Hypoxia PET imaging beyond 18 F-FMISO in patients with high-grade glioma: 18 F-FAZA and other hypoxia radiotracers
ConclusionHypoxia PET imaging has the potential to provide useful information for the clinicians and to guide hypoxia tailored treatments. According to the present literature, the most promising hypoxic tracer seems to be18F-FAZA, but well-designed and wide trials to validate hypoxia radiotracers and evaluate their clinical utility in daily practice are still lacking. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 5, 2020 Category: Radiology Source Type: research
Clinical and translational imaging 2020: update on progresses thanks to readers and editors
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 5, 2020 Category: Radiology Source Type: research
Radiolabeled somatostatin analogues for the diagnosis and therapy of NETs: upcoming new strategies
ConclusionsInteresting perspectives are opened by the availability of PET/MRI and full digital PET/CT due to the improved detector sensitivity and spatial resolution. At the same time, new strategies will be sought based on the association of PRRT with old and/or newer oncologic therapeutic strategies, or on the use of radionuclide cocktails. An intriguing future can be envisaged due to the commercial availability of radiopharmaceuticals labeled with alpha emitting radionuclides, which may allow better results compared to beta-emitters, likely due to the bystander and/or abscopal effect. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 23, 2020 Category: Radiology Source Type: research
The need of a clinically oriented reporting of 18 F-FDG PET/CT in non-small cell lung cancer (NSCLC)
ConclusionA multidisciplinary approach to cancer patients has a significant impact in their management and outcome. A clinically-oriented report is needed to transfer the relevant information to the clinician to fully exploit PET potential in NSCLC. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 23, 2020 Category: Radiology Source Type: research
18 F-FDG PET/CT role in Burkitt lymphoma
ConclusionsBL is an18F-FDG-avid lymphoma histotype and18F-FDG PET/CT is the best imaging tool to stage patients affected by BL. Preliminary findings about the usefulness of FDG PET/CT features in the evaluation of treatment response and prognosis are available without strong evidence. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 23, 2020 Category: Radiology Source Type: research
18 F-FMISO PET imaging: insights over MRI in patients with glioma
ConclusionHypoxia PET imaging has demonstrated potential benefits for grading, diagnostic and prognostic purposes, despite the lack of tangible results able to introduce such method in a wide clinical setting. MRI remains the gold standard in the morphologic evaluation of glioma, but the integration of results provided by18F-FMISO PET imaging concerning hypoxia might provide new crucial information in patients with glioma. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 15, 2020 Category: Radiology Source Type: research
18 F-FDG in the differential diagnosis of neurodegenerative dementias
AbstractThe diagnostic workflow of patients with cognitive decline needs an extensive clinical evaluation. The use of FDG-PET can be helpful because the finding of a rather specific pattern of hypometabolism could point to specific neurodegenerative disorders. In patients with memory impairment and visuo-spatial deficits, FDG-PET may reveal a pattern of temporo-parietal hypometabolism that is associated with Alzheimer ’s disease or a more extended area of hypometabolism that spreads to the occipital cortex, as in posterior cortical atrophy indicating signs of neurodegeneration in the associative visual cortex. In the spe...
Source: Clinical and Translational Imaging - November 27, 2019 Category: Radiology Source Type: research
Multimodal therapy of advanced differentiated thyroid cancer, with emphasis on the role of radioiodine
AbstractIntroductionDifferentiated thyroid cancer (DTC) accounts for 95% of all thyroid cancers and is generally an indolent tumor, tending to present with limited loco-regional disease with an excellent long-term survival after treatment. However, 5 –10% present with locally advanced disease and aero-digestive tract invasion or distant metastases that are the main cause of thyroid cancer-related deaths.MethodsThe present review aims to underline the complex management of advanced DTC including treatment of gross extra-thyroidal extension, recurrent loco-regional, or distant metastatic disease.ResultsRadioiodine therapy ...
Source: Clinical and Translational Imaging - November 21, 2019 Category: Radiology Source Type: research
Liquid biopsies and molecular imaging: friends or foes?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 21, 2019 Category: Radiology Source Type: research
Diagnostic performance of FDG PET in large vessel vasculitis
ConclusionsOverall, FDG PET has a good diagnostic performance for the detection of active disease in LVV. Future prospective studies, more consistent with the joint procedural recommendations in LVV, are needed to support the use of standardized procedures and reproducible criteria for defining the presence of LVV with FDG PET/CT. Hybrid imaging and novel radiopharmaceuticals, more specific than FDG, are the future of PET in this field. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 17, 2019 Category: Radiology Source Type: research
PSMA-PET/CT imaging in prostate cancer: why and when
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 14, 2019 Category: Radiology Source Type: research
Management of hyperglycemia in oncological patients scheduled for an FDG-PET/CT examination
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 27, 2019 Category: Radiology Source Type: research
Hybrid cardiac PET/MR: the value of multiparametric assessment in cardiac sarcoidosis
ConclusionHybrid cardiac PET/MR is a valuable tool for the diagnosis of cardiac sarcoidosis. Moreover, as it offers activity and tissue characterisation, it can be used to tailor and monitor treatment. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 19, 2019 Category: Radiology Source Type: research
PET/MRI for neuroendocrine tumors: a match made in heaven or just another hype?
ConclusionThe current literature reports successful technical feasibility of PET/MRI for imaging of NETs. While whole-body PET/CT in conjunction with an abdominal MRI may serve as a comprehensive approach for baseline staging, follow-up with PET/MRI may be preferred for those with liver-only disease. Another possible role for PET/MRI is to provide a multiparametric approach to follow-up of response to treatment. With further advances in MRI imaging acquisitions and post-processing techniques, PET/MRI may become more applicable to a broader group of patients with NETs, and possibly the imaging modality of choice for this pa...
Source: Clinical and Translational Imaging - September 19, 2019 Category: Radiology Source Type: research
Advanced approaches to imaging primary breast cancer: an update
ConclusionConventional BC-imaging modalities have both advantages and limitations. When utilized in combination, they are often complementary. For example, a limitation of mammography is low sensitivity in dense breasts. The addition of DBT lessens this limitation by providing three-dimensional (3D) images of the breast that minimizes the effect of overlying breast tissue. Additionally, US added to mammography in dense breasts increases screening sensitivity and has the advantages of accessibility and lack of ionizing radiation. MRI is currently the most sensitive method used for detecting BC. When MRI is not suitable for ...
Source: Clinical and Translational Imaging - September 19, 2019 Category: Radiology Source Type: research
