Reduction in variability of dopamine transporter measures using SPECT and ultra-high-resolution fan beam collimators: comparison with parallel-hole collimators in healthy controls for a clinical reference database
ConclusionThe SBR values obtained using UHR-FB have an age-related distribution comparable to that of healthy subjects but with lower variability. The reduction rate per decade was similar between the two databases but the gender effect was found only in the local database, probably related to the better performance of UHR-FB. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 24, 2024 Category: Radiology Source Type: research
Head-to-head comparison of [18F]FDG PET/MRI and [18F] FDG PET/CT for TNM staging in non-small cell lung cancer: a systematic review and meta-analysis
ConclusionsAccording to the pooled data, [18F]FDG PET/CT performed slightly better in terms of T staging than [18F]FDG PET/MRI. In contrast, with regard to N staging and M staging the staging accuracy of both imaging techniques was comparable. To ensure that results are reliable, more high-level investigations will be required to assess these imaging modalities, in addition to optimized PET/MRI procedures. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 23, 2024 Category: Radiology Source Type: research
Lymphoid organs ’ metabolism and its role in predicting the outcomes of patients with malignant melanoma treated with immunotherapy: an exploratory study
ConclusionsChanges in bone marrow FDG uptake may serve as potential indicators of treatment response and disease outcomes. SLR would be considered an interesting predictive and prognostic indicator. This study provides insights into the dynamic changes of metabolic parameters during immunotherapy and their clinical implications in malignant melanoma patients. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 13, 2024 Category: Radiology Source Type: research
GEP-NETs radiomics in action: a systematical review of applications and quality assessment
ConclusionFew studies focused on prognosis or treatment response prediction, indicating potential for future research. While overall improvements have been made, the majority of studies still exhibit low quality. Optimizing dataset quality, model assessment, and reporting of the radiomics workflow remains necessary. The three commonly used journal evaluation metrics may not accurately reflect the quality of a radiomics study. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 13, 2024 Category: Radiology Source Type: research
Value of 2-[18F]FDG-PET/CT in identifying immune-related adverse events in patients with melanoma or non-small cell lung cancer: a systematic scoping review
ConclusionStudies suggested that 2-[18F]FDG-PET/CT is a valuable, non-invasive tool for detecting adverse events to anticancer treatment with ICIs. Sensitivity for the most commonly investigated irAEs, including thyroiditis, colitis, and pneumonitis, was generally high. Specificity was more varying and poorly reported. Prospective studies exploring the clinical impact are needed to determine the role and optimal timing of 2-[18F]FDG-PET/CT in identifying irAEs. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - February 9, 2024 Category: Radiology Source Type: research
MR imaging characterization of pheochromocytoma: a comparison between typical and atypical tumor lesions
ConclusionThe imaging characterization of typical Pheos may be performed using MRI with specific imaging features; however, atypical Pheos represents a diagnostic challenge using MRI; in these tumors, cystic, necrotic, hemorrhagic, or fat changes may occur; thus, diagnostic pitfalls should be taken into consideration for MRI interpretation of such tumor type in clinical practice. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 30, 2024 Category: Radiology Source Type: research
Exploring the efficacy of FAPI PET/CT in the diagnosis and treatment management of colorectal cancer: a comprehensive literature review and initial experience
AbstractFAPI PET/CT, an innovative medical imaging technique, has emerged as a promising method to target fibroblast activation protein (FAP). This novel approach offers numerous benefits, such as increased tumor absorption and reduced background noise. As a result, FAPI PET/CT images demonstrate a favorable ratio of tumor signal to background, allowing for precise tumor staging, characterization, and detection. Given the heightened expression of FAP in colorectal cancer (CRC), FAPI PET/CT has the potential to revolutionize CRC staging, restaging, and monitoring, as well as enhance treatment management and improve patient ...
Source: Clinical and Translational Imaging - January 24, 2024 Category: Radiology Source Type: research
Is there a role for [18F]-FMISO PET to guide dose adaptive radiotherapy in head and neck cancer? A review of the literature
ConclusionsOur results show that currently there is insufficient evidence to propose [18F]FMISO PET for radiotherapy dose adaptation in HNC in a routine clinical setting. Part of the challenge is that hypoxia is a dynamic phenomenon, and thus areas identified on a single scan may not be representative. At present, it is anticipated that [18F]FMISO PET will remain useful within the research setting only. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 23, 2024 Category: Radiology Source Type: research
Interferences on red blood cell radiolabeling with 99mTc: where is my technetium?
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 18, 2024 Category: Radiology Source Type: research
Positron emission tomography/magnetic resonance in musculoskeletal disorders: proper sequences and workflow optimization
AbstractMagnetic resonance imaging (MRI) represents a gold standard imaging for detection of oncologic and non-oncologic musculoskeletal disorders (MSK), owing to its high soft tissue contrast. Positron Emission Tomography (PET) was proven to be clinically useful in MSK, owing to its early detection of metabolic disfunction and its high accuracy for monitoring therapy response. With hybrid PET/MRI system, simultaneous availability of both morphologic and metabolic features could potentially enhance the diagnostic accuracy in MSK. Some technical issue should be overcome for best imaging quality: specific MR sequences for ac...
Source: Clinical and Translational Imaging - January 17, 2024 Category: Radiology Source Type: research
The role of 68Ga-Pentixafor PET in Primary Aldosteronism: a systematic review and meta-analysis
Conclusion68Ga-Pentixafor PET displays substantial promise in enhancing the diagnosis of Primary Aldosteronism subtypes and precisely localizing aldosterone-producing adenoma. Furthermore,68Ga-Pentixafor PET imaging exhibits significant correlations with the clinical characteristics, clinical prognosis, immunohistochemistry, and nodule size in Primary Aldosteronism patients. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - January 17, 2024 Category: Radiology Source Type: research
Radio-guided surgery with beta emission: status and perspectives
AbstractSurgery is a key treatment for localized or locally advanced solid tumors. However, the application of wide safety margins can result in significant side effects and functional limitations for the patient. On the contrary, tissue-sparing surgery may leave residual tumor, which can lead to local recurrent cancer or distant metastases. To address these problems, intraoperative radio-guidance, such as beta radio-guided surgery (RGS), could be used to detect small cancerous tissue and selectively resect malignant areas. This paper provides a comprehensive review of RGS based on beta emission, focusing on the physical p...
Source: Clinical and Translational Imaging - January 4, 2024 Category: Radiology Source Type: research
Comparison between computed tomography and magnetic resonance imaging in detecting multiple myeloma lesions in the skull: A Â systematic review
ConclusionsPET/CT and MRI images presented limitations in detecting MM lesions in the skull compared to LDCT images. The evidence suggested that the greatest detection capability could be achieved by employing whole-body MRI complemented by LDCT images of the skull. Future studies are needed to confirm this result. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - December 7, 2023 Category: Radiology Source Type: research
Preliminary study of a novel FAP-targeted ligand 68Ga-DOTA-FL in colon cancer imaging using small-animal PET/CT
Conclusions68Ga-DOTA-FL can be used for the specific tumor imaging in mouse models, which might provide a novel alternative for FAP-targeted tumor imaging. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 20, 2023 Category: Radiology Source Type: research
Pet-radiomics in lymphoma and multiple myeloma: update of current literature
ConclusionPreliminary results suggest that PET-radiomic features, which reflect the biological heterogeneity and spatial distribution of lesions, may play a prognostic role in both lymphomas and MM. Nevertheless, before implementing these findings in clinical practice, it is imperative to standardize the methodological approaches and validate them in large prospective trials. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - November 13, 2023 Category: Radiology Source Type: research
