Thyroid incidentalomas in PSMA PET/CT: a systematic review and meta-analysis
ConclusionTI is rarely detected on PSMA PET/CT, and the risk of malignancy can reach considerable values in lesions with a focal pattern. Therefore, follow-up and appropriate clinical investigation of lesions with focal PSMA uptake in the thyroid are important. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 27, 2022 Category: Radiology Source Type: research
The diagnostic performance of 2-[18F]FDG PET/CT for the recurrent colorectal cancer in patients with elevated CEA versus normal CEA: a systematic review and meta-analysis
ConclusionsBased on the pooled results, we tentatively conclude that 2-[18F]FDG PET/CT has a good performance in recurrent CRC patients and the diagnostic performance of 2-[18F]FDG PET/CT will significantly improve if there is a prior CEA elevation. Further prospective studies with a larger sample size would draw more accurate conclusions. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 16, 2022 Category: Radiology Source Type: research
Myocardial perfusion imaging in the era of COVID-19: a systematic review
ConclusionWe observed through the article review that CT scans performed in combination with MPI are crucial and should be interpreted within the context of COVID, especially during outbreaks. Moreover, we discovered that in the initial months of the pandemic, the number of SPECT MPIs performed globally decreased, with the fall being more significant in some countries, primarily in low- to middle-income regions. Lastly, we found that individuals with a history of COVID-19 may be more prone to having MPIs that demonstrate abnormalities, such as ischemia.Graphical abstract (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 15, 2022 Category: Radiology Source Type: research
SSTR-based theranostics in neuroendocrine prostate cancer (NEPC)
ConclusionsSince the main evidence in NEPC cells is the predominance of SSTR-1, theoretically the design of a radiopharmaceutical with greater affinity to this receptor could be useful for therapeutic and diagnostic purposes; however, the possibility of using peptide receptor radionuclide therapy (PRRNT) in patients with intense uptake of available radiotherapists (e.g., [68 Ga]Ga-DOTA-TATE) should not be ignored in following researches. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 12, 2022 Category: Radiology Source Type: research
The diagnostic performance of 18F-FDG PET/CT in recurrent renal cell carcinoma: a systematic review and meta-analysis
Conclusion18F-FDG PET/CT could serve as a prominent surveillance technique with robust diagnostic performance in detecting recurrence in RCC patients, which may be adopted as a routine monitoring strategy for advanced RCC. However, further prospective studies are still required to demonstrate more thorough and precise performance metrics. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 8, 2022 Category: Radiology Source Type: research
Fair play: towards gender equality in nuclear medicine
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 6, 2022 Category: Radiology Source Type: research
Pharmacological protection of the thyroid gland against radiation damage from radioactive iodine labeled compounds in children: a systematic review
ConclusionsThe lack of well-designed studies impairs making strong recommendations on the optimal way to prevent thyroid damage when using radioactive coupled ligands for medical interventions. To improve the protection of the thyroid against radiation damage by I-131, well-designed randomized clinical trials with sufficient follow-up time, comparing new protective strategies ’ effects on valid and well-defined thyroid outcomes are needed. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 27, 2022 Category: Radiology Source Type: research
“It is folly to measure the true and the false by our own capacity”—M. de Montaigne
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 26, 2022 Category: Radiology Source Type: research
Ultrasmall iron oxide nanoparticles and gadolinium-based contrast agents in magnetic resonance imaging: a systematic review and meta-analysis
ConclusionStatistical studies confirmed that US-IO nanoparticles with a size of less than 5 nm in positive contrast MRI had higher r1 and approximately similar r2/r1 in different studies, as well as better than the Dotarem in increasing signal intensity. Therefore, US-IO NPs could be a hopeful candidate for use as T1-weighted contrast agents in MRI. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - October 15, 2022 Category: Radiology Source Type: research
The role of 18F-FDG PET/CT in abdominal and pelvic leiomyosarcoma: a literature review
ConclusionAlthough additional studies are needed,18F-FDG PET/CT seems to be a potential useful diagnostic tool in the clinical management of abdominopelvic LMS patients. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 30, 2022 Category: Radiology Source Type: research
Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging
ConclusionA dual-imaging modality with the combination of different tracing or contrast agents is a future development of aerosolised micro and nanoparticles for lung imaging to improve diagnosis success.Graphical abstract (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 29, 2022 Category: Radiology Source Type: research
Theranostic approach in liver cancer: an emerging paradigm to optimize personalized medicine
ConclusionThere is growing evidence for applicability of theranostic approach in these patients to enhance early identification, patient evaluation, targeted treatment, restaging, follow-up, and palliation of symptoms or slow down tumor progression. However, this field requires multidisciplinary expertise and collaboration. The increased access to tracers, training multidisciplinary teams, using novel trial designs, and establishing initiatives to share and re-analyze data from clinical imaging studies can encourage the use of molecular nuclear imaging in both clinical research and practical. It is also well recognized tha...
Source: Clinical and Translational Imaging - September 17, 2022 Category: Radiology Source Type: research
99mTc-labeled colloid SPECT/CT versus planar lymphoscintigraphy for sentinel lymph node detection in patients with breast cancer: a meta-analysis
ConclusionsThis meta-analysis favors SPECT/CT over PL for the identification of SLN in patients with primary breast cancer at staging due to higher DR, more SLNs depicted, and a significant proportion of subjects with additional detected SLNs by SPECT/CT compared to PL. Furthermore, SPECT/CT positively influences the surgical procedure. However, PL remains a satisfactory imaging option for imaging departments not equipped with SPECT/CT due to its good patient-based DR. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 14, 2022 Category: Radiology Source Type: research
Comparing [18F]FDG PET/CT response criteria in melanoma and lung cancer patients treated with immunotherapy: a systematic review
ConclusionThere is insufficient evidence to decide whether the predictive value of immunotherapy PET/CT criteria is superior to conventional ones for OS, in melanoma and lung cancer treated with immunotherapy. A different research strategy is needed to reach the answer: PET/CT research should focus on directly comparing (modifications of) immunotherapy and conventional PET/CT criteria within a homogenous population with standardized PET timing, immunotherapy categories and OS definition. A consortium-based comprehensive database with individual patient data could be the solution. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 29, 2022 Category: Radiology Source Type: research
PET radiotracers in glioma: a review of clinical indications and evidence
ConclusionsOur review provides the state of art role of PET/CT in neuro-oncology, as well as the future perspectives of newer radiotracers for application in the clinical management of patients with glioma. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 27, 2022 Category: Radiology Source Type: research
