Detection of Muscularis propria Invasion in Urothelial Carcinoma Using Artificial Intelligence
Conclusion: The algorithm we developed may greatly aid in accurate identification of muscularis propria invasion by imitating the thought process of the pathologist.PMID:38803309 | DOI:10.1177/15330338241257479 (Source: Cell Research)
Source: Cell Research - May 28, 2024 Category: Cytology Authors: Ibrahim Fahoum Rabab Naamneh Keren Silberberg Rami Hagege Dov Hershkovitz Source Type: research
The correlation between time-intensity curve parameters of transrectal contrast-enhanced ultrasound and pathological prognostic factors in rectal adenocarcinoma
CONCLUSIONS: TIC parameters derived from TR-CEUS exhibit correlations with specific pathological prognostic factors in rectal adenocarcinomas. This non-invasive method may hold promise for preoperatively assessing the prognosis of rectal adenocarcinoma patients.PMID:38805619 | DOI:10.11152/mu-4375 (Source: Medical Ultrasonography)
Source: Medical Ultrasonography - May 28, 2024 Category: Radiology Authors: Shitao Su Jianyuan Huang Xuanzhang Huang Xigui Li Yaoli Liu Jun Meng Yu Fan Xiaoyan He Shangyong Zhu Source Type: research
Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives
Adv Exp Med Biol. 2024;1452:65-96. doi: 10.1007/978-3-031-58311-7_4.ABSTRACTEpithelial ovarian cancer (EOC) is a complex disease with diverse histological subtypes, which, based on the aggressiveness and course of disease progression, have recently been broadly grouped into type I (low-grade serous, endometrioid, clear cell, and mucinous) and type II (high-grade serous, high-grade endometrioid, and undifferentiated carcinomas) categories. Despite substantial differences in pathogenesis, genetics, prognosis, and treatment response, clinical diagnosis and management of EOC remain similar across the subtypes. Debulking surger...
Source: Advances in Experimental Medicine and Biology - May 28, 2024 Category: Research Authors: Megha Mehrotra Pratham Phadte Priti Shenoy Sourav Chakraborty Sudeep Gupta Pritha Ray Source Type: research
LINC00887 Acts as an Enhancer RNA to Promote Medullary Thyroid Carcinoma Progression by Binding with FOXQ1
CONCLUSION: LINC00887 was identified as a key eRNA promoting the malignant phenotype of MTC cells. The involvement of FOXQ1 was essential for LINC00887 to play a pro-tumorigenic role in MTC. Our findings suggest that the FOXQ1/LINC00887 axis is a potential therapeutic target for MTC.PMID:38804344 | DOI:10.2174/0115680096258716231026063704 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - May 28, 2024 Category: Cancer & Oncology Authors: Daxiang Liu Wenjing Wang Yanzhao Wu Yongle Qiu Lan Zhang Source Type: research
Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives
Adv Exp Med Biol. 2024;1452:65-96. doi: 10.1007/978-3-031-58311-7_4.ABSTRACTEpithelial ovarian cancer (EOC) is a complex disease with diverse histological subtypes, which, based on the aggressiveness and course of disease progression, have recently been broadly grouped into type I (low-grade serous, endometrioid, clear cell, and mucinous) and type II (high-grade serous, high-grade endometrioid, and undifferentiated carcinomas) categories. Despite substantial differences in pathogenesis, genetics, prognosis, and treatment response, clinical diagnosis and management of EOC remain similar across the subtypes. Debulking surger...
Source: Adv Data - May 28, 2024 Category: Epidemiology Authors: Megha Mehrotra Pratham Phadte Priti Shenoy Sourav Chakraborty Sudeep Gupta Pritha Ray Source Type: research
Single-Cell Data Analysis Reveals Critical Hepatic Cells Subpopulations in the Progression of Non-alcoholic Fatty Liver Disease to Non-Alcoholic Steatohepatitis
CONCLUSION: The hepatic cells 2 might promote the progression of NAFLD to NASH by regulating metabolic activity, which might contribute to liver injury through inflammation.PMID:38803181 | DOI:10.2174/0113862073303213240523095742 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - May 28, 2024 Category: Chemistry Authors: Cuijuan Zhao Guixian Ji Xingliang Zhao Tengqi Ma Yanhua Li Wenbo Wu Lu Zhou Source Type: research
Recurrence in lobular carcinoma of the breast: A 14-year review
CONCLUSION: There are clinical implications for the management and follow-up for patients with a diagnosis of lobular cancer of the breast. Due to the low recurrence rate, now, the standard practice in our institution does not offer magnetic resonance imaging (MRI) as part of the follow-up for ILC patients. Other centres should establish local recurrence rates to aid development of appropriate management protocols.PMID:38804125 | DOI:10.1111/1754-9485.13715 (Source: Clin Med Res)
Source: Clin Med Res - May 28, 2024 Category: Research Authors: Nathan Burns Anita Bourke Source Type: research
Risk versus Benefit of Tyrosine Kinase Inhibitors for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Clin Pharmacol Ther. 2024 May 27. doi: 10.1002/cpt.3312. Online ahead of print.ABSTRACTAlthough the treatment landscape has rapidly evolved over the last years, hepatocellular carcinoma (HCC) is one of the most lethal cancers. With recent advances, both immunotherapy and tyrosine kinase inhibitors (TKIs)-based chemotherapy constitute the standard treatment for advanced HCC. A systematic search of randomized clinical trials employing TKIs was performed in 17 databases, obtaining 25 studies evaluating the prognosis, tumor response, and presence of adverse events (AEs) related to TKIs in HCC. Overall effect sizes were estimat...
Source: Clinical Pharmacology and Therapeutics - May 28, 2024 Category: Drugs & Pharmacology Authors: Tania Payo-Seraf ín Carolina M éndez-Blanco Paula Fern ández-Palanca Jennifer Mart ínez-Geijo Mar ía Reviejo Juan Jos é Ortiz-de-Urbina Javier Gonz ález-Gallego Jose J G Marin Jos é L Mauriz Beatriz San-Miguel Source Type: research
Recurrence in lobular carcinoma of the breast: A 14 ‐year review
ConclusionThere are clinical implications for the management and follow-up for patients with a diagnosis of lobular cancer of the breast. Due to the low recurrence rate, now, the standard practice in our institution does not offer magnetic resonance imaging (MRI) as part of the follow-up for ILC patients. Other centres should establish local recurrence rates to aid development of appropriate management protocols. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - May 28, 2024 Category: Radiology Authors: Nathan Burns,
Anita Bourke Tags: Medical Imaging —Original Article Source Type: research
Impact of anatomical liver resection for hepatocellular carcinoma in preventing early ‐phase local recurrence after surgery
ConclusionAR is superior in controlling local and early recurrence postoperatively for solitary HCC ≤5 cm in diameter compared with NR. (Source: Journal of Hepato-Biliary-Pancreatic Surgery)
Source: Journal of Hepato-Biliary-Pancreatic Surgery - May 28, 2024 Category: Surgery Authors: Akira Shimizu,
Koji Kubota,
Tsuyoshi Notake,
Noriyuki Kitagawa,
Hitoshi Masuo,
Takahiro Yoshizawa,
Hiroki Sakai,
Hikaru Hayashi,
Shiori Yamazaki,
Yuji Soejima Tags: ORIGINAL ARTICLE Source Type: research
Delayed metastatic endometrial carcinoma mimicking primary colon adenocarcinoma: A surprise histopathological finding
We describe a rare case of metastatic endometrial cancer in the colon presenting 5 years post radical hysterectomy and adjuvant radiotherapy in a 62-year-old female. She presented with a 1-week history of right upper quadrant pain, with no other associated symptoms. She was presumed to have a primary colorectal cancer based on her colonoscopy and CT findings; later proven other wise by immunohistochemistry (IHC). Endometrial cancer metastasis to the colon is rare, thus misdiagnosis can easily occur. Currently, there are 6 similar cases reported in the literature, all occurring in the absence of colorectal endometriosis....
Source: Clinical Case Reports - May 28, 2024 Category: General Medicine Authors: Hui Yuan Foong,
Jian Blundell,
Cameron Law,
Ross Warner Tags: CASE REPORT Source Type: research
Wnt/ β-catenin signaling is a therapeutic target in anaplastic thyroid carcinoma
ConclusionsWe tested Wnt inhibitor treatment, both in vitro and in vivo, as a potential novel therapy for this highly lethal disease. Future large-scale studies utilizing multiple Wnt inhibitors will lay the foundation for the development of these novel therapies for patients with ATC. (Source: Endocrine)
Source: Endocrine - May 28, 2024 Category: Endocrinology Source Type: research
Plasma exosomes contain protein biomarkers valuable for the diagnosis of lung cancer
AbstractAccumulating evidence indicates that exosomal proteins are critical in diagnosing malignant tumors. To identify novel exosomal biomarkers for lung cancer diagnosis, we isolated plasma exosomes from 517 lung cancer patients and 168 healthy controls (NLs) —186 lung adenocarcinoma (LUAD) patients (screening (SN): 20, validation (VD): 166), 159 lung squamous carcinoma (LUSC) patients (SN: 20, VD: 139), 172 benign nodules (LUBN) patients (SN: 20, VD: 152) and 168 NLs (SN: 20, VD: 148)—and randomly assigned them to the SN or VD group. Proteomic analy sis by LC–MS/MS and PRM were performed on all groups. The candida...
Source: Hormones and Cancer - May 28, 2024 Category: Cancer & Oncology Source Type: research
C-Reactive Protein-Albumin Ratio Predicts Objective Response to Enfortumab Vedotin in Metastatic Urothelial Carcinoma
ConclusionsThe evaluation of the CAR from a concise blood examination at the initiation of EV could effectively predict the treatment response to EV in patients with metastatic urothelial carcinoma after the progression of platinum-based chemotherapy and checkpoint inhibitors. (Source: Targeted Oncology)
Source: Targeted Oncology - May 28, 2024 Category: Cancer & Oncology Source Type: research
