Impact of gadolinium-based contrast agents on attenuation correction and tracer quantification in neuroendocrine malignancies in [68Ga]-DOTATOC PET/MRI
ConclusionNo major deviations between the measured values in pre- and post-contrast attenuation-corrected PET images have been observed. Minor alterations may occur due to the application of a contrast medium. This has to be accounted for in patients undergoing repeated PET/MR imaging, especially in the context of therapy monitoring.Advances in knowledgeOur lesion-based analysis examines the impact of gadolinium-based contrast agents on attenuation correction of PET/MRI and the subsequent influence on tracer quantification. Our lesion based approach did not found any major differences between both assessments, indicating t...
Source: Clinical and Translational Imaging - April 25, 2024 Category: Radiology Source Type: research
Investigating the diffuse pancreatic expression of [68Ga]Ga-DOTA-FAPI: location, timing, and molecular imaging approaches
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 23, 2024 Category: Radiology Source Type: research
The diagnostic performance of [18F]FDG PET/CT in the detection of melanoma recurrence: a systematic review and meta-analysis
ConclusionIt finds that [18F]FDG PET/CT has excellent diagnosis performance in identifying malignant melanoma recurrence. Its application could improve patient prognosis by detecting and treating recurrences earlier. Further studies need more prospective large samples. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 23, 2024 Category: Radiology Source Type: research
Interobserver assessment of metabolic patterns in progressive primary aphasia through the application of [18F]-Fluorodeoxiglucose PET/CT
ConclusionOverall, the findings of the present study are consistent with previous research on the use of [18F]-FDG PET/CT in the evaluation of PPA. The study adds to the existing literature by demonstrating the utility of [18F]-FDG PET/CT in differentiating the variants of primary progressive aphasia and by evaluating interobserver variability in image interpretation. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 22, 2024 Category: Radiology Source Type: research
Head-to-head comparison of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in the diagnosis of gastric and pancreatic cancer: a systematic review and meta-analysis
Conclusion[68Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [18F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [18F]FDG PET and [68Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 15, 2024 Category: Radiology Source Type: research
Early response assessment to targeted therapy in metastatic clear cell renal cancer using 68Ga-PSMA-11 PET/CT and comparison with CECT: a feasibility study
ConclusionEarly response assessment with68Ga-PSMA-11 PET/CT is feasible and provides more accurate prognostic information than CECT in metastatic clear cell RCC patients undergoing targeted therapy.Trial registration numberCTRI/2021/05/033805 (date of registration: 25/05/21) (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 9, 2024 Category: Radiology Source Type: research
[18F]FDG PET/CT imaging of spinal infections
AbstractThe annual incidence of spinal infections has been rising significantly over the last years and is expected to increase even further. Spinal infections may include infection of the vertebral body and intervertebral disc (spondylodiscitis), paravertebral abscess, epidural abscess and septic arthritis of the facet joints. Positron emission tomography (PET) with [18F]FDG has high sensitivity for detecting spinal infections, may help in differentiating between spinal infection subtypes and is able to detect dissemination of infection outside the spine. [18F]FDG PET/CT is especially indicated if MRI is inconclusive, in ...
Source: Clinical and Translational Imaging - April 8, 2024 Category: Radiology Source Type: research
Pediatric congenital pulmonary malformations: key findings at imaging
AbstractPediatric congenital pulmonary malformations are rare abnormalities which may affect airways, pulmonary parenchyma, and vasculature and diagnostic imaging plays a significant role in their identification and characterization. Although, nowadays, often the diagnosis of this heterogeneous group of malformations is performed prenatally by ultrasound and/or fetal magnetic resonance, after birth, computed tomography represents the main technique. Radiographs are often used as first line diagnostic tool while magnetic resonance demonstrated to be especially beneficial to investigate some malformations such as bronchogeni...
Source: Clinical and Translational Imaging - April 2, 2024 Category: Radiology Source Type: research
Equivocal bone lesions on PSMA PET/CT: systematic review and meta-analysis on their prevalence and malignancy rate
ConclusionsEquivocal bone lesions are often encountered on PSMA PET/CT but exihibit a low malignancy rate. Compared to other radioligands, [18F]PSMA-1007 requires special attention as it is associated with a higher frequency and lower rate of metastasis. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 28, 2024 Category: Radiology Source Type: research
Denoising approaches by SubtlePET ™ artificial intelligence in positron emission tomography (PET) for clinical routine application
AbstractPositron emission tomography (PET) plays an important role in the diagnosis and surveillance of neoplastic diseases. PET images may show higher noise levels than other imaging modalities, especially in a dose- or time-saving approach. Artificial Intelligence techniques can improve the signal-to-noise ratio in PET image reconstruction. Deep learning approaches have made significant advances in comprehensive data retrieval and de-noising. Artificial Intelligence de-noising in PET is a very promising approach that could allow shorter scan times or lower radiopharmaceutical dose administration. We reviewed studies abou...
Source: Clinical and Translational Imaging - March 11, 2024 Category: Radiology Source Type: research
The prognostic role of metabolic tumor burden in 18F-FDG PET/CT in the primary staging of rectal cancers
ConclusionThis research suggests that whole-body tumor burden assessed through staging FDG PET/CT can serve as an independent imaging biomarker for prognostication in rectal cancer patients. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 4, 2024 Category: Radiology Source Type: research
Assessment of diffuse bone marrow involvement on 18F-fluoro-D-glucose PET/computed tomography
ConclusionThe BM activity of the appendicular skeleton was more significant in distinguishing BM malignant and benign disorders. Range of humerus FDG uptake combined femurs SUVmax, neutrophil count and age was reliable for assessing diffuse BM involvement. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 4, 2024 Category: Radiology Source Type: research
Sentinel node biopsy in gynaecological cancers: state of art and future perspectives
ConclusionSentinel node biopsy has been widely validated in well-selected patients with early-stage vulvar, cervical and endometrial cancers. It is essential to standardise the acquisition protocol, including SPECT/CT imaging, for an improved surgical planning and a personalised approach. Recent technological advances, such as hybrid tracers and intraoperative tools, may efficiently guide gynaecological cancer surgery. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 4, 2024 Category: Radiology Source Type: research
Gender balance in skeletal radiology: suffrage rather than suffering?
AbstractReaching equity in the distribution of opportunity between men and women is in the agenda of premier international agencies worldwide, and in the last decades a significant improvement in women ’s access to care and education as well as in terms of equality in the labor market has been achieved. In the medical field and, in particular, in radiology, the number of women progressively increased but still much has to be done to guarantee equal opportunities. Aiming to provide an overview of the European musculoskeletal imaging community regarding gender equity, we developed a 39-item survey addressed to the 2481 mem...
Source: Clinical and Translational Imaging - March 1, 2024 Category: Radiology Source Type: research
Prognostic significance of [18F]FDG PET metabolic parameters in adults and children with soft-tissue sarcoma: a meta-analysis
ConclusionThis study suggests that [18F]FDG PET parameters could serve as important prognostic markers in adults with STS, but not in pediatric patients. Future studies with larger cohorts and uniform methodologies are critical to confirm and build upon these findings. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 27, 2024 Category: Radiology Source Type: research
