Comparison between 18 F-FDG and 18 F-NaF PET imaging for assessing bone metastases in breast cancer patients: a literature review

ConclusionBoth18F-NaF and18F-FDG are suitable for assessing skeletal involvement in BC patients. However, inherent different uptake mechanism highlights differences in diagnostic performance between these tracers, reflecting specific bone metastases ’ characteristics. Therefore, a complementary use of18F-NaF and18F-FDG PET imaging may be considered in clinically selected BC patients, such as those with suspicious bone involvement despite negative18F-FDG PET imaging, with prevalent CT-sclerotic bone findings or with apparently confined or oligo-metastatic cancer to exclude widespread disease.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research