Comparing [18F]FDG PET/CT response criteria in melanoma and lung cancer patients treated with immunotherapy: a systematic review
ConclusionThere is insufficient evidence to decide whether the predictive value of immunotherapy PET/CT criteria is superior to conventional ones for OS, in melanoma and lung cancer treated with immunotherapy. A different research strategy is needed to reach the answer: PET/CT research should focus on directly comparing (modifications of) immunotherapy and conventional PET/CT criteria within a homogenous population with standardized PET timing, immunotherapy categories and OS definition. A consortium-based comprehensive database with individual patient data could be the solution. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 29, 2022 Category: Radiology Source Type: research
PET radiotracers in glioma: a review of clinical indications and evidence
ConclusionsOur review provides the state of art role of PET/CT in neuro-oncology, as well as the future perspectives of newer radiotracers for application in the clinical management of patients with glioma. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 27, 2022 Category: Radiology Source Type: research
ImmunoPET for prostate cancer in the PSMA era: do we need other targets?
ConclusionImmunoPET pre-clinical studies have identified several biomarkers with potentially high impact on PC theranostics. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 21, 2022 Category: Radiology Source Type: research
COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives
DiscussionTherefore, awareness on vaccination status (timing, patient characteristics, and concurrent therapies) and knowledge on patterns of radiopharmaceutical uptake are necessary to properly interpret PET/CT findings. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 16, 2022 Category: Radiology Source Type: research
SARS-CoV-2 vaccination site as possible pitfall on somatostatin receptor imaging
We report the imaging findings of two NETs patients, A —following [177Lu] Lu-DOTATATE PRRT post therapy planar scintigraphy and single photon emission computed tomography with computed tomography (SPECT/CT), and B —following [68 Ga]Ga-DOTA-NOC positron emission tomography with computed tomography (PET/CT) respectively. Both studies were done few days after COVID-19 vaccination. Patient A showed a new focus of uptake in the left deltoid muscle; and Patient B showed uptake in the left deltoid and a left axillary lymph node. Nuclear Physicians need to be aware of pitfalls with somatostatin receptor radionuclide imaging p...
Source: Clinical and Translational Imaging - August 5, 2022 Category: Radiology Source Type: research
Whole-body tumor burden in PET/CT expert review
ConclusionPET/CT whole-body tumor burden has an invaluable potential to assess prognosis. The accelerated radiopharmaceutical development will provide molecules and mechanisms to determine WBTB with advanced imaging qualification tools to further adjust radiotherapeutic doses in oncology. WBTB will most likely only become routinely accessible in clinical practice when fully automated programs become available and standardized. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 5, 2022 Category: Radiology Source Type: research
Radiolabeled FAP inhibitors as new pantumoral radiopharmaceuticals for PET imaging: a pictorial essay
We present clinical cases of breast cancer, lung cancer, gastric cancer, hepatocellular carcinoma, gynecological cancers and peritoneal carcinomatosis, as well as an introduction of the biodistribution of FAPi. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 3, 2022 Category: Radiology Source Type: research
Advanced neuroimaging studies: a patient-centered revolution
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - August 3, 2022 Category: Radiology Source Type: research
Basic premises: searching for new targets and strategies in diffuse gliomas
ConclusionDiffuse gliomas show resistance to several molecularly targeted therapies and immunotherapies effective in other solid cancers. Glioma heterogeneity and the immunologically “cold” microenvironment have been invoked as possible reasons. Nonetheless, novel approaches can be beneficial in specific populations of glioma patients. In this complex interplay, medical imaging can reliably generate data at “-omics” level with predictive, theranostic, and/or prognostic p urposes. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 31, 2022 Category: Radiology Source Type: research
18F-Choline PET/CT or PET/MR and the evaluation of response to systemic therapy in prostate cancer: are we ready?
We report the cases of seven patients affected by PCa, in which [18F]F-choline PET (either with computed tomography —CT or magnetic resonance imaging—MR) contributed significantly in the systemic therapy response evaluation.Results and conclusion[18F]F-choline PET/CT or PET/MR demonstrated to be a useful imaging modality in the assessment of response to systemic therapy in metastatic PCa patients, irrespective of the stage of disease (either in hormone sensitive and in castrate resistant condition) and the kind of systemic treatment. In most cases, PSA serum values and [18F]F-choline PET showed a synchronous disease ev...
Source: Clinical and Translational Imaging - July 28, 2022 Category: Radiology Source Type: research
“We ask the ascetics to come down from the columns…”
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 28, 2022 Category: Radiology Source Type: research
Forensic applications of micro-computed tomography: a systematic review
ConclusionForensic applications of micro-CT progressively increased in the last 5 years with very promising results. According to this evidence, we might expect in the near future a shift of its use from research purposes to clinical forensic cases. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 26, 2022 Category: Radiology Source Type: research
The new era of bio-molecular imaging with O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) in neurosurgery of gliomas
ConclusionAlthough conventional MRI has been shown to be reliable technique to identify gliomas in terms of morphological concerns, some important limitations depending on the incapacity to reveal the tumor biology have emerged. The 18F-FET PET has been established to provide early information of functional nature including real tumor extension, grade, and metabolic residual disease. Therefore, the use of 18F-FET PET has progressively increased suggesting a potential shift from a morphological to functional plus morphological neurosurgery. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 23, 2022 Category: Radiology Source Type: research
Covid-19 and radiotherapy: a systematic review after 2 years of pandemic
DiscussionRT has played a key role in Covid-19 pandemic as it has proved more resilient than surgery and chemotherapy. The impact of the accelerated use of hypofractionated RT and telemedicine will make these strategies central also in the post-pandemic period. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 23, 2022 Category: Radiology Source Type: research
18F-FDG PET/CT in the clinical-diagnostic workup of patients treated with immunotherapy: when and how?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - July 23, 2022 Category: Radiology Source Type: research
