Radiolabelled Trastuzumab PET/CT imaging: a promising non-invasive tool for the in vivo assessment of HER2 status in breast cancer patients

ConclusionAdditional studies are needed to validate the potential role of radiolabelled trastuzumab PET/CT, demonstrating its effectiveness in detection of HER2-positive lesions and in identification of BC patients who could benefit from specific and personalized therapy.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research

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In conclusion, the combination of continuous dosing of veliparib and every-3-week carboplatin demonstrated activity and an acceptable toxicity profile. Decrease in SUVmax on 18 FLT-PET scan during the first cycle of this therapy can identify patients who are likely to have a response. IMPLICATIONS FOR PRACTICE: The BROCADE studies suggest that patients with BRCA mutation benefit from addition of the poly(ADP-ribose) polymerase inhibitor veliparib to carboplatin plus paclitaxel. This study demonstrates that a higher dose of veliparib is tolerable and active in combination with carboplatin alone. With growing interest in ima...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Conclusions: This pilot study indicated that the uptake of HER2 antagonist 99mTc-HPArk2 correlate with HER2 expression in breast cancer. 99mTc-HPArk2 SPECT/CT can provide specific, non-invasive evaluation of HER2 expression in breast cancer.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer I Source Type: research
606Introduction: Breast cancer (BC) is a common referral for 18F-FDG PET/CT especially in patients for which neodjuvant chemotherapy (NAC) is indicated. Radiomic features (RF) are associated with tumor heterogeneity and prediction of pathological complete response (pCR) in BC. We previously found that the application of a post-reconstruction filter on PET images lead to differences in BC metabolic phenotype on 18F-FDG PET/CT. In that setting, we aimed to assess if it would also affect prediction of pCR in BC patients. Methods: BC patients who underwent 18F-PET/CT at initial staging in our institution were recruited. 18F-PE...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer II Source Type: research
612Introduction: Breast cancer (BC) is a heterogeneous disease and different parameters such as expression of hormone receptors (HR), HER2, tumor grade or Ki-67 expression account for this heterogeneity. It has been reported that Radiomic features (RF) extracted from FDG PET images also reflected BC heterogeneity. However, RF are affected by various PET acquisition parameters and reconstruction or post-reconstruction processes. In that setting, we aimed to assess the impact of a Gaussian filter applied to post-reconstruction PET images for assessing BC tumor heterogeneity. Methods: Radiomics analysis was performed in a coh...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer II Source Type: research
Conclusions: The three different methods were no significant differences in normal organ. According to the MC based tumor absorbed dose of 225Ac was show that three times therapeutic effect than 211At -NOTA-trastuzumab.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Image Guided Therapy (Poster Session) Source Type: research
Conclusions: An early MRI assessment after two NACT cycles, specifically of the tumour's axillary lymph nodes, has the potential to predict short-term BCSS in patients with locally advanced HER2-negative breast cancers. PMID: 32394761 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
This study aimed to explore the applicability of kinetic modelling and parametric image analysis for absolute quantification of68Ga-ABY-025 uptake and HER2-receptor expression and how that relates to static SUVs.MethodsDynamic68Ga-ABY-025 PET of the upper abdomen was performed 0-45  min post-injection in 16 patients with metastatic breast cancer. Five patients underwent two examinations to test reproducibility. Parametric images of tracer delivery (K1) and irreversible binding (Ki) were created with an irreversible two-tissue compartment model and Patlak graphical analysis using an image-derived input function from ...
Source: EJNMMI Research - Category: Radiology Source Type: research
This study was conducted in order to investigate whether there is a correlation between the time-to-enhancement (TTE) in ultrafast MRI and histopathological characteristics of breast cancers.MethodsBetween January and August 2017, 274 consecutive breast cancer patients (mean age, 53.5  years; range, 25–80 years) who underwent ultrafast MRI and subsequent surgery were included for analysis. Ultrafast MRI scans were acquired using TWIST-VIBE or 4D TRAK-3D TFE sequences. TTE and maximum slope (MS) were derived from the ultrafast MRI. The repeated measures ANOVA, Mann–WhitneyU test and Kruskal –Wall...
Source: European Radiology - Category: Radiology Source Type: research
Minichromosome Maintenance Protein 2 (MCM2) is critical in initiating DNA replication during the cell division process. As expressed intensively in all phases of the active cell cycle, MCM2 has been proposed as a novel biomarker to determine cellular proliferation. We aimed at clarifying the prevalence and clinical significance of MCM2 in HER2-amplified breast cancer subtype. MCM2 expression was studied in 142 primary HER2-amplified breast carcinomas by applying a novel fluoro-chromogenic immunohistochemistry and tailored digital image analysis to determine labelling index (MCM2-LI). The presence of MCM2 was detected with ...
Source: Applied Immunohistochemistry and Molecular Morphology - Category: Chemistry Tags: Research Article Source Type: research
AbstractObjectivesTo evaluate the predictive value of virtual monoenergetic images (VMIs) by assessing tumor conspicuity on dual-layer spectral detector CT (SDCT) and correlate tumor conspicuity on VMI with prognostic biomarkers in patients with breast cancer.MethodsSixty-four patients underwent arterial phase and 90-s delayed phase dual-layer SDCT. A retrospective tumor conspicuity analysis of 14 benign tumors and 65 breast cancers was performed using conventional images (CIs) and VMI at 40  keV (VMI40) on arterial and delayed phase scans (CIART, VMI40ART, CIDE, VMI40DE). Mean Hounsfield units (HU) of tumors were mea...
Source: European Radiology - Category: Radiology Source Type: research
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