Diagnostic role of 11 C-methionine PET/CT in patients with multiple myeloma and other plasma cell malignancy: a literature review
AbstractIn patients with plasma cell malignancy (multiple myeloma and plasmacytoma), whole-body low-dose computed tomography, magnetic resonance imaging, and18F-FDG PET/CT are widely applied and suggested by international guidelines to assess the disease extension. Recently,11C-methionine PET/CT has proven to be promising in those patients compared to other diagnostic techniques. We aimed to review current literature on the state of the art of11C-methionine PET/CT in patients with plasma cell malignancy. PubMed/MEDLINE database was screened to find articles regarding the role of11C-methionine PET/CT in plasma cell malignan...
Source: Clinical and Translational Imaging - January 5, 2021 Category: Radiology Source Type: research
False iodine-131 MIBG scintigraphy findings in adrenal tumors: correlation with MR imaging
In this study, we report our experience regarding the occurrence of false radionuclide findings in adrenal iodine-131 MIBG scintigraphy. We present a total of five patients in which nuclear images were false negative or positive in three and two cases, respectively, according to the standard radionuclide established criteria. In particular, the three cases of false-negative MIBG images consisted of two patients with necrotic or cystic pheochromocytomas (Cases 1 and 3) and a patient with a small pheochromocytoma (Case 2); the two cases of false-positive MIBG imaging consisted of a patient with an adenoma showing intense tra...
Source: Clinical and Translational Imaging - December 16, 2020 Category: Radiology Source Type: research
Artificial intelligence techniques support nuclear medicine modalities to improve the diagnosis of Parkinson ’s disease and Parkinsonian syndromes
ConclusionThe recent literature provides strong evidence that AI techniques can play a fundamental role in the diagnosis of movement disorders by means of nuclear medicine modalities, therefore paving the way towards personalized medicine. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 14, 2020 Category: Radiology Source Type: research
Radiolabeled fibroblast activation protein inhibitor (FAPI) pet in oncology: has the time come for 18 F-fluorodeoxyglucose to think to a well-deserved retirement?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 30, 2020 Category: Radiology Source Type: research
Clinical applications of receptor-binding radiopharmaceutical 99m Tc-Tilmanocept: sentinel node biopsy and beyond
AbstractPurpose99mTc-tilmanocept is the first mannose-containing, receptor-directed, radiopharmaceutical for molecular imaging and mapping of sentinel lymph nodes (SLNs) in solid tumor staging. This review focuses on the approved and innovative clinical application of99mTc-tilmanocept.Results and conclusion99mTc-Tilmanocept is a new-generation radiotracer designed to overcome certain limitations of the conventionally used radiocolloids. The superior efficacy profile of99mTc-tilmanocept has been demonstrated in several preclinical and clinical studies based on its specific properties like rapid injection site clearance, hig...
Source: Clinical and Translational Imaging - November 17, 2020 Category: Radiology Source Type: research
Choline PET/CT and intraoperative management of primary brain tumors. New insights for contemporary neurosurgery
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 12, 2020 Category: Radiology Source Type: research
Pictorial review of the clinical applications of MIBG in neuroblastoma: current practices
ConclusionIodine-123-labeled meta-iodobenzylguanidine (mIBG) is the cornerstone of functional imaging for staging, therapeutic response monitoring, prognostication, and the detection of recurrence in patients with neuroblastoma. MIBG images are interpreted both qualitatively and semiquantitatively. The International Neuroblastoma Risk Group Staging System and the International Neuroblastoma Staging System are used to stage the disease extent before and after surgical resection, respectively. The Revised International Neuroblastoma Response Criteria, updated in 2017, stratify the treatment response based on findings on func...
Source: Clinical and Translational Imaging - November 5, 2020 Category: Radiology Source Type: research
PET –CT for staging patients with muscle invasive bladder cancer: is it more than just a fancy tool?
ConclusionPET –CT/MRI appears to have higher diagnostic accuracy than CT or MRI for local and distant staging of MIBC but it cannot (yet) be recommended in clinical practice because the quality of the evidence is insufficient and the effects on treatment decisions and patient’s outcome remain unclear. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 4, 2020 Category: Radiology Source Type: research
Radiolabelled PSMA PET/CT or PET/MRI in hepatocellular carcinoma (HCC): a systematic review
ConclusionRadiolabelled PSMA imaging seems to be useful in analyzing hepatocellular carcinoma. Further studies enrolling a wider population are needed to clarify the real clinical and diagnostic role of radiolabelled PSMA in this setting. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 27, 2020 Category: Radiology Source Type: research
CuATSM PET to diagnose age-related diseases: a systematic literature review
ConclusionCuATSM uptake is higher in neurological and cardiovascular diseases and associated with disease severity and duration. Further investigations using CuATSM PET in other age-related diseases are needed. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 22, 2020 Category: Radiology Source Type: research
18F-FDG PET/MRI in adult sarcomas
Conclusions18F-FDG PET/MRI has promising indications in patients with sarcomas, from disease staging to the assessment of response to treatment. Further studies are warranted to confirm these results, especially in subgroups with specific histopathological features. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 20, 2020 Category: Radiology Source Type: research
Value of chest computed tomography scan in diagnosis of COVID-19; a systematic review and meta-analysis
ConclusionSimultaneous observation of GGO and other features of viral pneumonia in CT scan had optimum performance in detection of COVID-19. However, it is suggested to make the final diagnosis based on both CT scan and RT-PCR, as none of the two diagnostic modalities are reliable alone. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 12, 2020 Category: Radiology Source Type: research
Diffusion tensor imaging of the roots of the brachial plexus: a systematic review and meta-analysis of normative values
ConclusionsThe FA and MD of the roots of the brachial plexus vary according to experimental conditions and participant factors. We provide summary estimates of the normative values in different conditions which may be valuable to researchers and clinicians alike. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 9, 2020 Category: Radiology Source Type: research
Accidental diagnosis of COVID-19 pneumonia after 18F FDG PET/CT: a case series
ConclusionSuspicious accidental COVID-19 findings in Nuclear Medicine Department need to be reported and appropriately evaluated to implement proper supportive treatment and infection control measures. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 23, 2020 Category: Radiology Source Type: research
FDG PET/CT versus somatostatin receptor PET/CT in TENIS syndrome: a systematic review and meta-analysis
ConclusionFDG PET/CT has a higher capability to detect metastases than SSTR PET/CT in patients with TENIS Syndrome. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 23, 2020 Category: Radiology Source Type: research
