A Hypothesis of Circulating MicroRNAs' Implication in High Incidence of Atrial Fibrillation and Other Electrocardiographic Abnormalities in Cancer Patients.
Authors: Kapodistrias N, Theocharopoulou G, Vlamos P Abstract MicroRNAs are short non-coding RNA molecules that control posttranscriptional gene expression and are present in tissues cells but also circulate in biological fluids in various forms (exosome, connected with proteins, apoptotic bodies, etc.). The roles that circulated extracellular serum microRNAs possess in cancer development, like in the delivery from a recipient cell to distant tissues and the repression of host genes resulting in the impairment of critical functions, are still undetermined. Disturbances, such as the higher incidence of atrial fibril...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Central-Line-Associated Bloodstream Infections (CLABSIs) Incidence and the Role of Obesity: A Prospective, Observational Study in Greece.
CONCLUSIONS: Better staff training focused on care bundles preventing infections, better medical training focused on less efforts for CVC insertion, and the use of Ultrasounds during the CVC insertion may be the main factors that can lead to lower CLABSI rates in obese patients. Further research relating CLABSI rates in ICU patients and obesity is needed. PMID: 32468303 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Number of Brain States in an N-Body Dynamical Scenario According to the Universal Bekenstein Entropy Bound.
Authors: Haranas I, Gkigkitzis I, Georgiadis S, McLeod D Abstract There is an intense interest in the modulation of brain neural circuits and its correlations with different behavioral states, memory, learning, as well as neuropsychological disorders. It is believed that brain cells form functional circuits, process information and mediate behavior. Therefore, the brain system may be thought of as a super-computing machine that turns information into thoughts, memories, and cognitions. Moreover, according to the quantum brain dynamics and quantum conscience hypotheses, quantum theory, the most fundamental theory of...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Burden and Sleeping Disorders of Family Caregivers of Hemodialysis Patients with Chronic Kidney Disease-End Stage: A Cross-Sectional Study.
Authors: Intas G, Rokana V, Stergiannis P, Chalari E, Anagnostopoulos F Abstract BACKGROUND: Chronic illnesses with high level of disability can affect not only the patients but also the main caregiver who supports them. The aim of this study was to investigate the burden and sleep disorders of family caregivers of hemodialysis patients. METHODS: This is a cross-sectional study. The sample of the study consisted of 310 family caregivers of hemodialysis patients. The tools used were the Pittsburgh Sleep Quality Index (PSQI) for sleep disorders assessment, the Zarit Burden Interview, and the Center for Epidemiolo...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Quality of Life in Type 2 Diabetes Mellitus Patients with Neuropsychological Deficits.
CONCLUSION: T2DM patients have cognitive deficits on several domains compared to healthy participants. Domain specific neuropsychological deficits in middle aged T2DM patients have a significant impact on HRQOL. PMID: 32468306 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

A Framework for Assessing the Impact of Information-Seeking Behavior on Cancer Patients' Long-Term Prognosis.
Authors: Persakis E, Kostagiolas P Abstract Cancer is considered as one of the main challenges of modern healthcare systems. Cancer patients are obliged to cope with the uncertainty of disease progression. Their anxiety regarding said uncertainty is intensified because they need to constantly make decisions concerning the management of their disease. Information and communication are considered important in cancer management. As a result, the research associated with the impact of healthcare information-seeking behavior on numerous cancer management aspects has intensified and grown in astonishing rates. This work ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Sleeping Disorders and Health-Related Quality of Life in Hemodialysis Patients with Chronic Renal Disease in Greece.
CONCLUSIONS: The HRQOL of hemodialysis patients with CKD-FS remains poor, interacting with important functions such as sleep, vitality, cognition, and sexual function. PMID: 32468308 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Subjective Quality of Life, Religiousness, and Spiritual Experience in Greek Orthodox Christians: Data from Healthy Aging and Patients with Cardiovascular Disease.
Authors: Giannoulis K, Giannouli V Abstract The goal of this study is to examine subjective quality of life-life satisfaction, religiousness, and spiritual experience in healthy younger and older adults, as well as in older patients suffering from severe cardiovascular disease, while examining the role of marital status, employment and socioeconomic status, existence of social network, urbanicity, education, depression, and personal opinion about the country's current socioeconomic situation. Results revealed that there are no age differences and that the role of demographic variables as predictors of religiousness...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Mini-Mental State Examination: Greek Normative Data Stratified by Age and Education in a Large Sample of 925 Community-Dwelling Healthy Participants.
Authors: Mougias A, Christidi F, Kaldi M, Kerossi MI, Athanasouli P, Politis A Abstract BACKGROUND: Cognitive screening measures are widely administered in everyday clinical practice in different geriatric settings. Despite the presence of several extended-like screening tests, Mini-Mental State Examination (MMSE) continues to be largely used not only by neuropsychologists, neurologists, and psychiatrists but also by general practitioners and other health-related specialties. AIM: We herein provide normative data for the MMSE in a large sample of community-dwelling healthy participants aged over 50 years o...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Role of the Family in the Care of Alzheimer Patients.
Authors: Xristina F, Demeter K, John G, Maria C Abstract According to the World Health Organisation (WHO 2002), people's life expectancy worldwide is continuously growing, and on the one hand, that is one of the greatest triumphs of humanity to date. But at the same time, it is also one of the most important challenges as the aging of the population raises economic and social requirements in all countries. PMID: 32468311 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Prevalence of Stroke Cases in Warangal, Telangana Region, India: A Hospital-Based Case Study.
Authors: Susmitha K, Chandrasekhar V, Kiran G, Divya A, Rani GS, Sarangapani M Abstract Stroke is becoming a main cause of early death and disability in developing countries like India, and it is mostly enhanced by increased predominance of major risk factors. A detailed knowledge about the nature and magnitude of the stroke cases in this particular area is not only important for acute treatment but also it helps to prevent hospital admissions due to reoccurring stroke. The present study was conducted in the Department of Stroke at MGM Hospital, Warangal, India, to study the patterns of stroke admissions. All the c...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Compliance of Patients with Acute Coronary Syndrome with Treatment Following Their Hospitalization from the Cardiac Coronary Unit.
CONCLUSION: Compliance of patients who suffered from ACS is at low level. There is a need for closed monitoring and use of wearable devices in order to improve the compliance rates. PMID: 32468313 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Using a Virtual Reality Serious Game to Assess the Performance of Older Adults with Frailty.
CONCLUSIONS: Results shed more light toward the possible use of VR for distant self-administered evaluation of the frail status. PMID: 32468314 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Characteristics and Survival Rates in Ward Patients Requiring Evaluation by  Intensivist in Greece.
CONCLUSIONS: The survival rates of these patients are quite low and possibly multifactorial due to the severity of the disease, the unnecessary call for an intensivist due to an irreversible condition, or the delayed call of an intensivist. PMID: 32468315 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

In Silico and In Vivo Studies on Quercetin as Potential Anti-Parkinson Agent.
In conclusion, quercetin possesses strong iron-chelating abilities and could be recommended as a disease-modifying therapy when administered in combination with L-dopa, early on in the course of Parkinson's disease. PMID: 32468451 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Exhaled Breath Condensate (EBC): Is It a Viable Source of Biomarkers for Lung Diseases?
Authors: Patsiris S, Exarchos T, Vlamos P Abstract The exhaled breath condensate is a source of biomarkers with many advantages and benefits compared to other traditional sampling techniques in respiratory medicine. It is a biological product that is formed by cooling the exhaled air via its guidance through a condenser. It is characterized as a cocktail of volatile and non-volatile compounds with water being the predominant constituent. Its composition presents a non-uniformed structure as the volatile and the non-volatile compounds vary in type and ratio. All these compounds originate from the whole respiratory t...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Treatment Development for Alzheimer's Disease: How Are We Doing?
Authors: Lyketsos CG Abstract Over 40 million people worldwide suffer from dementia. This number is projected to exceed 110 million by 2050 because of the aging of the worldwide population, especially in lower- and middle-income countries. The most common cause of dementia is believed to be Alzheimer's, a brain disease associated with deposition of beta-amyloid protein and hyperphosphorylation of intraneuronal tau protein leading to synaptic degradation, neuronal loss, brain circuit disruption, a range of symptoms, and eventually, if the person lives long enough, death. Over the last few decades, treatment developm...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Microbiome Hijacking Towards an Integrative Pest Management Pipeline.
We present such an approach, to combat Bactrocera oleae, a widespread pest whose impact is devastating on olive production. To date, there is no specific pesticide to control it. Herein, we propose a novel strategy to manage this pest via identifying novel pharmacological targets on the genome of its obligate endosymbiotic bacterium Candidatus Erwinia dacicola. Three genes were selected as pharmacological targets. The 3D models of the Helicase, Polymerase, and Protease-C gene products were designed and subsequently optimized by means of molecular dynamics simulations. Successively, a series of structure-based pharmacophore...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Regulation and Roles of Autophagy in the Brain.
Authors: Tavernarakis N Abstract Autophagy is crucial for neuronal integrity. Loss of key autophagic components leads to progressive neurodegeneration and structural defects in neuronal synapses. However, the molecular mechanisms regulating autophagy in the brain remain elusive. Similarly, while it is widely accepted that protein turnover is required for synaptic plasticity, the contribution of autophagy to the degradation of synaptic proteins is unknown. We find that BDNF signaling via the tropomyosin receptor kinase B (TrkB) and the phosphatidylinositol 3-kinase (PI3K)/Akt pathway suppresses autophagy in vivo. Au...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Three-Dimensional Models for Studying Neurodegenerative and Neurodevelopmental Diseases.
Authors: Tsaridou S, Skamnelou M, Iliadou M, Lokka G, Parlapani E, Mougkogianni M, Danalatos RI, Kanellou A, Chlorogiannis DD, Kyrousi C, Taraviras S Abstract Human brain possesses a unique anatomy and physiology. For centuries, methodological barriers and ethical challenges in accessing human brain tissues have restricted researchers into using 2-D cell culture systems and model organisms as a tool for investigating the mechanisms underlying neurological disorders in humans. However, our understanding regarding the human brain development and diseases has been recently extended due to the generation of 3D brain or...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Assessment of Factors Contributing to the Enhancement of Memory and Cognitive Abilities in the Context of Neurosciences.
Authors: Ktenas S Abstract The purpose of this paper is to present a brief on the evaluation of factors which contribute to cognitive ability enhancement under the spectrum of neuroscience, through the bibliographical research of scientific literature. The human brain has many possibilities, but it remains a largely uncharted area, which we just begin to understand in detail. One of its potentials, as concluded by the research, is its ability to adapt and improve its functioning by itself. Based on this physiological function, we can improve our ability to learn and remember, but we currently have limited resources...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Buccal Mucosa Biomarkers in Alzheimer's Disease.
Authors: Avramouli A, Vlamos P Abstract Alzheimer's disease (AD) precipitation in the elderly population increases the need for sensitive biomarkers that can be applied to large population screening. Buccal cells can be obtained easily, noninvasively, and contain many proteins related to cerebral processes. Hence, they offer an ideal candidate for AD biomarker discovery. The purpose of this study is to provide an overview of the current research landscape covering both clinical and methodological issues. A brief summary is given on related laboratory techniques to ascertain protein concentration changes due to AD. ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Engaging Social Interest and Creating Awareness for the Behavioural and Psychological Symptoms of Dementia.
Authors: Newman K Abstract Novel multimodal sensing study that has been installed and tested in a geriatric psychiatry inpatient unit is reviewed. Perspectives and experiences of behavioural and psychological symptoms of dementia are also examined. Further, the Spare a Thought for Dementia Through the Your Story My Story campaign, a project that seeks to amplify empowering stories from persons living with dementia and their friends and family carers in order to combat stigma and show carers that they are not alone in their journeys, is also discussed. PMID: 32468459 [PubMed - in process] (Source: Advances in Ex...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Structural Study of the DNA: Clock/Bmal1 Complex Provides Insights for the Role of Cortisol, hGR, and HPA Axis in Stress Management and Sleep Disorders.
Authors: Raftopoulou S, Nicolaides NC, Papageorgiou L, Amfilochiou A, Zakinthinos SG, George P, Eliopoulos E, Chrousos GP, Vlachakis D Abstract Herein, we deploy an in silico pipeline of structural bioinformatics, thermodynamics, and molecular dynamics to investigate the role of cortisol in circadian rhythms, biorhythms, stress response, and even sleep disorders. Our study shows that high concentrations of cortisol intercalate in the minor groove of DNA. This phenomenon widens the adjacent major grooves and provides the Clock/Bmal1 complex with more space to dock and interact with DNA. Then, the strong charges of c...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Effects of Quantum Entanglement on Chromatin and Gene Expression.
Authors: Harney M Abstract Quantum entanglement has recently been demonstrated in macroscopic structures at the scale of microns. The densely packed chromatin that efficiently stores DNA strands may allow for gene expression through epigenetic modifiers within the close proximity of nearby strands and may also experience gene expression through quantum entanglement of epigenetic modifiers. Such an approach may have an evolutionary advantage in the densely packed realm of chromatin. PMID: 32468461 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Olive Oil Polyphenols in Neurodegenerative Pathologies.
Authors: Salis C, Papageorgiou L, Papakonstantinou E, Hagidimitriou M, Vlachakis D Abstract Neurodegenerative diseases lead to the death of nerve cells in the brain or the spinal cord. A wide range of diseases are included within the group of neurodegenerative disorders, with the most common ones being dementia, Alzheimer's, and Parkinson's diseases. Millions of older people are suffering from such pathologies. The global increase of life expectancy unavoidably leads to a consequent increase in the number of people who will be at some degree affected by neurodegenerative-related diseases. At this moment, there is n...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Human Pluripotent Stem Cells as In Vitro Models of Neurodegenerative Diseases.
Authors: Machairaki V Abstract My main research focused in the last years has been the reprogramming of differentiated cell types, such as human fibroblasts, into pluripotent stem cells called induced pluripotent stem cells (iPSCs) and the application of this technology to studies of the nervous system and the diseases that affect it. We have been working on the generation of iPSC lines from Alzheimer's disease (AD) patients using recent developments in reprogramming strategies such as non-integrating episomal vectors to produce virus-free, clinical safe hiPSC. Our study shows that neurons differentiated from these...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Nutritional Lipidomics in Alzheimer's Disease.
Authors: Kalli E Abstract Lipids constitute almost 60% of the brain's dry weight, and they are thought to be involved in inflammation, neurotransmission and synaptic plasticity. The brain mostly contains sphingolipids, glycerophospholipids and cholesterol which are abundant in myelin and neuronal membranes. The recent rise of the promising area of lipidomic data can be used as a diagnosing tool at the early stages of Alzheimer's disease allowing novel therapeutic targets. In this review, altered lipid metabolites as well as the impact of diet in the progress of Alzheimer's disease (AD) are analyzed. PMID: 32468...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Stress and Wellbeing of Psychiatry Trainees: A Literature Review.
Authors: Lai R, Plakiotis C Abstract Medical training in Australia has been clouded in recent times by media reporting on the tragic suicides of multiple trainees. This has brought attention to the stressful demands of the medical profession and the often-poor wellbeing of trainees, who must balance both study and work demands. Psychiatry trainees in particular face unique stressors in the workplace, being in a profession that carries a high emotional burden. Psychiatry trainees encounter suicides by patients and colleagues at an alarmingly high rate and commonly experience isolation, unrealistic workloads and stig...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Brief Cognitive Tests in the Case of Dementia and Alzheimer's Disease Early Diagnosis.
The objective of this review study is to highlight the effectiveness of brief cognitive tests (BCT) in the case of dementia and Alzheimer's disease screening. Authors' future work will focus on the application of BCT in MCI diagnosis and evaluation. PMID: 32468467 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Synthesis, Molecular Docking Studies and Biological Evaluation of N-Acylarylhydrazones as Anti-Inflammatory Agents.
Authors: Devi TS, Rajitha G, Swathi K, Sudheer Kumar K, Umamaheswari A Abstract In the present work a series of N'-arylidene-2-(benzamido)-3-(naphthalen-2-yl)acrylohydrazides were synthesized by refluxing the intermediate 2-(benzamido)-3-(naphthalen-2-yl)acrylohydrazide with various substituted benzaldehyde in the presence of glacial acetic acid. The intermediate 2-(benzamido)-3-(naphthalen-2-yl)acrylohydrazide 2 was prepared by stirring 4-((naphthalen-2-yl)methylene)-2-phenyloxazol-5(4H)-one with hydrazine hydrate in the presence of absolute ethanol. The chemical structures of the compounds were established by IR,...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Exosome Biomarkers Revolutionize Preclinical Diagnosis of Neurodegenerative Diseases and Assessment of Treatment Responses in Clinical Trials.
Authors: Kapogiannis D Abstract Alzheimer's disease and other neurodegenerative diseases have long preclinical phases with active and progressively irreversible pathology. Therefore, biomarkers are essential for identifying patients early in the course of these diseases, when they may benefit the most from disease-modifying interventions. A limitation of biomarkers measured in the soluble phase of blood is their tenuous link to brain pathology. A new approach to biomarker discovery that addresses this limitation is deriving extracellular vesicles (EVs) enriched for neuronal and astrocytic origin from peripheral blo...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Biomarkers as a Different Approach in Prevention and Treatment of Drug Addiction (Preliminary Study).
CONCLUSION: The literature in the area of addiction is growing rapidly; however, the results are still mixed. Given the complexity of the problem, the goal should be the discovery of a minimal invasive and inexpensive diagnostic procedure to identify a prognostic and therapeutic target. The correlation of the expression of biomarkers on buccal cells could be valuable for the design of predictive and therapeutic strategies. PMID: 32468470 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Sleep Disorders and Restless Legs Syndrome in Hemodialysis Patients in Greece: A Cross-Sectional Study.
CONCLUSIONS: Sleep disorders are common symptoms among hemodialysis patients. The restless legs syndrome occurs at a lower frequency among hemodialysis patients but is a major problem for them. PMID: 32468471 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Craniofacial and Neurological Phenotype in a Patient with De Novo 18q Microdeletion and 18p Microduplication.
CONCLUSION: Almost all patients' clinical features were associated with 18q- syndrome. There are very few reported cases with similar genotype possibly caused by a de novo unequal recombination mechanism. PMID: 32468472 [PubMed - in process] (Source: Advances in Experimental Medicine and Biology)
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

What Do Recent Clinical Trials Teach Us About the Etiology of AD.
Authors: Robakis NK Abstract Alzheimer's disease (AD) is the most common type of dementia caused by severe neurodegeneration in the hippocampus and neocortical regions of the brain. In addition to neurodegeneration, AD brains contain high levels of amyloid plaques (APs) and neurofibrillary tangles (NFTs) which are used as neuropathological hallmarks of the disorder. Despite intense research efforts, the mechanism(s) of the AD neurodegeneration are imperfectly understood, hampering efforts for the development of efficient therapeutics. Furthermore, failure of clinical trials to benefit AD patients suggests that AD h...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Developmental Biology and Transgenic Avian Embryology: Body Alterity Bioart Wet Lab.
Authors: Zaretsky A Abstract Public experimental embryology opens a relationship between an embryo and an amateur transgenic designer. Artists produce real-world effects by forcing hereditary aesthetics on developing bodies. This lab was meant to aid in public understanding of the relationship between transgenics and aesthetics. How do we to take an active and hands-on tactical stance on the role of hereditary designer and how does this help in public analysis of the bioethics of genetic engineering. Through naming and funeral rites, we assign the embryos an uncertain amount of clout or cultural worth. This lab is ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Gene Editing, Sexual Reproduction, and the Arts: The Present, the Future, and the Imagined.
Authors: Buiani R Abstract In recent years, popular culture has been graced with countless news announcing novel developments in genome editing. While many experiments are still in their early stages, genome editing seems very promising. Often betraying a sensationalist and triumphant tone, news coverage focuses on the potentials that these developments will have for the advancement of the human species, i.e., the eradication of disease, the extension of life, the improvement of the body and its appearance, etc. The future looks hopeful and unproblematic according to these accounts. On the opposite end of the spect...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Amyotrophic Lateral Sclerosis: Current Status in Diagnostic Biomarkers.
Authors: Kadena K, Vlamos P Abstract Amyotrophic lateral sclerosis (ALS) is a rare, neurodegenerative disease that affects the human motor system. ALS is a highly heterogeneous disease, depending on several causative factors. The heterogeneity of the disease is also reflected in the variation of the symptoms in ALS patients. The worldwide annual incidence of ALS is about 2.08 per 100,000 with uniform rates in Caucasian populations and lower rates in African, Asian, and Hispanic populations, while the number of individuals with ALS is expected to grow significantly between 2015 and 2040 with an estimated increase of...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Synthesis and Characterization of Biologically Significant 5-[N,N-dialkylamino alkoxy] azaindole 2-one, 3-thiosemicarbazones and 5-[N,N-dialkylamino alkoxy] azaindole 3-hydrazone, 2-ones.
Authors: Swathi K, Rajitha G, Sarangapani M Abstract In the present work, new indole derivatives, i.e., 5-[N,N-di alkyl amino alkoxy] azaindole 2,3- di-one derivatives, are synthesized and characterized. These compounds were subjected to acute toxicity and then screened for antiepileptic activity on maximal electroshock seizure (MES) model in albino Wistar rats. In that study 5-[2-dimethyl amino ethoxy] Azaindole-3-hydrazone,2-one and 5-[2- dimethyl amino ethoxy] Azaindole 2-one,3-thiothiosemicarbazone(IIIa) showed good antiepileptic activity and less neurotoxicity compared to phenytoin. The purpose of the present ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Genetic Counseling for Adult-Onset Spinal and Bulbar Muscular Atrophy (Kennedy Syndrome): Multiple Cases of Prenatal Testing in a Family.
Authors: Yapijakis C, Laskaratos A, Angelopoulou A, Voumvourakis C Abstract X-linked spinal and bulbar muscular atrophy (SBMA), also known as Kennedy syndrome, is an adult-onset neurodegenerative disorder characterized by slowly progressive muscle atrophy and other severe symptoms gradually leading to reduced mobility and ultimately to death due to respiratory failure. Two decades ago we reported the first prenatal diagnosis of SBMA worldwide. Here we present a Greek family in which we have performed seven prenatal DNA tests for SBMA mutation after extensive genetic counseling. Since there is not yet a cure for SBM...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis.
Authors: Krokidis MG Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive and selective loss of motor neurons, muscle weakness, paralysis and death. The pathogenesis of ALS is not clearly understood, while reliable prognostic markers have not been identified to detect symptoms at earlier time points. The rapid development of microarray technology offers great potential for simultaneous analysis of the transcriptional expression of thousands of genes, aiming to determine novel candidate targets for efficient treatment. Additionally, metabolomics, as a high-throughpu...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Ocimum Sanctum Linn: A Potential Adjunct Therapy for Hyperhomocysteinemia-Induced Vascular Dementia.
In this study, the EEOS treatment in hyperhomocysteinemic rats has showed significant improvement in spatial learning and working memory performance. The EEOS treatment further increased nitric oxide bioavailability and significantly altered all serum and brain biochemical parameters in a dose-dependent manner. The docking analysis revealed that among all the phytoconstituents of Ocimum sanctum compound (IX), molludistin has showed good inhibitory activity against S-adenosyl homocysteine, thus preventing homocysteine formation and may be responsible for potential effects of EEOS against HHcy-induced VaD. From our results, ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Alzheimer's Disease: The Role of Mutations in Protein Folding.
Authors: Polychronidou E, Avramouli A, Vlamos P Abstract Misfolded proteins result when a protein follows the wrong folding pathway. Accumulation of misfolded proteins can cause disorders, known as amyloid diseases. Unfortunately, some of them are very common. The most prevalent one is Alzheimer's disease. Alzheimer's disease is a neurodegenerative disorder and the commonest form of dementia. The current study aims to assess the impact of somatic mutations in PSEN1 gene. The said mutations are the most common cause of familial Alzheimer's disease. As protein functionality can be affected by mutations, the study of ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Regulatory Role of MicroRNAs in Brain Development and Function.
Authors: Yapijakis C Abstract MicroRNAs (miRNAs) are small non-coding RNA molecules of about 20-22 nucleotides. After their posttranscriptional maturation, miRNAs are loaded into the ribonucleoprotein complex RISC and modulate gene expression by binding to the 3' untranslated region of their target mRNAs through base-pairing, which in turn triggers mRNA degradation or translational inhibition. There is mounting evidence that miRNAs regulate various biological processes, including cell proliferation, differentiation, and apoptosis. Several studies have shown that miRNAs play an important role in neurogenesis and bra...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Misfolding of Proteins.
Authors: Argyrou A Abstract Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's, and many others. The recent advances in the research of protein folding include computational models for the prediction of protein folding with enough accuracy. In order to understand the process of protein misfolding, a synopsis of the pro...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

S-MEDUTA: Combining Balanced Scorecard with Simulation and MCDA Techniques for the Evaluation of the Strategic Performance of an Emergency Department.
Authors: Manolitzas P, Grigoroudis E, Christodoulou J, Matsatsinis N Abstract The scope of this paper is to propose a new integrated methodology for the evaluation of the strategic performance of a healthcare organization. In order to find the optimal strategy for an emergency department, we propose the combination of BSC, simulation, and UTASTAR algorithm. Through the simulation model, the stakeholders have the ability to evaluate the effect of their decisions on a number of KPIs that are important for the successful implementation of strategy on the ED. This method is able to provide a set of completed results (e...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

An Architecture for Cooperative Mobile Health Applications.
Authors: Drakopoulos G, Mylonas P, Sioutas S Abstract Mobile health applications are steadily gaining momentum in the modern world given the omnipresence of various mobile or Wi-Fi connections. Given that the bandwidth of these connections increases over time, especially in conjunction with advanced modulation and error-correction codes, whereas the latency drops, the cooperation between mobile applications becomes gradually easier. This translates to reduced computational burden and heat dissipation for each isolated device but at the expense of increased privacy risks. This chapter presents a configurable and sca...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

An Educational Scenario for the Learning of the Conic Section: Studying the Ellipse with the Use of Digital Tools and Elements of Differentiated Instruction and Cognitive Neurosciences.
This study presents an educational scenario for the learning of the conic section, the ellipse. The scenario was designed based on the results of neuroeducation research and upon the principles of differentiated instruction. The proposition includes utilization of multiple representational tools as well as several tangible tools, the use of which can support the context of differentiated instruction according to the principles of cognitive neurosciences. In addition, it includes a large number of activities derived from the real world and other disciplines. The proposed scenario lasts four teaching periods, during which st...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Antibody Clustering Using a Machine Learning Pipeline that Fuses Genetic, Structural, and Physicochemical Properties.
Authors: Papageorgiou L, Maroulis D, Chrousos GP, Eliopoulos E, Vlachakis D Abstract Antibody V domain clustering is of paramount importance to a repertoire of immunology-related areas. Although several approaches have been proposed for antibody clustering, still no consensus has been reached. Numerous attempts use information from genes, protein sequences, 3D structures, and 3D surfaces in an effort to elucidate unknown action mechanisms directly related to their function and to either link them directly to diseases or drive the discovery of new medicines, such as antibody drug conjugates (ADC). Herein, we describ...
Source: Advances in Experimental Medicine and Biology - May 31, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research