology Source Type: research

SeHCAT test for bile acid malabsorption: may “the old” become “the gold one” in the diagnostic burden of chronic diarrhea?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 6, 2021 Category: Radiology Source Type: research

Assessment of therapy response to Regorafenib by 18 F-DOPA-PET/CT in patients with recurrent high-grade gliomas: a case series
DiscussionThese preliminary findings suggest that18F-DOPA PET/CT allows an early and reliable assessment of metabolic response to the REG treatment. A major advantage of PET seems to be obtained in patients in whom MR is unable to differentiate non-response vs tumor pseudo-progression. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 6, 2021 Category: Radiology Source Type: research