Nuclear imaging for diagnosing fracture-related infection
ConclusionRetrospective studies show promising results for both FDG-PET/CT and WBC scintigraphy with SPECT/CT in diagnosing FRI. A prospective, multicenter study (IFI trial), directly comparing MRI, FDG-PET/CT, and WBC scintigraphy with SPECT/CT in patients with suspected FRI, is currently in progress. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 9, 2020 Category: Radiology Source Type: research
Sentinel node identification with [99mTc]-tilmanocept SPECT/CT: a pictorial essay of clinical applications
Discussion[99mTc]-tilmanocept SPECT/CT resulted in an excellent choice for preoperative lymphatic mapping and presented an optimal biodistribution with a rapid injection-site clearance and persistent SLN retention that could lead to improved accuracy of sentinel node identification in selected cases of melanoma, oral and breast cancer. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 3, 2020 Category: Radiology Source Type: research
In memoriam of Professor Giovanni Lucignani
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - June 1, 2020 Category: Radiology Source Type: research
Metabolic connectivity in Alzheimer ’s diseases
AbstractMultiple studies have investigated the disruptions in structural and functional connectivity in aging, dementia and Alzheimer ’s disease (AD). The study of metabolic connectivity between brain regions using fluorodeoxyglucose positron emission tomography (FDG-PET) however, is a new focus of interest. Several methodological approaches, including seed-based correlation, independent and principal component analysis, and gra ph-theoretical approaches have been employed to study the metabolic disconnectivity in AD. We conducted a systematic search of the literature using the keywords metabolic connectivity and Alzheim...
Source: Clinical and Translational Imaging - May 25, 2020 Category: Radiology Source Type: research
Copper-mediated late-stage radiofluorination: five years of impact on preclinical and clinical PET imaging
ConclusionsCMRF has significantly expanded the chemical space that is accessible to fluorine-18 radiolabeling with production methods that can meet the regulatory requirements for use in Nuclear Medicine. Furthermore, it has enabled novel and improved syntheses of radiopharmaceuticals and facilitated subsequent PET imaging studies. The rapid adoption of CMRF will undoubtedly continue to simplify the production of imaging agents and inspire the development of new radiofluorination methodologies. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 25, 2020 Category: Radiology Source Type: research
Molecular imaging of cardiovascular inflammation and infection in people living with HIV infection
ConclusionThis review aimed to present an update on the evidence supporting the role of molecular imaging modalities with radionuclide techniques for imaging of cardiovascular inflammation and infection focusing on atherosclerotic cardiovascular disease, pericarditis, myocarditis, and endocarditis in PLHIV. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 18, 2020 Category: Radiology Source Type: research
Current role of 18F-FDG-PET in the differential diagnosis of the main forms of dementia
ConclusionThe large experience accumulated using FDG-PET for the differential diagnosis of the main conditions with dementia has been translated into more formal evidence to support its clinical use. Although FDG-PET form currently part of the clinical practice in many countries, there is still a lack of studies using standardized analysis that confirm specific patterns at individual level. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - May 6, 2020 Category: Radiology Source Type: research
The role of 18 F-FDG PET for COVID-19 infection: myth versus reality
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 29, 2020 Category: Radiology Source Type: research
Typical lung carcinoids: review of classification, radiological signs and nuclear imaging findings
ConclusionsTCs of lung are rare lung tumours placed within a defined classification system. MDCT morphological features combined with functional nuclear medicine imaging are an important tool for the detection of these rare neoplasms and contribute to their characterisation and staging. Therefore, MDCT and nuclear medicine parameters could give a preliminary orientation before the pathological examination, on the biological behaviour and the prognostic outcome of TCs. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 16, 2020 Category: Radiology Source Type: research
Correction to: 18 F-FMISO PET imaging: insights over MRI in patients with glioma
The original version of this article unfortunately contained a mistake. The sequence of all author names were incorrect. The correct names are: Riccardo Laudicella, Natale Quartuccio, Pierpaolo Alongi, Domenico Albano, Maria Gazzilli, Rexhep Durmo, Francesco Bertagna, Sergio Baldari. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 16, 2020 Category: Radiology Source Type: research
Comparison between 18 F-FDG and 18 F-NaF PET imaging for assessing bone metastases in breast cancer patients: a literature review
ConclusionBoth18F-NaF and18F-FDG are suitable for assessing skeletal involvement in BC patients. However, inherent different uptake mechanism highlights differences in diagnostic performance between these tracers, reflecting specific bone metastases ’ characteristics. Therefore, a complementary use of18F-NaF and18F-FDG PET imaging may be considered in clinically selected BC patients, such as those with suspicious bone involvement despite negative18F-FDG PET imaging, with prevalent CT-sclerotic bone findings or with apparently confined or oligo-metastatic cancer to exclude widespread disease. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 30, 2020 Category: Radiology Source Type: research
Nuclear medicine: a global perspective
(Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 24, 2020 Category: Radiology Source Type: research
Diagnostic performance and prognostic role of FDG PET/CT performed at staging in anal cancer
ConclusionsFDG PET/CT performed at staging has a good diagnostic performance in anal cancer patients. Some baseline metabolic parameters seem to have also a prognostic significance. Further research is required to validate these results. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 22, 2020 Category: Radiology Source Type: research
Role of [ 18 F]-FDG PET in patients with atypical parkinsonism associated with dementia
ConclusionAlthough available studies in patients with APS and dementia suffer from methodological limitations, the expert consensus emerged from the EANM/EAN recommendations was in favor of its use for specific clinical questions in these group of patients. Studies in a larger number of patients published after the publication of the joint recommendations have further supported the use of18F-FDG PET in patients with APS associated with dementia. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 17, 2020 Category: Radiology Source Type: research
Radiolabelled Trastuzumab PET/CT imaging: a promising non-invasive tool for the in vivo assessment of HER2 status in breast cancer patients
ConclusionAdditional studies are needed to validate the potential role of radiolabelled trastuzumab PET/CT, demonstrating its effectiveness in detection of HER2-positive lesions and in identification of BC patients who could benefit from specific and personalized therapy. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - March 17, 2020 Category: Radiology Source Type: research
