Comparison between 18 F-FDG and 18 F-NaF PET imaging for assessing bone metastases in breast cancer patients: a literature review

ConclusionBoth18F-NaF and18F-FDG are suitable for assessing skeletal involvement in BC patients. However, inherent different uptake mechanism highlights differences in diagnostic performance between these tracers, reflecting specific bone metastases ’ characteristics. Therefore, a complementary use of18F-NaF and18F-FDG PET imaging may be considered in clinically selected BC patients, such as those with suspicious bone involvement despite negative18F-FDG PET imaging, with prevalent CT-sclerotic bone findings or with apparently confined or oligo-metastatic cancer to exclude widespread disease.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research

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Fluorescent silica nanoparticles (SNPs) are introduced as a robust labeling strategy to visualize tumor cells within mineralized bone from in vitro and in vivo studies. SNP labeling efficiency of MDA ‐MB‐231 breast cancer cells is characterized using a broad range of bone processing and imaging techniques. SNPs are tools with the potential to increase the understanding of mineral contributions to bone metastasis. AbstractDuring breast cancer bone metastasis, tumor cells interact with bone microenvironment components including inorganic minerals. Bone mineralization is a dynamic process and varies spatiotemporally as a ...
Source: Small - Category: Nanotechnology Authors: Tags: Full Paper Source Type: research
In conclusion, the combination of continuous dosing of veliparib and every-3-week carboplatin demonstrated activity and an acceptable toxicity profile. Decrease in SUVmax on 18 FLT-PET scan during the first cycle of this therapy can identify patients who are likely to have a response. IMPLICATIONS FOR PRACTICE: The BROCADE studies suggest that patients with BRCA mutation benefit from addition of the poly(ADP-ribose) polymerase inhibitor veliparib to carboplatin plus paclitaxel. This study demonstrates that a higher dose of veliparib is tolerable and active in combination with carboplatin alone. With growing interest in ima...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Abstract An electrochemical biopsy probe was designed and fabricated to detect cancer tumors under the sonography guide without the need for any sample dissection (biopsy). The system was based on recording the hypoxic function of cancer tumors by Multi-wall carbon nanotubes (MWCNTs) sensing agents had been decorated on the tip of the needle electrodes by an electrostatic deposition method. This system named BGP successfully distinct 4T1 and MC4L2 breast tumors from normal lesions. It also diagnosed the treated tumors from vital ones. BGP as a clinically useful biosensor would detect the cancerous probability of a...
Source: Biosensors and Bioelectronics - Category: Biotechnology Authors: Tags: Biosens Bioelectron Source Type: research
ConclusionsThe restaging of patients who had ER-positive primary breast cancer and present with recurrent disease may include [18F]FES PET/CT as an initial test when standard imaging studies are equivocal or suspicious.
Source: EJNMMI Research - Category: Radiology Source Type: research
The authors tested the use of tablets to collect breast cancer risk data and compared the approach against paper-based scantrons. The goal was to examine the usability of digital technology for data collection in underserved populations. A total of 340 individuals were randomized to answer a breast health survey via either tablets (170) or paper forms (170). Post questionnaire surveys were conducted to evaluate the usability of tablets. Outcomes included completion time, satisfaction, and the numbers and types of questions raised by patients during the survey. There was no significant difference in questionnaire completion...
Source: International Journal of E-Health and Medical Communications - Category: Information Technology Authors: Tags: Health Information Systems Medicine & Healthcare Source Type: research
A 59-year-old woman with history of breast cancer and tuberculosis was referred to our hospital complaining of abdominal pain, distention and feeling feverish. A triphasic CT scan showed several cystic liver lesions, with a 110x72mm septate lesion in segments II-III with infiltrative morphology, as well as mediastinal and paraaortic lymph nodes(Image 1). A malignant etiology could not be ruled out.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
CONCLUSIONS: The performance of 30-9 is equivalent to that of MIB-1 in Ki67 assessment of breast cancer. The image analysis system can substitute for or support visual counting by a pathologist. PMID: 32440959 [PubMed - as supplied by publisher]
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Conclusions: The SPArc_seq optimization algorithm could effectively reduce the BDT compared to the original SPArc algorithm. The improved efficiency of the SPArc_seq algorithm has the potential to increase patient throughput, thereby reducing the operation cost of proton therapy. PMID: 32421375 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Authors: Cho E, Lee JH, Park EH, Byun KD Abstract AIMS: To evaluate the clinical utility of supraclavicular scanning for locoregional lymph node (LN) assessment in postoperative screening surveillance using ultrasonography (US) in patients who underwent breast cancer surgery. MATERIAL AND METHODS: From July 2004 to February 2019, 280 suspicious findings for locoregional recurrence in the lymph node (LRL) on postoperative screening US were detected in 266 asymptomatic patients who underwent breast cancer surgery. Suspicious features of LRL on US included the marked hypoechogenicity, round or irregular shape, ecc...
Source: Medical Ultrasonography - Category: Radiology Tags: Med Ultrason Source Type: research
RARITAN, NJ, May 13, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today results from the final analysis of the pivotal Phase 3 SPARTAN study demonstrating ERLEADA® (apalutamide) in combination with androgen deprivation therapy (ADT) significantly improved overall survival (OS), compared to ADT alone, in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) who were at high risk of developing metastases.[i] Results will be presented at the American Society of Clinical Oncology (ASCO) Virtual Scientific Program (Abstract #5516) beginning May 29th. ERLEADA® i...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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