Multimodal therapy of advanced differentiated thyroid cancer, with emphasis on the role of radioiodine

AbstractIntroductionDifferentiated thyroid cancer (DTC) accounts for 95% of all thyroid cancers and is generally an indolent tumor, tending to present with limited loco-regional disease with an excellent long-term survival after treatment. However, 5 –10% present with locally advanced disease and aero-digestive tract invasion or distant metastases that are the main cause of thyroid cancer-related deaths.MethodsThe present review aims to underline the complex management of advanced DTC including treatment of gross extra-thyroidal extension, recurrent loco-regional, or distant metastatic disease.ResultsRadioiodine therapy is an effective treatment of advanced and/or metastatic DTC which contributes significantly to patients ’ life expectancy. Multimodal approach based on surgical resection in combination with radioiodine therapy, interventional imaging treatment, and TSH suppression can significantly improve outcomes for this patients’ population.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research