Identification of a disulfidptosis-related lncRNA signature for the prognostic and immune landscape prediction in head and neck squamous cell carcinoma
ConclusionThese findings demonstrate that the developed DRlncRNA signature holds promise as a reliable prognostic marker and predictor of immunotherapy response in HNSCC patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 14, 2024 Category: Cancer & Oncology Source Type: research

Role of long non-coding RNA ELFN1-AS1 in carcinogenesis
AbstractAs one of the leading causes of death worldwide, cancer significantly burdens patients and the healthcare system. The role of long non-protein coding RNAs (lncRNAs) in carcinogenesis has been extensively studied. The lncRNA ELFN1-AS1 was discovered recently, and subsequent studies have revealed its aberrantly high expression in various cancer tissues. In vitro and in vivo experiments have consistently demonstrated the close association between increased ELFN1-AS1 expression and malignant tumor characteristics, particularly in gastrointestinal malignancies. Functional assays have further revealed the mechanistic rol...
Source: Hormones and Cancer - March 13, 2024 Category: Cancer & Oncology Source Type: research

GALNT2 targeted by miR-139-5p promotes proliferation of clear cell renal cell carcinoma via inhibition of LATS2 activation
AbstractPolypeptideN-Acetylgalactosaminyltransferase (GALNTs) are critical enzymes that initiate mucin type-O glycosylation, and are closely associated with the occurrence and development of multiple cancers. However, the significance of GALNT2 in clear cell renal cell carcinoma (ccRCC) progression remains largely undetermined. Based on public multi-omics analysis, GALNT2 was strongly elevated in ccRCC versus adjoining nontumor tissues, and it displayed a relationship with poor overall survival (OS) of ccRCC patients. In addition, GALNT2 over-expression accelerated proliferation of renal cancer cell (RCC) lines. In contras...
Source: Hormones and Cancer - March 13, 2024 Category: Cancer & Oncology Source Type: research

A programmed cell death-related gene signature to predict prognosis and therapeutic responses in liver hepatocellular carcinoma
ConclusionThis study provides new insights into clinical subtyping and the PCD-related prognostic signature may serve as a useful tool to predict prognosis and guide treatments for patients with HCC. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 11, 2024 Category: Cancer & Oncology Source Type: research

GABPB1 plays a cancer-promoting role in non-small cell lung cancer
ConclusionsOur research verified that GABPB1 promotes the tumorigenesis of NSCLC and has an inhibitory effect on tumor immunity. The specific role of GABPB1 may vary among different pathological types of NSCLC. This molecule can serve as a prognostic indicator for lung adenocarcinoma, and its methylation may represent a potential breakthrough in treatment by altering the tumor immune microenvironment in lung squamous cell carcinoma. The role and mechanism of action of GABPB1 in NSCLC should be further explored. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 11, 2024 Category: Cancer & Oncology Source Type: research

DDOST is associated with tumor immunosuppressive microenvironment in cervical cancer
AbstractEvidence has revealed that DDOST plays an important role in cancer development and progression. However, there are no reports on functions of DDOST in cervical tumorigenesis. Hence, we investigated the relationship of DDOST with prognosis, mutation, promoter methylation, immune cell infiltration, and drug sensitivity using bioinformatics techniques. Our results demonstrated that DDOST was significantly upregulated in a variety of tumor types and correlated with poor prognosis, including cervical cancer. Cox regression analysis dissected that high DDOST expression was associated with poor survival in cervical cancer...
Source: Hormones and Cancer - March 9, 2024 Category: Cancer & Oncology Source Type: research

Transarterial chemoembolization with/without immune checkpoint inhibitors plus tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: a single center, propensity score matching real-world study
ConclusionsTACE plus TKIs and ICIs appeared to deliver longer PFS and OS in HCC patients than TACE monotherapy. “TKIs + ICIs” co-treatment within 3 months after the first TACE procedure might be a better medication strategy. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 9, 2024 Category: Cancer & Oncology Source Type: research

Transcriptome and single-cell transcriptomics reveal prognostic value and potential mechanism of anoikis in skin cutaneous melanoma
ConclusionsIn conclusion, we have established a novel classification system for SKCM based on anoikis, which carries substantial clinical implications for SKCM patients. Notably, the elevated expression of theFASLG gene on cluster 1 of Tex cells could significantly impact SKCM prognosis through anoikis, thus offering a promising target for the development of immunotherapy for SKCM. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 9, 2024 Category: Cancer & Oncology Source Type: research

LncRNA XIST promotes bladder cancer progression by modulating miR-129-5p/TNFSF10 axis
ConclusionXIST, an elevated lncRNA in bladder cancer, inhibition of which could suppress the progression of BC. LncRNA XIST and miR-129-5p could form ceRNA to regulate the expression of TNFSF10. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 6, 2024 Category: Cancer & Oncology Source Type: research

Identification of gene variation feature for targeted therapy of non-small cell lung cancer through combined method of DNA and RNA sequencing
AbstractNext generation sequencing (NGS) is typically used to reveal tumor gene variation feature for targeted therapy of various types of human cancers, including non-small cell lung cancer (NSCLC). Here, we report the role and potential applicable value of combining DNA and RNA sequencing in gene variation detection in NSCLC. 386 NSCLC patients with stage II-IV were enrolled and detected using NGS sequencing of DNA and RNA panels that covered all well-documented target driver genes from the Chinese Society of Clinical Oncology (CSCO). The rate of epidermal growth factor receptor (EGFR) single nucleotide variation (SNV)/i...
Source: Hormones and Cancer - March 6, 2024 Category: Cancer & Oncology Source Type: research

SAA1 regulated by S1P/S1PR1 promotes the progression of ESCC via β-catenin activation
In conclusion, SAA1 promotes the progression of ESCC by increasing β-catenin phosphorylation at Ser675, and the S1P/S1PR1 pathway plays an important role in its upstream regulation. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 6, 2024 Category: Cancer & Oncology Source Type: research

Clinical experience of consolidative radiotherapy for localized metastatic non-small cell lung cancer who showed favorable tumor response after systemic treatment
ConclusionsIf the disease is sufficiently controlled and localized by systemic therapy, local consolidative radiotherapy is thought to improves local control rates with acceptable treatment-related toxicities in patients with localized metastatic NSCLC, especially those with oligo-progressive disease. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 6, 2024 Category: Cancer & Oncology Source Type: research

Identification and validation of a novel six-gene signature based on mucinous adenocarcinoma-related gene molecular typing in colorectal cancer
ConclusionMAC-related genes were able to classify CRC. A RiskScore signature based on the colorectal MAC-related molecular subtype was constructed, which had important clinical significance for guiding the accurate stratification of CRC patients. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research

The impact of radiomics in the management of soft tissue sarcoma
ConclusionsWith an increasing interest over the last years, the use of radiomics appears to have potential for assessing STSs from initial diagnosis to predicting treatment response. However, additional and extensive research is necessary to validate the effectiveness of radiomics parameters and to integrate them into a comprehensive decision support system. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research

Unveiling NUSAP1 as a common gene signature linking chronic HBV infection and HBV-related HCC
ConclusionNUSAP1 serves as a poor prognostic indicator for liver cancers, and potentially plays a crucial role in HBV-HCC progression by promoting proliferation and inhibiting apoptosis. (Source: Hormones and Cancer)
Source: Hormones and Cancer - March 5, 2024 Category: Cancer & Oncology Source Type: research